-
1
-
-
84918815964
-
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
-
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:5 (2015), E359–E386.
-
(2015)
Int J Cancer
, vol.136
, Issue.5
, pp. E359-E386
-
-
Ferlay, J.1
Soerjomataram, I.2
Dikshit, R.3
Eser, S.4
Mathers, C.5
Rebelo, M.6
-
2
-
-
84924910144
-
Global burden of cancer attributable to high body-mass index in 2012: a population-based study
-
Arnold, M., Pandeya, N., Byrnes, G., Renehan, A.G., Stevens, G.A., Ezzati, M., et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol 16:1 (2015), 36–46.
-
(2015)
Lancet Oncol
, vol.16
, Issue.1
, pp. 36-46
-
-
Arnold, M.1
Pandeya, N.2
Byrnes, G.3
Renehan, A.G.4
Stevens, G.A.5
Ezzati, M.6
-
3
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller, J.H., Harrington, D., Belani, C.P., Langer, C., Sandler, A., Krook, J., et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346:2 (2002), 92–98.
-
(2002)
N Engl J Med
, vol.346
, Issue.2
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
Langer, C.4
Sandler, A.5
Krook, J.6
-
4
-
-
85034624936
-
-
NCCN clinical practice guidelines in oncology: Non-small cell lung cancer version 5
-
NCCN clinical practice guidelines in oncology: Non-small cell lung cancer version 5. 2017.
-
(2017)
-
-
-
5
-
-
84992630838
-
Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
Novello, S., Barlesi, F., Califano, R., Cufer, T., Ekman, S., Levra, M.G., et al. Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 27:suppl 5 (2016), v1–27.
-
(2016)
Ann Oncol
, vol.27
, pp. v1-27
-
-
Novello, S.1
Barlesi, F.2
Califano, R.3
Cufer, T.4
Ekman, S.5
Levra, M.G.6
-
6
-
-
84871600705
-
Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea
-
Gerber, D.E., Schiller, J.H., Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea. J Clin Oncol 31:8 (2013), 1009–1020.
-
(2013)
J Clin Oncol
, vol.31
, Issue.8
, pp. 1009-1020
-
-
Gerber, D.E.1
Schiller, J.H.2
-
7
-
-
77950577933
-
Systemic therapies in metastatic non-small-cell lung cancer with emphasis on targeted therapies: the rational approach
-
Hirsh, V., Systemic therapies in metastatic non-small-cell lung cancer with emphasis on targeted therapies: the rational approach. Curr Oncol 17:2 (2010), 13–23.
-
(2010)
Curr Oncol
, vol.17
, Issue.2
, pp. 13-23
-
-
Hirsh, V.1
-
8
-
-
85034622367
-
-
Alimta [package insert]. Indianapolis, IN: Eli Lilly and Company;
-
Alimta [package insert]. Indianapolis, IN: Eli Lilly and Company; 2016.
-
(2016)
-
-
-
9
-
-
85034624776
-
-
Taxotere [package insert]. Bridgewater, NJ: Sanofi-Aventis U.S. LLC;
-
Taxotere [package insert]. Bridgewater, NJ: Sanofi-Aventis U.S. LLC; 2010.
-
(2010)
-
-
-
10
-
-
0034069620
-
Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
-
Shepherd, F.A., Dancey, J., Ramlau, R., Mattson, K., Gralla, R., O'Rourke, M., et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 18:10 (2000), 2095–2103.
-
(2000)
J Clin Oncol
, vol.18
, Issue.10
, pp. 2095-2103
-
-
Shepherd, F.A.1
Dancey, J.2
Ramlau, R.3
Mattson, K.4
Gralla, R.5
O'Rourke, M.6
-
11
-
-
2442661845
-
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
-
Hanna, N., Shepherd, F.A., Fossella, F.V., Pereira, J.R., de Marinis, F., von Pawel, J., et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 22:9 (2004), 1589–1597.
-
(2004)
J Clin Oncol
, vol.22
, Issue.9
, pp. 1589-1597
-
-
Hanna, N.1
Shepherd, F.A.2
Fossella, F.V.3
Pereira, J.R.4
de Marinis, F.5
von Pawel, J.6
-
12
-
-
0034934763
-
Treatment of advanced non-small-cell lung cancer: a review of current randomized clinical trials and an examination of emerging therapies
-
Haura, E.B., Treatment of advanced non-small-cell lung cancer: a review of current randomized clinical trials and an examination of emerging therapies. Cancer Control 8:4 (2001), 326–336.
-
(2001)
Cancer Control
, vol.8
, Issue.4
, pp. 326-336
-
-
Haura, E.B.1
-
13
-
-
84969188079
-
Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer: trials and treatment options
-
Desai, A., Menon, S.P., Dy, G.K., Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer: trials and treatment options. Cancer Biol Med 13:1 (2016), 77–86.
-
(2016)
Cancer Biol Med
, vol.13
, Issue.1
, pp. 77-86
-
-
Desai, A.1
Menon, S.P.2
Dy, G.K.3
-
14
-
-
32044464123
-
Epidermal growth factor receptor (EGFR) signaling in cancer
-
Normanno, N., De Luca, A., Bianco, C., Strizzi, L., Mancino, M., Maiello, M.R., et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366:1 (2006), 2–16.
-
(2006)
Gene
, vol.366
, Issue.1
, pp. 2-16
-
-
Normanno, N.1
De Luca, A.2
Bianco, C.3
Strizzi, L.4
Mancino, M.5
Maiello, M.R.6
-
15
-
-
84961831124
-
A phase II study of BEZ235 in patients with everoliums-resistant, advanced pancreatic neuroendocrine tumours
-
Fazio, N., Buzzoni, R., Baudin, E., Antonuzzo, L., Hubner, R., Lahner, H., et al. A phase II study of BEZ235 in patients with everoliums-resistant, advanced pancreatic neuroendocrine tumours. Anticancer Res 36:2 (2016), 713–719.
