-
1
-
-
84977610683
-
Antiplasmodial activity and phytochemical analysis of extracts from selected Ugandan medicinal plants
-
Adia, M. M., Emami, S. N., Byamukama, R., Faye, I., and Borg-Karlson, A.-K. (2016). Antiplasmodial activity and phytochemical analysis of extracts from selected Ugandan medicinal plants. J. Ethnopharmacol. 186, 14–19. doi: 10.1016/j.jep.2016.03.047
-
(2016)
J. Ethnopharmacol
, vol.186
, pp. 14-19
-
-
Adia, M.M.1
Emami, S.N.2
Byamukama, R.3
Faye, I.4
Borg-Karlson, A.-K.5
-
2
-
-
80052703808
-
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. And its influence on artemisinin content
-
Alam, P., and Abdin, M. Z. (2011). Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content. Plant Cell Rep. 30, 1919–1928. doi: 10.1007/s00299-011-1099-6
-
(2011)
Plant Cell Rep
, vol.30
, pp. 1919-1928
-
-
Alam, P.1
Abdin, M.Z.2
-
3
-
-
84948403521
-
The effect of over-expression of rate limiting enzymes on the yield of artemisinin in Artemisia annua
-
Alam, P. Kamaluddin, Sharaf-Eldin, M. A., Elkholy, S. F., and Abdin, M. Z. (2016). The effect of over-expression of rate limiting enzymes on the yield of artemisinin in Artemisia annua. Rendiconti Lincei 27, 311–319. doi: 10.1007/s12210-015-0481-7
-
(2016)
Rendiconti Lincei
, vol.27
, pp. 311-319
-
-
Alam, P.K.1
Sharaf-Eldin, M.A.2
Elkholy, S.F.3
Abdin, M.Z.4
-
4
-
-
84962718314
-
Production of artemisinin and its derivatives in hairy roots of Artemisia dubia induced by rola gene transformation
-
Amanullah, B. M., Rizvi, Z. F., and Zia, M. (2016). Production of artemisinin and its derivatives in hairy roots of Artemisia dubia induced by rola gene transformation. Pak. J. Bot. 48, 699–706.
-
(2016)
Pak. J. Bot
, vol.48
, pp. 699-706
-
-
Amanullah, B.M.1
Rizvi, Z.F.2
Zia, M.3
-
5
-
-
69449084289
-
Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens
-
Anterola, A., Shanle, E., Perroud, P.-F., and Quatrano, R. (2009). Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens. Transgenic Res. 18, 655–660. doi: 10.1007/s11248-009-9252-5
-
(2009)
Transgenic Res
, vol.18
, pp. 655-660
-
-
Anterola, A.1
Shanle, E.2
Perroud, P.-F.3
Quatrano, R.4
-
6
-
-
70449338387
-
Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants
-
Aquil, S., Husaini, A. M., Abdin, M. Z., and Rather, G. M. (2009). Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants. Planta Med. 75, 1453–1458. doi: 10.1055/s-0029-1185775
-
(2009)
Planta Med
, vol.75
, pp. 1453-1458
-
-
Aquil, S.1
Husaini, A.M.2
Abdin, M.Z.3
Rather, G.M.4
-
7
-
-
41849126781
-
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua
-
Baldi, A., and Dixit, V. K. (2008). Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. Bioresour. Technol. 99, 4609–4614. doi: 10.1016/j.biortech.2007.06.061
-
(2008)
Bioresour. Technol
, vol.99
, pp. 4609-4614
-
-
Baldi, A.1
Dixit, V.K.2
-
8
-
-
84891517990
-
Adherence to artemisinin-based combination therapy for the treatment of malaria: A systematic review of the evidence
-
Banek, K., Lalani, M., Staedke, S. G., and Chandramohan, D. (2014). Adherence to artemisinin-based combination therapy for the treatment of malaria: a systematic review of the evidence. Malar. J. 13:7. doi: 10.1186/1475-2875-13-7
-
(2014)
Malar. J
, vol.13
, pp. 7
-
-
Banek, K.1
Lalani, M.2
Staedke, S.G.3
Chandramohan, D.4
-
9
-
-
78149498336
-
Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L
-
Banyai, W., Kirdmanee, C., Mii, M., and Supaibulwatana, K. (2010a). Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L. Plant Cell Tissue Organ Cult. 103, 255–265. doi: 10.1007/s11240-010-9775-8
-
(2010)
Plant Cell Tissue Organ Cult
, vol.103
, pp. 255-265
-
-
Banyai, W.1
Kirdmanee, C.2
Mii, M.3
Supaibulwatana, K.4
-
10
-
-
78650779704
-
Overproduction of artemisinin in tetraploid
-
Banyai, W., Sangthong, R., Karaket, N., Inthima, P., Mii, M., and Supaibulwatana, K. (2010b). Overproduction of artemisinin in tetraploid Artemisia annua L. Plant Biotechnol. J. 27, 427–433. doi: 10.5511/plantbiotechnology.10.0726a
-
(2010)
Artemisia Annua L. Plant Biotechnol. J
, vol.27
, pp. 427-433
-
-
Banyai, W.1
Sangthong, R.2
Karaket, N.3
Inthima, P.4
Mii, M.5
Supaibulwatana, K.6
-
11
-
-
78650305586
-
Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment
-
Banyai, W., Mii, M., and Supaibulwatana, K. (2011). Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment. Plant Growth Regul. 63, 45–54. doi: 10.1007/s10725-010-9510-9
-
(2011)
Plant Growth Regul
, vol.63
, pp. 45-54
-
-
Banyai, W.1
Mii, M.2
Supaibulwatana, K.3
-
12
-
-
84982746262
-
Developing commercial production of semi-synthetic artemisinin, and of 2-farnesene, an isoprenoid produced by fermentation of Brazilian sugar
-
Benjamin, K. R., Silva, I. R., Cherubim, J. O. P., Mcphee, D., and Paddon, C. J. (2016). Developing commercial production of semi-synthetic artemisinin, and of 2-farnesene, an isoprenoid produced by fermentation of Brazilian sugar. J. Braz. Chem. Soc. 27, 1339–1345. doi: 10.5935/0103-5053.20160119
-
(2016)
J. Braz. Chem. Soc
, vol.27
, pp. 1339-1345
-
-
Benjamin, K.R.1
Silva, I.R.2
Cherubim, J.O.P.3
McPhee, D.4
Paddon, C.J.5
-
13
-
-
0002944810
-
Secondary metabolites of Artemisia annua and their biological activity
-
Bhakuni, R., Jain, D., Sharma, R., and Kumar, S. (2001). Secondary metabolites of Artemisia annua and their biological activity. Curr. Sci. 80, 35–48.
-
(2001)
Curr. Sci
, vol.80
, pp. 35-48
-
-
Bhakuni, R.1
Jain, D.2
Sharma, R.3
Kumar, S.4
-
14
-
-
84963805339
-
A plant-based transient expression system for the rapid production of malaria vaccine candidates
-
ed. S. Thomas (New York, NY: Springer
-
Boes, A., Reimann, A., Twyman, R. M., Fischer, R., Schillberg, S., and Spiegel, H. (2016). “A plant-based transient expression system for the rapid production of malaria vaccine candidates,” in Vaccine Design: Methods and Protocols: Vaccines for Veterinary Diseases, Vol. 2, ed. S. Thomas (New York, NY: Springer), 597–619.
