Increased accumulation of artemisinin and anthocyanins in Artemisia annua expressing the arabidopsis blue light receptor CRY1

Plant Molecular Biology Reporter

Volumn 27, Issue 3, 2009, Pages 334-341

  Hong, Gao Jie ^a   Hu, Wen Li ^a   Li, Jian Xu ^a   Chen, Xiao Ya ^a   Wang, Ling Jian ^a  

^a INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

Author keywords

Anthocyanin; Artemisia annua; Artemisinin; Cryptochrome 1; Sesquiterpene

Indexed keywords

AMORPHA; ARABIDOPSIS; ARTEMISIA ANNUA;

EID: 70350035886     PISSN: 07359640     EISSN: 15729818     Source Type: Journal    
DOI: 10.1007/s11105-008-0088-6     Document Type: Article

References (40)

1. Abdin MZ, Israr M, Rehman RU, Jain SK (2003) Artemisinin, a Novel Antimalarial drug: biochemical and molecular approaches for enhanced production. Planta Med 69:289-299. doi:10.1055/s-2003-38871.
2. Baurle I, Dean C (2006) The timing of developmental transitions in plants. Cell 125:655-664. doi:10.1016/j.cell.2006.05.005.
3. Bouwmeester HJ, Wallaart TE, Janssen MH, van Loo B, Jansen BJ, Posthumus MA, Schmidt CO, De Kraker JW, Konig WA, Franssen MC (1999) Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis. Phytochemistry 52:843-854. doi:10.1016/S0031-9422(99)00206-X.
4. Briggs WR, Olney MA (2001) Photoreceptors in plant photomorphogenesis to date. Five phytochromes, two cryptochromes, one phototropin, and one superchrome. Plant Physiol. 125:85-88. doi:10.1104/pp.125.1.85.
5. Brodelius M, Lundgren A, Mercke P, Brodelius PE (2002) Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum. Eur J Biochem 269:3570-3577. doi:10.1046/j.1432-1033.2002.03044.x.
6. Cai Y, Jia JW, Crock J, Lin ZX, Chen XY, Croteau R (2002) A cDNA clone for β-caryophyllene synthase from Artemisia annua. Phytochemistry 61:523-529. doi:10.1016/S0031-9422(02)00265-0.
7. Chen DH, Ye HC, Li GF (2000) Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation. Plant Sci. 155:179-185. doi:10.1016/S0168-9452(00)00217-X.
8. Cheng AX, Lou YG, Mao YB, Lu S, Wang LJ, Chen XY (2007) Plant terpenoids: biosynthesis and ecological functions. J Integr Plant Biol 49:179-186. doi:10.1111/j.1744-7909.2007.00395.x.
9. Christian F, Jorge JC (2004) Phenotypic characterization of a photomorphogenic mutant. Plant J 39:747-760. doi:10.1111/j.1365-313X.2004.02148.x.
10. Dixon RA, Paiva NL (1995) Stress-Induced phenylpropanoid metabolism. Plant Cell 7:1085-1097.
11. Ferreira JFS, Simon JE, Janick J (1995) Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions. Planta Med 61:167-170. doi:10.1055/s-2006-958040.
12. Giliberto L, Perrotta G, Pallara P, Weller JL, Fraser PD, Bramley PM, Fiore A, Tavazza M, Giuliano G (2005) Manipulation of the blue light photoreceptor Cryptochrome 2 in tomato affects vegetative development, flowering time, and fruit antioxidant content. Plant Physiol 137:199-208. doi:10.1104/pp.104.051987.
13. Greenwood B (2004) Between hope and a hard place. Nature 430:926-927. doi:10.1038/430926a.
14. Guo C, Liu CZ, Ye HC, Li GF (2004) Effect of temperature on growth and artemisinin biosynthesis in hairy root cultures of Artemisia annua. Acta Bot. Boreal-Occident Sin 24:1828-1831.
15. Jefferson RA, Kavanagh TA, Bevan MW (1987) GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. EMBO J 6:3901-3907.
16. Jia JW, Crock J, Lu S, Croteau R, Chen XY (1999) (3R)-Linalool synthase from Artemisia annua L.: cDNA isolation, characterization, and wound induction. Arch Biochem Biophys 372:143-149. doi:10.1006/abbi.1999.1466.
17. Kacser H, Acerenza L (1993) A universal method for achieving increases in metabolite production. Eur J Biochem 216:361-367. doi:10.1111/j.1432-1033.1993.tb18153.x.
18. Kim SH, Heo K, Chang YJ, Park SH, Rhee SK, Kim SU (2006) Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis. J Nat Prod 69:758-762. doi:10.1021/np050356u.
19. Klayman DL (1985) Qinghaosu (artemisinin): an antimalarial drug from China. Science 228:1049-1055. doi:10.1126/science.3887571.