-
(2016)
Anticancer Res
, vol.36
, Issue.2
, pp. 713-719
-
-
Fazio, N.1
Buzzoni, R.2
Baudin, E.3
Antonuzzo, L.4
Hubner, R.5
Lahner, H.6
-
16
-
-
84905579152
-
ALK-positive non-small cell lung cancer: mechanisms of resistance and emerging treatment options
-
Steuer, C.E., Ramalingam, S.S., ALK-positive non-small cell lung cancer: mechanisms of resistance and emerging treatment options. Cancer 120:16 (2014), 2392–2402.
-
(2014)
Cancer
, vol.120
, Issue.16
, pp. 2392-2402
-
-
Steuer, C.E.1
Ramalingam, S.S.2
-
17
-
-
85007614657
-
Second- and third-generation ALK inhibitors for non-small cell lung cancer
-
Wu, J., Savooji, J., Liu, D., Second- and third-generation ALK inhibitors for non-small cell lung cancer. J Hematol Oncol, 9, 2016, 19.
-
(2016)
J Hematol Oncol
, vol.9
, pp. 19
-
-
Wu, J.1
Savooji, J.2
Liu, D.3
-
18
-
-
84906812668
-
Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project
-
Blackhall, F.H., Peters, S., Bubendorf, L., Dafni, U., Kerr, K.M., Hager, H., et al. Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project. J Clin Oncol 32:25 (2014), 2780–2787.
-
(2014)
J Clin Oncol
, vol.32
, Issue.25
, pp. 2780-2787
-
-
Blackhall, F.H.1
Peters, S.2
Bubendorf, L.3
Dafni, U.4
Kerr, K.M.5
Hager, H.6
-
19
-
-
85007524757
-
Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer
-
Wang, S., Cang, S., Liu, D., Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer. J Hematol Oncol, 9, 2016, 34.
-
(2016)
J Hematol Oncol
, vol.9
, pp. 34
-
-
Wang, S.1
Cang, S.2
Liu, D.3
-
20
-
-
84928739294
-
AZD9291 in EGFR inhibitor–resistant non–small-cell lung cancer
-
Janne, P.A., Yang, J.C., Kim, D.W., Planchard, D., Ohe, Y., Ramalingam, S.S., et al. AZD9291 in EGFR inhibitor–resistant non–small-cell lung cancer. N Engl J Med 372:18 (2015), 1689–1699.
-
(2015)
N Engl J Med
, vol.372
, Issue.18
, pp. 1689-1699
-
-
Janne, P.A.1
Yang, J.C.2
Kim, D.W.3
Planchard, D.4
Ohe, Y.5
Ramalingam, S.S.6
-
21
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu, H.A., Arcila, M.E., Rekhtman, N., Sima, C.S., Zakowski, M.F., Pao, W., et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res 19:8 (2013), 2240–2247.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.8
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
Sima, C.S.4
Zakowski, M.F.5
Pao, W.6
-
22
-
-
85034640126
-
-
Xalkori [summary of product characteristics]. Sandwick, UK: Pfizer Limited;
-
Xalkori [summary of product characteristics]. Sandwick, UK: Pfizer Limited; 2016.
-
(2016)
-
-
-
23
-
-
85034636276
-
-
Xalkori [package insert]. New York, NY: Pfizer inc;
-
Xalkori [package insert]. New York, NY: Pfizer inc; 2017.
-
(2017)
-
-
-
24
-
-
85034630891
-
-
Alecensa [package insert]. South San Francisco, CA: Genentech, Inc.;
-
Alecensa [package insert]. South San Francisco, CA: Genentech, Inc.; 2016.
-
(2016)
-
-
-
25
-
-
85034660909
-
-
Zykadia [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;
-
Zykadia [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2016.
-
(2016)
-
-
-
26
-
-
84896957081
-
Ceritinib in ALK-rearranged non–small-cell lung cancer
-
Shaw, A.T., Kim, D.W., Mehra, R., Tan, D.S., Felip, E., Chow, L.Q., et al. Ceritinib in ALK-rearranged non–small-cell lung cancer. N Engl J Med 370:13 (2014), 1189–1197.
-
(2014)
N Engl J Med
, vol.370
, Issue.13
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
Tan, D.S.4
Felip, E.5
Chow, L.Q.6
-
27
-
-
84964343904
-
Alectinib in crizotinib-refractory ALK-rearranged non–small-cell lung cancer: a phase II global study
-
Ou, S.H., Ahn, J.S., De, P.L., Govindan, R., Yang, J.C., Hughes, B., et al. Alectinib in crizotinib-refractory ALK-rearranged non–small-cell lung cancer: a phase II global study. J Clin Oncol 34:7 (2016), 661–668.
-
(2016)
J Clin Oncol
, vol.34
, Issue.7
, pp. 661-668
-
-
Ou, S.H.1
Ahn, J.S.2
De, P.L.3
Govindan, R.4
Yang, J.C.5
Hughes, B.6
-
28
-
-
84996588123
-
Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice
-
Caccese, M., Ferrara, R., Pilotto, S., Carbognin, L., Grizzi, G., Calio, A., et al. Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice. Expert Opin Pharmacother 17 (2016), 2253–2266.
-
(2016)
Expert Opin Pharmacother
, vol.17
, pp. 2253-2266
-
-
Caccese, M.1
Ferrara, R.2
Pilotto, S.3
Carbognin, L.4
Grizzi, G.5
Calio, A.6
-
29
-
-
85027524894
-
Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer
-
Peters, S., Camidge, D.R., Shaw, A.T., Gadgeel, S., Ahn, J.S., Kim, D.W., et al. Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer. N Engl J Med 377:9 (2017), 829–838.
