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Volumn , Issue , 2017, Pages 1-17

Mass Production of Artemisinin Using Hairy Root Cultivation of Artemisia annua in Bioreactor

Author keywords

Artemisinin; Gas phase bioreactors; Hairy root culture; Liquid phase bioreactors; Mathematical modeling

Indexed keywords


EID: 85139115556     PISSN: 2511834X     EISSN: 25118358     Source Type: Book Series    
DOI: 10.1007/978-3-319-32004-5_20-1     Document Type: Chapter
Times cited : (7)

References (71)
  • 1
    • 78650486233 scopus 로고    scopus 로고
    • Antimalarial drugs: Modes of action and mechanisms of parasite resistance
    • Muller IB, Hyde JE (2010) Antimalarial drugs: Modes of action and mechanisms of parasite resistance. Future Microbiol 5:1857-1873
    • (2010) Future Microbiol , vol.5 , pp. 1857-1873
    • Muller, I.B.1    Hyde, J.E.2
  • 2
    • 0001123285 scopus 로고    scopus 로고
    • Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action
    • Cumming JN, Ploypradith P, Posner GH (1997) Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action. Adv Pharmacol 37:253-297
    • (1997) Adv Pharmacol , vol.37 , pp. 253-297
    • Cumming, J.N.1    Ploypradith, P.2    Posner, G.H.3
  • 4
    • 77950362015 scopus 로고    scopus 로고
    • The molecular mechanism of action of artemisinin— the debate continues
    • O'Neill PM, Barton VE, Ward SA (2010) The molecular mechanism of action of artemisinin— the debate continues. Molecules 15:1705
    • (2010) Molecules , vol.15 , pp. 1705
    • O'Neill, P.M.1    Barton, V.E.2    Ward, S.A.3
  • 7
    • 0026584198 scopus 로고
    • Stereoselective total synthesis of (+)artemisinin, the antimalarial constituent of Artemisia annua L
    • Avery MA, Chong WKM, Jennings-White C (1992) Stereoselective total synthesis of (+)artemisinin, the antimalarial constituent of Artemisia annua L. J Am Chem Soc 114:974-979
    • (1992) J am Chem Soc , vol.114 , pp. 974-979
    • Avery, M.A.1    Chong, W.2    Jennings-White, C.3
  • 8
    • 7944222115 scopus 로고    scopus 로고
    • Artemisinins: Mechanisms of action and potential for resistance
    • Krishna S, Uhlemann AC, Haynes RK (2004) Artemisinins: Mechanisms of action and potential for resistance. Drug Resist Updat 7:233-244
    • (2004) Drug Resist Updat , vol.7 , pp. 233-244
    • Krishna, S.1    Uhlemann, A.C.2    Haynes, R.K.3
  • 10
    • 0036435747 scopus 로고    scopus 로고
    • Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects
    • Lefevre G, Carpenter P, Souppart C, Schmidli H, McClean M, Stypinski D (2002) Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. Br J Clin Pharmacol 54:485-492
    • (2002) Br J Clin Pharmacol , vol.54 , pp. 485-492
    • Lefevre, G.1    Carpenter, P.2    Souppart, C.3    Schmidli, H.4    McClean, M.5    Stypinski, D.6
  • 11
    • 0001069615 scopus 로고
    • Selection and breeding for high artemisinin (qinghaosu) yielding strains of Artemisia annua
    • Delabays N, Benakis A, Collet G (1993) Selection and breeding for high artemisinin (qinghaosu) yielding strains of Artemisia annua. Acta Hortic 330:203-206
    • (1993) Acta Hortic , vol.330 , pp. 203-206
    • Delabays, N.1    Benakis, A.2    Collet, G.3
  • 13
    • 0000878173 scopus 로고    scopus 로고
    • Artemisia annua: Botany, horticulture, pharmacology
    • Wiley, New York
    • Ferreira JFS, Simon JE, Janick J (2010) Artemisia annua: Botany, horticulture, pharmacology. In: Horticultural reviews. Wiley, New York, pp 319-371
    • (2010) Horticultural Reviews , pp. 319-371
    • Ferreira, J.1    Simon, J.E.2    Janick, J.3
  • 14
