-
1
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Apr
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001 Apr 5;344(14):1038–1042.
-
(2001)
N Engl J Med
, vol.344
, Issue.14
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
2
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Apr
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001 Apr 5;344(14):1031–1037.
-
(2001)
N Engl J Med
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
3
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Aug
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002 Aug 15;347(7):472–480.
-
(2002)
N Engl J Med
, vol.347
, Issue.7
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
-
4
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Mar
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001 Mar 15;344(11):783–792.
-
(2001)
N Engl J Med
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
5
-
-
84923052492
-
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
-
Feb
-
Swain SM, Baselga J, Kim SB, et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med. 2015 Feb 19;372(8):724–734.
-
(2015)
N Engl J Med
, vol.372
, Issue.8
, pp. 724-734
-
-
Swain, S.M.1
Baselga, J.2
Kim, S.B.3
-
6
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Jun
-
Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011 Jun 30;364(26):2507–2516.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
7
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
-
Jul
-
Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma:a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012 Jul 28;380(9839):358–365.
-
(2012)
Lancet
, vol.380
, Issue.9839
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
8
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Jun
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010 Jun 24;362(25):2380–2388.
-
(2010)
N Engl J Med
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
9
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
-
Feb
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405):an open label, randomised phase 3 trial. Lancet Oncol. 2010 Feb;11(2):121–128.
-
(2010)
Lancet Oncol
, vol.11
, Issue.2
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
10
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Sep
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009 Sep 3;361(10):947–957.• First evidence of the TKI gefitinib in comparision with chemotherapy in the context of a clinically selected patient population of lung adenocarcinoma, with the highest chance of carrying a sensitizing mutation of the EGFR gene.
-
(2009)
N Engl J Med
, vol.361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
11
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
Mar
-
Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC):a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012 Mar;13(3):239–246.• First prospective evidence of the efficacy of TKI erlotinib in comparision with chemotherapy in patients with EGFR-mutated lung adenocarcinoma.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
12
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sep
-
Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013 Sep 20;31(27):3327–3334.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
-
13
-
-
84892997539
-
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial
-
Feb
-
Wu YL, Zhou C, Hu CP, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6):an open-label, randomised phase 3 trial. Lancet Oncol. 2014 Feb;15(2):213–222.
-
(2014)
Lancet Oncol
, vol.15
, Issue.2
, pp. 213-222
-
-
Wu, Y.L.1
Zhou, C.2
Hu, C.P.3
-
14
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
-
Aug
-
Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802):a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011 Aug;12(8):735–742.
-
(2011)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
15
-
-
84954510453
-
Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
-
Apr
-
Barlesi F, Mazieres J, Merlio JP, et al. Routine molecular profiling of patients with advanced non-small-cell lung cancer:results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT). Lancet. 2016 Apr 2;387(10026):1415–1426.
-
(2016)
Lancet
, vol.387
, Issue.10026
, pp. 1415-1426
-
-
Barlesi, F.1
Mazieres, J.2
Merlio, J.P.3
-
16
-
-
84982094993
-
Identifying the appropriate FISH criteria for defining MET copy number-driven lung adenocarcinoma through oncogene overlap analysis
-
Aug
-
Noonan SA, Berry L, Lu X, et al. Identifying the appropriate FISH criteria for defining MET copy number-driven lung adenocarcinoma through oncogene overlap analysis. J Thorac Oncol. 2016 Aug;11(8):1293–1304.
-
(2016)
J Thorac Oncol
, vol.11
, Issue.8
, pp. 1293-1304
-
-
Noonan, S.A.1
Berry, L.2
Lu, X.3
-
17
-
-
84954288742
-
Large-scale screening for somatic mutations in lung cancer
-
Apr
-
Rosell R, Karachaliou N., Large-scale screening for somatic mutations in lung cancer. Lancet. 2016 Apr 2;387(10026):1354–1356.
-
(2016)
Lancet
, vol.387
, Issue.10026
, pp. 1354-1356
-
-
Rosell, R.1
Karachaliou, N.2
-
18
-
-
0035907231
-
Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
-
May
-
Stoica GE, Kuo A, Aigner A, et al. Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin. J Biol Chem. 2001 May 18;276(20):16772–16779.
-
(2001)
J Biol Chem
, vol.276
, Issue.20
, pp. 16772-16779
-
-
Stoica, G.E.1
Kuo, A.2
Aigner, A.3
-
19
-
-
0037184128
-
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
-
Sep
-
Stoica GE, Kuo A, Powers C, et al. Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types. J Biol Chem. 2002 Sep 27;277(39):35990–35998.
-
(2002)
J Biol Chem
, vol.277
, Issue.39
, pp. 35990-35998
-
-
Stoica, G.E.1
Kuo, A.2
Powers, C.3
-
20
-
-
0031035052
-
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
-
Jan
-
Iwahara T, Fujimoto J, Wen D, et al. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene. 1997 Jan 30;14(4):439–449.
-
(1997)
Oncogene
, vol.14
, Issue.4
, pp. 439-449
-
-
Iwahara, T.1
Fujimoto, J.2
Wen, D.3
-
21
-
-
54049120220
-
Activating mutations in ALK provide a therapeutic target in neuroblastoma
-
Oct
-
George RE, Sanda T, Hanna M, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. 2008 Oct 16;455(7215):975–978.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 975-978
-
-
George, R.E.1
Sanda, T.2
Hanna, M.3
-
22
-
-
77649091118
-
A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
-
Mar
-
Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res. 2010 Mar 1;16(5):1561–1571.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.5
, pp. 1561-1571
-
-
Mino-Kenudson, M.1
Chirieac, L.R.2
Law, K.3
-
23
-
-
0028198206
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma
-
Mar
-
Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma. Science. 1994 Mar 4;263(5151):1281–1284.
