Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli

Biotechnology and Bioengineering

Volumn 115, Issue 1, 2018, Pages 156-164

  Harder, Björn Johannes ^a   Bettenbrock, Katja ^a   Klamt, Steffen ^a  

^a MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

Author keywords

dynamic metabolic control; Escherichia coli; genetic switch; itaconic acid production; two stage process; volumetric productivity

Indexed keywords

ECOLOGY; ESCHERICHIA COLI; GENE EXPRESSION; PRODUCTIVITY; SUBSTRATES;

GENETIC SWITCHES; ITACONIC ACID; METABOLIC CONTROL; TWO-STAGE PROCESS; VOLUMETRIC PRODUCTIVITY;

INDUSTRIAL MANAGEMENT;

ISOCITRATE DEHYDROGENASE; ITACONIC ACID; TRICARBOXYLIC ACID; SUCCINIC ACID DERIVATIVE;

ARTICLE; AUXOTROPHY; BACTERIAL GROWTH; BACTERIAL STRAIN; CITRIC ACID CYCLE; COMPARATIVE STUDY; CORYNEBACTERIUM GLUTAMICUM; ESCHERICHIA COLI; ESSENTIAL GENE; GENETIC REGULATION; GLUCOSE TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PHENOTYPE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE DEPENDENCE; UNTRANSLATED REGION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLIC ENGINEERING; METABOLISM; PROCEDURES; RADIATION RESPONSE; TEMPERATURE;

CITRIC ACID CYCLE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; METABOLIC ENGINEERING; SUCCINATES; TEMPERATURE;

EID: 85035036524     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.26446     Document Type: Article

References (29)