-
(2016)
Vaccine Design: Methods and Protocols: Vaccines for Veterinary Diseases
, vol.2
, pp. 597-619
-
-
Boes, A.1
Reimann, A.2
Twyman, R.M.3
Fischer, R.4
Schillberg, S.5
Spiegel, H.6
-
15
-
-
0033230281
-
Amorpha-4, 11-diene synthase catalyses the first probable step in artemisinin biosynthesis
-
Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H., Van Loo, B., Jansen, B. J., Posthumus, M. A., et al. (1999). Amorpha-4, 11-diene synthase catalyses the first probable step in artemisinin biosynthesis. Phytochemistry 52, 843–854. doi: 10.1016/S0031-9422(99)00206-X
-
(1999)
Phytochemistry
, vol.52
, pp. 843-854
-
-
Bouwmeester, H.J.1
Wallaart, T.E.2
Janssen, M.H.3
Van Loo, B.4
Jansen, B.J.5
Posthumus, M.A.6
-
16
-
-
84858274584
-
Adaptation and agronomic performance of Artemisia annua L. Under lowland humid tropical conditions
-
Brisibe, E. A., Udensi, O., Chukwurah, P. N., De Magalhäes, P. M., Figueira, G. M., and Ferreira, J. F. (2012). Adaptation and agronomic performance of Artemisia annua L. under lowland humid tropical conditions. Ind. Crops Prod. 39, 190–197. doi: 10.1016/j.indcrop.2012.02.018
-
(2012)
Ind. Crops Prod
, vol.39
, pp. 190-197
-
-
Brisibe, E.A.1
Udensi, O.2
Chukwurah, P.N.3
De Magalhäes, P.M.4
Figueira, G.M.5
Ferreira, J.F.6
-
17
-
-
78649475176
-
The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao)
-
Brown, G. D. (2010). The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao). Molecules 15, 7603–7698. doi: 10.3390/molecules15117603
-
(2010)
Molecules
, vol.15
, pp. 7603-7698
-
-
Brown, G.D.1
-
18
-
-
44749094144
-
Functions of rol genes in plant secondary metabolism
-
Bulgakov, V. P. (2008). Functions of rol genes in plant secondary metabolism. Biotechnol. Adv. 26, 318–324. doi: 10.1016/j.biotechadv.2008.03.001
-
(2008)
Biotechnol. Adv
, vol.26
, pp. 318-324
-
-
Bulgakov, V.P.1
-
19
-
-
79952287861
-
Production of biologically active recombinant human factor H in Physcomitrella
-
Buttner-Mainik, A., Parsons, J., Jerome, H., Hartmann, A., Lamer, S., Schaaf, A., et al. (2011). Production of biologically active recombinant human factor H in Physcomitrella. Plant Biotechnol. J. 9, 373–383. doi: 10.1111/j.1467-7652.2010.00552.x
-
(2011)
Plant Biotechnol. J
, vol.9
, pp. 373-383
-
-
Buttner-Mainik, A.1
Parsons, J.2
Jerome, H.3
Hartmann, A.4
Lamer, S.5
Schaaf, A.6
-
20
-
-
0036780907
-
Evolutionary and historical aspects of the burden of malaria
-
Carter, R., and Mendis, K. N. (2002). Evolutionary and historical aspects of the burden of malaria. Clin. Microbiol. Rev. 15, 564–594. doi: 10.1128/CMR.15.4.564-594.2002
-
(2002)
Clin. Microbiol. Rev
, vol.15
, pp. 564-594
-
-
Carter, R.1
Mendis, K.N.2
-
21
-
-
0034729780
-
Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. Transgenic plants via Agrobacterium tumefaciens-mediated transformation
-
Chen, D., Ye, H., and Li, G. (2000). Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation. Plant Sci. 155, 179–185. doi: 10.1016/S0168-9452(00)00217-X
-
(2000)
Plant Sci
, vol.155
, pp. 179-185
-
-
Chen, D.1
Ye, H.2
Li, G.3
-
22
-
-
84930486745
-
Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene
-
Chen, J.-L., Fang, H.-M., Ji, Y.-P., Pu, G.-B., Guo, Y.-W., Huang, L.-L., et al. (2011). Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene. Planta Med. 77, 1759–1765. doi: 10.1055/s-0030-1271038
-
(2011)
Planta Med
, vol.77
, pp. 1759-1765
-
-
Chen, J.-L.1
Fang, H.-M.2
Ji, Y.-P.3
Pu, G.-B.4
Guo, Y.-W.5
Huang, L.-L.6
-
23
-
-
85013993791
-
GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua
-
Chen, M., Yan, T., Shen, Q., Lu, X., Pan, Q., Huang, Y., et al. (2017). GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua. New Phytol. 214, 304–316. doi: 10.1111/nph.14373
-
(2017)
New Phytol
, vol.214
, pp. 304-316
-
-
Chen, M.1
Yan, T.2
Shen, Q.3
Lu, X.4
Pan, Q.5
Huang, Y.6
-
24
-
-
84880514843
-
The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L
-
Chen, Y., Shen, Q., Wang, Y., Wang, T., Wu, S., Zhang, L., et al. (2013). The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L. Plant Biotechnol. Rep. 7, 287–295. doi: 10.1007/s11816-012-0262-z
-
(2013)
Plant Biotechnol. Rep
, vol.7
, pp. 287-295
-
-
Chen, Y.1
Shen, Q.2
Wang, Y.3
Wang, T.4
Wu, S.5
Zhang, L.6
-
25
-
-
84863905764
-
Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin
-
Cockram, J., Hill, C., Burns, C., Arroo, R. R., Woolley, J. G., Flockart, I., et al. (2012). Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin. Plant Genet. Resour. 10, 152–154. doi: 10.1017/S1479262112000159
-
(2012)
Plant Genet. Resour
, vol.10
, pp. 152-154
-
-
Cockram, J.1
Hill, C.2
Burns, C.3
Arroo, R.R.4
Woolley, J.G.5
Flockart, I.6
-
26
-
-
77249141616
-
History of the discovery of the malaria parasites and their vectors
-
Cox, F. (2010). History of the discovery of the malaria parasites and their vectors. Parasit. Vectors 3:5. doi: 10.1186/1756-3305-3-5
-
(2010)
Parasit. Vectors
, vol.3
, pp. 5
-
-
Cox, F.1
-
27
-
-
85007415665
-
Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism
-
Czechowski, T., Larson, T. R., Catania, T. M., Harvey, D., Brown, G. D., and Graham, I. A. (2016). Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism. Proc. Natl. Acad. Sci. U.S.A. 113, 15150–15155. doi: 10.1073/pnas.1611567113
-
(2016)
Proc. Natl. Acad. Sci. U.S.A.
, vol.113
, pp. 15150-15155
-
-
Czechowski, T.1
Larson, T.R.2
Catania, T.M.3
Harvey, D.4
Brown, G.D.5
Graham, I.A.6
-
28
-
-
84946030569
-
Impact of exogenous elicitors on artemisinin production and trichome density in Artemisia annua L. Under subtropical conditions
-
Dangash, A., Pandya, N., Bharillya, A., Jhala, A., and Jain, D. (2014). Impact of exogenous elicitors on artemisinin production and trichome density in Artemisia annua L. under subtropical conditions. Not. Sci. Biol. 6, 349–353. doi: 10.15835/nsb.6.3.9109
-
(2014)
Not. Sci. Biol
, vol.6
, pp. 349-353
-
-
Dangash, A.1
Pandya, N.2
Bharillya, A.3
Jhala, A.4
Jain, D.5
-
29
-
-
0001069615
-
Selection and breeding for high artemisinin (Qinghaosu) yielding strains of Artemisia annua
-
Delabays, N., Collet, G., and Benakis, A. (1993). Selection and breeding for high artemisinin (Qinghaosu) yielding strains of Artemisia annua. Acta Hortic. 330, 203–208. doi: 10.17660/ActaHortic.1993.330.24
-
(1993)
Acta Hortic
, vol.330
, pp. 203-208
-
-
Delabays, N.1
Collet, G.2
Benakis, A.3
-
30
-
-
0035214418
-
The genetics of artemisinin content in Artemisia annua L. And the breeding of high yielding cultivars
-
Delabays, N., Simonnet, X., and Gaudin, M. (2001). The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars. Curr. Med. Chem. 8, 1795–1801. doi: 10.2174/0929867013371635
-
(2001)
Curr. Med. Chem
, vol.8
, pp. 1795-1801
-
-
Delabays, N.1
Simonnet, X.2
Gaudin, M.3
-
31
-
-
84948659157
-
Genetic transformation of Artemisia carvifolia buch with rol genes enhances artemisinin accumulation
-
Dilshad, E., Cusido, R. M., Estrada, K. R., Bonfill, M., and Mirza, B. (2015a). Genetic transformation of Artemisia carvifolia buch with rol genes enhances artemisinin accumulation. PLOS ONE 10:e0140266. doi: 10.1371/journal.pone.0140266
-
(2015)
PLOS ONE
, pp. 10
-
-
Dilshad, E.1
Cusido, R.M.2
Estrada, K.R.3
Bonfill, M.4
Mirza, B.5
-
32
-
-
84946091818
-
Enhanced artemisinin yield by expression of rol genes
-
Dilshad, E., Cusido, R. M., Palazon, J., Estrada, K. R., Bonfill, M., and Mirza, B. (2015b). Enhanced artemisinin yield by expression of rol genes in Artemisia annua. Malar. J. 14, 424. doi: 10.1186/s12936-015-0951-5
