Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury

Molecular Nutrition and Food Research

Volumn 55, Issue 9, 2011, Pages 1423-1434

  Fabisiak, James P ^a   Medvedovic, Mario ^b   Alexander, Danny C ^c   McDunn, Jonathan E ^c   Concel, Vincent J ^a   Bein, Kiflai ^a   Jang, An Soo ^a,d   Berndt, Annerose ^e   Vuga, Louis J ^f   Brant, Kelly A ^a   Pope Varsalona, Hannah ^a   Dopico, Richard A ^a   Ganguly, Koustav ^a   Upadhyay, Swapna ^a   Li, Qian ^b   Hu, Zhen ^b   Kaminski, Naftali ^f   Leikauf, George D ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c METABOLON INC   (United States)

^d Soonchunhyang University   (South Korea)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Oxidation; ARDS; Mitochondrion; Protein folding; Smoke inhalation

Indexed keywords

ACROLEIN; ENZYME; TRANSCRIPTOME;

ACUTE LUNG INJURY; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEMALE; GENE EXPRESSION PROFILING; GENETICS; LUNG; METABOLISM; METABOLOME; MOUSE; MOUSE STRAIN;

ACROLEIN; ACUTE LUNG INJURY; ANIMALS; ENZYMES; FEMALE; GENE EXPRESSION PROFILING; LUNG; METABOLOME; MICE; MICE, INBRED STRAINS; TRANSCRIPTOME;

MUS; NICOTIANA TABACUM;

EID: 80052537544     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100291     Document Type: Article

References (58)