-
(1994)
Science
, vol.263
, Issue.5151
, pp. 1281-1284
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
-
24
-
-
84931067455
-
Novel ALK fusion partners in lung cancer
-
Jun
-
Iyevleva AG, Raskin GA, Tiurin VI, et al. Novel ALK fusion partners in lung cancer. Cancer Letters. 2015 Jun 28;362(1):116–121.
-
(2015)
Cancer Letters
, vol.362
, Issue.1
, pp. 116-121
-
-
Iyevleva, A.G.1
Raskin, G.A.2
Tiurin, V.I.3
-
25
-
-
48549098388
-
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
-
Jul
-
Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res. 2008 Jul 1;68(13):4971–4976.
-
(2008)
Cancer Res
, vol.68
, Issue.13
, pp. 4971-4976
-
-
Choi, Y.L.1
Takeuchi, K.2
Soda, M.3
-
26
-
-
57349113565
-
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
-
Oct
-
Takeuchi K, Choi YL, Soda M, et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res. 2008 Oct 15;14(20):6618–6624.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.20
, pp. 6618-6624
-
-
Takeuchi, K.1
Choi, Y.L.2
Soda, M.3
-
27
-
-
37549057005
-
The anaplastic lymphoma kinase in the pathogenesis of cancer
-
Jan
-
Chiarle R, Voena C, Ambrogio C, et al. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008 Jan;8(1):11–23.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.1
, pp. 11-23
-
-
Chiarle, R.1
Voena, C.2
Ambrogio, C.3
-
28
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Jul
-
Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res. 2008 Jul 1;14(13):4275–4283.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.13
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
-
29
-
-
70349510460
-
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers
-
Sep
-
Lin E, Li L, Guan Y, et al. Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Mol Cancer Res. 2009 Sep;7(9):1466–1476.
-
(2009)
Mol Cancer Res
, vol.7
, Issue.9
, pp. 1466-1476
-
-
Lin, E.1
Li, L.2
Guan, Y.3
-
30
-
-
54049118823
-
Oncogenic mutations of ALK kinase in neuroblastoma
-
Oct
-
Chen Y, Takita J, Choi YL, et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008 Oct 16;455(7215):971–974.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 971-974
-
-
Chen, Y.1
Takita, J.2
Choi, Y.L.3
-
31
-
-
54049149961
-
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
-
Oct
-
Janoueix-Lerosey I, Lequin D, Brugieres L, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 2008 Oct 16;455(7215):967–970.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 967-970
-
-
Janoueix-Lerosey, I.1
Lequin, D.2
Brugieres, L.3
-
32
-
-
54049094708
-
Identification of ALK as a major familial neuroblastoma predisposition gene
-
Oct
-
Mosse YP, Laudenslager M, Longo L, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008 Oct 16;455(7215):930–935.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 930-935
-
-
Mosse, Y.P.1
Laudenslager, M.2
Longo, L.3
-
33
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Dec
-
Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190–1203.
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
34
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Aug
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007 Aug 2;448(7153):561–566.•• The first work identifying the EML4-ALK genetic alteration in NSCLC.
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
35
-
-
80053386829
-
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis
-
Oct
-
Shaw AT, Yeap BY, Solomon BJ, et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement:a retrospective analysis. Lancet Oncol. 2011 Oct;12(11):1004–1012.
-
(2011)
Lancet Oncol
, vol.12
, Issue.11
, pp. 1004-1012
-
-
Shaw, A.T.1
Yeap, B.Y.2
Solomon, B.J.3
-
36
-
-
84859508816
-
ALK translocation and crizotinib in non-small cell lung cancer: an evolving paradigm in oncology drug development
-
May
-
Scagliotti G, Stahel RA, Rosell R, et al. ALK translocation and crizotinib in non-small cell lung cancer:an evolving paradigm in oncology drug development. Eur J Cancer. 2012 May;48(7):961–973.
-
(2012)
Eur J Cancer
, vol.48
, Issue.7
, pp. 961-973
-
-
Scagliotti, G.1
Stahel, R.A.2
Rosell, R.3
-
37
-
-
84869462031
-
Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology
-
Ou SH, Bartlett CH, Mino-Kenudson M, et al. Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer:a success story to usher in the second decade of molecular targeted therapy in oncology. Oncologist. 2012;17(11):1351–1375.
-
(2012)
Oncologist
, vol.17
, Issue.11
, pp. 1351-1375
-
-
Ou, S.H.1
Bartlett, C.H.2
Mino-Kenudson, M.3
-
38
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Sep
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009 Sep 10;27(26):4247–4253.
-
(2009)
J Clin Oncol
, vol.27
, Issue.26
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
39
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Jun
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013 Jun 20;368(25):2385–2394.
-
(2013)
N Engl J Med
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
40
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Dec
-
Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014 Dec 4;371(23):2167–2177.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.W.3
-
41
-
-
65249095599
-
The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
-
Apr
-
Wong DW, Leung EL, So KK, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. 2009 Apr 15;115(8):1723–1733.
-
(2009)
Cancer
, vol.115
, Issue.8
, pp. 1723-1733
-
-
Wong, D.W.1
Leung, E.L.2
So, K.K.3
-
42
-
-
84899120690
-
ALK testing in non-small cell lung carcinoma: what now?