-
(2015)
Artemisia Annua. Malar. J
, vol.14
, pp. 424
-
-
Dilshad, E.1
Cusido, R.M.2
Palazon, J.3
Estrada, K.R.4
Bonfill, M.5
Mirza, B.6
-
33
-
-
0028042851
-
Localization of artemisinin and artemisitene in foliar tissues of glanded and glandless biotypes of Artemisia annua L
-
Duke, M. V., Paul, R. N., Elsohly, H. N., Sturtz, G., and Duke, S. O. (1994). Localization of artemisinin and artemisitene in foliar tissues of glanded and glandless biotypes of Artemisia annua L. Int. J. Plant Sci. 155, 365–372. doi: 10.1086/297173
-
(1994)
Int. J. Plant Sci
, vol.155
, pp. 365-372
-
-
Duke, M.V.1
Paul, R.N.2
Elsohly, H.N.3
Sturtz, G.4
Duke, S.O.5
-
34
-
-
85014580951
-
Protection against Plasmodium falciparum malaria by PfSPZ vaccine
-
Epstein, J. E., Paolino, K. M., Richie, T. L., Sedegah, M., Singer, A., Ruben, A. J., et al. (2017). Protection against Plasmodium falciparum malaria by PfSPZ vaccine. JCI Insight 2:e89154. doi: 10.1172/jci.insight.89154
-
(2017)
JCI Insight
, pp. 2
-
-
Epstein, J.E.1
Paolino, K.M.2
Richie, T.L.3
Sedegah, M.4
Singer, A.5
Ruben, A.J.6
-
35
-
-
83255177147
-
Generation of the potent anti-malarial drug artemisinin in tobacco
-
Farhi, M., Marhevka, E., Ben-Ari, J., Algamas-Dimantov, A., Liang, Z., Zeevi, V., et al. (2011). Generation of the potent anti-malarial drug artemisinin in tobacco. Nat. Biotechnol. 29, 1072–1074. doi: 10.1038/nbt.2054
-
(2011)
Nat. Biotechnol
, vol.29
, pp. 1072-1074
-
-
Farhi, M.1
Marhevka, E.2
Ben-Ari, J.3
Algamas-Dimantov, A.4
Liang, Z.5
Zeevi, V.6
-
36
-
-
0029201602
-
Floral morphology of Artemisia annua with special reference to trichomes
-
Ferreira, J. F., and Janick, J. (1995). Floral morphology of Artemisia annua with special reference to trichomes. Int. J. Plant Sci. 156, 807–815. doi: 10.1086/297304
-
(1995)
Int. J. Plant Sci
, vol.156
, pp. 807-815
-
-
Ferreira, J.F.1
Janick, J.2
-
37
-
-
25844459061
-
Cultivation and genetics of Artemisia annua L. For increased production of the antimalarial artemisinin
-
Ferreira, J. F., Laughlin, J., Delabays, N., and De Magalhães, P. M. (2005). Cultivation and genetics of Artemisia annua L. for increased production of the antimalarial artemisinin. Plant Genet. Resour. 3, 206–229. doi: 10.1079/PGR200585
-
(2005)
Plant Genet. Resour
, vol.3
, pp. 206-229
-
-
Ferreira, J.F.1
Laughlin, J.2
Delabays, N.3
De Magalhães, P.M.4
-
38
-
-
20144383719
-
Molecular tools to study Physcomitrella patens
-
Frank, W., Decker, E., and Reski, R. (2005). Molecular tools to study Physcomitrella patens. Plant Biol. 7, 220–227. doi: 10.1055/s-2005-865645
-
(2005)
Plant Biol
, vol.7
, pp. 220-227
-
-
Frank, W.1
Decker, E.2
Reski, R.3
-
39
-
-
84975307968
-
A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop
-
Fuentes, P., Zhou, F., Erban, A., Karcher, D., Kopka, J., and Bock, R. (2016). A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop. eLife 5:e13664. doi: 10.7554/eLife.13664
-
(2016)
Elife
, vol.5
, pp. 664
-
-
Fuentes, P.1
Zhou, F.2
Erban, A.3
Karcher, D.4
Kopka, J.5
Bock, R.6
-
40
-
-
0031588814
-
Genetic transformation of Artemisia annua by Agrobacterium tumefaciens and artemisinin synthesis in transformed cultures
-
Ghosh, B., Mukherjee, S., and Jha, S. (1997). Genetic transformation of Artemisia annua by Agrobacterium tumefaciens and artemisinin synthesis in transformed cultures. Plant Sci. 122, 193–199. doi: 10.4103/0973-1296.127372
-
(1997)
Plant Sci
, vol.122
, pp. 193-199
-
-
Ghosh, B.1
Mukherjee, S.2
Jha, S.3
-
41
-
-
74549123642
-
The genetic map of Artemisia annua L. Identifies loci affecting yield of the antimalarial drug artemisinin
-
Graham, I. A., Besser, K., Blumer, S., Branigan, C. A., Czechowski, T., Elias, L., et al. (2010). The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin. Science 327, 328–331. doi: 10.1126/science.1182612
-
(2010)
Science
, vol.327
, pp. 328-331
-
-
Graham, I.A.1
Besser, K.2
Blumer, S.3
Branigan, C.A.4
Czechowski, T.5
Elias, L.6
-
42
-
-
77649337416
-
Salicylic acid and methyl jasmonate but not Rose Bengal enhance artemisinin production through invoking burst of endogenous singlet oxygen
-
Guo, X.-X., Yang, X.-Q., Yang, R.-Y., and Zeng, Q.-P. (2010). Salicylic acid and methyl jasmonate but not Rose Bengal enhance artemisinin production through invoking burst of endogenous singlet oxygen. Plant Sci. 178, 390–397. doi: 10.1016/j.plantsci.2010.01.014
-
(2010)
Plant Sci
, vol.178
, pp. 390-397
-
-
Guo, X.-X.1
Yang, X.-Q.2
Yang, R.-Y.3
Zeng, Q.-P.4
-
43
-
-
84966538972
-
Promoting artemisinin biosynthesis in Artemisia annua plants by substrate channeling
-
Han, J., Wang, H., Kanagarajan, S., Hao, M., Lundgren, A., and Brodelius, P. E. (2016). Promoting artemisinin biosynthesis in Artemisia annua plants by substrate channeling. Mol. Plant 9, 946–948. doi: 10.1016/j.molp.2016.03.004
-
(2016)
Mol. Plant
, vol.9
, pp. 946-948
-
-
Han, J.1
Wang, H.2
Kanagarajan, S.3
Hao, M.4
Lundgren, A.5
Brodelius, P.E.6
-
44
-
-
33645535441
-
Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in Artemisia annua L
-
Han, J. L., Liu, B. Y., Ye, H. C., Wang, H., Li, Z. Q., and Li, G. F. (2006). Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in Artemisia annua L. J. Integr. Plant Biol. 48, 482–487. doi: 10.1111/j.1744-7909.2006.00208.x
-
(2006)
J. Integr. Plant Biol
, vol.48
, pp. 482-487
-
-
Han, J.L.1
Liu, B.Y.2
Ye, H.C.3
Wang, H.4
Li, Z.Q.5
Li, G.F.6
-
45
-
-
85015877565
-
Glandular trichome-specific expression of alcohol dehydrogenase 1 (ADH1) using a promoter-GUS fusion in Artemisia annua L
-
He, Q., Fu, X., Shi, P., Liu, M., Shen, Q., and Tang, K. (2017). Glandular trichome-specific expression of alcohol dehydrogenase 1 (ADH1) using a promoter-GUS fusion in Artemisia annua L. Plant Cell Tissue Organ Cult. 130, 61–72. doi: 10.1007/s11240-017-1204-9
-
(2017)
Plant Cell Tissue Organ Cult
, vol.130
, pp. 61-72
-
-
He, Q.1
Fu, X.2
Shi, P.3
Liu, M.4
Shen, Q.5
Tang, K.6
-
46
-
-
70350035886
-
Increased accumulation of artemisinin and anthocyanins in Artemisia annua expressing the Arabidopsis blue light receptor CRY1
-
Hong, G.-J., Hu, W.-L., Li, J.-X., Chen, X.-Y., and Wang, L.-J. (2009). Increased accumulation of artemisinin and anthocyanins in Artemisia annua expressing the Arabidopsis blue light receptor CRY1. Plant Mol. Biol. Rep. 27, 334–341. doi: 10.1007/s11105-008-0088-6
-
(2009)
Plant Mol. Biol. Rep
, vol.27
, pp. 334-341
-
-
Hong, G.-J.1
Hu, W.-L.2
Li, J.-X.3
Chen, X.-Y.4
Wang, L.-J.5
-
47
-
-
85046055583
-
Stable production of the antimalarial drug artemisinin in the moss Physcomitrella patens
-
Ikram, N. K. B., Beyraghdar Kashkooli, A., Peramuna, A. V., Van Der Krol, A. R., Bouwmeester, H., and Simonsen, H. T. (2017). Stable production of the antimalarial drug artemisinin in the moss Physcomitrella patens. Front. Bioeng. Biotechnol. 5:47. doi: 10.3389/fbioe.2017.00047
-
(2017)
Front. Bioeng. Biotechnol
, vol.5
, pp. 47
-
-
Ikram, N.K.B.1
Beyraghdar Kashkooli, A.2
Peramuna, A.V.3
Van Der Krol, A.R.4
Bouwmeester, H.5
Simonsen, H.T.6
-
48
-
-
84928045168
-
Stable heterologous expression of biologically active terpenoids in green plant cells
-
Ikram, N. K., Zhan, X., Pan, X., King, B. C., and Simonsen, H. T. (2015). Stable heterologous expression of biologically active terpenoids in green plant cells. Front. Plant Sci. 6:129. doi: 10.3389/fpls.2015.00129
-
(2015)
Front. Plant Sci
, vol.6
, pp. 129
-
-