    • 0029808207 scopus 로고    scopus 로고
    • Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua
    • Ferreira JS, Janick J (1996) Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua. Plant Cell Tissue Organ Cult 44:211-217
    • (1996) Plant Cell Tissue Organ Cult , vol.44 , pp. 211-217
    • Ferreira, J.S.1    Janick, J.2
  • 15
    • 0034163670 scopus 로고    scopus 로고
    • Transgenic hairy roots: Recent trends and applications
    • Giri A, Narasu ML (2000) Transgenic hairy roots: Recent trends and applications. Biotechnol Adv 18:1-22
    • (2000) Biotechnol Adv , vol.18 , pp. 1-22
    • Giri, A.1    Narasu, M.L.2
  • 16
    • 33947219525 scopus 로고    scopus 로고
    • Hairy root culture for mass-production of high-value secondary metabolites
    • Srivastava S, Srivastava AK (2007) Hairy root culture for mass-production of high-value secondary metabolites. Crit Rev Biotechnol 27:29-43
    • (2007) Crit Rev Biotechnol , vol.27 , pp. 29-43
    • Srivastava, S.1    Srivastava, A.K.2
  • 17
    • 0031465841 scopus 로고    scopus 로고
    • Flavonoids in root cultures of Scutellaria baicalensis
    • Nishikawa K, Ishimaru K (1997) Flavonoids in root cultures of Scutellaria baicalensis. J Plant Physiol 151:633-638
    • (1997) J Plant Physiol , vol.151 , pp. 633-638
    • Nishikawa, K.1    Ishimaru, K.2
  • 18
    • 33646680249 scopus 로고    scopus 로고
    • Hairy root and its application in plant genetic engineering
    • Hu Z-B, Du M (2006) Hairy root and its application in plant genetic engineering. J Integr Plant Biol 48:121-127
    • (2006) J Integr Plant Biol , vol.48 , pp. 121-127
    • Hu, Z.-B.1    Du, M.2
  • 19
    • 0043023565 scopus 로고    scopus 로고
    • Scale-up of Artemisia annua L. hairy root cultures produces complex patterns of terpenoid gene expression
    • Souret FF, Kim Y, Wyslouzil BE, Wobbe KK, Weathers PJ (2003) Scale-up of Artemisia annua L. hairy root cultures produces complex patterns of terpenoid gene expression. Biotechnol Bioeng 83:653-667
    • (2003) Biotechnol Bioeng , vol.83 , pp. 653-667
    • Souret, F.F.1    Kim, Y.2    Wyslouzil, B.E.3    Wobbe, K.K.4    Weathers, P.J.5
  • 20
    • 29044445562 scopus 로고    scopus 로고
    • Medicinal plants: Traditions of yesterday and drugs of tomorrow
    • Gurib-Fakim A (2006) Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol Asp Med 27:1-93
    • (2006) Mol Asp Med , vol.27 , pp. 1-93
    • Gurib-Fakim, A.1
  • 21
    • 0030981836 scopus 로고    scopus 로고
    • State of the art of the production of the antimalarial compound artemisinin in plants
    • Van Geldre E, Vergauwe A, Van den Eeckhout E (1997) State of the art of the production of the antimalarial compound artemisinin in plants. Plant Mol Biol 33:199-209
    • (1997) Plant Mol Biol , vol.33 , pp. 199-209
    • Van Geldre, E.1    Vergauwe, A.2    Van Den Eeckhout, E.3
  • 22
    • 0006937659 scopus 로고
    • Effect of agronomic practices on plant yield and antimalarial constituents of Artemisia annua L
    • Laughlin JC (1993) Effect of agronomic practices on plant yield and antimalarial constituents of Artemisia annua L. Acta Hortic 331:53-61
    • (1993) Acta Hortic , vol.331 , pp. 53-61
    • Laughlin, J.C.1
  • 24
    • 84937252155 scopus 로고    scopus 로고
    • Transplanting and harvesting effect on artemisinin biosynthesis and herb yield in Artemisia annua L
    • Paul S, Khanuja SPS, Gupta MM (2015) Transplanting and harvesting effect on artemisinin biosynthesis and herb yield in Artemisia annua L. Agrofor Syst 89:751-757
    • (2015) Agrofor Syst , vol.89 , pp. 751-757
