-
1
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992;11:3887-95.
-
(1992)
EMBO J
, vol.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
2
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 1999;11:141-51.
-
(1999)
Immunity
, vol.11
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
3
-
-
0035846991
-
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
-
Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 2001;291:319-22.
-
(2001)
Science
, vol.291
, pp. 319-322
-
-
Nishimura, H.1
Okazaki, T.2
Tanaka, Y.3
Nakatani, K.4
Hara, M.5
Matsumori, A.6
Sasayama, S.7
Mizoguchi, A.8
Hiai, H.9
Minato, N.10
Honjo, T.11
-
4
-
-
0037815272
-
PD-1 inhibits antiviral immunity at the effector phase in the liver
-
Iwai Y, Terawaki S, Ikegawa M, Okazaki T, Honjo T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J Exp Med. 2003;198:39-50.
-
(2003)
J Exp Med
, vol.198
, pp. 39-50
-
-
Iwai, Y.1
Terawaki, S.2
Ikegawa, M.3
Okazaki, T.4
Honjo, T.5
-
5
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439:682-7.
-
(2006)
Nature
, vol.439
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
Zhu, B.4
Allison, J.P.5
Sharpe, A.H.6
Freeman, G.J.7
Ahmed, R.8
-
6
-
-
84878229777
-
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
-
Utzschneider DT, Legat A, Fuertes Marraco SA, Carrie L, Luescher I, Speiser DE, et al. T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion. Nat Immunol. 2013;14:603-10.
-
(2013)
Nat Immunol
, vol.14
, pp. 603-610
-
-
Utzschneider, D.T.1
Legat, A.2
Fuertes Marraco, S.A.3
Carrie, L.4
Luescher, I.5
Speiser, D.E.6
Zehn, D.7
-
7
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027-34.
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
Bourque, K.4
Chernova, T.5
Nishimura, H.6
Fitz, L.J.7
Malenkovich, N.8
Okazaki, T.9
Byrne, M.C.10
Horton, H.F.11
Fouser, L.12
Carter, L.13
Ling, V.14
Bowman, M.R.15
Carreno, B.M.16
Collins, M.17
Wood, C.R.18
Honjo, T.19
-
8
-
-
0037126021
-
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
-
Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 2002;99:12293-7.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12293-12297
-
-
Iwai, Y.1
Ishida, M.2
Tanaka, Y.3
Okazaki, T.4
Honjo, T.5
Minato, N.6
-
9
-
-
13844294372
-
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
-
Iwai Y, Terawaki S, Honjo T. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int Immunol. 2005;17:133-44.
-
(2005)
Int Immunol
, vol.17
, pp. 133-144
-
-
Iwai, Y.1
Terawaki, S.2
Honjo, T.3
-
10
-
-
84887862839
-
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
-
Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol. 2013;14:1212-8.
-
(2013)
Nat Immunol
, vol.14
, pp. 1212-1218
-
-
Okazaki, T.1
Chikuma, S.2
Iwai, Y.3
Fagarasan, S.4
Honjo, T.5
-
11
-
-
84945554100
-
Phase I study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
-
Patnaik A, Kang SP, Rasco D, Papadopoulos KP, Elassaiss-Schaap J, et al. Phase I study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. Clin Cancer Res. 2015. doi: 10.1158/1078-0432.CCR-14-2607.
-
(2015)
Clin Cancer Res
-
-
Patnaik, A.1
Kang, S.P.2
Rasco, D.3
Papadopoulos, K.P.4
Elassaiss-Schaap, J.5
-
12
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013;369:134-44.
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
Wolchok, J.D.7
Hersey, P.8
Joseph, R.W.9
Weber, J.S.10
Dronca, R.11
Gangadhar, T.C.12
Patnaik, A.13
Zarour, H.14
Joshua, A.M.15
Gergich, K.16
Elassaiss-Schaap, J.17
Algazi, A.18
Mateus, C.19
Boasberg, P.20
Tumeh, P.C.21
Chmielowski, B.22
Ebbinghaus, S.W.23
Li, X.N.24
Kang, S.P.25
Ribas, A.26
more..
-
13
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
-
Robert C, Ribas A, Wolchock JD, Hodi FS, Hamid O, Kefford R, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014;384:1109-17.
-
(2014)
Lancet
, vol.384
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchock, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
Weber, J.S.7
Joshua, A.M.8
Hwu, W.J.9
Gaghadar, T.C.10
Patnaik, A.11
Dronca, R.12
Zarour, H.13
Joseph, R.W.14
Boasberg, P.15
Chmielowski, B.16
Mateus, C.17
Postow, M.A.18
Gergich, K.19
Elassaiss-Schaap, J.20
Li, X.N.21
Iannone, R.22
Ebbinghaus, S.W.23
Kang, S.P.24
Daud, A.25
more..
