Predisposition Locus for Major Depression at Chromosome 12q22-12q23.2

American Journal of Human Genetics

Volumn 73, Issue 6, 2003, Pages 1271-1281

  Abkevich, Victor ^a   Camp, Nicola J ^b,f   Hensel, Charles H ^a   Neff, Chris D ^a   Russell, Deanna L ^a   Hughes, Dana C ^b   Plenk, Agnes M ^c   Lowry, Michael R ^b,f   Richards, R Lynn ^e   Carter, Catherine ^d   Frech, Georges C ^a   Stone, Steven ^a   Rowe, Kerry ^b   Chau, Chi Ai ^b   Cortado, Kathleen ^b   Hunt, Angelene ^b   Luce, Karanina ^b   O'Neil, Gayanne ^b   Poarch, Jeff ^b   Potter, Jennifer ^a   Poulsen, Gregg H ^b   Saxton, Heidi ^d   Bernat Sestak, Michelle ^b   Thompson, Victor ^a   Gutin, Alexander ^a   Skolnick, Mark H ^a   Shattuck, Donna ^a   Cannon Albright, Lisa ^b   more..

^a Myriad Genetic Laboratories   (United States)

^b INTERMOUNTAIN HEALTHCARE   (United States)

^c Children's Center   (United States)

^d Valley Mental Health   (United States)

^e University of Utah ^*

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 12Q; CHROMOSOME IDENTIFICATION; CHROMOSOME MARKER; CONTROLLED STUDY; ECONOMIC ASPECT; FAMILIAL DISEASE; FAMILY HISTORY; FEMALE; GENE; GENE LOCUS; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOME; HEALTH CARE COST; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MICROSATELLITE MARKER; PEDIGREE; PRIORITY JOURNAL; SCREENING; SEX DIFFERENCE; UNITED STATES;

EID: 9144235671     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/379978     Document Type: Article

References (54)