    • Paul, S.1    Khanuja, S.2    Gupta, M.M.3
  • 27
    • 0011583806 scopus 로고
    • Toward the production of artemisinin through tissue culture: Determining nutrient-hormone combinations suitable for cell suspension cultures
    • Basile D, Akhtari N, Durand Y, Nair MSR (1993) Toward the production of artemisinin through tissue culture: Determining nutrient-hormone combinations suitable for cell suspension cultures. In Vitro Cell Dev Biol Plant 29:143-147
    • (1993) Vitro Cell Dev Biol Plant , vol.29 , pp. 143-147
    • Basile, D.1    Akhtari, N.2    Durand, Y.3    Nair, M.4
  • 28
    • 0030864387 scopus 로고    scopus 로고
    • Production of artemisinin by hairy root cultures of Artemisia annua L
    • Liu CZ, Wang YC, Ouyang F, Ye HC, Li GF (1997) Production of artemisinin by hairy root cultures of Artemisia annua L. Biotechnol Lett 19:927-929
    • (1997) Biotechnol Lett , vol.19 , pp. 927-929
    • Liu, C.Z.1    Wang, Y.C.2    Ouyang, F.3    Ye, H.C.4    Li, G.F.5
  • 29
    • 84940449489 scopus 로고    scopus 로고
    • Use of model-based nutrient feeding for improved production of artemisinin by hairy roots of Artemisia annua in a modified stirred tank bioreactor
    • Patra N, Srivastava AK (2015) Use of model-based nutrient feeding for improved production of artemisinin by hairy roots of Artemisia annua in a modified stirred tank bioreactor. Appl Biochem Biotechnol 177:373-388
    • (2015) Appl Biochem Biotechnol , vol.177 , pp. 373-388
    • Patra, N.1    Srivastava, A.K.2
  • 31
    • 84953367209 scopus 로고    scopus 로고
    • Artemisinin production by plant hairy root cultures in gasand liquid-phase bioreactors
    • Patra N, Srivastava A (2016) Artemisinin production by plant hairy root cultures in gasand liquid-phase bioreactors. Plant Cell Rep 35:143-153
    • (2016) Plant Cell Rep , vol.35 , pp. 143-153
    • Patra, N.1    Srivastava, A.2
  • 33
    • 36749020540 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells
    • Srivastava JK, Gupta S (2007) Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells. J Agric Food Chem 55:9470-9478
    • (2007) J Agric Food Chem , vol.55 , pp. 9470-9478
    • Srivastava, J.K.1    Gupta, S.2
  • 34
    • 0029107288 scopus 로고
    • Establishment of normal and transformed root cultures of Artemisia-annua L for Artemisinin production
    • Jaziri M, Shimomura K, Yoshimatsu K, Fauconnier ML, Marlier M, Homes J (1995) Establishment of normal and transformed root cultures of Artemisia-annua L for Artemisinin production. J Plant Physiol 145:175-177
    • (1995) J Plant Physiol , vol.145 , pp. 175-177
    • Jaziri, M.1    Shimomura, K.2    Yoshimatsu, K.3    Fauconnier, M.L.4    Marlier, M.5    Homes, J.6
  • 35
    • 52949096489 scopus 로고    scopus 로고
    • Hairy roots induction and artemisinin analysis in Artemisia dubia and Artemisia indica
    • Mannan A, Shaheen N, Arshad W, Rizwana QA, Zia M, Mirza B (2008) Hairy roots induction and artemisinin analysis in Artemisia dubia and Artemisia indica. Afr J Biotechnol 7:3288-3292
    • (2008) Afr J Biotechnol , vol.7 , pp. 3288-3292
    • Mannan, A.1    Shaheen, N.2    Arshad, W.3    Rizwana, Q.A.4    Zia, M.5    Mirza, B.6
  • 36
    • 85101163769 scopus 로고    scopus 로고
    • DMSO stimulates production of Artemisinin and also suggests that the sesquiterpene may function as a ROS sink in Artemisia annua
    • Weathers PJ, Mannan A, Liu C, Towler MJ, Vail D, Lorence A (2009) DMSO stimulates production of Artemisinin and also suggests that the sesquiterpene may function as a ROS sink in Artemisia annua. In Vitro Cell Dev Biol Animal 45:S69.