-
14
-
-
84907498839
-
Randomized comparison of two doses of the anti-PD-1 monoclonal antibody MK-3475 for ipilimumab-refractory (IPI-R) and IPI-naive (IPI-N) melanoma (MEL)
-
Hamid O, Robert C, Ribas A, Wolchok F, Hodi S, Kefford R, et al. Randomized comparison of two doses of the anti-PD-1 monoclonal antibody MK-3475 for ipilimumab-refractory (IPI-R) and IPI-naive (IPI-N) melanoma (MEL). J Clin Oncol. 2014;32(Suppl):3000.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3000
-
-
Hamid, O.1
Robert, C.2
Ribas, A.3
Wolchok, F.4
Hodi, S.5
Kefford, R.6
-
15
-
-
84941024351
-
Pembrolizumab (pembro; MK-3475) for advanced melanoma (MEL): randomized comparison of two dosing schedules
-
Robert C, Joshua AM, Weber JS, Ribas A, Hodi FS, Kefford RF, et al. Pembrolizumab (pembro; MK-3475) for advanced melanoma (MEL): randomized comparison of two dosing schedules. Ann Oncol. 2014;25:1-41.
-
(2014)
Ann Oncol
, vol.25
, pp. 1-41
-
-
Robert, C.1
Joshua, A.M.2
Weber, J.S.3
Ribas, A.4
Hodi, F.S.5
Kefford, R.F.6
Daud, A.7
Wolchuck, J.D.8
Hwu, W.9
Gangadhar, T.C.10
Patnaik, A.11
Hershey, P.12
Dronka, R.13
Zarour, H.14
Ge, Y.15
Lindia, J.A.16
Giannotti, M.17
Ebbinghaus, S.18
Kang, S.19
Hamid, M.Z.20
more..
-
16
-
-
84907543029
-
Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL)
-
LBA9000.
-
Ribas AF, Hodi S, Kefford R, Hamid O, Daud A, Wolchok AD, et al. Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL). J Clin Oncol. 2014;32(Suppl):LBA9000.
-
(2014)
J Clin Oncol
, vol.32
-
-
Ribas, A.F.1
Hodi, S.2
Kefford, R.3
Hamid, O.4
Daud, A.5
Wolchok, A.D.6
-
17
-
-
84907973066
-
Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475
-
Kefford R, Ribas A, Hamid O, Robert C, Daud A, Wolchok JD, et al. Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. J Clin Oncol. 2014;32(Suppl):3005.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3005
-
-
Kefford, R.1
Ribas, A.2
Hamid, O.3
Robert, C.4
Daud, A.5
Wolchok, J.D.6
-
18
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, Weber JS, Hamid O, Lebbe C, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15:7412-20.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
Weber, J.S.4
Hamid, O.5
Lebbe, C.6
Maio, M.7
Binder, M.8
Bohnsack, O.9
Nichol, G.10
Humphrey, R.11
Hodi, F.S.12
-
19
-
-
84998797406
-
Patterns of response in patients with advanced melanoma treated with pembrolizumab (MK-3475) and evaluation of immune-related response criteria (irRC)
-
Hodi FS, Ribas A, Daud A, Hamid O, Robert C, Keford R, et al. Patterns of response in patients with advanced melanoma treated with pembrolizumab (MK-3475) and evaluation of immune-related response criteria (irRC). J Immunother Cancer. 2014;2:103.
-
(2014)
J Immunother Cancer
, vol.2
, pp. 103
-
-
Hodi, F.S.1
Ribas, A.2
Daud, A.3
Hamid, O.4
Robert, C.5
Keford, R.6
Hwu, W.J.7
Gaghadar, T.C.8
Joshua, A.M.9
Hersey, P.10
Weber, J.11
Joseph, R.W.12
Zarour, H.13
Dronca, R.14
Gammage, L.15
Hille, D.16
-
20
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
-
Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol. 2015. doi: 10.1016/S1470-2045(15)00083-2
-
(2015)
Lancet Oncol
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
Schadendorf, D.4
Hamid, O.5
Robert, C.6
-
21
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, Arance A, Grob J, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;25:2521-32.