-
(2017)
N Engl J Med
, vol.377
, Issue.9
, pp. 829-838
-
-
Peters, S.1
Camidge, D.R.2
Shaw, A.T.3
Gadgeel, S.4
Ahn, J.S.5
Kim, D.W.6
-
30
-
-
84930939429
-
Targeted therapies in non-small cell lung cancer—beyond EGFR and ALK
-
Rothschild, S.I., Targeted therapies in non-small cell lung cancer—beyond EGFR and ALK. Cancers (Basel) 7:2 (2015), 930–949.
-
(2015)
Cancers (Basel)
, vol.7
, Issue.2
, pp. 930-949
-
-
Rothschild, S.I.1
-
31
-
-
84929481480
-
Pembrolizumab for the treatment of non–small-cell lung cancer
-
Garon, E.B., Rizvi, N.A., Hui, R., Leighl, N., Balmanoukian, A.S., Eder, J.P., et al. Pembrolizumab for the treatment of non–small-cell lung cancer. N Engl J Med 372:21 (2015), 2018–2028.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
32
-
-
84958202246
-
Metastatic squamous cell non-small-cell lung cancer (NSCLC): disrupting the drug treatment paradigm with immunotherapies
-
Scarpace, S.L., Metastatic squamous cell non-small-cell lung cancer (NSCLC): disrupting the drug treatment paradigm with immunotherapies. Drugs Context, 4, 2015, 212289.
-
(2015)
Drugs Context
, vol.4
, pp. 212289
-
-
Scarpace, S.L.1
-
33
-
-
84930960194
-
Immune checkpoint blockade in hematologic malignancies
-
Armand, P., Immune checkpoint blockade in hematologic malignancies. Blood 125:22 (2015), 3393–3400.
-
(2015)
Blood
, vol.125
, Issue.22
, pp. 3393-3400
-
-
Armand, P.1
-
34
-
-
84944312666
-
Advances in immunotherapy for treatment of lung cancer
-
Bustamante Alvarez, J.G., Gonzalez-Cao, M., Karachaliou, N., Santarpia, M., Viteri, S., Teixido, C., et al. Advances in immunotherapy for treatment of lung cancer. Cancer Biol Med 12:3 (2015), 209–222.
-
(2015)
Cancer Biol Med
, vol.12
, Issue.3
, pp. 209-222
-
-
Bustamante Alvarez, J.G.1
Gonzalez-Cao, M.2
Karachaliou, N.3
Santarpia, M.4
Viteri, S.5
Teixido, C.6
-
35
-
-
84962038946
-
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
-
Fehrenbacher, L., Spira, A., Ballinger, M., Kowanetz, M., Vansteenkiste, J., Mazieres, J., et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet 387:10030 (2016), 1837–1846.
-
(2016)
Lancet
, vol.387
, Issue.10030
, pp. 1837-1846
-
-
Fehrenbacher, L.1
Spira, A.2
Ballinger, M.3
Kowanetz, M.4
Vansteenkiste, J.5
Mazieres, J.6
-
36
-
-
84955171240
-
Pembrolizumab for the treatment of PD-L1 positive advanced or metastatic non-small cell lung cancer
-
Dang, T.O., Ogunniyi, A., Barbee, M.S., Drilon, A., Pembrolizumab for the treatment of PD-L1 positive advanced or metastatic non-small cell lung cancer. Expert Rev Anticancer Ther 16:1 (2016), 13–20.
-
(2016)
Expert Rev Anticancer Ther
, vol.16
, Issue.1
, pp. 13-20
-
-
Dang, T.O.1
Ogunniyi, A.2
Barbee, M.S.3
Drilon, A.4
-
37
-
-
85034651161
-
-
Tecentriq [package insert]. South San Francicso, CA: Genentech, Inc.;
-
Tecentriq [package insert]. South San Francicso, CA: Genentech, Inc.; 2017.
-
(2017)
-
-
-
38
-
-
85034653135
-
-
Opdivo [package insert]. Princeton, NJ: Bristol-Myers Squibb Company;
-
Opdivo [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2017.
-
(2017)
-
-
-
39
-
-
85034635992
-
-
Opdivo nivolumab. Committee for Medicinal Products for Human Use;
-
European Medicines Agency. Opdivo nivolumab. Committee for Medicinal Products for Human Use; 2016.
-
(2016)
-
-
European Medicines Agency1
-
40
-
-
85034651652
-
-
Keytruda [package insert]. Whitehouse Station, NJ: Merck & Co., Inc.;
-
Keytruda [package insert]. Whitehouse Station, NJ: Merck & Co., Inc.; 2017.
-
(2017)
-
-
-
41
-
-
85034666954
-
-
Keytruda [summary of product characteristics]. Hertfordshire, United Kingdom; Merck Sharp & Dohme, Limited;
-
Keytruda [summary of product characteristics]. Hertfordshire, United Kingdom; Merck Sharp & Dohme, Limited; 2017.
-
(2017)
-
-
-
42
-
-
85034669488
-
European Commission approves MSD's anti-PD-1 therapy, Keytruda (pembrolizumab), for both first-line and previously treated patients with advanced melanoma
-
Merck Sharpe & Dohme Kenilworth, NJ
-
Sharpe, Merck., Corp, Dohme., European Commission approves MSD's anti-PD-1 therapy, Keytruda (pembrolizumab), for both first-line and previously treated patients with advanced melanoma. 2015, Merck Sharpe & Dohme, Kenilworth, NJ.
-
(2015)
-
-
Sharpe, M.1
Corp, D.2
-
43
-
-
85034632863
-
-
Drug Administration. FDA approves Keytruda for advanced non-small cell lung cancer [approval letter];
-
US Food and Drug Administration. FDA approves Keytruda for advanced non-small cell lung cancer [approval letter]; 2014.