    • (2009) Vitro Cell Dev Biol Animal , vol.45
    • Weathers, P.J.1    Mannan, A.2    Liu, C.3    Towler, M.J.4    Vail, D.5    Lorence, A.6
  • 37
    • 0042412388 scopus 로고    scopus 로고
    • Influence of different strains of Agrobacterium rhizogenes on induction of hairy roots and artemisinin production in Artemisia annua
    • Giri A, Ravindra ST, Dhingra V, Narasu ML (2001) Influence of different strains of Agrobacterium rhizogenes on induction of hairy roots and artemisinin production in Artemisia annua. Curr Sci 81:378-382
    • (2001) Curr Sci , vol.81 , pp. 378-382
    • Giri, A.1    Ravindra, S.T.2    Dhingra, V.3    Narasu, M.L.4
  • 38
    • 84910138626 scopus 로고    scopus 로고
    • Study of various factors for enhancement of Artemisinin in Artemisia annua hairy roots
    • Patra N, Srivastava AK, Sharma S (2013) Study of various factors for enhancement of Artemisinin in Artemisia annua hairy roots. Int J Chem Eng Appl 4:157-160
    • (2013) Int J Chem Eng Appl , vol.4 , pp. 157-160
    • Patra, N.1    Srivastava, A.K.2    Sharma, S.3
  • 39
    • 84910115739 scopus 로고    scopus 로고
    • Statistical media optimization for enhanced biomass and Artemisinin production in Artemisia annua hairy roots
    • Khemani LD, Srivastava MM, Srivastava S, Springer, Berlin/Heidelberg
    • Patra N, Sharma S, Srivastava AK (2012) Statistical media optimization for enhanced biomass and Artemisinin production in Artemisia annua hairy roots. In: Khemani LD, Srivastava MM, Srivastava S (eds) Chemistry of phytopotentials: Health, energy and environmental erspectives. Springer, Berlin/Heidelberg, pp 173-176
    • (2012) Chemistry of Phytopotentials: Health, Energy and Environmental Erspectives , pp. 173-176
    • Patra, N.1    Sharma, S.2    Srivastava, A.K.3
  • 40
    • 0036187045 scopus 로고    scopus 로고
    • Secondary metabolism of hairy root cultures in bioreactors
    • Kim Y, Wyslouzil B, Weathers P (2002) Secondary metabolism of hairy root cultures in bioreactors. In Vitro Cell Dev Biol Plant 38:1-10
    • (2002) Vitro Cell Dev Biol Plant , vol.38 , pp. 1-10
    • Kim, Y.1    Wyslouzil, B.2    Weathers, P.3
  • 41
    • 84856271502 scopus 로고    scopus 로고
    • In vitro azadirachtin production by hairy root cultivation of Azadirachta indica in nutrient mist bioreactor
    • Srivastava S, Srivastava AK (2012) In vitro azadirachtin production by hairy root cultivation of Azadirachta indica in nutrient mist bioreactor. Appl Biochem Biotechnol 166:365-378
    • (2012) Appl Biochem Biotechnol , vol.166 , pp. 365-378
    • Srivastava, S.1    Srivastava, A.K.2
  • 43
    • 85101094672 scopus 로고    scopus 로고
    • Exogenous sugars affect Artemisinin production in Artemisia annua L transcription and metabolite measurements
    • Arsenault P, Vail D, Wobbe K, Weathers P (2010) Exogenous sugars affect Artemisinin production in Artemisia annua L transcription and metabolite measurements. In Vitro Cell Dev Biol Animal 46:S83-SS4
    • (2010) In Vitro Cell Dev Biol Animal , vol.46 , pp. S83-S84
    • Arsenault, P.1    Vail, D.2    Wobbe, K.3    Weathers, P.4
  • 44
    • 0034921833 scopus 로고    scopus 로고
    • A comparative study of mist and bubble column reactors in the in vitro production of artemisinin
