Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment

Plant Growth Regulation

Volumn 63, Issue 1, 2011, Pages 45-54

  Banyai, Waleerat ^a,b   Mii, Masahiro ^b   Supaibulwatana, Kanyaratt ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Artemisia annua; Artemisinin; Flowering; Gene expression

Indexed keywords

ARTEMISIA ANNUA;

EID: 78650305586     PISSN: 01676903     EISSN: 15735087     Source Type: Journal    
DOI: 10.1007/s10725-010-9510-9     Document Type: Article

References (40)

1. Abdin MZ, Israr M, Rehman RU, Jain SK (2003) Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production. Planta Med 69: 289-299.
2. Acton N, Klayman DL (1985) Artemisinin, a new sesquiterpene lactone endoperoxide from Artemisia annua. Planta Med 5: 441-442.
3. Alonso-Ramirez A, Rodriguez D, Reyes D, Jimenez JA, Nicolas G, Lopez-Climent M et al (2009) Evidence for a role of gibberellins in salicylic acid-modulated early plant responses to abiotic stress in Arabidopsis seeds. Plant Physiol 150: 1335-1344.
4. Avery MA, Chong WKM, Jennings-White C (1992) Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L. J Am Chem Soc 114: 974-979.
5. Bagchi GD, Jain DC, Kumar S (1997) Arteether: a potent plant growth inhibitor from Artemisia annua. Phytochemistry 45: 1131-1133.
6. Banyai W, Kirdmanee C, Mii M, Supaibulwatana K (2010) Overexpression and sense suppression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L. Plant Cell Tiss Organ Cult. doi: 10. 1007/s11240-010-9775-8.
7. Baraldi R, Isacchi B, Predieri S, Marconi G, Vincieri FF, Bilia AR (2008) Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth. Biochem Syst Ecol 36: 340-348.
8. Bertea CM, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V et al (2005) Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta Med 71: 0-7.
9. Dayan FE, Hernandez A, Allen SN, Moraes RM, Vroman JA, Avery MA et al (1999) Comparative phytotoxicity of artemisinin and several sesquiterpene analogues. Phytochemistry 50: 607-614.
10. Enfissi EMA, Fraser PD, Lois LM, Boronat A, Schuch W, Bramley PM (2005) Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathway for the production of health-promoting isoprenoids in tomato. Plant Biotechnol J 3: 17-27.
11. Feng LL, Yang RY, Yang XQ, Zeng XM, Lu WJ, Zeng QP (2009) Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgenic Artemisia annua. Plant Sci 177: 57-67.
12. Ferreira JFS, Simon JE, Janick J (1995) Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions. Planta Med 61: 167-170.
13. Gomi K, Matsuoka M (2003) Gibberellin signaling pathway. Curr Opin Plant Biol 6: 489-493.
14. Hedden P, Phillips AL (2000) Gibberellin metabolism: new insights revealed by the genes. Trends Plant Sci 5: 523-530.
15. Jaleel CA, Gopi R, Manivannan P, Sankar B, Kishorekumar A, Panneerselvam R (2007) Antioxidant potentials and ajmalicine accumulation in Catharanthus roseus after treatment with gibberellic acid. Colloids Surf B Biointerf 60: 195-200.
16. Jing F, Zhang L, Li M, Tang Y, Wang Y, Wang Y et al (2009) Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway. Biologia 64: 319-323.
17. Klayman DL (1985) Qinghaosu (artemisinin): an antimalarial drug from China. Science 228: 1049-1055.
18. Krishna S, Bustamante L, Haynes RK, Staines HM (2008) Artemisinins: their growing importance in medicine. Trends Pharmacol Sci 29: 520-527.
19. Liu Y, Wang H, Ye HC, Li GF (2005) Advances in the plant isoprenoid biosynthesis pathway and its metabolic engineering. J Interg Plant Biol 47: 769-782.
20. Mannan A, Liu C, Arsenault PR, Towler MJ, Vail DR, Lorence A et al (2010) DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures. Plant Cell Rep 29: 143-152.
21. 9-tetrahydrocannabinol in Cannabis sativa at flowering stage. J Integr Plant Biol 51: 553-561.
22. Morales MR, Charles DJ, Simon JE (1993) Seasonal accumulation of artemisinin in Artemisia annua. Acta Horticult 334: 416-420.
23. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassay with tobacco tissue cultures. Plant Physiol 15: 473-497.
24. Mutabingwa TK (2005) Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy. Acta Trop 95: 305-315.
25. Nicot N, Hausman JF, Hoffmann L, Evers D (2005) Housekeeping gene selection for real-time RT-PCR normalization in potato during biotic and abiotic stress. J Exp Bot 56(421): 2907-2914.
26. Olsson ME, Olofsson LM, Lindahl AL, Lundgren A, Brodelius M, Brodelius PE (2009) Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L. Phytochemistry 70: 1123-1128.
27. Pras N, Visser JF, Batterman S, Woerdenbag HJ, Malingre TM, Lugt CB (1991) Laboratory selection of Artemisia annua for high artemisinin yielding types. Phytochem Anal 2: 80-83.
28. Pu GB, Ma DM, Chen JL, Ma LQ, Wang H, Li GF et al (2009) Salicylic acid activates artemisinin biosynthesis in Artemisia annua L. Plant Cell Rep 28: 1127-1135.
29. Qian Z, Gong K, Zhang L, Lv J, Jing F, Wang Y et al (2007) A simple and efficient procedure to enhance artemisinin content in Artemisia annua L. by seeding to salinity stress. Afr J Biotechnol 6: 1410-1413.
30. Qureshi MI, Israr M, Abdin MZ, Iqbal M (2005) Responses of Artemisia annua L. to lead and salt-induced oxidative stress. Environ Exp Bot 53: 185-193.
31. Shukla A, Farooqi AHA, Shukla YN, Sharma S (1992) Effect of triacontanol and chlormequat on growth, plant hormones and artemisinin yield in Artemisia annua L. Plant Growth Regul 11: 165-171.
32. Smith TC, Weathers PJ, Cheetham RD (1997) Effect of gibberellic acid on hairy root cultures of Artemisia annua: growth and artemisinin production. In Vitro Cell Dev Biol-Plant 33: 75-79.
33. Towler MJ, Weathers PJ (2007) Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. Plant Cell Rep 26: 2129-2136.
34. van Nieuwerburgh FC, Vande Casteele SR, Maes L, Goossens A, Inze D, van Bocxlaer J, Deforce DL (2006) Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-offlight tandem mass spectrometry. J Chromatogr A 1118: 180-187.
35. Vandenberghe DR, Vergauwe AN, van Montagu M, van den Eeckhout EG (1995) Simultaneous determination of artemisinin and its bioprecursors of Artemisia annua. J Nat Products 58: 798-803.
36. Wang ML, Jiang YS, Wei JQ, Wei X, Qi XX, Jiang SY et al (2007) Effects of irradiance on growth, photosynthetic characteristics, and artemisinin content of Artemisia annua L. Photosynthetica 46: 17-20.
37. 3) on salt-stressed rice (Oryza sativa L.) shoots. Plant Sci 178: 170-175.
38. White NJ (2008) Qinghaosu (Artemisinin): the price of success. Science 320: 330-334.
39. Woerdenbag HJ, Luers JFJ, van Uden W, Pras N, Malingre TM, Alfermann AW (1993) Production of the new antimalarial drug in shoot cultures of Artemisia annua L. Plant Cell Tissue Org Cult 32: 247-257.
40. 3 and flowering induce the conversion of artemisinic acid to artemisinin in Artemisia annua plants. Russ J Plant Physiol 52: 58-62.