-
1
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70:461-77.
-
(2007)
J Nat Prod
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
2
-
-
33751120932
-
Production of isoprenoid pharmaceuticals by engineered microbes
-
Chang MCY, Keasling JD. Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol. 2006;2:674-81.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 674-681
-
-
Chang, M.C.Y.1
Keasling, J.D.2
-
6
-
-
0036668385
-
Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex
-
Simonsen HT, Larsen MD, Nielsen MW, et al. Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex. Phytochem. 2002;60:817-20.
-
(2002)
Phytochem
, vol.60
, pp. 817-820
-
-
Simonsen, H.T.1
Larsen, M.D.2
Nielsen, M.W.3
-
7
-
-
0035134406
-
In vitro screening of Indian medicinal plants for antiplasmodial activity
-
Simonsen HT, Nordskjold JB, Smitt UW, et al. In vitro screening of Indian medicinal plants for antiplasmodial activity. J. Ethnopharm. 2001;74:195-204.
-
(2001)
J. Ethnopharm
, vol.74
, pp. 195-204
-
-
Simonsen, H.T.1
Nordskjold, J.B.2
Smitt, U.W.3
-
9
-
-
23044490704
-
Plants as a source of anti-cancer agents
-
22 August
-
Gordon M Cragg, David J Newman. Plants as a source of anti-cancer agents. Journal of Ethnopharmacology. 22 August 2005;100(1-2): 72-79.
-
(2005)
Journal of Ethnopharmacology
, vol.100
, Issue.1-2
, pp. 72-79
-
-
Cragg, G.M.1
Newman, D.J.2
-
10
-
-
33845736982
-
Biosynthesis and engineering of isoprenoid small molecules
-
Withers ST, Keasling JD. Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechn. 2007;73:980-90.
-
(2007)
Appl Microbiol Biotechn
, vol.73
, pp. 980-990
-
-
Withers, S.T.1
Keasling, J.D.2
-
11
-
-
77953422987
-
Source of New Hope Against Malaria is in Short Supply Martin Enserink
-
7 January
-
Withers. Source of New Hope Against Malaria is in Short Supply Martin Enserink Science 7 January 2005;307(5706):33.
-
(2005)
Science
, vol.307
, Issue.5706
, pp. 33
-
-
Withers1
-
12
-
-
84882270583
-
-
online, Acccesed on 18 December 2008. URL:, 2008
-
Phyton Biotech. History. Product information [online]. Acccesed on 18 December 2008. URL: http://www.phytonbiotech.com/. 2008.
-
Phyton Biotech. History. Product information
-
-
-
13
-
-
0037629456
-
Micropropagation of Thapsia garganica - a medicinal plant
-
Makunga NP, Jäger AK, Van Staden J. Micropropagation of Thapsia garganica - a medicinal plant. Plant Cell Rep. 2003;21:967-73.
-
(2003)
Plant Cell Rep
, vol.21
, pp. 967-973
-
-
Makunga, N.P.1
Jäger, A.K.2
Van Staden, J.3
-
14
-
-
0042308774
-
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
-
Denmeade SR, Jakobsen CM, Janssen S. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst. 2003;95:990-1000.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 990-1000
-
-
Denmeade, S.R.1
Jakobsen, C.M.2
Janssen, S.3
-
15
-
-
33644765198
-
Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug
-
Janssen S, Rosen DM, Ricklis RM, et al. Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug. The Prostate. 2006;66:358-68.
-
(2006)
The Prostate
, vol.66
, pp. 358-368
-
-
Janssen, S.1
Rosen, D.M.2
Ricklis, R.M.3
-
16
-
-
33644773458
-
Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells
-
Søhoel H, Jensen AM, Moller JV, et al. Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. Bioorg Med Chem. 2006; 14:2810-15.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 2810-2815
-
-
Søhoel, H.1
Jensen, A.M.2
Moller, J.V.3
-
17
-
-
0037043709
-
Structural changes in the calcium pump accompanying the dissociation of calcium
-
Toyoshima C, Nomura H. Structural changes in the calcium pump accompanying the dissociation of calcium. Nature. 2002;418:605-11.
-
(2002)
Nature
, vol.418
, pp. 605-611
-
-
Toyoshima, C.1
Nomura, H.2
-
18
-
-
0033850926
-
Medicinal plant biotechnology: The Apiaceae family as an example of development
-
Ekiert H. Medicinal plant biotechnology: the Apiaceae family as an example of development. Pharmazie. 2000;55:561-67.