    • Kim Y, Wyslouzil BE, Weathers PJ (2001) A comparative study of mist and bubble column reactors in the in vitro production of artemisinin. Plant Cell Rep 20:451-455
    • (2001) Plant Cell Rep , vol.20 , pp. 451-455
    • Kim, Y.1    Wyslouzil, B.E.2    Weathers, P.J.3
  • 45
    • 0038373003 scopus 로고    scopus 로고
    • Growth dynamics of Artemisia annua hairy roots in three culture systems
    • Kim YJ, Weathers PJ, Wyslouzil BE (2003) Growth dynamics of Artemisia annua hairy roots in three culture systems. Biotechnol Bioeng 83:428-443
    • (2003) Biotechnol Bioeng , vol.83 , pp. 428-443
    • Kim, Y.J.1    Weathers, P.J.2    Wyslouzil, B.E.3
  • 46
    • 0034463004 scopus 로고    scopus 로고
    • Isolation and production of artemisinin and stigmasterol in hairy root cultures of Artemisia annua
    • Xie D, Wang L, Ye H, Li G (2000) Isolation and production of artemisinin and stigmasterol in hairy root cultures of Artemisia annua. Plant Cell Tissue Organ Cult 63:161-166
    • (2000) Plant Cell Tissue Organ Cult , vol.63 , pp. 161-166
    • Xie, D.1    Wang, L.2    Ye, H.3    Li, G.4
  • 47
    • 48449091807 scopus 로고    scopus 로고
    • Design, development, and applications of mist bioreactors for micropropagation and hairy root culture
    • Gupta SD, Ibaraki Y, Springer, Amsterdam
    • Towler M, Kim Y, Wyslouzil B, Correll M, Weathers P (2006) Design, development, and applications of mist bioreactors for micropropagation and hairy root culture. In: Gupta SD, Ibaraki Y (eds) Plan tissue culture engineering. Springer, Amsterdam, pp 119-134
    • (2006) Plan Tissue Culture Engineering , pp. 119-134
    • Towler, M.1    Kim, Y.2    Wyslouzil, B.3    Correll, M.4    Weathers, P.5
  • 48
    • 79958060183 scopus 로고    scopus 로고
    • Artemisinin production in Artemisia annua: Studies in planta and results of a novel delivery method for treating malaria and other neglected diseases
    • Weathers PJ, Arsenault PR, Covello PS, McMickle A, Teoh KH, Reed DW (2011) Artemisinin production in Artemisia annua: Studies in planta and results of a novel delivery method for treating malaria and other neglected diseases. Phytochem Rev 10:173-183
    • (2011) Phytochem Rev , vol.10 , pp. 173-183
    • Weathers, P.J.1    Arsenault, P.R.2    Covello, P.S.3    McMickle, A.4    Teoh, K.H.5    Reed, D.W.6
  • 49
    • 84940446960 scopus 로고    scopus 로고
    • Mass scale artemisinin production in a stirred tank bioreactor using hairy roots of Artemisia annua
    • Patra N, Srivastava AK (2014a) Mass scale artemisinin production in a stirred tank bioreactor using hairy roots of Artemisia annua. Int J Biosci Biochem Bioinfo 4:467-474
    • (2014) Int J Biosci Biochem Bioinfo , vol.4 , pp. 467-474
    • Patra, N.1    Srivastava, A.K.2
  • 50
    • 0025325736 scopus 로고
    • Growth and Hyoscyamine production of hairy root cultures of Datura-Stramonium in a modified stirred tank reactor
    • Hilton MG, Rhodes MJC (1990) Growth and Hyoscyamine production of hairy root cultures of Datura-Stramonium in a modified stirred tank reactor. Appl Microbiol Biotechnol 33:132-138
    • (1990) Appl Microbiol Biotechnol , vol.33 , pp. 132-138