Ikram, N.K.1
Zhan, X.2
Pan, X.3
King, B.C.4
Simonsen, H.T.5
-
49
-
-
84960981829
-
Overexpression of AaWRKY1 leads to an enhanced content of artemisinin in Artemisia annua
-
Jiang, W., Fu, X., Pan, Q., Tang, Y., Shen, Q., Lv, Z., et al. (2016). Overexpression of AaWRKY1 leads to an enhanced content of artemisinin in Artemisia annua. Biomed Res. Int. 2016:7314971. doi: 10.1155/2016/7314971
-
(2016)
Biomed Res. Int
, vol.2016
-
-
Jiang, W.1
Fu, X.2
Pan, Q.3
Tang, Y.4
Shen, Q.5
Lv, Z.6
-
50
-
-
84964814115
-
In vivo assembly of DNA-fragments in the moss, Physcomitrella patens
-
King, B. C., Vavitsas, K., Ikram, N. K. B. K., Schrøder, J., Scharff, L. B., Hamberger, B., et al. (2016). In vivo assembly of DNA-fragments in the moss, Physcomitrella patens. Sci. Rep. 6:25030. doi: 10.1038/srep25030
-
(2016)
Sci. Rep
, vol.6
, pp. 25030
-
-
King, B.C.1
Vavitsas, K.2
Ikram, N.K.B.K.3
Schrøder, J.4
Scharff, L.B.5
Hamberger, B.6
-
51
-
-
84886285232
-
Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin
-
Kjær, A., Grevsen, K., and Jensen, M. (2012). Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin. AoB Plants 2012:ls018. doi: 10.1093/aobpla/pls018
-
(2012)
Aob Plants
-
-
Kjær, A.1
Grevsen, K.2
Jensen, M.3
-
52
-
-
0021948029
-
Qinghaosu (Artemisinin): An antimalarial drug from China
-
Klayman, D. L. (1985). Qinghaosu (artemisinin): an antimalarial drug from China. Science 228, 1049–1055. doi: 10.1126/science.3887571
-
(1985)
Science
, vol.228
, pp. 1049-1055
-
-
Klayman, D.L.1
-
53
-
-
84961771731
-
UK malaria treatment guidelines 2016
-
Lalloo, D. G., Shingadia, D., Bell, D. J., Beeching, N. J., Whitty, C. J. M., and Chiodini, P. L. (2016). UK malaria treatment guidelines 2016. J. Infect. 72, 635–649. doi: 10.1016/j.jinf.2016.02.001
-
(2016)
J. Infect
, vol.72
, pp. 635-649
-
-
Lalloo, D.G.1
Shingadia, D.2
Bell, D.J.3
Beeching, N.J.4
Whitty, C.J.M.5
Chiodini, P.L.6
-
54
-
-
84871755746
-
A survey of artemisinic and dihydroartemisinic acid contents in glasshouse and global field-grown populations of the artemisinin-producing plant Artemisia annua L
-
Larson, T. R., Branigan, C., Harvey, D., Penfield, T., Bowles, D., and Graham, I. A. (2013). A survey of artemisinic and dihydroartemisinic acid contents in glasshouse and global field-grown populations of the artemisinin-producing plant Artemisia annua L. Ind. Crops Prod. 45, 1–6. doi: 10.1016/j.indcrop.2012.12.004
-
(2013)
Ind. Crops Prod
, vol.45
, pp. 1-6
-
-
Larson, T.R.1
Branigan, C.2
Harvey, D.3
Penfield, T.4
Bowles, D.5
Graham, I.A.6
-
55
-
-
84995900407
-
Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
-
Laursen, T., Borch, J., Knudsen, C., Bavishi, K., Torta, F., Martens, H. J., et al. (2016). Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum. Science 354, 890–893. doi: 10.1126/science.aag2347
-
(2016)
Science
, vol.354
, pp. 890-893
-
-
Laursen, T.1
Borch, J.2
Knudsen, C.3
Bavishi, K.4
Torta, F.5
Martens, H.J.6
-
56
-
-
84955628982
-
Artemisia annua glandular secretory trichomes: The biofactory of antimalarial agent artemisinin
-
Ling, X., Hexin, T., and Lei, Z. (2016). Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin. Sci. Bull. 61, 26–36. doi: 10.1007/s11434-015-0980-z
-
(2016)
Sci. Bull
, vol.61
, pp. 26-36
-
-
Ling, X.1
Hexin, T.2
Lei, Z.3
-
57
-
-
0037010764
-
Effect of light irradiation on hairy root growth and artemisinin biosynthesis of Artemisia annua L
-
Liu, C.-Z., Guo, C., Wang, Y.-C., and Ouyang, F. (2002). Effect of light irradiation on hairy root growth and artemisinin biosynthesis of Artemisia annua L. Proc. Biochem. 38, 581–585. doi: 10.1016/S0032-9592(02)00165-6
-
(2002)
Proc. Biochem
, vol.38
, pp. 581-585
-
-
Liu, C.-Z.1
Guo, C.2
Wang, Y.-C.3
Ouyang, F.4
-
58
-
-
84983050078
-
Characterization of a trichome-specific promoter of the aldehyde dehydrogenase 1 (ALDH1) gene in Artemisia annua
-
Liu, M., Shi, P., Fu, X., Brodelius, P. E., Shen, Q., Jiang, W., et al. (2016). Characterization of a trichome-specific promoter of the aldehyde dehydrogenase 1 (ALDH1) gene in Artemisia annua. Plant Cell Tissue Organ Cult. 126, 469–480. doi: 10.1007/s11240-016-1015-4
-
(2016)
Plant Cell Tissue Organ Cult
, vol.126
, pp. 469-480
-
-
Liu, M.1
Shi, P.2
Fu, X.3
Brodelius, P.E.4
Shen, Q.5
Jiang, W.6
-
59
-
-
33645530257
-
Trichome dynamics and artemisinin accumulation during development and senescence of Artemisia annua leaves
-
Lommen, W., Schenk, E., Bouwmeester, H., and Verstappen, F. (2006). Trichome dynamics and artemisinin accumulation during development and senescence of Artemisia annua leaves. Planta Med. 72, 336–345. doi: 10.1055/s-2005-916202
-
(2006)
Planta Med
, vol.72
, pp. 336-345
-
-
Lommen, W.1
Schenk, E.2
Bouwmeester, H.3
Verstappen, F.4
-
60
-
-
84879467952
-
Promotion of artemisinin biosynthesis in transgenic Artemisia annua by overexpressing ADS, CYP71AV1 and CPR genes
-
Lu, X., Shen, Q., Zhang, L., Zhang, F., Jiang, W., Lv, Z., et al. (2013a). Promotion of artemisinin biosynthesis in transgenic Artemisia annua by overexpressing ADS, CYP71AV1 and CPR genes. Ind. Crops Prod. 49, 380–385. doi: 10.1016/j.indcrop.2013.04.045
-
(2013)
Ind. Crops Prod
, vol.49
, pp. 380-385
-
-
Lu, X.1
Shen, Q.2
Zhang, L.3
Zhang, F.4
Jiang, W.5
Lv, Z.6
-
61
-
-
84877622109
-
AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea
-
Lu, X., Zhang, L., Zhang, F., Jiang, W., Shen, Q., Zhang, L., et al. (2013b). AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea. New Phytol. 198, 1191–1202. doi: 10.1111/nph.12207
-
(2013)
New Phytol
, vol.198
, pp. 1191-1202
-
-
Lu, X.1
Zhang, L.2
Zhang, F.3
Jiang, W.4
Shen, Q.5
Zhang, L.6
-
62
-
-
0023110445
-
The chemistry, pharmacology, and clinical applications of qinghaosu (Artemisinin) and its derivatives
-
Luo, X. D., and Shen, C. C. (1987). The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives. Med. Res. Rev. 7, 29–52. doi: 10.1002/med.2610070103
-
(1987)
Med. Res. Rev
, vol.7
, pp. 29-52
-
-
Luo, X.D.1
Shen, C.C.2
-
63
-
-
84988431182
-
Overexpression of a Novel NAC domain-containing transcription factor gene (AaNAC1) enhances the content of artemisinin and increases tolerance to drought and Botrytis cinerea in Artemisia annua
-
Lv, Z., Wang, S., Zhang, F., Chen, L., Hao, X., Pan, Q., et al. (2016). Overexpression of a Novel NAC domain-containing transcription factor gene (AaNAC1) enhances the content of artemisinin and increases tolerance to drought and Botrytis cinerea in Artemisia annua. Plant Cell Physiol. 57, 1961–1971. doi: 10.1093/pcp/pcw118
-
(2016)
Plant Cell Physiol
, vol.57
, pp. 1961-1971
-
-
Lv, Z.1
Wang, S.2
Zhang, F.3
Chen, L.4
Hao, X.5
Pan, Q.6
-
64
-
-
74449088435
-
Terpenoid metabolic profiling analysis of transgenic Artemisia annua L. By comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry
-
Ma, C., Wang, H., Lu, X., Wang, H., Xu, G., and Liu, B. (2009). Terpenoid metabolic profiling analysis of transgenic Artemisia annua L. by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. Metabolomics 5, 497–506. doi: 10.1007/s11306-009-0170-6
-
(2009)
Metabolomics
, vol.5
, pp. 497-506
-
-
Ma, C.1
Wang, H.2
Lu, X.3
Wang, H.4
Xu, G.5
Liu, B.6
-
65
-
-
85021297816
-
Overexpression of a type I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase
-
Ma, D., Li, G., Alejos-Gonzalez, F., Zhu, Y., Xue, Z., Wang, A., et al. (2017a). Overexpression of a type I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase. Plant J. 91, 466–479. doi: 10.1111/tpj.13583