20. Korth KL, Jaggard DA, Dixon RA (2000) Developmental and light-regulated post-translational control of 3-hydroxy-3-methylglutaryl-CoA reductase levels in potato. Plant J 23:507-516. doi:10.1046/j.1365-313x.2000.00821.x.
21. Li QH, Yang HQ (2007) Cryptochrome signaling in plants. Photochem Photobiol 83:94-101. doi:10.1111/j.1751-1097.2007.00194.x.
22. Liersch R, Soicke H, Stehr C, Tullner HU (1986) Formation of artemisinin in Artemisia annua during one vegetation period* 1. Planta Med 52:387-390. doi:10.1055/s-2007-969193.
23. Lin C, Robertson DE, Ahmad M, Raibekas AA, Jorns MS, Dutton PL, Cashmore AR (1995) Association of flavin adenine dinucleotide with the Arabidopsis blue light receptor CRY1. Science 269:968-970. doi:10.1126/science.7638620.
24. Liu CZ, Wang YC, Ouyang F, Ye HC, Li GF (1997) Production of artemisinin by hairy root cultures of Artemisia annua L. Biotechnol Lett 19:927-929. doi:10.1023/A:1018362309677.
25. Liu CZ, Guo C, Wang YC, Ouyang F (2002) Effect of light irradiation on hairy root growth and artemisinin biosynthesis of Artemisia annua L. Process Biochem 38:581-585. doi:10.1016/S0032-9592(02)00165-6.
26. Lu S, Xu R, Jia JW, Pang J, Matsuda SPT, Chen XY (2002) Cloning and functional characterization of a β-pinene synthase from Artemisia annua that shows a circadian pattern of expression. Plant Physiol. 130:477-486. doi:10.1104/pp.006544.
27. Luo XD, Shen CC (1987) The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives. Med Res Rev 7:29-52. doi:10.1002/med.2610070103.
28. Luo J, Butelli E, Hill L, Parr A, Niggeweg R, Bailey P, Weisshaar B, Martin C (2008) AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato; expression in fruit results in very high levels of both types of polyphenol. Plant J 56(2):316-326. doi:10.1111/j.1365-313X.2008.03597.x.
29. Mao J, Zhang YC, Sang Y, Li QH, Yang HQ (2005) A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening. Proc Natl Acad Sci U S A 102:12270-12275. doi:10.1073/pnas.0501011102.
30. Mas P (2005) Circadian clock signaling in Arabidopsis thaliana: from gene expression to physiology and development. Int J Dev Biol 49:491-500. doi:10.1387/ijdb.041968pm.
31. Shetty P (2004) Global fund switches to artemisinin. Lancet Infect Dis 4:477-477. doi:10.1016/S1473-3099(04)01087-4.
32. Tellez MR, Canel C, Rimando AM, Duke SO (1999) Differential accumulation of isoprenoids in glanded and glandless Artemisia annua L. Phytochemistry 52:1035-1040. doi:10.1016/S0031-9422(99)00308-8.
33. Teoh KH, Polichuk DR, Reed DW, Nowak G, Covello PS (2006) Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett 580:1411-1416. doi:10.1016/j.febslet.2006.01.065.
34. Verpoorte R, van der Heijden R, Memelink J (2000) Engineering the plant cell factory for secondary metabolite production. Transgenic Res 9:323-343. doi:10.1023/A:1008966404981.
35. Wang H, Liu Y, Chong K, Liu BY, Ye HC, Li ZQ, Yan F, Li GF (2007) Earlier flowering induced by over-expression of CO gene does not accompany increase of artemisinin biosynthesis in Artemisia annua. Plant Biol 9:442-446. doi:10.1055/s-2006-924634.
36. Wang JW, Wang LJ, Mao YB, Cai WJ, Xue HW, Chen XY (2005) Control of root cap formation by MicroRNA-targeted auxin response factors in Arabidopsis. Plant Cell 17(8):2204-2216. doi:10.1105/tpc.105.033076.
37. WHO Roll Back Malaria Department (2005) World Health Organization drives efforts to boost antimalarial drug supply. WHO, Geneva, http://www.who.int/mediacentre/news/releases/2005/pr24/en/.
38. Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJH, Ross ARS, Covello PS (2008) The molecular cloning of artemisinic aldehyde Δ11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem 283:21501-21508. doi:10.1074/jbc.M803090200.
39. Zhang YC, Gong SF, Li QH, Sang Y, Yang HQ (2006) Functional and signaling mechanism analysis of rice CRYPTOCHROME 1. Plant J 46:971-983. doi:10.1111/j.1365-313X.2006.02753.x.
40. Zhao SS, Zeng MY (1986) Determination of qinghaosu in Artemisia annua L. by high performance liquid chromatography. Chin J Pharm Anal 6:3-5.