Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality

Journal of Neuroscience

Volumn 37, Issue 48, 2017, Pages 11688-11700

  Metzger, Michael W ^a   Walser, Sandra M ^a   Dedic, Nina ^a   Aprile Garcia, Fernando ^b,h   Jakubcakova, Vladimira ^a   Adamczyk, Marek ^a   Webb, Katharine J ^a   Uhr, Manfred ^a   Refojo, Damian ^a,b   Schmidt, Mathias V ^a   Friess, Elisabeth ^a   Steiger, Axel ^a   Kimura, Mayumi ^a   Chen, Alon ^a,c   Holsboer, Florian ^a,i   Arzt, Eduardo ^a,b   Wurst, Wolfgang ^d,e,f,g   Deussing, Jan M ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^g UNIVERSITY OF MUNICH   (Germany)

^h MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

ⁱ HMNC Brain Health   (Germany)

Author keywords

Humanized mouse model; Mood disorder; P2X7 receptor; Purinergic signaling; Sleep; Stress

Indexed keywords

ARGININE; GLUTAMINE; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC SOCIAL DEFEAT STRESS TEST; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DARK LIGHT BOX TEST; ELECTROENCEPHALOGRAPHY; ELEVATED PLUS MAZE TEST; EXPERIMENTAL BEHAVIORAL TEST; FORCED SWIM TEST; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOSITY; HIPPOCAMPAL CA3 REGION; IN SITU HYBRIDIZATION; MALE; MOOD DISORDER; MOUSE; NONHUMAN; OPEN FIELD TEST; PHENOTYPE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLEEP PARAMETERS; SLEEP QUALITY; SLEEP WAKING CYCLE; SOCIAL AVOIDANCE BEHAVIOR; URINE SNIFFING TEST; 129 MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETIC VARIATION; GENETICS; HETEROZYGOTE; HIPPOCAMPUS; HUMAN; PHYSIOLOGY; SLEEP; TRANSGENIC MOUSE;

ANIMALS; ARGININE; CELLS, CULTURED; GENETIC VARIATION; GLUTAMINE; HETEROZYGOTE; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MOOD DISORDERS; RECEPTORS, PURINERGIC P2X7; SLEEP;

EID: 85036568063     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3487-16.2017     Document Type: Article

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