-
(2017)
Plant J
, vol.91
, pp. 466-479
-
-
Ma, D.1
Li, G.2
Alejos-Gonzalez, F.3
Zhu, Y.4
Xue, Z.5
Wang, A.6
-
66
-
-
85011867619
-
Overexpression and suppression of Artemisia annua 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 gene (AaHDR1) differentially regulate artemisinin and terpenoid biosynthesis. Front
-
Ma, D., Li, G., Zhu, Y., and Xie, D.-Y. (2017b). Overexpression and suppression of Artemisia annua 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 gene (AaHDR1) differentially regulate artemisinin and terpenoid biosynthesis. Front. Plant Sci. 8:77. doi: 10.3389/fpls.2017.00077
-
(2017)
Plant Sci
, vol.8
, pp. 77
-
-
Ma, D.1
Li, G.2
Zhu, Y.3
Xie, D.-Y.4
-
67
-
-
84955663049
-
A genome-wide scenario of terpene pathways in self-pollinated Artemisia annua
-
Ma, D.-M., Wang, Z., Wang, L., Alejos-Gonzales, F., Sun, M.-A., and Xie, D.-Y. (2015). A genome-wide scenario of terpene pathways in self-pollinated Artemisia annua. Mol. Plant 8, 1580–1598. doi: 10.1016/j.molp.2015.07.004
-
(2015)
Mol. Plant
, vol.8
, pp. 1580-1598
-
-
Ma, D.-M.1
Wang, Z.2
Wang, L.3
Alejos-Gonzales, F.4
Sun, M.-A.5
Xie, D.-Y.6
-
68
-
-
84994403323
-
Compartmentalized metabolic engineering for artemisinin biosynthesis and effective malaria treatment by oral delivery of plant Cells
-
Malhotra, K., Subramaniyan, M., Rawat, K., Kalamuddin, M., Qureshi, M. I., Malhotra, P., et al. (2016). Compartmentalized metabolic engineering for artemisinin biosynthesis and effective malaria treatment by oral delivery of plant Cells. Mol. Plant 9, 1464–1477. doi: 10.1016/j.molp.2016.09.013
-
(2016)
Mol. Plant
, vol.9
, pp. 1464-1477
-
-
Malhotra, K.1
Subramaniyan, M.2
Rawat, K.3
Kalamuddin, M.4
Qureshi, M.I.5
Malhotra, P.6
-
69
-
-
0034664686
-
Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L
-
Mercke, P., Bengtsson, M., Bouwmeester, H. J., Posthumus, M. A., and Brodelius, P. E. (2000). Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. Arch. Biochem. Biophys. 381, 173–180. doi: 10.1006/abbi.2000.1962
-
(2000)
Arch. Biochem. Biophys
, vol.381
, pp. 173-180
-
-
Mercke, P.1
Bengtsson, M.2
Bouwmeester, H.J.3
Posthumus, M.A.4
Brodelius, P.E.5
-
70
-
-
84973120144
-
Artemisinin-based antimalarial research: Application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
-
Muangphrom, P., Seki, H., Fukushima, E. O., and Muranaka, T. (2016). Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites. J. Nat. Med. 70, 318–334. doi: 10.1007/s11418-016-1008-y
-
(2016)
J. Nat. Med
, vol.70
, pp. 318-334
-
-
Muangphrom, P.1
Seki, H.2
Fukushima, E.O.3
Muranaka, T.4
-
71
-
-
78751585312
-
Enhancement of artemisinin content by constitutive expression of the HMG-CoA reductase gene in high-yielding strain of Artemisia annua L
-
Nafis, T., Akmal, M., Ram, M., Alam, P., Ahlawat, S., Mohd, A., et al. (2011). Enhancement of artemisinin content by constitutive expression of the HMG-CoA reductase gene in high-yielding strain of Artemisia annua L. Plant Biotechnol. Rep. 5, 53–60. doi: 10.1007/s11816-010-0156-x
-
(2011)
Plant Biotechnol. Rep
, vol.5
, pp. 53-60
-
-
Nafis, T.1
Akmal, M.2
Ram, M.3
Alam, P.4
Ahlawat, S.5
Mohd, A.6
-
72
-
-
0022549052
-
Production of artemisinin in tissue cultures of Artemisia Annua
-
Nair, M. S. R., Acton, N., Klayman, D. L., Kendrick, K., Basile, D. V., and Mante, S. (1986). Production of artemisinin in tissue cultures of Artemisia Annua. J. Nat. Prod. 49, 504–507. doi: 10.1021/np50045a021
-
(1986)
J. Nat. Prod
, vol.49
, pp. 504-507
-
-
Nair, M.S.R.1
Acton, N.2
Klayman, D.L.3
Kendrick, K.4
Basile, D.V.5
Mante, S.6
-
73
-
-
85016150556
-
Anti-plasmodial activity of norcaesalpin D and extracts of four medicinal plants used traditionally for treatment of malaria. BMC Complement
-
Nondo, R. S. O., Moshi, M. J., Erasto, P., Masimba, P. J., Machumi, F., Kidukuli, A. W., et al. (2017). Anti-plasmodial activity of norcaesalpin D and extracts of four medicinal plants used traditionally for treatment of malaria. BMC Complement. Altern. Med. 17:167. doi: 10.1186/s12906-017-1673-8
-
(2017)
Altern. Med
, vol.17
, pp. 167
-
-
Nondo, R.S.O.1
Moshi, M.J.2
Erasto, P.3
Masimba, P.J.4
Machumi, F.5
Kidukuli, A.W.6
-
74
-
-
79952328863
-
Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L
-
Olofsson, L., Engstrom, A., Lundgren, A., and Brodelius, P. (2011). Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. BMC Plant Biol. 11:45. doi: 10.1186/1471-2229-11-45
-
(2011)
BMC Plant Biol
, vol.11
, pp. 45
-
-
Olofsson, L.1
Engstrom, A.2
Lundgren, A.3
Brodelius, P.4
-
75
-
-
69249228525
-
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L
-
Olsson, M. E., Olofsson, L. M., Lindahl, A.-L., Lundgren, A., Brodelius, M., and Brodelius, P. E. (2009). Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L. Phytochemistry 70, 1123–1128. doi: 10.1016/j.phytochem.2009.07.009
-
(2009)
Phytochemistry
, vol.70
, pp. 1123-1128
-
-
Olsson, M.E.1
Olofsson, L.M.2
Lindahl, A.-L.3
Lundgren, A.4
Brodelius, M.5
Brodelius, P.E.6
-
76
-
-
84876784070
-
High-level semi-synthetic production of the potent antimalarial artemisinin
-
Paddon, C. J., Westfall, P., Pitera, D., Benjamin, K., Fisher, K., Mcphee, D., et al. (2013). High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496, 528–532. doi: 10.1038/nature12051
-
(2013)
Nature
, vol.496
, pp. 528-532
-
-
Paddon, C.J.1
Westfall, P.2
Pitera, D.3
Benjamin, K.4
Fisher, K.5
McPhee, D.6
-
77
-
-
84937759708
-
Sclareol production in the moss Physcomitrella patens and observations on growth and terpenoid biosynthesis
-
Pan, X.-W., Han, L., Zhang, Y.-H., Chen, D.-F., and Simonsen, H. T. (2015). Sclareol production in the moss Physcomitrella patens and observations on growth and terpenoid biosynthesis. Plant Biotechnol. Rep. 9, 149–159. doi: 10.1007/s11816-015-0353-8
-
(2015)
Plant Biotechnol. Rep
, vol.9
, pp. 149-159
-
-
Pan, X.-W.1
Han, L.2
Zhang, Y.-H.3
Chen, D.-F.4
Simonsen, H.T.5
-
78
-
-
84980010054
-
In vitro generation of high artemisinin yielding salt tolerant somaclonal variant and development of SCAR marker in Artemisia annua L
-
Pandey, N., Meena, R. P., Rai, S. K., and Pandey-Rai, S. (2016). In vitro generation of high artemisinin yielding salt tolerant somaclonal variant and development of SCAR marker in Artemisia annua L. Plant Cell Tissue Organ Cult. 127, 301–314. doi: 10.1007/s11240-016-1050-1
-
(2016)
Plant Cell Tissue Organ Cult
, vol.127
, pp. 301-314
-
-
Pandey, N.1
Meena, R.P.2
Rai, S.K.3
Pandey-Rai, S.4
-
79
-
-
84894285319
-
Short term UV-B radiation-mediated transcriptional responses and altered secondary metabolism of in vitro propagated plantlets of Artemisia annua L
-
Pandey, N., and Pandey-Rai, S. (2014). Short term UV-B radiation-mediated transcriptional responses and altered secondary metabolism of in vitro propagated plantlets of Artemisia annua L. Plant Cell Tissue Organ Cult. 116, 371–385. doi: 10.1007/s11240-013-0413-0
-
(2014)
Plant Cell Tissue Organ Cult
, vol.116
, pp. 371-385
-
-
Pandey, N.1
Pandey-Rai, S.2
-
80
-
-
85139115556
-
Mass production of artemisinin using hairy root cultivation of Artemisia annua in bioreactor
-
eds A. Pavlov and T. Bleys (Cham: Springer International Publishing
-
Patra, N., and Srivastava, A. K. (2017). “Mass production of artemisinin using hairy root cultivation of Artemisia annua in bioreactor,” in Bioprocessing of Plant in Vitro Systems, eds A. Pavlov and T. Bleys (Cham: Springer International Publishing), 1–17.