1. Beauprez, J. J., De Mey, M., & Soetaert, W. K. (2010). Microbial succinic acid production: Natural versus metabolic engineered producers. Process Biochemistry, 45, 1103–1114.
2. Becker, J., & Wittmann, C. (2015). Advanced biotechnology: Metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products. Angewandte Chemie-International Edition, 54, 3328–3350.
3. Burg, J. M., Cooper, C. B., Ye, Z., Reed, B. R., Moreb, E. A., & Lynch, M. D. (2016). Large-scale bioprocess competitiveness: The potential of dynamic metabolic control in two-stage fermentations. Current Opinion in Chemical Engineering, 14, 121–136.
4. Causey, T. B., Zhou, S., Shanmugam, K. T., & Ingram, L. O. (2003). Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: Homoacetate production. Proceedings of the National Academy of Sciences of the United States of America, 100, 825–832.
5. Cho, H.-S., Seo, S. W., Kim, Y. M., Jung, G. Y., & Park, J. M. (2012). Engineering glycerladehyde-3-phosphate dehydrogenase for switching control of glycolysis in Escherichia coli. Biotechnology and Bioengineering, 109, 2612–2619.
6. Chubukov, V., & Sauer, U. (2014). Environmental dependence of stationary-phase metabolism in Bacillus subtilis and Escherichia coli. Applied and Environmental Microbiology, 80, 2901–2909.
7. Datsenko, K. A., & Wanner, B. L. (2000). One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proceedings of the National Academy of Sciences of the United States of America, 97, 6640–6645.
8. De Mey, M., Maertens, J., Boogmans, S., Soetaert, W. K., Vandamme, E. J., Cunin, R., & Foulquié-Moreno, M. R. (2010). Promoter knock-in: A novel rational method for the fine tuning of genes. BMC Biotechnology, 10, 26–26.
9. Gupta, A., Reizman, I. M. B., Reisch, C. R., & Prather, K. L. J. (2017). Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit. Nature Biotechnology, 35, 273–279.
10. Hädicke, O., Bettenbrock, K., & Klamt, S. (2015). Enforced ATP futile cycling increases specific productivity and yield of anaerobic lactate production in Escherichia coli. Biotechnology and Bioengineering, 112, 2195–2199.
11. Hädicke, O., & Klamt, S. (2015). Manipulation of the ATP pool as a tool for metabolic engineering. Biochemical Society Transactions, 43, 1140–1145.
12. Harder, B. J., Bettenbrock, K., & Klamt, S. (2016). Model-based metabolic engineering enables high yield itaconic acid production by Escherichia coli. Metabolic Engineering, 38, 29–37.
13. Klamt, S., Saez-Rodriguez, J., & Gilles, E. D. (2007). Structural and functional analysis of cellular networks with CellNetAnalyzer. BMC Systems Biology, 1, 2.
14. Lieb, M. (1966). Studies of heat-inducible lambda bacteriophage. I. Order of genetic sites and properties of mutant prophages. Journal of Molecular Biology, 16, 149–163.
15. Liu, J., Kandasamy, V., Wurtz, A., Jensen, P. R., & Solem, C. (2016). Stimulation of acetoin production in metabolically engineered Lactococcus lactis by increasing ATP demand. Applied Microbiology and Biotechnology, 100, 9509–9517.
16. Love, C. A., Lilley, P. E., & Dixon, N. E. (1996). Stable high-copy-number bacteriophage lambda promoter vectors for overproduction of proteins in Escherichia coli. Gene, 176, 49–53.
17. Meyer, B. J., Maurer, R., & Ptashne, M. (1980). Gene regulation at the right operator (OR) of bacteriophage λ. Journal of Molecular Biology, 139(2), 163–194.
18. Michalowski, A., Siemann-Herzberg, M., & Takors, R. (2017). Escherichia coli HGT: Engineered for high glucose throughput even under slowly growing or resting conditions. Metabolic Engineering, 40, 93–103.
19. Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., & Palsson, B. O. (2011). A comprehensive genome-scale reconstruction of Escherichia coli metabolism-2011. Molecular Systems Biology, 7, 535.
20. Steinsiek, S., Stagge, S., & Bettenbrock, K. (2014). Analysis of Escherichia coli mutants with a linear respiratory chain. PLoS ONE, 9(1), e87307.
21. Tanaka, S., Lerner, S. A., & Lin, E. C. (1967). Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol. Journal of Bacteriology, 93, 642–648.
22. Thomason, L. C., Costantino, N., & Court, D. L. (2007). E. coli genome manipulation by P1 transduction. Current Protocols in Molecular Biology, 1, 17.11–17.18.
23. Valdez-Cruz, N. A., Caspeta, L., Pérez, N. O., Ramírez, O. T., & Trujillo-Roldán, M. A. (2010). Production of recombinant proteins in E. coli by the heat inducible expression system based on the phage lambda pL and/or pR promoters. Microbial Cell Factories, 9, 18.
24. Van Dien, S. (2013). From the first drop to the first truckload: Commercialization of microbial processes for renewable chemicals. Current Opinion in Biotechnology, 24, 1061–1068.
25. Venayak, N., Anesiadis, N., Cluett, W. R., & Mahadevan, R. (2015). Engineering metabolism through dynamic control. Current Opinion in Biotechnology, 34, 142–152.
26. Werpy, T., & Petersen, G. (2004). Top value added chemicals from biomass: Volume I—Results of screeining for potential candidates from sugars and synthesis gas. U.S. Department of Energy 1. https://energy.gov/eere/bioenergy/downloads/top-value-added-chemicals-biomass-volume-i-results-screening-potential
27. Zhou, L., Deng, C., Cui, W.-J., Liu, Z.-M., & Zhou, Z.-M. (2015). Efficient L-alanine production by a thermo-regulated switch in Escherichia coli. Applied Biochemistry and Biotechnology, 178, 324–337.
28. Zhou, L., Niu, D.-D., Tian, K.-M., Chen, X.-Z., Prior, B. A., Shen, W., … Wang, Z.-X. (2012). Genetically switched D-lactate production in Escherichia coli. Metabolic Engineering, 14, 560–568.
29. Zhou, L., Zuo, Z.-R., Chen, X.-Z., Niu, D.-D., Tian, K.-M., Prior, B. A., … Wang Z.-X. (2010). Evaluation of genetic manipulation strategies on D-lactate production by Escherichia coli. Current Microbiology, 62, 981–989.