-
(2015)
N Engl J Med
, vol.25
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.5
Mortier, L.6
-
22
-
-
84929481480
-
Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer
-
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, et al. Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer. N Engl J Med. 2015;372:2018-28.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
23
-
-
84920993558
-
Phase Ib study of pembrolizumab (pembro; MK-3475) in patients (pts) with human papillomavirus virus (HPV)-positive and negative head and neck cancer (HNC)
-
LBA31
-
Chow LQM, Burtness B, Weiss J, Berger R, Eder JP, Gonzalez E, et al. Phase Ib study of pembrolizumab (pembro; MK-3475) in patients (pts) with human papillomavirus virus (HPV)-positive and negative head and neck cancer (HNC). Ann Oncol. 2014;25:LBA31.
-
(2014)
Ann Oncol
, vol.25
-
-
Chow, L.Q.M.1
Burtness, B.2
Weiss, J.3
Berger, R.4
Eder, J.P.5
Gonzalez, E.6
Pulini, J.7
Johnson, J.8
Dolled-Filhart, M.9
Emancipator, K.10
Pathiraja, K.11
Gause, C.K.12
Cheng, J.13
Lunceford, J.14
Seiwert, T.15
-
24
-
-
84937041504
-
Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012
-
Muro K, Bang Y-J, Shankaran V, Geva R, Catenacci D, Gupta S, et al. Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012. J Clin Oncol. 2015;33 (Suppl 3):3.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3
-
-
Muro, K.1
Bang, Y.-J.2
Shankaran, V.3
Geva, R.4
Catenacci, D.5
Gupta, S.6
Eder, J.P.7
Berger, R.8
Gonzalez, E.J.9
Ray, A.10
Emancipator, K.11
Pathiraja, K.12
Lunceford, J.13
Cheng, J.14
Koshiji, M.15
Chung, H.C.16
-
25
-
-
84998797367
-
Pembrolizumab for Advanced Urothelial Cancer: Updated Results of a Phase 1b Study
-
2-26-2015. Orlando, Florida: Presented at 2015 American Society of Clinical Oncology Genitourinary Cancers Symposium
-
O'Donnell PH, Plimack ER, Bellmunt J, Berger R, Montgomery B, Heath JK, et al. Pembrolizumab for Advanced Urothelial Cancer: Updated Results of a Phase 1b Study. 2-26-2015. Orlando, Florida: Presented at 2015 American Society of Clinical Oncology Genitourinary Cancers Symposium; 2015.
-
(2015)
-
-
O'Donnell, P.H.1
Plimack, E.R.2
Bellmunt, J.3
Berger, R.4
Montgomery, B.5
Heath, J.K.6
-
26
-
-
84929342219
-
A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer
-
San Antonio, Texas: Presented at: San Antonio Breast Cancer Symposium
-
Nanda R, Chow LQ, Dees EC, Berger R, Gupta S, Geva R, et al. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. San Antonio, Texas: Presented at: San Antonio Breast Cancer Symposium; 2014.
-
(2014)
-
-
Nanda, R.1
Chow, L.Q.2
Dees, E.C.3
Berger, R.4
Gupta, S.5
Geva, R.6
-
27
-
-
84925717350
-
PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical hodgkin lymphoma after brentuximab vedotin failure: preliminary results from a phase 1b study (KEYNOTE-013)
-
Moskowitz CH, Ribrag V, Michot JM, Martinelli G, Zinzani PL, Guiterrez M, et al. PD-1 blockade with the monoclonal antibody pembrolizumab (MK-3475) in patients with classical hodgkin lymphoma after brentuximab vedotin failure: preliminary results from a phase 1b study (KEYNOTE-013). Blood. 2014;124:290.
-
(2014)
Blood
, vol.124
, pp. 290
-
-
Moskowitz, C.H.1
Ribrag, V.2
Michot, J.M.3
Martinelli, G.4
Zinzani, P.L.5
Guiterrez, M.6
Maeyer, G.7
Jacob, A.G.8
Giallella, K.9
Anderson, J.W.10
Derosier, M.11
Wang, J.12
Yang, Z.13
Rubin, E.14
Rose, S.15
Shipp, M.A.16
Armand, P.17
-
28
-
-
84938760671
-
Clinical Safety and Efficacy of Pembrolizumab (MK-3475) in Patients with Malignant Pleural Mesothelioma (MPM): Preliminary Results from KEYNOTE-028
-
Philadelphia, PA: Presented at: American Association for Cancer Research 2015 Annual Meeting
-
Alley E, Molife LR, Santoro A, Beckey K, Yuan S, Cheng JD, et al. Clinical Safety and Efficacy of Pembrolizumab (MK-3475) in Patients with Malignant Pleural Mesothelioma (MPM): Preliminary Results from KEYNOTE-028. Philadelphia, PA: Presented at: American Association for Cancer Research 2015 Annual Meeting; 2015.