-
(2014)
-
-
Food, U.S.1
-
44
-
-
84966341112
-
FDA approval summary: pembrolizumab for the treatment of patients with metastatic non-small cell lung cancer whose tumors express programmed death ligand 1
-
Sul, J., Blumenthal, G.M., Jiang, X., He, K., Keegan, P., Pazdur, R., FDA approval summary: pembrolizumab for the treatment of patients with metastatic non-small cell lung cancer whose tumors express programmed death ligand 1. Oncologist 21:5 (2016), 643–650.
-
(2016)
Oncologist
, vol.21
, Issue.5
, pp. 643-650
-
-
Sul, J.1
Blumenthal, G.M.2
Jiang, X.3
He, K.4
Keegan, P.5
Pazdur, R.6
-
45
-
-
85034651369
-
-
Merck & Co., Inc. KEYTRUDA® (pembrolizumab) approved as first anti-PD-1 therapy in Japan for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) whose tumors express high levels of PD-L1 [press release]. Kenilworth, NJ: Merck & Co., Inc;
-
Merck & Co., Inc. KEYTRUDA® (pembrolizumab) approved as first anti-PD-1 therapy in Japan for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) whose tumors express high levels of PD-L1 [press release]. Kenilworth, NJ: Merck & Co., Inc; 2016.
-
(2016)
-
-
-
46
-
-
84937204733
-
MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer: antitumor activity and association with tumor PD-L1 expression
-
Abstract CT105
-
Gandhi, L., Balmanoukian, A., Hui, R., Hamid, O., Rizvi, N.A., Leighl, N., et al. MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer: antitumor activity and association with tumor PD-L1 expression. Cancer Res, 74(19 suppl), 2014 Abstract CT105.
-
(2014)
Cancer Res
, vol.74
, Issue.19
-
-
Gandhi, L.1
Balmanoukian, A.2
Hui, R.3
Hamid, O.4
Rizvi, N.A.5
Leighl, N.6
-
47
-
-
84984686125
-
Long-term overall survival for patients with advanced NSCLC enrolled in the KEYNOTE-001 study of pembrolizumab (pembro). Presented at: ASCO Annual Meeting, June 3–7, 2016, Chicago, IL. Abstract 9026
-
Hui, R., Gandhi, L., Costa, E.C., Felip, E., Ahn, M.-J., Eder, J.P., et al. Long-term overall survival for patients with advanced NSCLC enrolled in the KEYNOTE-001 study of pembrolizumab (pembro). Presented at: ASCO Annual Meeting, June 3–7, 2016, Chicago, IL. Abstract 9026. J Clin Oncol, 34(suppl), 2016, 9026.
-
(2016)
J Clin Oncol
, vol.34
, pp. 9026
-
-
Hui, R.1
Gandhi, L.2
Costa, E.C.3
Felip, E.4
Ahn, M.-J.5
Eder, J.P.6
-
48
-
-
84998611074
-
Pembrolizumab
-
Khoja, L., Butler, M.O., Kang, S.P., Ebbinghaus, S., Joshua, A.M., Pembrolizumab. J Immunother Cancer, 3, 2015, 36.
-
(2015)
J Immunother Cancer
, vol.3
, pp. 36
-
-
Khoja, L.1
Butler, M.O.2
Kang, S.P.3
Ebbinghaus, S.4
Joshua, A.M.5
-
49
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
-
Herbst, R.S., Baas, P., Kim, D.W., Felip, E., Pérez-Gracia, J.L., Han, J.Y., et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387:10027 (2016), 1540–1550.
-
(2016)
Lancet
, vol.387
, Issue.10027
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
Felip, E.4
Pérez-Gracia, J.L.5
Han, J.Y.6
-
50
-
-
84955203058
-
KEYNOTE-024: Phase III trial of pembrolizumab (MK-3475) vs platinum-based chemotherapy as first-line therapy for patients with metastatic non-small cell lung cancer (NSCLC) that expresses programmed cell death ligand 1 (PD-L1)
-
Abstract TPS8103
-
Brahmer, J.R., Kim, E.S., Zhang, J., Smith, M.M., Rangwala, R.A., O'Brien, M.E.R., KEYNOTE-024: Phase III trial of pembrolizumab (MK-3475) vs platinum-based chemotherapy as first-line therapy for patients with metastatic non-small cell lung cancer (NSCLC) that expresses programmed cell death ligand 1 (PD-L1). J Clin Oncol, 33(suppl), 2015 Abstract TPS8103.
-
(2015)
J Clin Oncol
, vol.33
-
-
Brahmer, J.R.1
Kim, E.S.2
Zhang, J.3
Smith, M.M.4
Rangwala, R.A.5
O'Brien, M.E.R.6
-
51
-
-
84994802263
-
Pembrolizumab versus chemotherapy for PD-L1–positive non–small-cell lung cancer
-
Reck, M., Rodriguez-Abreu, D., Robinson, A.G., Hui, R., Csoszi, T., Fulop, A., et al. Pembrolizumab versus chemotherapy for PD-L1–positive non–small-cell lung cancer. N Engl J Med 375:19 (2016), 1823–1833.
-
(2016)
N Engl J Med
, vol.375
, Issue.19
, pp. 1823-1833
-
-
Reck, M.1
Rodriguez-Abreu, D.2
Robinson, A.G.3
Hui, R.4
Csoszi, T.5
Fulop, A.6
-
52
-
-
85034656562
-
-
Business Wire. Merck's KEYTRUDA® (pembrolizumab) demonstrates superior progression-free and overall survival compared to chemotherapy as first-line treatment in patients with advanced non-small cell lung cancer [press release]. Published June 16.
-
Business Wire. Merck's KEYTRUDA® (pembrolizumab) demonstrates superior progression-free and overall survival compared to chemotherapy as first-line treatment in patients with advanced non-small cell lung cancer [press release]. Published June 16, 2016. http://www.businesswire.com/news/home/20160616005393/en/Merck%E2%80%99s-KEYTRUDA%C2%AE%C2%A0-pembrolizumab-Demonstrates-Superior-Progression-Free-Survival.