-
May
-
Kerr KM. ALK testing in non-small cell lung carcinoma:what now? J Thorac Oncol. 2014 May;9(5):593–595.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.5
, pp. 593-595
-
-
Kerr, K.M.1
-
43
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Oct
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010 Oct 28;363(18):1693–1703.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
45
-
-
84893498337
-
Fishing for ALK with immunohistochemistry may predict response to crizotinib
-
Sep-Oct
-
Bavieri M, Tiseo M, Lantuejoul S, et al. Fishing for ALK with immunohistochemistry may predict response to crizotinib. Tumori. 2013 Sep-Oct;99(5):e229–e232.
-
(2013)
Tumori
, vol.99
, Issue.5
, pp. e229-e232
-
-
Bavieri, M.1
Tiseo, M.2
Lantuejoul, S.3
-
46
-
-
84996562920
-
Does immunohistochemistry represent a robust alternative technique in determining drugable predictive gene alterations in non-small cell lung cancer?
-
Apr
-
Rossi G, Ragazzi M, Tamagnini I, et al. Does immunohistochemistry represent a robust alternative technique in determining drugable predictive gene alterations in non-small cell lung cancer? Curr Drug Targets. 2015 Apr 22. [Epub ahead of print]
-
(2015)
Curr Drug Targets
-
-
Rossi, G.1
Ragazzi, M.2
Tamagnini, I.3
-
47
-
-
84925411861
-
Fluorescence in situ hybridization, immunohistochemistry, and next-generation sequencing for detection of EML4-ALK rearrangement in lung cancer
-
Mar
-
Pekar-Zlotin M, Hirsch FR, Soussan-Gutman L, et al. Fluorescence in situ hybridization, immunohistochemistry, and next-generation sequencing for detection of EML4-ALK rearrangement in lung cancer. Oncologist. 2015 Mar;20(3):316–322.
-
(2015)
Oncologist
, vol.20
, Issue.3
, pp. 316-322
-
-
Pekar-Zlotin, M.1
Hirsch, F.R.2
Soussan-Gutman, L.3
-
48
-
-
84894514080
-
Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances
-
Mar
-
Cabillic F, Gros A, Dugay F, et al. Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances. J Thorac Oncol. 2014 Mar;9(3):295–306.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.3
, pp. 295-306
-
-
Cabillic, F.1
Gros, A.2
Dugay, F.3
-
49
-
-
84922540993
-
Discrepancies between FISH and immunohistochemistry for assessment of the ALK status are associated with ALK ‘borderline’-positive rearrangements or a high copy number: a potential major issue for anti-ALK therapeutic strategies
-
Jan
-
Ilie MI, Bence C, Hofman V, et al. Discrepancies between FISH and immunohistochemistry for assessment of the ALK status are associated with ALK ‘borderline’-positive rearrangements or a high copy number:a potential major issue for anti-ALK therapeutic strategies. Ann Oncol. 2015 Jan;26(1):238–244.
-
(2015)
Ann Oncol
, vol.26
, Issue.1
, pp. 238-244
-
-
Ilie, M.I.1
Bence, C.2
Hofman, V.3
-
50
-
-
84962881211
-
ALK protein analysis by IHC staining after recent regulatory changes: A comparison of two widely used approaches, revision of the literature, and a new testing algorithm
-
Apr
-
Marchetti A, Di Lorito A, Pace MV, et al. ALK protein analysis by IHC staining after recent regulatory changes:A comparison of two widely used approaches, revision of the literature, and a new testing algorithm. J Thorac Oncol. 2016 Apr;11(4):487–495.
-
(2016)
J Thorac Oncol
, vol.11
, Issue.4
, pp. 487-495
-
-
Marchetti, A.1
Di Lorito, A.2
Pace, M.V.3
-
51
-
-
84894600245
-
Atypical negative ALK break-apart FISH harboring a crizotinib-responsive ALK rearrangement in non-small-cell lung cancer
-
Mar
-
Ren S, Hirsch FR, Varella-Garcia M, et al. Atypical negative ALK break-apart FISH harboring a crizotinib-responsive ALK rearrangement in non-small-cell lung cancer. J Thorac Oncol. 2014 Mar;9(3):e21–e23.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.3
, pp. e21-e23
-
-
Ren, S.1
Hirsch, F.R.2
Varella-Garcia, M.3
-
52
-
-
84889078337
-
Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization
-
Dec
-
Selinger CI, Rogers TM, Russell PA, et al. Testing for ALK rearrangement in lung adenocarcinoma:a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization. Mod Pathol. 2013 Dec;26(12):1545–1553.
-
(2013)
Mod Pathol
, vol.26
, Issue.12
, pp. 1545-1553
-
-
Selinger, C.I.1
Rogers, T.M.2
Russell, P.A.3
-
53
-
-
84899477450
-
An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators
-
May
-
Wynes MW, Sholl LM, Dietel M, et al. An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators. J Thorac Oncol. 2014 May;9(5):631–638.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.5
, pp. 631-638
-
-
Wynes, M.W.1
Sholl, L.M.2
Dietel, M.3
-
54
-
-
84865743662
-
The use of quantitative real-time reverse transcriptase PCR for 5ʹ and 3ʹ portions of ALK transcripts to detect ALK rearrangements in lung cancers
-
Sep
-
Wang R, Pan Y, Li C, et al. The use of quantitative real-time reverse transcriptase PCR for 5ʹ and 3ʹ portions of ALK transcripts to detect ALK rearrangements in lung cancers. Clin Cancer Res. 2012 Sep 1;18(17):4725–4732.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.17
, pp. 4725-4732
-
-
Wang, R.1
Pan, Y.2
Li, C.3
-
55
-
-
84925400673
-
Detection of EML4-ALK in lung adenocarcinoma using pleural effusion with FISH, IHC, and RT-PCR methods
-
Liu L, Zhan P, Zhou X, et al. Detection of EML4-ALK in lung adenocarcinoma using pleural effusion with FISH, IHC, and RT-PCR methods. Plos One. 2015;10(3):e0117032.