1. Malo, D., Vogan, K., Vidal, S., Hu, J. et al., Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites. Genomics 1994, 23, 51-61.
2. Skamene, E., Schurr, E., Gros, P., Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections. Ann. Rev. Med. 1998, 49, 275-287.
3. Jaboda, N., Jankowski, A., Dougaparsad, S., Picard, V. et al., Natural resistance to intracellular infections: natural resistance-associated protein 1 (NRAMP1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J. Exp. Med. 2000, 192, 1237-1247.
4. Poltorak, A., He, X., Smirnova, I., Liu, M. Y. et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScSr mice: mutations in Tlr4 gene. Science 1998, 282, 2085-2088.
5. Liu, P., Wang, Y., Vikis, H., Maciag, A. et al., Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat. Genet. 2006, 38, 888-895.
6. Leikauf, G. D., Concel, V. J., Liu, P., Bein, K. et al., Haplotype association mapping of acute lung injury in mice implicates activin A receptor, type 1. Am. J. Respir. Crit. Care Med. 2011 183, 1499-1509.
7. German, J. B., Hammock, B. D., Watkins, S. M., Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 2005, 1, 3-9.
8. Nicholson, J. K., Connelly, J., Lindon, J. C., Holmes, E., Metabolomics: a platform for studying drug toxicity and gene function. Nat. Rev. Drug Discov. 2002, 1, 153-161.
9. Roessner, U., Browne, J., What is metabolomics all about? Biotechniques 2009, 46, 363-365.
10. Wishart, D. S., Knox, C., Guo, A. C., Eisner, R. et al., HMDB: a knowledge base of the human metabolome. Nucl. Acids Res. 2009, 37, D603-D610.
11. Lundy, C. T., Shield, J. P. H., Kvittingen, E. A., Vinorum, O. J. et al., Acute respiratory distress syndrome in long-chain 3-hydroxyacyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies. J. Inherit. Metab. Dis. 2003, 26, 537-541.
12. Leikauf, G. D., Leming, L. M., O'Donell, J. R., Doupnik, C. A., Bronchial responsiveness and inflammation in guinea pigs exposed to acrolein. J. Appl. Physiol. 1989, 66, 171-178.
13. Evans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M., Milgram, E., Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal. Chem. 2009, 81, 6656-6657.
14. Lawton, K. A., Berger, A., Mitchell, M., Milgram, K. E. et al., Analysis of the adult plasma metabolome. Pharmacogenomics 2008, 9, 383-397.
15. Strittmatter, E. F., Ferguson, P. L., Tang, K., Smith, R. D., Proteome analyses using accurate mass and elution time peptide tags with capillary LC time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom. 2003, 14, 980-991.
16. Dehaven, C. D., Evans, A. M., Dai, H., Lawton, K. A., Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J. Cheminform. 2010, 2, 9.
17. 1H-nuclear magnetic resonance quantitative metabolomics and computional analysis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2011, 300, L4-L11.
18. Tang, M., Zhang, T., Xue, Y., Wang, S. et al., Dose-dependent in vivo metabolic characteristics of titanium dioxide nanoparticles. J. Nanosci. Nanotechnol. 2010, 10, 8575-8583.
19. Kramer, M. G., Vaughn, T. T., Pletscher, L. S., King-Ellison, E. et al., Genetic variation in body weight growth and composition in the intercross large (LG/J) and small (SM/J) inbred strains of mice. Genet. Mol. Biol. 1998, 21, 211-218.
20. Womack, J. E., Yan, D. L., Potier, M., Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotroic effects on multiple hydrolases. Science 1981, 212, 63-65.
21. Engel, D., Clark, E. A., Held, L., Kimball, H., Clagett, J., Immune responsiveness of SM/J mice. Cellular characteristics and genetic analysis of hyperresponsiveness to B cell mitogens. J. Exp. Med. 1981, 154, 726-736.
22. Gratton, M. A., Eleftheriadou, A., Garcia, J., Verduzco, E. et al., Noise-induced changes in gene expression in the cochlaeae of mice differing in their susceptibility to noise damage. Hear. Res. 2011, 277, 211-226.
23. Prows, D. R., Hafertepen, A. P., Gibbons, W. J., Jr., Winterberg, A. V., Nick, T. G., A genetic mouse model to investigate hyperoxic acute lung injury survival. Physiol. Genomics 2007, 30, 262-270.
24. Vancza, E. M., Galdanes, K., Gunnison, A., Hatch, G., Gordon, T., Age, strain, and gender as factors for increased sensitivity of the mouse lung to inhaled ozone. Toxicol. Sci. 2009, 107, 535-543.
25. Sharma, S., Black, S. M., Carnitine homeostasis, mitochondrial function, and cardiovascular disease. Drug Discov. Today Dis. Mech. 2009, 6, e-31-e-39.
26. Bremer, J., Carnitine - metabolism and function. Physiol. Rev. 1983, 63, 1420-1480.
27. Kerner, J., Hoppel, C., Fatty acid import into mitochondria. Biochim, Biophys. Acta 2000, 1486, 1-17.
28. Lysiak, W., Lilly, K., diLisa, F., Toth, P. P., Bieber, L. L., Quantification of the effect of L-carnitine on the levels of acid soluble short-chain acyl CoA and CoA in rat heart and liver mitochondria. J. Biol. Chem. 1988, 269.