-
(2016)
-
-
-
53
-
-
84994430500
-
Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study
-
Langer, C.J., Gadgeel, S.M., Borghaei, H., Papadimitrakopoulou, V.A., Patnaik, A., Powell, S.F., et al. Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Lancet Oncol 17:11 (2016), 1497–1508.
-
(2016)
Lancet Oncol
, vol.17
, Issue.11
, pp. 1497-1508
-
-
Langer, C.J.1
Gadgeel, S.M.2
Borghaei, H.3
Papadimitrakopoulou, V.A.4
Patnaik, A.5
Powell, S.F.6
-
54
-
-
85034663323
-
Phase III, randomized, open-label study of durvalumab (MEDI4736) in combination with tremelimumab or durvalumab alone versus platinum-based chemotherapy in first-line treatment of patients with advanced/metastatic NSCLC: MYSTIC
-
Rizvi, N., Barlesi, F., Brahmer, J., Felip, E., Forde, P., Garrasino, M., et al. Phase III, randomized, open-label study of durvalumab (MEDI4736) in combination with tremelimumab or durvalumab alone versus platinum-based chemotherapy in first-line treatment of patients with advanced/metastatic NSCLC: MYSTIC. J Immunother Cancer, 3(suppl 2), 2015, P171.
-
(2015)
J Immunother Cancer
, vol.3
, pp. P171
-
-
Rizvi, N.1
Barlesi, F.2
Brahmer, J.3
Felip, E.4
Forde, P.5
Garrasino, M.6
-
55
-
-
84960498096
-
Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study
-
Antonia, S., Goldberg, S.B., Balmanoukian, A., Chaft, J.E., Sanborn, R.E., Gupta, A., et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol 17:3 (2016), 299–308.
-
(2016)
Lancet Oncol
, vol.17
, Issue.3
, pp. 299-308
-
-
Antonia, S.1
Goldberg, S.B.2
Balmanoukian, A.3
Chaft, J.E.4
Sanborn, R.E.5
Gupta, A.6
-
56
-
-
85034633214
-
Phase 3, double-blind, placebo-controlled study of MEDI4736 after chemoradiation in stage III, locally advanced, unresectable NSCLC (PACIFIC)
-
Cho, B.C., Kim, J.H., Villegas, A., Frusch, N., Murakami, S., Shi, K., et al. Phase 3, double-blind, placebo-controlled study of MEDI4736 after chemoradiation in stage III, locally advanced, unresectable NSCLC (PACIFIC). J Thorac Oncol, 10(9 suppl 2), 2015, S668.
-
(2015)
J Thorac Oncol
, vol.10
, Issue.9
, pp. S668
-
-
Cho, B.C.1
Kim, J.H.2
Villegas, A.3
Frusch, N.4
Murakami, S.5
Shi, K.6
-
57
-
-
84971637115
-
A phase III study of curvalumab (MEDI4736) with or without tremelimumab for previously treated patients with advanced NSCLC: rationale and protocol design of the ARCTIC study
-
Planchard, D., Yokoi, T., McCleod, M.J., Fischer, J.R., Kim, Y.C., Ballas, M., et al. A phase III study of curvalumab (MEDI4736) with or without tremelimumab for previously treated patients with advanced NSCLC: rationale and protocol design of the ARCTIC study. Clin Lung Cancer 17:3 (2016), 232–236.
-
(2016)
Clin Lung Cancer
, vol.17
, Issue.3
, pp. 232-236
-
-
Planchard, D.1
Yokoi, T.2
McCleod, M.J.3
Fischer, J.R.4
Kim, Y.C.5
Ballas, M.6
-
58
-
-
84984681469
-
Avelumab (MSB0010718C; anti-PD-L1) as a first-line treatment for patients with advanced NSCLC from the JAVELIN solid tumor phase 1b trial: safety, clinical activity, and PD-L1 expression
-
Abstract 9036
-
Verschraegen, C.F., Chen, F., Spigel, D.R., Iannotti, N., McClay, E.F., Redfern, C.H., et al. Avelumab (MSB0010718C; anti-PD-L1) as a first-line treatment for patients with advanced NSCLC from the JAVELIN solid tumor phase 1b trial: safety, clinical activity, and PD-L1 expression. J Clin Oncol, 34(suppl), 2016 Abstract 9036.
-
(2016)
J Clin Oncol
, vol.34
-
-
Verschraegen, C.F.1
Chen, F.2
Spigel, D.R.3
Iannotti, N.4
McClay, E.F.5
Redfern, C.H.6
-
59
-
-
85006253164
-
Avelumab (MSB0010718C; anti-PD-L1) vs platinum-based doublet as first-line treatment for metastatic or recurrent PD-L1-positive non-small-cell lung cancer: The phase 3 JAVELIN Lung 100 trial
-
Abstract TPS9105
-
Reck, M., DeGreen, H.P., Rose, A.L., Pavlakis, N., Derjcke, S.M., Radic, J., et al. Avelumab (MSB0010718C; anti-PD-L1) vs platinum-based doublet as first-line treatment for metastatic or recurrent PD-L1-positive non-small-cell lung cancer: The phase 3 JAVELIN Lung 100 trial. J Clin Oncol, 34(suppl), 2016 Abstract TPS9105.
-
(2016)
J Clin Oncol
, vol.34
-
-
Reck, M.1
DeGreen, H.P.2
Rose, A.L.3
Pavlakis, N.4
Derjcke, S.M.5
Radic, J.6
-
60
-
-
84962857991
-
The prevalence and clinicopathological features of programmed death-ligand 1 (PD-L1) expression: a pooled analysis of literatures
-
Lin, Z., Xu, Y., Zhang, Y., He, Q., Zhang, J., He, J., et al. The prevalence and clinicopathological features of programmed death-ligand 1 (PD-L1) expression: a pooled analysis of literatures. Oncotarget 7:12 (2016), 15033–15046.