-
(2015)
Plos One
, vol.10
, Issue.3
, pp. e0117032
-
-
Liu, L.1
Zhan, P.2
Zhou, X.3
-
56
-
-
84867557923
-
A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer
-
Oct
-
Soda M, Isobe K, Inoue A, et al. A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer. Clin Cancer Res. 2012 Oct 15;18(20):5682–5689.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.20
, pp. 5682-5689
-
-
Soda, M.1
Isobe, K.2
Inoue, A.3
-
57
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
May
-
Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007 May 1;67(9):4408–4417.
-
(2007)
Cancer Res
, vol.67
, Issue.9
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
-
58
-
-
84911372597
-
Crizotinib in ROS1-rearranged non-small-cell lung cancer
-
Nov
-
Shaw AT, Ou SH, Bang YJ, et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2014 Nov 20;371(21):1963–1971.• The first evidence of the activity of crizotinib in patients with NSCLC and ROS1 rearrangement.
-
(2014)
N Engl J Med
, vol.371
, Issue.21
, pp. 1963-1971
-
-
Shaw, A.T.1
Ou, S.H.2
Bang, Y.J.3
-
59
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
-
Oct
-
Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer:updated results from a phase 1 study. Lancet Oncol. 2012 Oct;13(10):1011–1019.
-
(2012)
Lancet Oncol
, vol.13
, Issue.10
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
60
-
-
80051780280
-
Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005
-
June
-
Crino L, Kim D, Riely GJ, et al. Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC):PROFILE 1005. ASCO Meet Abstr. 2011 June 9;29(15_suppl):7514.
-
(2011)
ASCO Meet Abstr
, vol.29
, Issue.15
, pp. 7514
-
-
Crino, L.1
Kim, D.2
Riely, G.J.3
-
61
-
-
84865431278
-
Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
-
May
-
Kim D-W, Ahn M-J, Shi Y, et al. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). ASCO Meet Abstr. 2012 May 30;30(15_suppl):7533.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15
, pp. 7533
-
-
Kim, D.-W.1
Ahn, M.-J.2
Shi, Y.3
-
62
-
-
84874983556
-
Impact of crizotinib treatment on patient-reported symptoms and quality of life (QoL) in advanced ALK-positive non-small cell lung cancer (NSCLC) [1231PD]
-
Proceedings of the 37th European Society for Medical Oncology meeting; 2012
-
Blackhall FH, Evans TL, Han J, et al. Impact of crizotinib treatment on patient-reported symptoms and quality of life (QoL) in advanced ALK-positive non-small cell lung cancer (NSCLC) [1231PD]. Ann Oncol. 2012;23(Suppl 9):ixe 403. Proceedings of the 37th European Society for Medical Oncology meeting; 2012.
-
(2012)
Ann Oncol
, vol.23
, pp. ixe 403
-
-
Blackhall, F.H.1
Evans, T.L.2
Han, J.3
-
63
-
-
84996516683
-
Crizotinib vs chemotherapy in ALK+ advanced non-small cell lung cancer (NSCLC): final survival results from PROFILE 1007
-
May
-
Shaw AT, Janne PA, Besse B, et al. Crizotinib vs chemotherapy in ALK+ advanced non-small cell lung cancer (NSCLC):final survival results from PROFILE 1007. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9066.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9066
-
-
Shaw, A.T.1
Janne, P.A.2
Besse, B.3
-
64
-
-
2442661845
-
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
-
May
-
Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol. 2004 May 1;22(9):1589–1597.
-
(2004)
J Clin Oncol
, vol.22
, Issue.9
, pp. 1589-1597
-
-
Hanna, N.1
Shepherd, F.A.2
Fossella, F.V.3
-
65
-
-
84979247636
-
Phase 3 study of first-line crizotinib vs pemetrexed-cisplatin/carboplatin (PCC) in East Asian patients (pts) with ALK+ advanced non-squamous non-small cell lung cancer (NSCLC)
-
May
-
Lu S, Mok T, Lu Y, et al. Phase 3 study of first-line crizotinib vs pemetrexed-cisplatin/carboplatin (PCC) in East Asian patients (pts) with ALK+ advanced non-squamous non-small cell lung cancer (NSCLC). ASCO Meet Abstr. 2016 May 31;34(15_suppl):9058.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9058
-
-
Lu, S.1
Mok, T.2
Lu, Y.3
-
66
-
-
84893399587
-
Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC
-
Feb
-
Ou SH, Janne PA, Bartlett CH, et al. Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC. Ann Oncol. 2014 Feb;25(2):415–422.
-
(2014)
Ann Oncol
, vol.25
, Issue.2
, pp. 415-422
-
-
Ou, S.H.1
Janne, P.A.2
Bartlett, C.H.3
-
67
-
-
84870317390
-
Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
-
Dec
-
Weickhardt AJ, Scheier B, Burke JM, et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol. 2012 Dec;7(12):1807–1814.