29. Rinaldo, P., Cowan, T. M., Matern, D., Acylcarnitine profile analysis. Genet. Med. 2008, 10, 151.
30. Saggerson, D., Malonyl-CoA, a key signaling molecule in mammalian cells. Ann. Rev. Nutr. 2008, 28, 253-272.
31. Paulson, D. J., Ward, K. M., Shug, A. L., Malonyl CoA inhibition of carnitine palmitoyltrasferase in rat heart mitochondria. FEBS Lett. 1984, 176, 381-384.
32. Rasmussen, B. B., Holmback, U. C., Volpi, E., Morio-Liondore, B. et al., Malonyl coenzyme A and regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J. Clin. Invest. 2002, 110, 1687-1693.
33. +, bivalent metal ions, and malonyl CoA. Biochem. J. 1982, 202, 397-405.
34. Cinti, D. L., Cook, L., Nagi, M. N., Suneja, S. K., The fatty acid chain elongation system in mammalian endoplasmic reticulum. Prog. Lipid Res. 1992, 31, 1-51.
35. Cheverud, J., Pletscher, L. S., Vaughn, T. T., Marshall, B., Differential response to dietary fat in large (LG/J) and small (SM/J) inbred mouse strains. Physiol. Genomics 1999, 1, 33-39.
36. Paul, H. S., Adipi, S. A., Effect of carnitine on branched chain amino acid oxidation. J. Clin. Chem. Biochem. 1978, 234, E494-E499.
37. Platell, C., Kong, S.-E., McCauley, R., Hall, J. C., Branched-chain amino acids. J. Gastroenterol. Hepatol. 2000, 15, 706-717.
38. Ferrando, A. A., Williams, B. D., Stuart, C. A., Lane, H. W., Wolfe, R. R., Oral branched-chain amino acids decrease whole-body proteolysis. J. Parenteral Enteral Nutr. 1995, 19, 47-54.
39. Shinnick, F. L., Harper, A. E., Branched-chain amino acid oxidation in isolated rat tissue preparations. Biochim. Biophys. Acta 1976, 437, 477-486.
40. Lehninger, A. L., Biochemistry: The Molecular Basis of Cell Structure and Function. Worth Publishers, New York 1975.
41. Kemp, R. G., Foe, L. G., Allosteric regulatory properties of muscle phosphofructokinase. Mol. Cell. Biochem. 1983, 57, 147-154.
42. Yin, H., Jin, X. B., Gong, Q., Yang, H. et al., Fructose-1, 6-diphosphate attenuates acute lung injury induced by lipopolysaccharide in mice. Int. Immunolpharmacol. 2008, 8, 1842-1847.
43. Shibamoto, T., Parker, J. C., Fructose-1, 6-diphosphate augments paraquat injury in isolated dog lungs. J. Appl. Physiol. 1991, 71, 1830-1835.
44. Sillero, M. A. G., Sillero, A., Sols, A., Enzymes involved in fructose metabolism in liver and the glyceraldehyde metabolic crossroads. Eur. J. Biochem. 1969, 10, 345-350.
45. Ehrich, T. H., Kenney-Hunt, J. P., Pletscher, L. S., Cheverud, J. M., Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from divergent growth lines. Genet. Res. Camb. 2005, 85, 211-222.
46. Ehrich, T. H., Hrbek, T., Kenney-Hunt, J. P., Pletscher, L. S. et al., Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes 2005, 54, 1863.
47. Towler, M. C., Hardie, D. G., AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 2007, 100, 328-341.
48. Park, H., Kaushik, V., Constant, S., Prentki, M. et al., Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J. Biol. Chem. 2002, 277, 32571-32577.
49. Ruderman, N., Park, H., Kaushik, V., AMPK as a metabolic switch in rat muscle, liver, and adipose tissue after exercise. Acta Physiol. Scand. 2003, 178, 435-442.
50. Saha, A. K., Schwarsin, A. J., Roduit, R., Masse, F. et al., Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and AMP-activated protein kinase activator 5-aminoimidazole-4-carboxaminde-1-beta-D-ribofuranoside. J. Biol. Chem. 2000, 275, 24279-24283.
51. Chesney, J., 6-Phosphofructo-2-kinase/fructose-2, 6-bisphosphotase and tumor cell glycolysis. Curr. Opin. Clin. Nutr. Metab. Care 2006, 9, 535-539.
52. Almeida, A., Moncada, S., Bolanos, J. P., Nitric oxide switches on glycoloysis through AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat. Cell Biol. 2004, 6, 45-51.
53. Pontremoli, S., Melloni, E., Viotti, P. L., Michetti, M. et al., Isovalerylcarnitine is a specific activator of high calcium requiring calpain forms. Biochem. Biophys. Res. Commun. 1990, 167, 373-380.
54. Ferrara, F., Bertelli, A., Falchi, M., Evaluation of carnitine, acetylcarnitine, and isovalerylcarnitine on immune function and apoptosis. Drugs Exp. Clin. Res. 2005, 31, 109-114.
55. Delaney, J., Neville, W. A., Swain, A., Miles, A. et al., Phenylacetylglycine, a putative biomarker of phospholipidosis: its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model. Biomarkers 2004, 9, 271-290.
56. Wu, Y. C., Hsu, P. K., Su, K. C., Liu, L. Y. et al., Bile acid aspiration in suspected ventilator-associated pneumonia. Chest 2009, 136, 118-124.
57. Zecca, E., De Luca, D., Baroni, S., Vento, G. et al., Bile acid-induced lung injury in newborn infants: a bronchoalveolar lavage fluid study. Pediatrics 2008, 121, e146-e149.
58. Thomas, C., Gioiello, A., Noriega, L., Strehle, A. et al., TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009, 10, 167-177.