-
(2016)
Oncotarget
, vol.7
, Issue.12
, pp. 15033-15046
-
-
Lin, Z.1
Xu, Y.2
Zhang, Y.3
He, Q.4
Zhang, J.5
He, J.6
-
61
-
-
84964746711
-
PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis
-
Passiglia, F., Bronte, G., Bazan, V., Natoli, C., Rizzo, S., Galvano, A., et al. PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis. Oncotarget 7:15 (2016), 19738–19747.
-
(2016)
Oncotarget
, vol.7
, Issue.15
, pp. 19738-19747
-
-
Passiglia, F.1
Bronte, G.2
Bazan, V.3
Natoli, C.4
Rizzo, S.5
Galvano, A.6
-
62
-
-
85034666125
-
-
Dako North America, Inc. PD-L1 IHC 22C3 pharmDx. Dako North America Inc: Carpinteria, CA;
-
Dako North America, Inc. PD-L1 IHC 22C3 pharmDx. Dako North America Inc: Carpinteria, CA; 2015.
-
(2015)
-
-
-
63
-
-
85034641123
-
-
Dako Agilent Pathology Solutions. PD-L1 IHC 28–8 pharmDx: Interpretation Manual—Non-squamous non-small cell lung cancer (ROW Version);
-
Dako Agilent Pathology Solutions. PD-L1 IHC 28–8 pharmDx: Interpretation Manual—Non-squamous non-small cell lung cancer (ROW Version); 2016.
-
(2016)
-
-
-
65
-
-
85034659658
-
-
Roche Group Media Relations. Roche announces FDA approval for VENTANA PD-L1 (SP142) Assay to support immunotherapy treatment decisions in lung cancer [press release]. Published October 27; 2016. <>.
-
Roche Group Media Relations. Roche announces FDA approval for VENTANA PD-L1 (SP142) Assay to support immunotherapy treatment decisions in lung cancer [press release]. Published October 27; 2016. < http://www.prnewswire.com/news-releases/roche-announces-fda-approval-for-ventana-pd-l1-sp142-assay-to-support-immunotherapy-treatment-decisions-in-lung-cancer-300352191.html>.
-
-
-
-
66
-
-
85034643634
-
-
The Blueprint Project: harmonizing companion diagnostics across a class of targeted therapies. New Orleans, LA;
-
Hirsch FR, Averbuch S, Emami T, Walker J, Williams A, Stanforth D, et al. The Blueprint Project: harmonizing companion diagnostics across a class of targeted therapies. New Orleans, LA; 2016.
-
(2016)
-
-
Hirsch, F.R.1
Averbuch, S.2
Emami, T.3
Walker, J.4
Williams, A.5
Stanforth, D.6
-
67
-
-
85034622856
-
-
A blueprint proposal for companion diagnostic comparability. <> [accessed July 20].
-
Averbuch S, Emancipator K, McCaffery I, McEilhinny A, Stanforth D, Walker J, et al. A blueprint proposal for companion diagnostic comparability. < https://www.fda.gov/downloads/medicaldevices/newsevents/workshopsconferences/ucm439440.pdf> [accessed July 20, 2017].
-
(2017)
-
-
Averbuch, S.1
Emancipator, K.2
McCaffery, I.3
McEilhinny, A.4
Stanforth, D.5
Walker, J.6
-
68
-
-
84906860520
-
Second ESMO consensus conference on lung cancer: pathology and molecular biomarkers for non-small-cell lung cancer
-
Kerr, K.M., Bubendorf, L., Edelman, M.J., Marchetti, A., Mok, T., Novello, S., et al. Second ESMO consensus conference on lung cancer: pathology and molecular biomarkers for non-small-cell lung cancer. Ann Oncol 25:9 (2014), 1681–1690.
-
(2014)
Ann Oncol
, vol.25
, Issue.9
, pp. 1681-1690
-
-
Kerr, K.M.1
Bubendorf, L.2
Edelman, M.J.3
Marchetti, A.4
Mok, T.5
Novello, S.6
-
69
-
-
84976879317
-
Development of a prototype immunohistochemistry assay to measure programmed death ligand-1 expression in tumor tissue
-
Dolled-Filhart, M., Locke, D., Murphy, T., Lynch, F., Yearley, J.H., Frisman, D., et al. Development of a prototype immunohistochemistry assay to measure programmed death ligand-1 expression in tumor tissue. Arch Pathol Lab Med 140:11 (2016), 1259–1266.
-
(2016)
Arch Pathol Lab Med
, vol.140
, Issue.11
, pp. 1259-1266
-
-
Dolled-Filhart, M.1
Locke, D.2
Murphy, T.3
Lynch, F.4
Yearley, J.H.5
Frisman, D.6
-
70
-
-
84942253619
-
Development of an automated PD-L1 immunohistochemistry (IHC) assay for non-small cell lung cancer
-
Phillips, T., Simmons, P., Inzunza, H.D., Cogswell, J., Novotny, J. Jr., Taylor, C., et al. Development of an automated PD-L1 immunohistochemistry (IHC) assay for non-small cell lung cancer. Appl Immunohistochem Mol Morphol 23:8 (2015), 541–549.
-
(2015)
Appl Immunohistochem Mol Morphol
, vol.23
, Issue.8
, pp. 541-549
-
-
Phillips, T.1
Simmons, P.2
Inzunza, H.D.3
Cogswell, J.4
Novotny, J.5
Taylor, C.6
-
71
-
-
85019468495
-
Clinical applications of PD-L1 bioassays for cancer immunotherapy
-
Liu, D., Wang, S., Bindeman, W., Clinical applications of PD-L1 bioassays for cancer immunotherapy. J Hematol Oncol, 10, 2017, 110.