-
(2017)
Bioprocessing of Plant in Vitro Systems
, pp. 1-17
-
-
Patra, N.1
Srivastava, A.K.2
-
81
-
-
84959422900
-
Synthetic malaria drug meets market resistance: first commercial deployment of synthetic biology for medicine has modest impact
-
Peplow, M. (2016). Synthetic malaria drug meets market resistance: first commercial deployment of synthetic biology for medicine has modest impact. Nature 530, 389–391. doi: 10.1038/530390a
-
(2016)
Nature
, vol.530
, pp. 389-391
-
-
Peplow, M.1
-
82
-
-
33646148490
-
Amorpha-4,11-diene synthase: Mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate
-
Picaud, S., Mercke, P., He, X., Sterner, O., Brodelius, M., Cane, D. E., et al. (2006). Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate. Arch. Biochem. Biophys. 448, 150–155. doi: 10.1016/j.abb.2005.07.015
-
(2006)
Arch. Biochem. Biophys
, vol.448
, pp. 150-155
-
-
Picaud, S.1
Mercke, P.2
He, X.3
Sterner, O.4
Brodelius, M.5
Cane, D.E.6
-
83
-
-
17744370937
-
Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L
-
Picaud, S., Olofsson, L., Brodelius, M., and Brodelius, P. E. (2005). Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L. Arch. Biochem. Biophys. 436, 215–226. doi: 10.1016/j.abb.2005.02.012
-
(2005)
Arch. Biochem. Biophys
, vol.436
, pp. 215-226
-
-
Picaud, S.1
Olofsson, L.2
Brodelius, M.3
Brodelius, P.E.4
-
84
-
-
84961711370
-
Molecular Farming in Artemisia annua, a promising approach to improve anti-malarial drug production
-
Pulice, G., Pelaz, S., and Matías-Hernández, L. (2016). Molecular Farming in Artemisia annua, a promising approach to improve anti-malarial drug production. Front. Plant Sci. 7:329. doi: 10.3389/fpls.2016.00329
-
(2016)
Front. Plant Sci
, vol.7
, pp. 329
-
-
Pulice, G.1
Pelaz, S.2
Matías-Hernández, L.3
-
85
-
-
0031930234
-
Development, genetics and molecular biology of mosses
-
Reski, R. (1998). Development, genetics and molecular biology of mosses. Bot. Acta 111, 1–15. doi: 10.1111/j.1438-8677.1998.tb00670.x
-
(1998)
Bot. Acta
, vol.111
, pp. 1-15
-
-
Reski, R.1
-
86
-
-
84942192711
-
Moss-made pharmaceuticals: From bench to bedside
-
Reski, R., Parsons, J., and Decker, E. L. (2015). Moss-made pharmaceuticals: from bench to bedside. Plant Biotechnol. J. 13, 1191–1198. doi: 10.1111/pbi.12401
-
(2015)
Plant Biotechnol. J
, vol.13
, pp. 1191-1198
-
-
Reski, R.1
Parsons, J.2
Decker, E.L.3
-
87
-
-
85017225316
-
A perspective on the development of plant-made vaccines in the fight against Ebola virus
-
Rosales-Mendoza, S., Nieto-Gómez, R., and Angulo, C. (2017). A perspective on the development of plant-made vaccines in the fight against Ebola virus. Front. Immunol. 8:252. doi: 10.3389/fimmu.2017.00252
-
(2017)
Front. Immunol
, vol.8
, pp. 252
-
-
Rosales-Mendoza, S.1
Nieto-Gómez, R.2
Angulo, C.3
-
88
-
-
84893042280
-
The potential of Physcomitrella patens as a platform for the production of plant-based vaccines
-
Rosales-Mendoza, S., Orellana-Escobedo, L., Romero-Maldonado, A., Decker, E. L., and Reski, R. (2014). The potential of Physcomitrella patens as a platform for the production of plant-based vaccines. Expert Rev. Vaccines 13, 203–212. doi: 10.1586/14760584.2014.872987
-
(2014)
Expert Rev. Vaccines
, vol.13
, pp. 203-212
-
-
Rosales-Mendoza, S.1
Orellana-Escobedo, L.2
Romero-Maldonado, A.3
Decker, E.L.4
Reski, R.5
-
89
-
-
77955002164
-
The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua
-
Rydén, A.-M., Ruyter-Spira, C., Quax, W. J., Osada, H., Muranaka, T., Kayser, O., et al. (2010). The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua. Planta Med. 76, 1778–1783. doi: 10.1055/s-0030-1249930
-
(2010)
Planta Med
, vol.76
, pp. 1778-1783
-
-
Rydén, A.-M.1
Ruyter-Spira, C.2
Quax, W.J.3
Osada, H.4
Muranaka, T.5
Kayser, O.6
-
90
-
-
0031170922
-
Efficient gene targeting in the moss Physcomitrella patens
-
Schaefer, D. G., and Zrÿd, J. P. (1997). Efficient gene targeting in the moss Physcomitrella patens. Plant J. 11, 1195–1206. doi: 10.1046/j.1365-313X.1997.11061195.x
-
(1997)
Plant J
, vol.11
, pp. 1195-1206
-
-
Schaefer, D.G.1
Zrÿd, J.P.2
-
91
-
-
84930477385
-
Overexpression of the cytochrome P450 monooxygenase (Cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae)
-
Shen, Q., Chen, Y., Wang, T., Wu, S., Lu, X., Zhang, L., et al. (2012). Overexpression of the cytochrome P450 monooxygenase (cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae). Genet. Mol. Res. 11, 3298–3309. doi: 10.4238/2012.September.12.13
-
(2012)
Genet. Mol. Res
, vol.11
, pp. 3298-3309
-
-
Shen, Q.1
Chen, Y.2
Wang, T.3
Wu, S.4
Lu, X.5
Zhang, L.6
-
92
-
-
84965149417
-
The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis in Artemisia annua
-
Shen, Q., Lu, X., Yan, T., Fu, X., Lv, Z., Zhang, F., et al. (2016a). The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis in Artemisia annua. New Phytol. 210, 1269–1281. doi: 10.1111/nph.13874
-
(2016)
New Phytol
, vol.210
, pp. 1269-1281
-
-
Shen, Q.1
Lu, X.2
Yan, T.3
Fu, X.4
Lv, Z.5
Zhang, F.6
-
93
-
-
84955639558
-
Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L
-
Shen, Q., Yan, T., Fu, X., and Tang, K. (2016b). Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L. Sci. Bull. 61, 18–25. doi: 10.1007/s11434-015-0983-9
-
(2016)
Sci. Bull
, vol.61
, pp. 18-25
-
-
Shen, Q.1
Yan, T.2
Fu, X.3
Tang, K.4
-
94
-
-
85010792423
-
Promotion of artemisinin content in Artemisia annua by overexpression of multiple artemisinin biosynthetic pathway genes
-
Shi, P., Fu, X., Liu, M., Shen, Q., Jiang, W., Li, L., et al. (2017). Promotion of artemisinin content in Artemisia annua by overexpression of multiple artemisinin biosynthetic pathway genes. Plant Cell Tissue Organ Cult. 129, 251–259. doi: 10.1007/s11240-017-1173-z
-
(2017)
Plant Cell Tissue Organ Cult
, vol.129
, pp. 251-259
-
-
Shi, P.1
Fu, X.2
Liu, M.3
Shen, Q.4
Jiang, W.5
Li, L.6
-
95
-
-
84870203643
-
Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up
-
Shretta, R., and Yadav, P. (2012). Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up. Malar. J. 11:399. doi: 10.1186/1475-2875-11-399
-
(2012)
Malar. J
, vol.11
, pp. 399
-
-
Shretta, R.1
Yadav, P.2
-
96
-
-
73649104921
-
Perspectives on using Physcomitrella patens as an alternative production platform for thapsigargin and other terpenoid drug candidates
-
Simonsen, H. T., Drew, D. P., and Lunde, C. (2009). Perspectives on using Physcomitrella patens as an alternative production platform for thapsigargin and other terpenoid drug candidates. Perspect. Medicin. Chem. 3, 1–6. doi: 10.4137/PMC.S2220
-
(2009)
Perspect. Medicin. Chem
, vol.3
, pp. 1-6
-
-
Simonsen, H.T.1
Drew, D.P.2
Lunde, C.3
-
97
-
-
0035134406
-
In vitro screening of Indian medicinal plants for antiplasmodial activity
-
Simonsen, H. T., Nordskjold, J. B., Smitt, U. W., Nyman, U., Palpu, P., Joshi, P., et al. (2001). In vitro screening of Indian medicinal plants for antiplasmodial activity. J. Ethnopharmacol. 74, 195–204. doi: 10.1016/S0378-8741(00)00369-X
-
(2001)
J. Ethnopharmacol
, vol.74
, pp. 195-204
-
-
Simonsen, H.T.1
Nordskjold, J.B.2
Smitt, U.W.3
Nyman, U.4
Palpu, P.5
Joshi, P.6
-
98
-
-
84897989097
-
Guaianolide sesquiterpenoids - Their pharmacology and biosynthesis
-
eds K. G. Ramawat and J. M. Merillon (Berlin: Springer-Verlag
-
Simonsen, H. T., Weitzel, C., and Christensen, S. B. (2013). “Guaianolide sesquiterpenoids - Their pharmacology and biosynthesis,” in Handbook of Natural Products - Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, eds K. G. Ramawat and J. M. Merillon (Berlin: Springer-Verlag), 3069–3098.