-
(2000)
Pharmazie
, vol.55
, pp. 561-567
-
-
Ekiert, H.1
-
19
-
-
0037550813
-
Somatic embryogenesis in cell cultures of Thapsia garganica: Correlation between the state of differentiation and the content of thapsigargins
-
Jäger AK, Schottländer B, Smitt UW, et al. Somatic embryogenesis in cell cultures of Thapsia garganica: Correlation between the state of differentiation and the content of thapsigargins. Plant Cell Rep. 1993;12:517-20.
-
(1993)
Plant Cell Rep
, vol.12
, pp. 517-520
-
-
Jäger, A.K.1
Schottländer, B.2
Smitt, U.W.3
-
20
-
-
33746075187
-
Improved in vitro rooting and hyperhydricity in regenerating tissues of Thapsia garganica L
-
Makunga NP, Jäger AK, Van Staden J. Improved in vitro rooting and hyperhydricity in regenerating tissues of Thapsia garganica L. Plant Cell Tiss Organ Cult. 2006;86:77-86.
-
(2006)
Plant Cell Tiss Organ Cult
, vol.86
, pp. 77-86
-
-
Makunga, N.P.1
Jäger, A.K.2
Van Staden, J.3
-
21
-
-
0043206088
-
A rapid and efficient method for regeneration of plantlets from embryo explants of cumin (Cuminum cyminum)
-
Ebrahimie E, Habashi AA, Ghareyazie B, et al. A rapid and efficient method for regeneration of plantlets from embryo explants of cumin (Cuminum cyminum). Plant Cell Tiss Org Cult. 2003;75:19-25.
-
(2003)
Plant Cell Tiss Org Cult
, vol.75
, pp. 19-25
-
-
Ebrahimie, E.1
Habashi, A.A.2
Ghareyazie, B.3
-
22
-
-
33847776061
-
Total synthesis of thapsigargin, a potent SERCA pump inhibitor
-
Ball M, Andrews SP, Wierschem F, et al. Total synthesis of thapsigargin, a potent SERCA pump inhibitor. Org Lett. 2007;9:663-6.
-
(2007)
Org Lett
, vol.9
, pp. 663-666
-
-
Ball, M.1
Andrews, S.P.2
Wierschem, F.3
-
23
-
-
48149106189
-
Metabolic engineering of microorganisms for isoprenoid production
-
Kirby J, Keasling JD. Metabolic engineering of microorganisms for isoprenoid production. Nat Prod Rep. 2008;25:656-61.
-
(2008)
Nat Prod Rep
, vol.25
, pp. 656-661
-
-
Kirby, J.1
Keasling, J.D.2
-
24
-
-
34247182988
-
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
-
Chang MC, Eachus RA, Trieu W, et al. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol. 2007;3:274-277.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 274-277
-
-
Chang, M.C.1
Eachus, R.A.2
Trieu, W.3
-
25
-
-
84882255012
-
Guaianolides in Apiaceae, perspectives on pharmacology and biosynthesis
-
in press
-
Simonsen HT, Reichwald K, Krichau N (in press). Guaianolides in Apiaceae, perspectives on pharmacology and biosynthesis. Phytochem Rev.
-
Phytochem Rev
-
-
Simonsen, H.T.1
Reichwald, K.2
Krichau, N.3
-
26
-
-
44449098258
-
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase
-
Paradise EM, Kirby J, Chan R, et al. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. Biotech Bioeng. 2008;100:371-78.
-
(2008)
Biotech Bioeng
, vol.100
, pp. 371-378
-
-
Paradise, E.M.1
Kirby, J.2
Chan, R.3
-
27
-
-
33746337924
-
Metabolic engineering of terpenoid biosynthesis in plants
-
Aharoni A, Jongsma MA, Kim T-Y, et al. Metabolic engineering of terpenoid biosynthesis in plants. Phytochem Rev. 2006;5:49-58.
-
(2006)
Phytochem Rev
, vol.5
, pp. 49-58
-
-
Aharoni, A.1
Jongsma, M.A.2
Kim, T.-Y.3
-
28
-
-
6444235290
-
Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of taxol
-
Besumbes O, Sauret-Gueto S, Phillips MA, et al. Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of taxol. Biotechnol Bioeng. 2004;88:168-75.
-
(2004)
Biotechnol Bioeng
, vol.88
, pp. 168-175
-
-
Besumbes, O.1
Sauret-Gueto, S.2
Phillips, M.A.3
-
29
-
-
20144382868
-
Do we need another model plant?