-
(2017)
J Hematol Oncol
, vol.10
, pp. 110
-
-
Liu, D.1
Wang, S.2
Bindeman, W.3
-
72
-
-
84990842182
-
Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma
-
Rebelatto, M.C., Midha, A., Mistry, A., Sabalos, C., Schechter, N., Li, X., et al. Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma. Diagn Pathol, 11(1), 2016, 95.
-
(2016)
Diagn Pathol
, vol.11
, Issue.1
, pp. 95
-
-
Rebelatto, M.C.1
Midha, A.2
Mistry, A.3
Sabalos, C.4
Schechter, N.5
Li, X.6
-
73
-
-
84975493654
-
Development of a companion diagnostic PD-L1 immunohistochemistry assay for pembrolizumab therapy in non-small-cell lung cancer
-
Roach, C., Zhang, N., Corigliano, E., Jansson, M., Toland, G., Ponto, G., et al. Development of a companion diagnostic PD-L1 immunohistochemistry assay for pembrolizumab therapy in non-small-cell lung cancer. Appl Immunohistochem Mol Morphol 24:6 (2016), 392–397.
-
(2016)
Appl Immunohistochem Mol Morphol
, vol.24
, Issue.6
, pp. 392-397
-
-
Roach, C.1
Zhang, N.2
Corigliano, E.3
Jansson, M.4
Toland, G.5
Ponto, G.6
-
74
-
-
84992573817
-
Development of a companion diagnostic for pembrolizumab in non–small cell lung cancer using immunohistochemistry for programmed death ligand-1
-
[Epub ahead of print]
-
Dolled-Filhart, M., Roach, C., Toland, G., Stanforth, D., Jansson, M., Lubiniecki, G.M., et al. Development of a companion diagnostic for pembrolizumab in non–small cell lung cancer using immunohistochemistry for programmed death ligand-1. Arch Pathol Lab Med, 2016 [Epub ahead of print].
-
(2016)
Arch Pathol Lab Med
-
-
Dolled-Filhart, M.1
Roach, C.2
Toland, G.3
Stanforth, D.4
Jansson, M.5
Lubiniecki, G.M.6
-
75
-
-
85034631094
-
-
Pembrolizumab vs docetaxel for previously treated advanced NSCLC with a PD-L1 tumor proportion score (TPS) 1%-49%: results from KEYNOTE-010. Presented at: ASCO Annual Meeting, June 3–7, Chicago, IL. Abstract 9024.
-
Garon EB, Herbst RS, Kim D-W, Felip E, Perez-Gracia JL, Han J-Y, et al. Pembrolizumab vs docetaxel for previously treated advanced NSCLC with a PD-L1 tumor proportion score (TPS) 1%-49%: results from KEYNOTE-010. Presented at: ASCO Annual Meeting, June 3–7, 2016, Chicago, IL. Abstract 9024.
-
(2016)
-
-
Garon, E.B.1
Herbst, R.S.2
Kim, D.-W.3
Felip, E.4
Perez-Gracia, J.L.5
Han, J.-Y.6
-
76
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D.R., Steins, M., Ready, N.E., et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 373:17 (2015), 1627–1639.
-
(2015)
N Engl J Med
, vol.373
, Issue.17
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
-
77
-
-
84974691152
-
PD-L1 expression and survival among patients with advanced non-small cell lung cancer treated with chemotherapy
-
Sorensen, S.F., Zhou, W., Dolled-Filhart, M., Georgsen, J.B., Wang, Z., Emancipator, K., et al. PD-L1 expression and survival among patients with advanced non-small cell lung cancer treated with chemotherapy. Transl Oncol 9:1 (2016), 64–69.
-
(2016)
Transl Oncol
, vol.9
, Issue.1
, pp. 64-69
-
-
Sorensen, S.F.1
Zhou, W.2
Dolled-Filhart, M.3
Georgsen, J.B.4
Wang, Z.5
Emancipator, K.6
-
78
-
-
84951938171
-
Pembrolizumab for the treatment of thoracic malignancies: current landscape and future directions
-
Karim, S., Leighl, N., Pembrolizumab for the treatment of thoracic malignancies: current landscape and future directions. Future Oncol 12:1 (2016), 9–23.
-
(2016)
Future Oncol
, vol.12
, Issue.1
, pp. 9-23
-
-
Karim, S.1
Leighl, N.2
-
79
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer, J., Reckamp, K.L., Baas, P., Crino, L., Eberhardt, W.E., Poddubskaya, E., et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 373:2 (2015), 123–135.
-
(2015)
N Engl J Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crino, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
-
80
-
-
85008239423
-
Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
-
Rittmeyer, A., Barlesi, F., Waterkamp, D., Park, K., Ciardiello, F., von Pawel, J., et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 389:10066 (2017), 255–265.
-
(2017)
Lancet
, vol.389
, Issue.10066
, pp. 255-265
-
-
Rittmeyer, A.1
Barlesi, F.2
Waterkamp, D.3
Park, K.4
Ciardiello, F.5
von Pawel, J.6
-
81
-
-
85011421950
-
A phase 3 trial of nivolumab vs investigator's choice (IC) of platinum-based doublet chemotherapy (PT-DC) as first-line therapy for stage iv/recurrent programmed death ligand 1 (PD-L1)-positive NSCLC
-
[Abstract LBA7-PR]
-
Socinski, M., Horn, L., Steins, M., Ciuleanu, T.E., Ready, N., Nair, R.G., et al. A phase 3 trial of nivolumab vs investigator's choice (IC) of platinum-based doublet chemotherapy (PT-DC) as first-line therapy for stage iv/recurrent programmed death ligand 1 (PD-L1)-positive NSCLC. Ann Oncol, 27(suppl 6), 2016 [Abstract LBA7-PR].