-
(2013)
Handbook of Natural Products - Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes
, pp. 3069-3098
-
-
Simonsen, H.T.1
Weitzel, C.2
Christensen, S.B.3
-
99
-
-
85018482360
-
Amalgamation of synthetic biology and chemistry for high-throughput nonconventional synthesis of the antimalarial drug artemisinin
-
Singh, D., Mcphee, D., Paddon, C. J., Cherry, J., Maurya, G., Mahale, G., et al. (2017). Amalgamation of synthetic biology and chemistry for high-throughput nonconventional synthesis of the antimalarial drug artemisinin. Org. Process Res. Dev. 21, 551–558. doi: 10.1021/acs.oprd.6b00414
-
(2017)
Org. Process Res. Dev
, vol.21
, pp. 551-558
-
-
Singh, D.1
McPhee, D.2
Paddon, C.J.3
Cherry, J.4
Maurya, G.5
Mahale, G.6
-
100
-
-
0037185534
-
The mechanism of the spontaneous autoxidation of dihydroartemisinic acid
-
Sy, L.-K., and Brown, G. D. (2002). The mechanism of the spontaneous autoxidation of dihydroartemisinic acid. Tetrahedron 58, 897–908. doi: 10.1016/S0040-4020(01)01193-0
-
(2002)
Tetrahedron
, vol.58
, pp. 897-908
-
-
Sy, L.-K.1
Brown, G.D.2
-
101
-
-
85035753927
-
Overexpression ALDH1 gene increased artemisinin content in Artemisia annua L
-
Tang, K., Chen, Y., Shen, Q., Wang, T., Wu, S., and Wang, G. (2012a). Overexpression ALDH1 gene increased artemisinin content in Artemisia annua L. China Patent Application CN201210014242.
-
(2012)
China Patent Application
-
-
Tang, K.1
Chen, Y.2
Shen, Q.3
Wang, T.4
Wu, S.5
Wang, G.6
-
102
-
-
85035797382
-
Overexpression DBR2 gene increased artemisinin content in Artemisia annua L
-
Tang, K., Shen, Q., Chen, Y., Wang, T., Wu, S., and Lu, X. (2012b). Overexpression DBR2 gene increased artemisinin content in Artemisia annua L. China Patent Application CN201210014227.
-
(2012)
China Patent Application CN201210014227
-
-
Tang, K.1
Shen, Q.2
Chen, Y.3
Wang, T.4
Wu, S.5
Lu, X.6
-
103
-
-
84897965680
-
Transgenic approach to increase artemisinin content in Artemisia annua L
-
Tang, K., Shen, Q., Yan, T., and Fu, X. (2014). Transgenic approach to increase artemisinin content in Artemisia annua L. Plant Cell Rep. 33, 605–615. doi: 10.1007/s00299-014-1566-y
-
(2014)
Plant Cell Rep
, vol.33
, pp. 605-615
-
-
Tang, K.1
Shen, Q.2
Yan, T.3
Fu, X.4
-
104
-
-
68149089486
-
Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua
-
Teoh, K. H., Polichuk, D. R., Reed, D. W., and Covello, P. S. (2009). Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua. Botany 87, 635–642. doi: 10.1139/B09-032
-
(2009)
Botany
, vol.87
, pp. 635-642
-
-
Teoh, K.H.1
Polichuk, D.R.2
Reed, D.W.3
Covello, P.S.4
-
105
-
-
32344437343
-
Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin
-
Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., and Covello, P. S. (2006). Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett. 580, 1411–1416. doi: 10.1016/j.febslet.2006.01.065
-
(2006)
FEBS Lett
, vol.580
, pp. 1411-1416
-
-
Teoh, K.H.1
Polichuk, D.R.2
Reed, D.W.3
Nowak, G.4
Covello, P.S.5
-
106
-
-
84879688878
-
The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage
-
Ting, H. M., Wang, B., Rydén, A. M., Woittiez, L., Herpen, T., Verstappen, F. W., et al. (2013). The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage. New Phytol. 199, 352–366. doi: 10.1111/nph.12274
-
(2013)
New Phytol
, vol.199
, pp. 352-366
-
-
Ting, H.M.1
Wang, B.2
Rydén, A.M.3
Woittiez, L.4
Herpen, T.5
Verstappen, F.W.6
-
107
-
-
84876555972
-
The use of combining ability analysis to identify elite parents for Artemisia annua F1 hybrid production
-
Townsend, T., Segura, V., Chigeza, G., Penfield, T., Rae, A., Harvey, D., et al. (2013). The use of combining ability analysis to identify elite parents for Artemisia annua F1 hybrid production. PLOS ONE 8:e61989. doi: 10.1371/journal.pone.0061989
-
(2013)
PLOS ONE
, pp. 8
-
-
Townsend, T.1
Segura, V.2
Chigeza, G.3
Penfield, T.4
Rae, A.5
Harvey, D.6
-
108
-
-
80053976628
-
The discovery of artemisinin (Qinghaosu) and gifts from Chinese medicine. Nat
-
Tu, Y. (2011). The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat. Med. 17, 1217–1220. doi: 10.1038/nm.2471
-
(2011)
Med
, vol.17
, pp. 1217-1220
-
-
Tu, Y.1
-
109
-
-
0033035094
-
Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication
-
Van Agtmael, M. A., Eggelte, T. A., and Van Boxtel, C. J. (1999). Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication. Trends Pharmacol. Sci. 20, 199–205. doi: 10.1016/S0165-6147(99)01302-4
-
(1999)
Trends Pharmacol. Sci
, vol.20
, pp. 199-205
-
-
Van Agtmael, M.A.1
Eggelte, T.A.2
Van Boxtel, C.J.3
-
110
-
-
78649953180
-
Nicotiana benthamiana as a production platform for artemisinin precursors
-
Van Herpen, T. W., Cankar, K., Nogueira, M., Bosch, D., Bouwmeester, H. J., and Beekwilder, J. (2010). Nicotiana benthamiana as a production platform for artemisinin precursors. PLOS ONE 5:e14222. doi: 10.1371/journal.pone.0014222
-
(2010)
PLOS ONE
, pp. 5
-
-
Van Herpen, T.W.1
Cankar, K.2
Nogueira, M.3
Bosch, D.4
Bouwmeester, H.J.5
Beekwilder, J.6
-
111
-
-
0035129779
-
Amorpha-4,11-diene synthase: Cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
-
Wallaart, T. E., Bouwmeester, H. J., Hille, J., Poppinga, L., and Maijers, N. C. (2001). Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin. Planta 212, 460–465. doi: 10.1007/s004250000428
-
(2001)
Planta
, vol.212
, pp. 460-465
-
-
Wallaart, T.E.1
Bouwmeester, H.J.2
Hille, J.3
Poppinga, L.4
Maijers, N.C.5
-
112
-
-
84982854633
-
Transient production of artemisinin in Nicotiana benthamiana is boosted by a specific lipid transfer protein from A. Annua
-
Wang, B., Kashkooli, A. B., Sallets, A., Ting, H.-M., De Ruijter, N. C., Olofsson, L., et al. (2016). Transient production of artemisinin in Nicotiana benthamiana is boosted by a specific lipid transfer protein from A. annua. Metab. Eng. 38, 159–169. doi: 10.1016/j.ymben.2016.07.004
-
(2016)
Metab. Eng
, vol.38
, pp. 159-169
-
-
Wang, B.1
Kashkooli, A.B.2
Sallets, A.3
Ting, H.-M.4
De Ruijter, N.C.5
Olofsson, L.6
-
113
-
-
76449083479
-
Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L. Ind
-
Wang, H., Ma, C., Li, Z., Ma, L., Wang, H., Ye, H., et al. (2010). Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L. Ind. Crops Prod. 31, 214–218. doi: 10.1016/j.indcrop.2009.10.008
-
(2010)
Crops Prod
, vol.31
, pp. 214-218
-
-
Wang, H.1
Ma, C.2
Li, Z.3
Ma, L.4
Wang, H.5
Ye, H.6
-
114
-
-
34548455035
-