-
Reski R. Do we need another model plant? Plant Biol. 2005;7:219.
-
(2005)
Plant Biol
, vol.7
, pp. 219
-
-
Reski, R.1
-
30
-
-
0031930234
-
Development, genetics and molecular biology of mosses
-
Reski R. Development, genetics and molecular biology of mosses. Botanica Acta. 1998;111:1-15.
-
(1998)
Botanica Acta
, vol.111
, pp. 1-15
-
-
Reski, R.1
-
31
-
-
36148950459
-
Moss bioreactors producing improved biopharmaceuticals
-
Decker EL, Reski R. Moss bioreactors producing improved biopharmaceuticals. Curr opin Plant Biotech. 2007;18:393-98.
-
(2007)
Curr opin Plant Biotech
, vol.18
, pp. 393-398
-
-
Decker, E.L.1
Reski, R.2
-
32
-
-
37249011824
-
Current achievements in the production of complex biopharmaceuticals with moss bioreactors
-
Decker EL, Reski R. Current achievements in the production of complex biopharmaceuticals with moss bioreactors. Bioprocess Biosyst Eng. 2008;31:3-9.
-
(2008)
Bioprocess Biosyst Eng
, vol.31
, pp. 3-9
-
-
Decker, E.L.1
Reski, R.2
-
33
-
-
34147185919
-
High-level expression of secreted complex glycosylated recombinant human erythropoietin in the Physcomitrella Delta-fuc-t Delta-xyl-t mutant
-
Weise A, Altmann F, Rodriguez-Franco M, et al. High-level expression of secreted complex glycosylated recombinant human erythropoietin in the Physcomitrella Delta-fuc-t Delta-xyl-t mutant. Plant Biotech J. 2007;5:389-401.
-
(2007)
Plant Biotech J
, vol.5
, pp. 389-401
-
-
Weise, A.1
Altmann, F.2
Rodriguez-Franco, M.3
-
34
-
-
20144372901
-
Glyco-engineering of moss lacking plant-specific sugar residues
-
Huether CM, Lienhart O, Baur A, et al. Glyco-engineering of moss lacking plant-specific sugar residues. Plant Biol. 2005;7:292-9.
-
(2005)
Plant Biol
, vol.7
, pp. 292-299
-
-
Huether, C.M.1
Lienhart, O.2
Baur, A.3
-
35
-
-
0017404566
-
Isolation and preliminary characterization of auxotrophic and analog resistant mutants of moss, Physcomitella patens
-
Ashton NW, Cove DJ. Isolation and preliminary characterization of auxotrophic and analog resistant mutants of moss, Physcomitella patens. Mol Gen Genet. 1977;154:87-95.
-
(1977)
Mol Gen Genet
, vol.154
, pp. 87-95
-
-
Ashton, N.W.1
Cove, D.J.2
-
37
-
-
14944380630
-
Physcomitrella patens is highly tolerant against drought, salt and osmotic stress
-
Frank W, Ratnadewi D, Reski R. Physcomitrella patens is highly tolerant against drought, salt and osmotic stress. Planta. 2005a; 220:384-94.
-
(2005)
Planta
, vol.220
, pp. 384-394
-
-
Frank, W.1
Ratnadewi, D.2
Reski, R.3
-
38
-
-
0037004346
-
A new moss genetics: Targeted mutagenesis in Physcomitrella patens
-
Schaefer DG. A new moss genetics: Targeted mutagenesis in Physcomitrella patens. Annu Rev Plant Biol. 2002;53:477-501.
-
(2002)
Annu Rev Plant Biol
, vol.53
, pp. 477-501
-
-
Schaefer, D.G.1
-
39
-
-
20144383719
-
Molecular tools to study Physcomitrella patens
-
Frank W, Decker EL, Reski R. Molecular tools to study Physcomitrella patens. Plant Biol. 2005b;7:220-7.
-
(2005)
Plant Biol
, vol.7
, pp. 220-227
-
-
Frank, W.1
Decker, E.L.2
Reski, R.3
-
40
-
-
13244299112
-
Quantitative promoter analysis in Physcomitrella patens: A set of plant vectors activating gene expression within three orders of magnitude
-
Horstmann V, Huether CM, Jost W, et al. Quantitative promoter analysis in Physcomitrella patens: a set of plant vectors activating gene expression within three orders of magnitude. BMC Biotech. 2004;4:13.