-
(2016)
Ann Oncol
, vol.27
-
-
Socinski, M.1
Horn, L.2
Steins, M.3
Ciuleanu, T.E.4
Ready, N.5
Nair, R.G.6
-
82
-
-
84964858970
-
Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients
-
Ilie, M., Hofman, V., Dietel, M., Soria, J.C., Hofman, P., Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients. Virchows Arch 468:5 (2016), 511–525.
-
(2016)
Virchows Arch
, vol.468
, Issue.5
, pp. 511-525
-
-
Ilie, M.1
Hofman, V.2
Dietel, M.3
Soria, J.C.4
Hofman, P.5
-
83
-
-
84957839638
-
CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition
-
Buchbinder, E.I., Desai, A., CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition. Am J Clin Oncol 39:1 (2016), 98–106.
-
(2016)
Am J Clin Oncol
, vol.39
, Issue.1
, pp. 98-106
-
-
Buchbinder, E.I.1
Desai, A.2
-
84
-
-
84945554100
-
Phase I study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
-
Patnaik, A., Kang, S.P., Rasco, D., Papadopoulos, K.P., Elassaiss-Schaap, J., Beeram, M., et al. Phase I study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. Clin Cancer Res 21:19 (2015), 4286–4293.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.19
, pp. 4286-4293
-
-
Patnaik, A.1
Kang, S.P.2
Rasco, D.3
Papadopoulos, K.P.4
Elassaiss-Schaap, J.5
Beeram, M.6
-
85
-
-
84969988424
-
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial
-
Seiwert, T.Y., Burtness, B., Mehra, R., Weiss, J., Berger, R., Eder, J.P., et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol 17:7 (2016), 956–965.
-
(2016)
Lancet Oncol
, vol.17
, Issue.7
, pp. 956-965
-
-
Seiwert, T.Y.1
Burtness, B.2
Mehra, R.3
Weiss, J.4
Berger, R.5
Eder, J.P.6
-
86
-
-
84992103934
-
Archival vs new tumor samples for assessing PD-L1 expression in the KEYNOTE-010 study of pembrolizumab (pembro) vs docetaxel (doce) for previously treated advanced NSCLC
-
Abstract 3030
-
Herbst, R.S., Baas, P., Perez-Garcia, J.L., Felip, E., Kim, D.W., Han, J.Y., et al. Archival vs new tumor samples for assessing PD-L1 expression in the KEYNOTE-010 study of pembrolizumab (pembro) vs docetaxel (doce) for previously treated advanced NSCLC. J Clin Oncol, 34(suppl), 2016 Abstract 3030.
-
(2016)
J Clin Oncol
, vol.34
-
-
Herbst, R.S.1
Baas, P.2
Perez-Garcia, J.L.3
Felip, E.4
Kim, D.W.5
Han, J.Y.6
-
87
-
-
84960080350
-
Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies
-
Ilie, M., Long-Mira, E., Bence, C., Butori, C., Lassalle, S., Bouhlel, L., et al. Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies. Ann Oncol 27:1 (2016), 147–153.
-
(2016)
Ann Oncol
, vol.27
, Issue.1
, pp. 147-153
-
-
Ilie, M.1
Long-Mira, E.2
Bence, C.3
Butori, C.4
Lassalle, S.5
Bouhlel, L.6
-
88
-
-
84928761118
-
Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N.A., Hellmann, M.D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J.J., et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348:6230 (2015), 124–128.
-
(2015)
Science
, vol.348
, Issue.6230
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
-
89
-
-
85034668433
-
-
Impact of tumor mutation burden on the efficacy of first-line nivolumab in stage iv or recurrent non-small cell lung cancer: an exploratory analysis of CheckMate 026. Presented at: AACR Annual Meeting 2017, Washington, DC, April
-
Peters S, Creelan B, Hellman MD, Socinski MA, Reck M, Bhagavatheeswaran P, et al. Impact of tumor mutation burden on the efficacy of first-line nivolumab in stage iv or recurrent non-small cell lung cancer: an exploratory analysis of CheckMate 026. Presented at: AACR Annual Meeting 2017, Washington, DC, April 1–5, 2017.
-
(2017)
, pp. 1-5
-
-
Peters, S.1
Creelan, B.2
Hellman, M.D.3
Socinski, M.A.4
Reck, M.5
Bhagavatheeswaran, P.6
-
90
-
-
85009840975
-
Phase II single arm trial (BIRCH) of atezolizumab as first line or subsequent therapy for locally advanced or metastatic PD-L1 selected NSCLC
-
Besse, B., Johnson, M.L., Janne, P.A., Garissino, M., Eberhardt, W.E.E., Peters, S., et al. Phase II single arm trial (BIRCH) of atezolizumab as first line or subsequent therapy for locally advanced or metastatic PD-L1 selected NSCLC. Eur J Cancer 51:suppl 3 (2015), S717–718.
-
(2015)
Eur J Cancer
, vol.51
, pp. S717-718
-
-
Besse, B.1
Johnson, M.L.2
Janne, P.A.3
Garissino, M.4
Eberhardt, W.E.E.5
Peters, S.6
-
91
-
-
85015290448
-
Primary analysis from OAK, a randomized phase III study comparing atezolizumab with docetaxel in 2L/3L NSCLC
-
[Abstract LBA44_PR]
-
Barlesi, F., Von Pawel, J., Kowalski, D., Leach, J., Gandara, D., Chen, D.S., et al. Primary analysis from OAK, a randomized phase III study comparing atezolizumab with docetaxel in 2L/3L NSCLC. Ann Oncol, 27(Suppl. 6), 2016 [Abstract LBA44_PR].
-
(2016)
Ann Oncol
, vol.27
-
-
Barlesi, F.1
Von Pawel, J.2
Kowalski, D.3
Leach, J.4
Gandara, D.5
Chen, D.S.6
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