    • Hilton, M.G.1    Rhodes, M.2
  • 51
    • 0024817550 scopus 로고
    • Comparison of growth-properties of carrot hairy root in various bioreactors
    • Kondo O, Honda H, Taya M, Kobayashi T (1989) Comparison of growth-properties of carrot hairy root in various bioreactors. Appl Microbiol Biotechnol 32:291-294
    • (1989) Appl Microbiol Biotechnol , vol.32 , pp. 291-294
    • Kondo, O.1    Honda, H.2    Taya, M.3    Kobayashi, T.4
  • 52
    • 84910126956 scopus 로고    scopus 로고
    • Enhanced production of Artemisinin by hairy root cultivation of Artemisia annua in a modified stirred tank reactor
    • Patra N, Srivastava AK (2014b) Enhanced production of Artemisinin by hairy root cultivation of Artemisia annua in a modified stirred tank reactor. Appl Biochem Biotechnol 174:2209-2222
    • (2014) Appl Biochem Biotechnol , vol.174 , pp. 2209-2222
    • Patra, N.1    Srivastava, A.K.2
  • 53
    • 33750949589 scopus 로고    scopus 로고
    • Azadirachtin production in stirred tank reactors by Azadirachta indica suspension culture
    • Prakash G, Srivastava AK (2007) Azadirachtin production in stirred tank reactors by Azadirachta indica suspension culture. Process Biochem 42:93-97
    • (2007) Process Biochem , vol.42 , pp. 93-97
    • Prakash, G.1    Srivastava, A.K.2
  • 54
    • 0027134555 scopus 로고
    • Development of a bioreactor for high density culture of hairy roots
    • Kim Y, Yoo Y (1993) Development of a bioreactor for high density culture of hairy roots. Biotechnol Tech 7:859-862
    • (1993) Biotechnol Tech , vol.7 , pp. 859-862
    • Kim, Y.1    Yoo, Y.2
  • 55
    • 0242409158 scopus 로고    scopus 로고
    • Comparison of various bioreactors on growth and artemisinin biosynthesis of Artemisia annua L. shoot cultures
    • Liu CZ, Guo C, Wang YC, Ouyang F (2003) Comparison of various bioreactors on growth and artemisinin biosynthesis of Artemisia annua L. shoot cultures. Process Biochem 39:45-49
    • (2003) Process Biochem , vol.39 , pp. 45-49
    • Liu, C.Z.1    Guo, C.2    Wang, Y.C.3    Ouyang, F.4
  • 56
    • 38349018105 scopus 로고    scopus 로고
    • Growth of hairy-root cultures in various bioreactors for the production of secondary metabolites
    • Mishra BN, Ranjan R (2008) Growth of hairy-root cultures in various bioreactors for the production of secondary metabolites. Biotechnol Appl Biochem 49:1-10
    • (2008) Biotechnol Appl Biochem , vol.49 , pp. 1-10
    • Mishra, B.N.1    Ranjan, R.2
  • 57
    • 0031729286 scopus 로고    scopus 로고
    • Enhanced production of artemisinin by Artemisia annua L hairy root cultures in a modified inner-loop airlift bioreactor
    • Liu C, Wang Y, Guo C, Ouyang F, Ye H, Li G (1998) Enhanced production of artemisinin by Artemisia annua L hairy root cultures in a modified inner-loop airlift bioreactor. Bioprocess Eng 19:389-392
    • (1998) Bioprocess Eng , vol.19 , pp. 389-392
    • Liu, C.1    Wang, Y.2    Guo, C.3    Ouyang, F.4    Ye, H.5    Li, G.6
  • 58
    • 85101115099 scopus 로고
    • Oxygen requirements and mass-transfer in hairy-root cultures
    • Yu SX, Doran PM (1993) Oxygen requirements and mass-transfer in hairy-root cultures. Abstr Pap Am Chem Soc 205: 151-BIOT.