-
(2012)
J Thorac Oncol
, vol.7
, Issue.12
, pp. 1807-1814
-
-
Weickhardt, A.J.1
Scheier, B.2
Burke, J.M.3
-
68
-
-
84879086307
-
Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients
-
Jul
-
Weickhardt AJ, Doebele RC, Purcell WT, et al. Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer. 2013 Jul 1;119(13):2383–2390.
-
(2013)
Cancer
, vol.119
, Issue.13
, pp. 2383-2390
-
-
Weickhardt, A.J.1
Doebele, R.C.2
Purcell, W.T.3
-
69
-
-
84865776102
-
Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants
-
Sep
-
Heuckmann JM, Balke-Want H, Malchers F, et al. Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants. Clin Cancer Res. 2012 Sep 1;18(17):4682–4690.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.17
, pp. 4682-4690
-
-
Heuckmann, J.M.1
Balke-Want, H.2
Malchers, F.3
-
70
-
-
70349342712
-
EML4-ALK: honing in on a new target in non-small-cell lung cancer
-
Sep
-
Horn L, Pao W. EML4-ALK:honing in on a new target in non-small-cell lung cancer. J Clin Oncol. 2009 Sep 10;27(26):4232–4235.
-
(2009)
J Clin Oncol
, vol.27
, Issue.26
, pp. 4232-4235
-
-
Horn, L.1
Pao, W.2
-
71
-
-
77953291664
-
The biology and treatment of EML4-ALK non-small cell lung cancer
-
Jul
-
Sasaki T, Rodig SJ, Chirieac LR, et al. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer. 2010 Jul;46(10):1773–1780.
-
(2010)
Eur J Cancer
, vol.46
, Issue.10
, pp. 1773-1780
-
-
Sasaki, T.1
Rodig, S.J.2
Chirieac, L.R.3
-
72
-
-
84904055782
-
EML4-ALK fusions: propelling cancer but creating exploitable chaperone dependence
-
Jun
-
Workman P, van Montfort R. EML4-ALK fusions:propelling cancer but creating exploitable chaperone dependence. Cancer Discov. 2014 Jun;4(6):642–645.
-
(2014)
Cancer Discov
, vol.4
, Issue.6
, pp. 642-645
-
-
Workman, P.1
van Montfort, R.2
-
73
-
-
84860352732
-
ALKTreating -positive lung cancer–early successes and future challenges
-
May
-
Camidge DR, Doebele RC. ALKTreating -positive lung cancer–early successes and future challenges. Nat Rev Clin Oncol. 2012 May;9(5):268–277.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, Issue.5
, pp. 268-277
-
-
Camidge, D.R.1
Doebele, R.C.2
-
74
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Oct
-
Choi YL, Soda M, Yamashita Y, et al. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010 Oct 28;363(18):1734–1739.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
75
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Mar
-
Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012 Mar 1;18(5):1472–1482.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
76
-
-
84903466222
-
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
-
Jun
-
Friboulet L, Li N, Katayama R, et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov. 2014 Jun;4(6):662–673.
-
(2014)
Cancer Discov
, vol.4
, Issue.6
, pp. 662-673
-
-
Friboulet, L.1
Li, N.2
Katayama, R.3
-
77
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
Feb
-
Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012 Feb 8;4(120):120ra17.
-
(2012)
Sci Transl Med
, vol.4
, Issue.120
, pp. 120ra17
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
-
79
-
-
84996600582
-
Abstract B232: activity of a potent and selective phase I ALK inhibitor LDK378 in naive and crizotinib-resistant preclinical tumor models
-
Nov
-
Li N, Michellys P-Y, Kim S, et al. Abstract B232:activity of a potent and selective phase I ALK inhibitor LDK378 in naive and crizotinib-resistant preclinical tumor models. Am Assoc Cancer Res. 2011 Nov 12;10(11 Supplement):B232–B232.
-
(2011)
Am Assoc Cancer Res
, vol.10
, Issue.11
, pp. B232
-
-
Li, N.1
Michellys, P.-Y.2
Kim, S.3
-
80
-
-
84903482432
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Mar
-
Shaw AT, Kim DW, Mehra R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014 Mar 27;370(13):1189–1197.
-
(2014)
N Engl J Med
, vol.370
, Issue.13
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
-
81
-
-
84930005738
-
1295Pefficacy and safety of ceritinib in patients (PTS) with advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC): an update of ascend-1
-
September
-
Felip E, Kim D, Mehra R, et al. 1295Pefficacy and safety of ceritinib in patients (PTS) with advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC):an update of ascend-1. Ann Oncol. 2014 September 1;25(suppl 4):iv456–iv457.
-
(2014)
Ann Oncol
, vol.25
, pp. iv456-iv457
-
-
Felip, E.1
Kim, D.2
Mehra, R.3
-
82
-
-
84960194194
-
Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial
-
Apr
-
Kim DW, Mehra R, Tan DS, et al. Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1):updated results from the multicentre, open-label, phase 1 trial. Lancet Oncol. 2016 Apr;17(4):452–463.
-
(2016)
Lancet Oncol
, vol.17
, Issue.4
, pp. 452-463
-
-
Kim, D.W.1
Mehra, R.2
Tan, D.S.3
-
83
-
-
84996563397
-
Genetic landscape of ALK+ non-small cell lung cancer (NSCLC) patients (pts) and response to ceritinib in ASCEND-1
-
May
-
Tan DS-W, Kim D-W, Thomas M, et al. Genetic landscape of ALK+ non-small cell lung cancer (NSCLC) patients (pts) and response to ceritinib in ASCEND-1. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9064.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9064
-
-
Tan, D.S.-W.1
Kim, D.-W.2
Thomas, M.3
-
84
-
-
84941674243
-
ASCEND-2: A single-arm, open-label, multicenter phase II study of ceritinib in adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ)
-
May
-
Mok T, Spigel D, Felip E, et al. ASCEND-2:A single-arm, open-label, multicenter phase II study of ceritinib in adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with chemotherapy and crizotinib (CRZ). ASCO Meet Abstr. 2015 May 18;33(15_suppl):8059.