-
(2004)
BMC Biotech
, vol.4
, pp. 13
-
-
Horstmann, V.1
Huether, C.M.2
Jost, W.3
-
41
-
-
27644515982
-
Controlled expression of recombinant proteins in Physcomitrella patens by a conditional heatshock promoter: A tool for plant research and biotechnology
-
Saidi Y, Finka A, Chakhporanian M, et al. Controlled expression of recombinant proteins in Physcomitrella patens by a conditional heatshock promoter: A tool for plant research and biotechnology. Plant Mol Biol. 2005;59:697-711.
-
(2005)
Plant Mol Biol
, vol.59
, pp. 697-711
-
-
Saidi, Y.1
Finka, A.2
Chakhporanian, M.3
-
42
-
-
34547915249
-
+ via sodium ATPase (PpENA1) ensures normal growth of Physcomitrella patens under moderate salt stress
-
+ via sodium ATPase (PpENA1) ensures normal growth of Physcomitrella patens under moderate salt stress. Plant Phys. 2007;144:1786-96.
-
(2007)
Plant Phys
, vol.144
, pp. 1786-1796
-
-
Lunde, C.1
Drew, D.P.2
Jacobs, A.K.3
-
43
-
-
2442553073
-
The moss Physcomitrella patens releases a tetracyclic diterpene
-
Schwartzenberg von K, Schultze W, Kassner H. The moss Physcomitrella patens releases a tetracyclic diterpene. Plant Cell Rep. 2004;22:780-6.
-
(2004)
Plant Cell Rep
, vol.22
, pp. 780-786
-
-
Schwartzenberg von, K.1
Schultze, W.2
Kassner, H.3
-
44
-
-
33750505476
-
Identification and functional analysis of bifunctional ent-kaurene synthase from the moss Physcomitrella patens
-
Hayashia K-I, Kawaideb H, Notomib M, et al. Identification and functional analysis of bifunctional ent-kaurene synthase from the moss Physcomitrella patens. FEBS Lett. 2006;580:6175-81.
-
(2006)
FEBS Lett
, vol.580
, pp. 6175-6181
-
-
Hayashia, K.-I.1
Kawaideb, H.2
Notomib, M.3
-
45
-
-
30544434619
-
Combinatorial biosynthesis of reduced polyketides
-
Weissman KJ, Leadlay PF. Combinatorial biosynthesis of reduced polyketides. Nature Rev Microbio. 2005;3:925-36.
-
(2005)
Nature Rev Microbio
, vol.3
, pp. 925-936
-
-
Weissman, K.J.1
Leadlay, P.F.2
-
46
-
-
33751103661
-
Combinatorial biosynthesis in symbiotic bacteria
-
Piel J. Combinatorial biosynthesis in symbiotic bacteria. Nat Chem Biol. 2006;2:661-2.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 661-662
-
-
Piel, J.1
-
47
-
-
16844363378
-
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
-
Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005;105:4163-9.
-
(2005)
Blood
, vol.105
, pp. 4163-4169
-
-
Guzman, M.L.1
Rossi, R.M.2
Karnischky, L.3
-
48
-
-
0034485867
-
The efficacy and safety of feverfew (Tanacetum parthenium L.): An update of a systematic review
-
Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr. 2000;3:509-14.
-
(2000)
Public Health Nutr
, vol.3
, pp. 509-514
-
-
Ernst, E.1
Pittler, M.H.2
-
49
-
-
0000839814
-
(+)-Germacrene A biosynthesis - The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory
-
De Kraker JW, Franssen MCR, de Groot A, et al. (+)-Germacrene A biosynthesis - The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory. Plant Physiol. 1998; 117:1381-92.
-
(1998)
Plant Physiol
, vol.117
, pp. 1381-1392
-
-
De Kraker, J.W.1
Franssen, M.C.R.2
de Groot, A.3
-
50
-
-
0035999702
-
Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory
-
De Kraker JW, Franssen MCR, Joerink M, et al. Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. Plant Physiol. 2002;129:257-68.
-
(2002)
Plant Physiol
, vol.129
, pp. 257-268
-
-
De Kraker, J.W.1
Franssen, M.C.R.2
Joerink, M.3
-
51
-
-
44349092096
-
Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis
-
Okada K, Kasahara H, Yamaguchi S, et al. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. Plant Cell Phys. 2008; 49:604-16.
-
(2008)
Plant Cell Phys
, vol.49
, pp. 604-616
-
-
Okada, K.1
Kasahara, H.2
Yamaguchi, S.3
|