1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edition. American Psychiatric Association, Washington, DC
2. Angst J, Angst F, Stassen HH (1999) Suicide risk in patients with major depressive disorder. J Clin Psychiatry 60 Suppl 2:57-62
3. Balciuniene J, Yuan QP, Engstrom C, Lindblad K, Nylander PO, Sundvall M, Schalling M, Pettersson U, Adolfsson R, Jazin EE (1998) Linkage analysis of candidate loci in families with recurrent major depression. Mol Psychiatry 3:162-168
4. Bertelsen A, Harvald B, Hauge M (1977) A Danish twin study of manic-depressive disorders. Br J Psychiatry 130:330-351
5. Blackwood DHR, Fordyce A, Walker MT, St. Clair DM, Porteous DJ, Muir WJ (2001) Schizophrenia and affective disorders - cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 69:428-433
6. Brownstein MJ, Carpten JD, Smith JR (1996) Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. Biotechniques 20:1004-1006, 1008-1010
7. Brzustowicz LM, Hodgkinson KA, Chow EWC, Honer WG, Bassett AS (2000) Location of major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288:678-682
8. Camp NJ, Neuhausen SL, Tiobech J, Polloi A, Coon H, Myles-Worsley M (2001) Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method. Am J Hum Genet 69:1278-1289
9. Cox N, Reich T, Rice J, Elston R, Schober J, Keats B (1989) Segregation and linkage analyses of bipolar and major depressive illnesses in multigenerational pedigrees. J Psychiatr Res 23:109-123
10. Craddock N, Owen M, Burge S, Kurian B, Thomas P, McGuffin P (1994) Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis). Br J Psychiatry 164:355-358
11. Davidson JR, Meltzer-Brody SE (1999) The underrecognition and undertreatment of depression: what is the breadth and depth of the problem? J Clin Psychiatry 60 Suppl 7:4-9
12. Degn B, Lundorf MD, Wang A, Vang M, Mors O, Kruse TA, Ewald H (2001) Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands. Mol Psychiatry 6:450-455
13. Detera-Wadleigh SD, Barden N, Craddock N, Ewald H, Foroud T, Kelsoe J, McQuillin A (1999) Chromosomes 12 and 16 workshop. Am J Med Genet 88:255-259
14. Ekholm JM, Kieseppa T, Partonen T, Paunio T, Perola M, Lonnqvist J, Peltonen L (2001) Genome-wide scan for predisposition loci for bipolar disorder in Finnish families; evidence for a locus on 4q28.3. Am J Med Genet 105:580-581
15. Englund SA, Klein DN (1990) The genetics of neurotic-reactive depression: a reanalysis of Shapiro's (1970) twin study using diagnostic criteria. J Affect Disord 18:247-252
16. Ewald H (2002) A genome wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Am J Med Genet 114:760
17. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Turri M, Fairburn C, Goodwin G, Neale MC, Fiddy S, Mott R, Allison DB, Flint J (2003) Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 72: 879-890
18. Göring HHH, Terwilliger JD (2000) Linkage analysis in the presence of errors I: Complex-valued recombination fractions and complex phenotypes. Am J Hum Genet 66:1095-1106
19. Greenberg PE, Stiglin LE, Finkelstein SN, Berndt ER (1993) The economic burden of depression in 1990. J Clin Psychiatry 54:405-418
20. Hirschfeld RM, Keller MB, Panico S, Arons BS, Barlow D, Davidoff F, Endicott J, Froom J, Goldstein M, Gorman JM, Marek RG, Maurer TA, Meyer R, Phillips K, Ross J, Schwenk TL, Sharfstein SS, Thase ME, Wyatt RJ (1997) The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. JAMA 277:333-340
21. Jones I, Jakobsen N, Green EK, Elvidge GP, Owen MJ, Craddock N (2002) Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's disease. Mol Psychiatry 7:424-427
22. Jorde LB, Skolnick MH (1981) Demographic and genetic application of computerized record linking: the Utah Mormon genealogy. Information et Sciences Humaines 56-57:105-117
23. Kelsoe JR (2003) Arguments for the genetic basis of the bipolar spectrum. J Affect Disord 73:183-197
24. Kendler KS, Gardner CO, Neale MC, Prescott CA (2001) Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychol Med 31:605-616
25. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 51:8-19
26. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlein A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K (2002) A high-resolution recombination map of the human genome. Nature Genet 31: 225-226
27. Kort EN, Ballinger DG, Ding W, Hunt SC, Bowen BR, Abkevich V, Bulka K, Campbell B, Capener C, Gutin A, Harshman K, McDermott M, Thorne T, Wang H, Wardell B, Wong J, Hopkins PN, Skolnick M, Samuels M (2000) Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23. Am J Hum Genet 66:1845-1856
28. Lander ES, Green P (1987) Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 84:2363-2367
29. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
30. Marazita ML, Neiswanger K, Cooper M, Zubenko GS, Giles DE, Frank E, Kupfer DJ, Kaplan BB (1997) Genetic segregation analysis of early-onset recurrent unipolar depression. Am J Hum Genet 61:1370-1383
31. Maziade M, Chagnon Y, Roy MA, Fournier A, Merette C (2002) A genome scan of extended French Canadian families affected by schizophrenia or bipolar disorder revealed common and specific susceptibility loci. Am J Med Genet 114: 858
32. McLellan T, Jorde LB, Skolnick MH (1984) Genetic distances between the Utah Mormons and related populations. Am J Hum Genet 36:836-857
33. Moldin SO, Reich T, Rice JP (1991) Current perspectives on the genetics of unipolar depression. Behav Genet 21:211-242
34. Morissette J, Villeneuve A, Bordeleau L, Rochette D, Laberge C, Gagne B, Laprise C, Bouchard G, Plante M, Gobeil L, Shink E, Weissenbach J, Barden N (1999) Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24. Am J Med Genet 88:567-587
35. Murray CJ, Lopez AD (1996) Evidence-based health policy: lessons from the Global Burden of Disease Study. Science 274:740-743
36. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
37. Pincus HA, Pettit AR (2001) The societal costs of chronic major depression. J Clin Psychiatry 62 Suppl 6:5-9
38. Robins LN, Regier DA (1991) Psychiatric disorders in America: the epidemiologic catchment area study. The Free Press, New York
39. Samuels ME, Forbey KC, Reid JE, Abkevich V, Bulka K, Wardell BR, Bowen BR, Hopkins PN, Hunt SC, Ballinger DG, Skolnick MH, Wagner S (2001) Identification of a common variant in the lipoprotein lipase gene in a large Utah kindred ascertained for coronary heart disease: the -93G/D9N variant predisposes to low HDL-C/high triglycerides. Clin Genet 59:88-98
40. Spak L, Spak F, Allebeck P (2000) Alcoholism and depression in a Swedish female population: co-morbidity and risk factors. Acta Psychiatr Scand 102:44-51
41. Spaner D, Bland RC, Newman SC (1994) Epidemiology of psychiatric disorders in Edmonton. Major depressive disorder. Acta Psychiatr Scand Suppl 376:7-15
42. Stone S, Abkevich V, Hunt SC, Gutin A, Russell DL, Neff CD, Riley R, Frech GC, Hensel CH, Jammulapati S, Potter J, Sexton D, Tran T, Gibbs D, Iliev D, Gress R, Bloomquist B, Amatruda J, Rae PMM, Adams TD, Skolnick MH, Shattuck D (2002) A major predisposition locus for severe obesity, at 4p15-p14. Am J Hum Genet 70:1459-1468
43. Sullivan PF, Neale MC, Kendler KS (2000) Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 157:1552-1562
44. Tanna VI, Wilson AF, Winokur C, Elston RC (1989) Linkage study of pure depressive disease. J Psychiatr Res 23:99-107
45. Tanna VI, Winokur C, Elston RC, Go RC (1976) A linkage study of pure depressive disease: the use of the sib-pair method. Biol Psychiatry 11:767-771
46. Thomas A, Gutin A, Abkevich V, Bansal A (2000) Multilocus linkage analysis by blocked Gibbs sampling. Statistics and Computing 10:259-269
47. Torgersen S (1986) Genetic factors in moderately severe and mild affective disorders. Arch Gen Psychiatry 43:222-226
48. Tsuang MT, Faraone SV, Green RR (1994) Genetic epidemiology of mood disorders. In: Papolos DF, Lachman HM (eds) Genetic studies in affective disorders. Wiley, New York
49. Weissman MM, Bruce ML, Leaf PJ, Florio LP, Hlozer C III (1991) Affective disorders. In: Robins LN, Regier DA (eds) Psychiatric disorders in America. Free Press, New York, pp 53-80
50. Wilcox MA, Faraone SV, Su J, Van Eerdewegh P, Tsuang MT (2002) Genome scan of three quantitative traits in schizophrenia pedigrees. Biol Psychiatry 52:847-854
51. World Health Organization (1990) Composite International Diagnostic Interview (CIDI), version 1.0. World Health Organization, Geneva
52. Zubenko GS, Hughes HB 3rd, Maher BS, Stiffler JS, Zubenko WN, Marazita ML (2002a) Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. Am J Med Genet 114:980-987
53. Zubenko GS, Hughes HB, Stiffler JS, Zubenko WN, Kaplan BB (2002b) Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10 cM resolution. Am J Med Genet 114:413-422
54. Zubenko GS, Zubenko WN, Spiker DG, Giles DE, Kaplan BB (2001) The malignancy of recurrent, early-onset major depression: a family study. Am J Med Genet 105:690-699