-
(2015)
-
-
Alley, E.1
Molife, L.R.2
Santoro, A.3
Beckey, K.4
Yuan, S.5
Cheng, J.D.6
-
29
-
-
84930413267
-
Anti-programmed cell death-1 therapy and insulin-dependent diabetes: a case report
-
Martin-Liberal J, Furness AJ, Joshi K, Peggs KS, Quezada SA, Larkin J. Anti-programmed cell death-1 therapy and insulin-dependent diabetes: a case report. Cancer Immunol Immunother. 2015. doi: 10.1007/s00262-015-1689-1.
-
(2015)
Cancer Immunol Immunother
-
-
Martin-Liberal, J.1
Furness, A.J.2
Joshi, K.3
Peggs, K.S.4
Quezada, S.A.5
Larkin, J.6
-
30
-
-
84997637224
-
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
-
Laubli H, Balmelli C, Bossard M, Pfister O, Glatz K, Zippelius A. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. J Immunother. 2015;3:11.
-
(2015)
J Immunother
, vol.3
, pp. 11
-
-
Laubli, H.1
Balmelli, C.2
Bossard, M.3
Pfister, O.4
Glatz, K.5
Zippelius, A.6
-
31
-
-
84895904745
-
Mitigating the toxic effects of anticancer immunotherapy
-
Gangadhar TC, Vonderheide RH. Mitigating the toxic effects of anticancer immunotherapy. Nat Rev Clin Oncol. 2014;11:91-9.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 91-99
-
-
Gangadhar, T.C.1
Vonderheide, R.H.2
-
32
-
-
84926416165
-
Optimal management of immune-related toxicities associated with checkpoint inhibitors in lung cancer
-
Howell M, Lee R, Bowyer S, Fusi A, Lorigan P. Optimal management of immune-related toxicities associated with checkpoint inhibitors in lung cancer. Lung Cancer. 2015;88:117-23.
-
(2015)
Lung Cancer
, vol.88
, pp. 117-123
-
-
Howell, M.1
Lee, R.2
Bowyer, S.3
Fusi, A.4
Lorigan, P.5
-
33
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
Leming, P.D.11
Spigel, D.R.12
Antonia, S.J.13
Horn, L.14
Drake, C.G.15
Pardoll, D.M.16
Chen, L.17
Sharfman, W.H.18
Anders, R.A.19
Taube, J.M.20
McMiller, T.L.21
Xu, H.22
Korman, A.J.23
Jure-Kunkel, M.24
Agrawal, S.25
McDonald, D.26
Kollia, G.D.27
Gupta, A.28
Wigginton, J.M.29
Sznol, M.30
more..
-
34
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455-65.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
Drake, C.G.7
Camacho, L.H.8
Kauh, J.9
Odunsi, K.10
Pitot, H.C.11
Hamid, O.12
Bhatia, S.13
Martins, R.14
Eaton, K.15
Chen, S.16
Salay, T.M.17
Alaparthy, S.18
Grosso, J.F.19
Korman, A.J.20
Parker, S.M.21
Agrawal, S.22
Goldberg, S.M.23
Pardoll, D.M.24
Gupta, A.25
Wigginton, J.M.26
more..
-
35
-
-
84905991829
-
Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome
-
CT104.
-
Daud AI, Hamid O, Antoni-Ribas F, Hodi S, Hwu WJ, Kefford R, et al. Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome. Cancer Res. 2014;74(Suppl):CT104.
-
(2014)
Cancer Res
, vol.74
-
-
Daud, A.I.1
Hamid, O.2
Antoni-Ribas, F.3
Hodi, S.4
Hwu, W.J.5
Kefford, R.6
-
36
-
-
84998781124
-
Relationship between programmed death ligand 1 (PD-L1) expression and clinical outcome in patients with melanoma treated with pembrolizumab (MK-3475)
-
Zurich, Switzerland: Presented at Society for Melanoma Research 2014 International Congress
-
Daud A, Hamid O, Robert C, Hodi S, Wolchuck JD, Hwu WJ, et al. Relationship between programmed death ligand 1 (PD-L1) expression and clinical outcome in patients with melanoma treated with pembrolizumab (MK-3475). Zurich, Switzerland: Presented at Society for Melanoma Research 2014 International Congress; 2014.