-
(2015)
ASCO Meet Abstr
, vol.33
, Issue.15
, pp. 8059
-
-
Mok, T.1
Spigel, D.2
Felip, E.3
-
85
-
-
84938266539
-
Progression-free and overall survival in ALK-positive NSCLC patients treated with sequential Crizotinib and Ceritinib
-
Jun
-
Gainor JF, Tan DS, De Pas T, et al. Progression-free and overall survival in ALK-positive NSCLC patients treated with sequential Crizotinib and Ceritinib. Clin Cancer Res. 2015 Jun 15;21(12):2745–2752.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.12
, pp. 2745-2752
-
-
Gainor, J.F.1
Tan, D.S.2
De Pas, T.3
-
86
-
-
84941630750
-
ASCEND-3: A single-arm, open-label, multicenter phase II study of ceritinib in ALKi-naive adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC)
-
May
-
Felip E, Orlov S, Park K, et al. ASCEND-3:A single-arm, open-label, multicenter phase II study of ceritinib in ALKi-naive adult patients (pts) with ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC). ASCO Meet Abstr. 2015 May 18;33(15_suppl):8060.
-
(2015)
ASCO Meet Abstr
, vol.33
, Issue.15
, pp. 8060
-
-
Felip, E.1
Orlov, S.2
Park, K.3
-
87
-
-
79955964568
-
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
-
May
-
Sakamoto H, Tsukaguchi T, Hiroshima S, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679–690.
-
(2011)
Cancer Cell
, vol.19
, Issue.5
, pp. 679-690
-
-
Sakamoto, H.1
Tsukaguchi, T.2
Hiroshima, S.3
-
88
-
-
84878347085
-
CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study
-
Jun
-
Seto T, Kiura K, Nishio M, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study):a single-arm, open-label, phase 1-2 study. Lancet Oncol. 2013 Jun;14(7):590–598.
-
(2013)
Lancet Oncol
, vol.14
, Issue.7
, pp. 590-598
-
-
Seto, T.1
Kiura, K.2
Nishio, M.3
-
89
-
-
84908569219
-
Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study
-
Sep
-
Gadgeel SM, Gandhi L, Riely GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG):results from the dose-finding portion of a phase 1/2 study. Lancet Oncol. 2014 Sep;15(10):1119–1128.
-
(2014)
Lancet Oncol
, vol.15
, Issue.10
, pp. 1119-1128
-
-
Gadgeel, S.M.1
Gandhi, L.2
Riely, G.J.3
-
90
-
-
84964343904
-
Alectinib in Crizotinib-refractory ALK-rearranged non-small-cell lung cancer: A phase II global study
-
Mar
-
Ou SH, Ahn JS, De Petris L, et al. Alectinib in Crizotinib-refractory ALK-rearranged non-small-cell lung cancer:A phase II global study. J Clin Oncol. 2016 Mar 1;34(7):661–668.
-
(2016)
J Clin Oncol
, vol.34
, Issue.7
, pp. 661-668
-
-
Ou, S.H.1
Ahn, J.S.2
De Petris, L.3
-
91
-
-
84959324643
-
Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial
-
Feb
-
Shaw AT, Gandhi L, Gadgeel S, et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer:a single-group, multicentre, phase 2 trial. Lancet Oncol. 2016 Feb;17(2):234–242.
-
(2016)
Lancet Oncol
, vol.17
, Issue.2
, pp. 234-242
-
-
Shaw, A.T.1
Gandhi, L.2
Gadgeel, S.3
-
92
-
-
85031653462
-
Efficacy and safety of alectinib in ALK+ non-small-cell lung cancer (NSCLC): pooled data from two pivotal phase II studies (NP28673 and NP28761)
-
May
-
Yang JC-H, Ou S-HI, De Petris L, et al. Efficacy and safety of alectinib in ALK+ non-small-cell lung cancer (NSCLC):pooled data from two pivotal phase II studies (NP28673 and NP28761). ASCO Meet Abstr. 2016 May 31;34(15_suppl):e20507.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. e20507
-
-
Yang, J.C.-H.1
Ou, S.-H.I.2
De Petris, L.3
-
93
-
-
84996583575
-
Pooled mutation analysis for the NP28673 and NP28761 studies of alectinib in ALK+ non-small-cell lung cancer (NSCLC)
-
May
-
Puig O, Yang JC-H, Ou S-HI, et al. Pooled mutation analysis for the NP28673 and NP28761 studies of alectinib in ALK+ non-small-cell lung cancer (NSCLC). ASCO Meet Abstr. 2016 May 31;34(15_suppl):9061.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9061
-
-
Puig, O.1
Yang, J.C.-H.2
Ou, S.-H.I.3
-
94
-
-
84978614669
-
Alectinib (ALC) versus crizotinib (CRZ) in ALK-inhibitor naive ALK-positive non-small cell lung cancer (ALK+ NSCLC): Primary results from the J-ALEX study
-
May
-
Nokihara H, Hida T, Kondo M, et al. Alectinib (ALC) versus crizotinib (CRZ) in ALK-inhibitor naive ALK-positive non-small cell lung cancer (ALK+ NSCLC):Primary results from the J-ALEX study. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9008.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9008
-
-
Nokihara, H.1
Hida, T.2
Kondo, M.3
-
95
-
-
84995904711
-
Abstract 781: The potent ALK inhibitor AP26113 can overcome mechanisms of resistance to first- and second-generation ALK TKIs in preclinical models
-
Aug
-
Zhang S, Nadworny S, Wardwell SD, et al. Abstract 781:The potent ALK inhibitor AP26113 can overcome mechanisms of resistance to first- and second-generation ALK TKIs in preclinical models. Cancer Res. 2015 Aug 01;75(15 Supplement):781–781.