Sugars proportionately affect artemisinin production
-
Wang, Y., and Weathers, P. (2007). Sugars proportionately affect artemisinin production. Plant Cell Rep. 26, 1073–1081. doi: 10.1007/s00299-006-0295-2
-
(2007)
Plant Cell Rep
, vol.26
, pp. 1073-1081
-
-
Wang, Y.1
Weathers, P.2
-
115
-
-
80054111080
-
Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L
-
Wang, Y., Yang, K., Jing, F., Li, M., Deng, T., Huang, R., et al. (2011). Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L. Mol. Biol. 45, 751. doi: 10.1134/S0026893311040145
-
(2011)
Mol. Biol
, vol.45
, pp. 751
-
-
Wang, Y.1
Yang, K.2
Jing, F.3
Li, M.4
Deng, T.5
Huang, R.6
-
116
-
-
33749049315
-
Artemisinin: The biosynthetic pathway and Its regulation in Artemisia annua, a terpenoid-rich species
-
Weathers, P. J., Elkholy, S., and Wobbe, K. K. (2006). Artemisinin: the biosynthetic pathway and Its regulation in Artemisia annua, a terpenoid-rich species. In Vitro Cell Dev. Biol. Plant 42, 309–317. doi: 10.1079/IVP2006782
-
(2006)
Vitro Cell Dev. Biol. Plant
, vol.42
, pp. 309-317
-
-
Weathers, P.J.1
Elkholy, S.2
Wobbe, K.K.3
-
117
-
-
84856611060
-
Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective
-
Wen, W., and Yu, R. (2011). Artemisinin biosynthesis and its regulatory enzymes: progress and perspective. Pharmacogn. Rev. 5, 189–194. doi: 10.4103/0973-7847.91118
-
(2011)
Pharmacogn. Rev
, vol.5
, pp. 189-194
-
-
Wen, W.1
Yu, R.2
-
118
-
-
0000688429
-
Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L
-
Woerdenbag, H., Lüers, J. J., Van Uden, W., Pras, N., Malingré, T., and Alfermann, A. W. (1993). Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L. Plant Cell Tissue Organ Cult. 32, 247–257. doi: 10.1007/BF00029850
-
(1993)
Plant Cell Tissue Organ Cult
, vol.32
, pp. 247-257
-
-
Woerdenbag, H.1
Lüers, J.J.2
Van Uden, W.3
Pras, N.4
Malingré, T.5
Alfermann, A.W.6
-
120
-
-
85035810385
-
-
World Malaria Report. Geneva: WHO
-
World Health Organization [WHO] (2016). World Malaria Report. Geneva: WHO.
-
(2016)
-
-
-
121
-
-
84871846483
-
Enhancement of artemisinin biosynthesis by overexpressing dxr, cyp71av1 and cpr in the plants of Artemisia annua L
-
Xiang, L., Zeng, L. X., Yuan, Y., Chen, M., Wang, F., Liu, X. Q., et al. (2012). Enhancement of artemisinin biosynthesis by overexpressing dxr, cyp71av1 and cpr in the plants of Artemisia annua L. Plant Omics 5, 503–507.
-
(2012)
Plant Omics
, vol.5
, pp. 503-507
-
-
Xiang, L.1
Zeng, L.X.2
Yuan, Y.3
Chen, M.4
Wang, F.5
Liu, X.Q.6
-
122
-
-
84925543546
-
Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment
-
Xiang, L., Zhu, S., Zhao, T., Zhang, M., Liu, W., Chen, M., et al. (2015). Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment. Plant Growth Regul. 75, 435–441. doi: 10.1007/s10725-014-0004-z
-
(2015)
Plant Growth Regul
, vol.75
, pp. 435-441
-
-
Xiang, L.1
Zhu, S.2
Zhao, T.3
Zhang, M.4
Liu, W.5
Chen, M.6
-
123
-
-
84994291465
-
Artemisinin biosynthesis in Artemisia annua and metabolic engineering: Questions, challenges, and perspectives
-
Xie, D.-Y., Ma, D.-M., Judd, R., and Jones, A. L. (2016). Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives. Phytochem. Rev. 15, 1093–1114. doi: 10.1007/s11101-016-9480-2
-
(2016)
Phytochem. Rev
, vol.15
, pp. 1093-1114
-
-
Xie, D.-Y.1
Ma, D.-M.2
Judd, R.3
Jones, A.L.4
-
124
-
-
40849086415
-
Abiotic stress-induced expression of artemisinin biosynthesis genes in Artemisia annua L
-
Yin, L., Zhao, C., Huang, Y., Yang, R.-Y., and Zeng, Q.-P. (2008). Abiotic stress-induced expression of artemisinin biosynthesis genes in Artemisia annua L. Chin. J. Appl. Environ. Biol. 14, 1–15.
-
(2008)
Chin. J. Appl. Environ. Biol
, vol.14
, pp. 1-15
-
-
Yin, L.1
Zhao, C.2
Huang, Y.3
Yang, R.-Y.4
Zeng, Q.-P.5
-
125
-
-
84859128468
-
The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L
-
Yu, Z.-X., Li, J.-X., Yang, C.-Q., Hu, W.-L., Wang, L.-J., and Chen, X.-Y. (2012). The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L. Mol. Plant 5, 353–365. doi: 10.1093/mp/ssr087
-
(2012)
Mol. Plant
, vol.5
, pp. 353-365
-
-
Yu, Z.-X.1
Li, J.-X.2
Yang, C.-Q.3
Hu, W.-L.4
Wang, L.-J.5
Chen, X.-Y.6
-
126
-
-
84979911437
-
Metabolic engineering of the moss Physcomitrella patens to produce the sesquiterpenoids patchoulol and α/β-santalene
-
Zhan, X., Zhang, Y.-H., Chen, D.-F., and Simonsen, H. T. (2014). Metabolic engineering of the moss Physcomitrella patens to produce the sesquiterpenoids patchoulol and α/β-santalene. Front. Plant Sci. 5:636. doi: 10.3389/fpls.2014.00636
-
(2014)
Front. Plant Sci
, vol.5
, pp. 636
-
-
Zhan, X.1
Zhang, Y.-H.2
Chen, D.-F.3
Simonsen, H.T.4
-
127
-
-
84874279179
-
Overexpression of the Artemisia orthologue of ABA receptor, AaPYL9, enhances ABA sensitivity and improves artemisinin content in Artemisia annua L
-
Zhang, F., Lu, X., Lv, Z., Zhang, L., Zhu, M., Jiang, W., et al. (2013). Overexpression of the Artemisia orthologue of ABA receptor, AaPYL9, enhances ABA sensitivity and improves artemisinin content in Artemisia annua L. PLOS ONE 8:e56697. doi: 10.1371/journal.pone.0056697
-
(2013)
PLOS ONE
, pp. 8
-
-
Zhang, F.1
Lu, X.2
Lv, Z.3
Zhang, L.4
Zhu, M.5
Jiang, W.6
-
128
-
-
67349227971
-
Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing
-
Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., et al. (2009). Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing. Biotechnol. Appl. Biochem. 52, 199–207. doi: 10.1042/BA20080068
-
(2009)
Biotechnol. Appl. Biochem
, vol.52
, pp. 199-207
-
-
Zhang, L.1
Jing, F.2
Li, F.3
Li, M.4
Wang, Y.5
Wang, G.6
-
129
-
-
79954608615
-
The production of artemisinin precursors in tobacco
-
Zhang, Y., Nowak, G., Reed, D. W., and Covello, P. S. (2011). The production of artemisinin precursors in tobacco. Plant Biotechnol. J. 9, 445–454. doi: 10.1111/j.1467-7652.2010.00556.x
-
(2011)
Plant Biotechnol. J
, vol.9
, pp. 445-454
-
-
Zhang, Y.1
Nowak, G.2
Reed, D.W.3
Covello, P.S.4
-
130
-
-
52049090608
-
The molecular cloning of artemisinic aldehyde Δ11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua
-
Zhang, Y., Teoh, K. H., Reed, D. W., Maes, L., Goossens, A., Olson, D. J., et al. (2008). The molecular cloning of artemisinic aldehyde Δ11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J. Biol. Chem. 283, 21501–21508. doi: 10.1074/jbc.M803090200
-
(2008)
J. Biol. Chem
, vol.283
, pp. 21501-21508
-
-
Zhang, Y.1
Teoh, K.H.2
Reed, D.W.3
Maes, L.4
Goossens, A.5
Olson, D.J.6
|