Identification of 5′ AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol

Journal of Biological Chemistry

Volumn 289, Issue 22, 2014, Pages 15449-15462

  Shearn, Colin T ^a   Backos, Donald S ^a   Orlicky, David J ^a   Smathers McCullough, Rebecca L ^b   Petersen, Dennis R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYLATION;

AMP-ACTIVATED KINASE; AMPK ACTIVITY; HEPATOCELLULAR; LIVER DISEASE; MURINE MODEL; REDUCING ACTIVITY;

ALDEHYDES;

4 HYDROXYNONENAL; 5 AMINOIMIDAZOLE 4 CARBOXYAMIDE RIBONUCLEOSIDE; 5' AMP ACTIVATED KINASE; 5' AMP ACTIVATED KINASE ALPHA; 5' AMP ACTIVATED KINASE BETA; ACETYL COENZYME A CARBOXYLASE; ALCOHOL; ALDEHYDE DERIVATIVE; BIOTIN HYDRAZIDE; CYSTEINE; HYDRAZIDE; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; RECOMBINANT ENZYME; RIBONUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; 4-HYDROXY-2-NONENAL; ALDEHYDE; CENTRAL DEPRESSANT AGENT; CYSTEINE PROTEINASE INHIBITOR;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; MALE; MICHAEL ADDITION; MOLECULAR MODEL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; AMP-ACTIVATED KINASE (AMPK); ANIMAL; C57BL MOUSE; CHEMICAL MODEL; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; FATTY LIVER; HEPG2 CELL LINE; LIVER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ALCOHOL; AMP-ACTIVATED KINASE (AMPK); LIPID PEROXIDATION; LIVER; OXIDATIVE STRESS;

ALDEHYDES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; ETHANOL; FATTY LIVER; HEP G2 CELLS; HUMANS; LIPID PEROXIDATION; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN CARBONYLATION; SIGNAL TRANSDUCTION;

EID: 84901724383     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.543942     Document Type: Article

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