-
(2015)
Cancer Res
, vol.75
, Issue.15
, pp. 781
-
-
Zhang, S.1
Nadworny, S.2
Wardwell, S.D.3
-
96
-
-
84928036655
-
Treatment efficacy and resistance mechanisms using the second-generation ALK inhibitor AP26113 in human NPM-ALK-positive anaplastic large cell lymphoma
-
Apr
-
Ceccon M, Mologni L, Giudici G, et al. Treatment efficacy and resistance mechanisms using the second-generation ALK inhibitor AP26113 in human NPM-ALK-positive anaplastic large cell lymphoma. Mol Cancer Res. 2015 Apr;13(4):775–783.
-
(2015)
Mol Cancer Res
, vol.13
, Issue.4
, pp. 775-783
-
-
Ceccon, M.1
Mologni, L.2
Giudici, G.3
-
97
-
-
84991683188
-
1330: Brigatinib efficacy and safety in patients (Pts) with anaplastic lymphoma kinase (ALK)-positive (ALK+) non-small cell lung cancer (NSCLC) in a phase 1/2 trial
-
Rosell R, Gettinger SN, Bazhenova LA, et al. 1330:Brigatinib efficacy and safety in patients (Pts) with anaplastic lymphoma kinase (ALK)-positive (ALK+) non-small cell lung cancer (NSCLC) in a phase 1/2 trial. J Thorac Oncol. 2016;11(4):S114.
-
(2016)
J Thorac Oncol
-
-
Rosell, R.1
Gettinger, S.N.2
Bazhenova, L.A.3
-
98
-
-
84979307521
-
Brigatinib (BRG) in patients (pts) with crizotinib (CRZ)-refractory ALK+ non-small cell lung cancer (NSCLC): first report of efficacy and safety from a pivotal randomized phase (ph) 2 trial (ALTA)
-
May
-
Kim D-W, Tiseo M, Ahn M-J, et al. Brigatinib (BRG) in patients (pts) with crizotinib (CRZ)-refractory ALK+ non-small cell lung cancer (NSCLC):first report of efficacy and safety from a pivotal randomized phase (ph) 2 trial (ALTA). ASCO Meet Abstr. 2016 May 31;34(15_suppl):9007.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9007
-
-
Kim, D.-W.1
Tiseo, M.2
Ahn, M.-J.3
-
99
-
-
84995503237
-
Activity of brigatinib (BRG) in crizotinib (CRZ) resistant patients (pts) according to ALK mutation status
-
May
-
Gettinger SN, Zhang S, Hodgson JG, et al. Activity of brigatinib (BRG) in crizotinib (CRZ) resistant patients (pts) according to ALK mutation status. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9060.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9060
-
-
Gettinger, S.N.1
Zhang, S.2
Hodgson, J.G.3
-
100
-
-
84925687730
-
Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib
-
Dec
-
Ou SH, Klempner SJ, Greenbowe JR, et al. Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib. J Thorac Oncol. 2014 Dec;9(12):1821–1825.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.12
, pp. 1821-1825
-
-
Ou, S.H.1
Klempner, S.J.2
Greenbowe, J.R.3
-
101
-
-
84902455683
-
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(m etheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations
-
Jun
-
Johnson TW, Richardson PF, Bailey S, et al. Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(m etheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J Med Chem. 2014 Jun 12;57(11):4720–4744.
-
(2014)
J Med Chem
, vol.57
, Issue.11
, pp. 4720-4744
-
-
Johnson, T.W.1
Richardson, P.F.2
Bailey, S.3
-
102
-
-
84937521317
-
PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to first and second generation ALK inhibitors in preclinical models
-
Jul
-
Zou HY, Friboulet L, Kodack DP, et al. PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to first and second generation ALK inhibitors in preclinical models. Cancer Cell. 2015 Jul 13;28(1):70–81.
-
(2015)
Cancer Cell
, vol.28
, Issue.1
, pp. 70-81
-
-
Zou, H.Y.1
Friboulet, L.2
Kodack, D.P.3
-
103
-
-
84975304175
-
Clinical activity and safety of the ALK/ROS1 TKI inhibitor PF-06463922 in advanced NSCLC
-
Bauer T, Solomon B, Besse B. Clinical activity and safety of the ALK/ROS1 TKI inhibitor PF-06463922 in advanced NSCLC. J Thor Oncol. 2015;10:S239.
-
(2015)
J Thor Oncol
, vol.10
, pp. S239
-
-
Bauer, T.1
Solomon, B.2
Besse, B.3
-
104
-
-
84954050562
-
Resensitization to Crizotinib by the Lorlatinib ALK resistance mutation L1198F
-
Jan
-
Shaw AT, Friboulet L, Leshchiner I, et al. Resensitization to Crizotinib by the Lorlatinib ALK resistance mutation L1198F. N Engl J Med. 2016 Jan 7;374(1):54–61.