-
(2014)
-
-
Daud, A.1
Hamid, O.2
Robert, C.3
Hodi, S.4
Wolchuck, J.D.5
Hwu, W.J.6
-
37
-
-
84929939531
-
The prognostic value of PD-L1 expression for non-small cell lung cancer patients: A meta-analysis
-
Wang A, Wang HY, Liu Y, Zhao MC, Zhang HJ, Lu ZY, et al. The prognostic value of PD-L1 expression for non-small cell lung cancer patients: A meta-analysis. Eur J Surg Oncol. 2015;41:450-6.
-
(2015)
Eur J Surg Oncol
, vol.41
, pp. 450-456
-
-
Wang, A.1
Wang, H.Y.2
Liu, Y.3
Zhao, M.C.4
Zhang, H.J.5
Lu, Z.Y.6
Fang, Y.C.7
Chen, X.F.8
Liu, G.T.9
-
38
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515:563-7.
-
(2014)
Nature
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
Fine, G.D.4
Hamid, O.5
Gordon, M.S.6
Sosman, J.A.7
McDermott, D.F.8
Powderly, J.D.9
Gettinger, S.N.10
Kohrt, H.E.11
Horn, L.12
Lawrence, D.P.13
Rost, S.14
Leabman, M.15
Xiao, Y.16
Mokatrin, A.17
Koeppen, H.18
Hegde, P.S.19
Mellman, I.20
Chen, D.S.21
Hodi, F.S.22
more..
-
39
-
-
84922086584
-
Baseline tumor size as an independent prognostic factor for overall survival in paitnets with metastatic melanoma treated with the anti-PD-1 monoclonal antibody MK-3475
-
Joseph RW, Elassaiss-Schaap J, Wolchock JD, Joshua AM, Ribas A, Hodi FS, et al. Baseline tumor size as an independent prognostic factor for overall survival in paitnets with metastatic melanoma treated with the anti-PD-1 monoclonal antibody MK-3475. J Clin Oncol. 2014;32(Suppl):305.
-
(2014)
J Clin Oncol
, vol.32
, pp. 305
-
-
Joseph, R.W.1
Elassaiss-Schaap, J.2
Wolchock, J.D.3
Joshua, A.M.4
Ribas, A.5
Hodi, F.S.6
-
40
-
-
84964381911
-
Baseline tumor size and PD-L1 expression are independently associated wtih clinical outcomes in patients with metastatic melanoma treated with pembrolizumab (MK-3475)
-
Joseph RW, Elassaiss-Schaap J, Wolchock JD, Joshua AM, Ribas A, Hodi S, et al. Baseline tumor size and PD-L1 expression are independently associated wtih clinical outcomes in patients with metastatic melanoma treated with pembrolizumab (MK-3475). Pigment Cell Melanoma Res. 2014;27:1188.
-
(2014)
Pigment Cell Melanoma Res
, vol.27
, pp. 1188
-
-
Joseph, R.W.1
Elassaiss-Schaap, J.2
Wolchock, J.D.3
Joshua, A.M.4
Ribas, A.5
Hodi, S.6
Hamid, O.7
Robert, C.8
Daud, A.9
Hwu, W.J.10
Kefford, R.11
Hersey, P.12
Weber, J.13
Patnaik, A.14
Dolled-Filhart, M.15
Emancipator, K.16
Kang, P.17
Ebbinghaus, S.18
Anderson, K.19
Gangadhar, T.C.20
more..
-
41
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh PC, Harview CL, Yearly JH, Shintaku P, Taylor EJM, Robert L, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515:568-71.
-
(2014)
Nature
, vol.515
, pp. 568-571
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearly, J.H.3
Shintaku, P.4
Taylor, E.J.M.5
Robert, L.6
Chmielowski, B.7
West, A.N.8
Spacic, M.9
Henry, G.10
Ciobanu, V.11
Carmona, M.12
Kivork, C.13
Seja, C.14
Cherry, G.15
Guitierrez, A.16
Grogan, T.R.17
Mateus, C.18
Tomasic, G.19
Glaspy, J.A.20
Emerson, R.21
Robert, C.22
Ribas, A.23
more..
-
42
-
-
84928761118
-
Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-8.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
Lee, W.7
Yuan, J.8
Wong, P.9
Ho, T.S.10
Miller, M.L.11
Rekhtman, N.12
Moreira, A.L.13
Ibrahim, F.14
Bruggeman, C.15
Gasmi, B.16
Zappasodi, R.17
Maeda, Y.18
Sander, C.19
Garon, E.B.20
Merghoub, T.21
Wolchok, J.D.22
Schumacher, T.N.23
Chan, T.A.24
more..
-
43
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372:2006-17.
-
(2015)
N Engl J Med
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
Robert, C.4
Grossmann, K.5
McDermott, D.6
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