    • (1993) Abstr Pap am Chem Soc , vol.205 , pp. 151
    • Yu, S.X.1    Doran, P.M.2
  • 63
    • 33947579184 scopus 로고    scopus 로고
    • Using an aerosol deposition model to increase hairy root growth in a mist reactor
    • Towler MJ, Wyslouzil BE, Weathers PJ (2007) Using an aerosol deposition model to increase hairy root growth in a mist reactor. Biotechnol Bioeng 96:881-891
    • (2007) Biotechnol Bioeng , vol.96 , pp. 881-891
    • Towler, M.J.1    Wyslouzil, B.E.2    Weathers, P.J.3
  • 64
    • 84864402772 scopus 로고    scopus 로고
    • Mathematical modelling approach for concentration and productivity enhancement of 1,3-propanediol using Clostridium diolis
    • Kaur G, Srivastava AK, Chand S (2012) Mathematical modelling approach for concentration and productivity enhancement of 1,3-propanediol using Clostridium diolis. Biochem Eng J 68:34-41
    • (2012) Biochem Eng J , vol.68 , pp. 34-41
    • Kaur, G.1    Srivastava, A.K.2    Chand, S.3
  • 65
    • 84878772626 scopus 로고    scopus 로고
    • Bioconversion of glycerol to 1,3-propanediol: A mathematical model-based nutrient feeding approach for high production using Clostridium diolis
    • Kaur G, Srivastava AK, Chand S (2013) Bioconversion of glycerol to 1,3-propanediol: A mathematical model-based nutrient feeding approach for high production using Clostridium diolis. Bioresour Technol 142:82-87
    • (2013) Bioresour Technol , vol.142 , pp. 82-87
    • Kaur, G.1    Srivastava, A.K.2    Chand, S.3
  • 66
    • 0037083058 scopus 로고    scopus 로고
    • Overexpression of alcohol dehydrogenase or pyruvate decarboxylase improves growth of hairy roots at reduced oxygen concentrations
    • Shiao TL, Ellis MH, Dolferus R, Dennis ES, Doran PM (2002) Overexpression of alcohol dehydrogenase or pyruvate decarboxylase improves growth of hairy roots at reduced oxygen concentrations. Biotechnol Bioeng 77:455-461
    • (2002) Biotechnol Bioeng , vol.77 , pp. 455-461
    • Shiao, T.L.1    Ellis, M.H.2    Dolferus, R.3    Dennis, E.S.4    Doran, P.M.5
  • 68
    • 84922962782 scopus 로고    scopus 로고
    • Model based fed batch cultivation and elicitation for the overproduction of ajmalicine from hairy roots of Catharanthus roseus
    • Thakore D, Srivastava AK, Sinha AK (2015) Model based fed batch cultivation and elicitation for the overproduction of ajmalicine from hairy roots of Catharanthus roseus. Biochem Eng J 97:73-80
    • (2015) Biochem Eng J , vol.97 , pp. 73-80
    • Thakore, D.1    Srivastava, A.K.2    Sinha, A.K.3
  • 69
    • 33846887319 scopus 로고    scopus 로고
    • Scalability of a disposable bioreactor from 25 L-500 L run in perfusion mode with a CHO-based cell line: A tech review
    • Pierce LN, Shabram PW (2004) Scalability of a disposable bioreactor from 25 L-500 L run in perfusion mode with a CHO-based cell line: A tech review. Bioprocess J 3:51-56
    • (2004) Bioprocess J , vol.3 , pp. 51-56
    • Pierce, L.N.1    Shabram, P.W.2
  • 71
    • 0021320445 scopus 로고
    • Etoposide: A semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent
    • Sinkule JA (1984) Etoposide: A semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent. Pharmacotherapy 4:61-73
    • (1984) Pharmacotherapy , vol.4 , pp. 61-73
    • Sinkule, J.A.1


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