-
(2016)
N Engl J Med
, vol.374
, Issue.1
, pp. 54-61
-
-
Shaw, A.T.1
Friboulet, L.2
Leshchiner, I.3
-
105
-
-
79955770627
-
Abstract A243: characterization of NMS‐E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK‐dependent lymphoma and non‐small cell lung cancer models
-
Dec
-
Ardini E, Menichincheri M, De Ponti C, et al. Abstract A243:characterization of NMS‐E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK‐dependent lymphoma and non‐small cell lung cancer models. Am Assoc Cancer Res. 2009 Dec 10;8(12 Supplement):A244–A244.
-
(2009)
Am Assoc Cancer Res
, vol.8
, Issue.12
, pp. A244
-
-
Ardini, E.1
Menichincheri, M.2
De Ponti, C.3
-
106
-
-
84905173703
-
Abstract A232: In vitro and in vivo activity of NMS-E628 against ALK mutations resistant to Xalkori
-
Nov
-
Ardini E, Menichincheri M, Banfi P, et al. Abstract A232:In vitro and in vivo activity of NMS-E628 against ALK mutations resistant to Xalkori. Am Assoc Cancer Res. 2011 Nov 12;10(11 Supplement):A232–A232.
-
(2011)
Am Assoc Cancer Res
, vol.10
, Issue.11
, pp. A232
-
-
Ardini, E.1
Menichincheri, M.2
Banfi, P.3
-
107
-
-
84948117368
-
Durable clinical response to Entrectinib in NTRK1-rearranged non-small cell lung cancer
-
Dec
-
Farago AF, Le LP, Zheng Z, et al. Durable clinical response to Entrectinib in NTRK1-rearranged non-small cell lung cancer. J Thorac Oncol. 2015 Dec;10(12):1670–1674.
-
(2015)
J Thorac Oncol
, vol.10
, Issue.12
, pp. 1670-1674
-
-
Farago, A.F.1
Le, L.P.2
Zheng, Z.3
-
108
-
-
85019858836
-
-
AACR Annual Meeting, New Orleans, LA:
-
Drilon A, Braud FD, Siena S, Entrectinib, an oral pan-Trk, ROS1, and ALK inhibitor in TKI-naïve patients with advanced solid tumors harboring gene rearrangements. AACR Annual Meeting; 2016 April 16–20; New Orleans, LA.
-
(2016)
Entrectinib, an oral pan-Trk, ROS1, and ALK inhibitor in TKI-naïve patients with advanced solid tumors harboring gene rearrangements
-
-
Drilon, A.1
Braud, F.D.2
Siena, S.3
-
109
-
-
84996595508
-
Plasma genotyping of patients enrolled on the expansion phase I/II trial of X-396 in patients (pts) with ALK+ non-small cell lung cancer (NSCLC)
-
May
-
Horn L, Wakelee HA, Reckamp KL, et al. Plasma genotyping of patients enrolled on the expansion phase I/II trial of X-396 in patients (pts) with ALK+ non-small cell lung cancer (NSCLC). ASCO Meet Abstr. 2016 May 31;34(15_suppl):9056.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9056
-
-
Horn, L.1
Wakelee, H.A.2
Reckamp, K.L.3
-
110
-
-
79957487193
-
CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib
-
May
-
Costa DB, Kobayashi S, Pandya SS, et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol. 2011 May 20;29(15):e443–e445.
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. e443-e445
-
-
Costa, D.B.1
Kobayashi, S.2
Pandya, S.S.3
-
111
-
-
84938269464
-
CSF concentration of Crizotinib in two ALK-positive non-small-cell lung cancer patients with CNS metastases deriving clinical benefit from treatment
-
May
-
Metro G, Lunardi G, Floridi P, et al. CSF concentration of Crizotinib in two ALK-positive non-small-cell lung cancer patients with CNS metastases deriving clinical benefit from treatment. J Thorac Oncol. 2015 May;10(5):e26–e27.
-
(2015)
J Thorac Oncol
, vol.10
, Issue.5
, pp. e26-e27
-
-
Metro, G.1
Lunardi, G.2
Floridi, P.3
-
112
-
-
84929508050
-
Clinical experience with Crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases
-
Jun
-
Costa DB, Shaw AT, Ou SH, et al. Clinical experience with Crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases. J Clin Oncol. 2015 Jun 10;33(17):1881–1888.
-
(2015)
J Clin Oncol
, vol.33
, Issue.17
, pp. 1881-1888
-
-
Costa, D.B.1
Shaw, A.T.2
Ou, S.H.3
-
113
-
-
84979027920
-
Intracranial efficacy of Crizotinib versus Chemotherapy in patients with advanced ALK-positive non-small-cell lung cancer: results from PROFILE 1014
-
Solomon BJ, Cappuzzo F, Felip E, et al. Intracranial efficacy of Crizotinib versus Chemotherapy in patients with advanced ALK-positive non-small-cell lung cancer:results from PROFILE 1014. J Clin Oncol. 2016 Aug 20;34(24):2858–2865.
-
(2016)
J Clin Oncol
-
-
Solomon, B.J.1
Cappuzzo, F.2
Felip, E.3
-
114
-
-
84954318418
-
Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis
-
Jan
-
Johung KL, Yeh N, Desai NB, et al. Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis. J Clin Oncol. 2016 Jan 10;34(2):123–129.
-
(2016)
J Clin Oncol
, vol.34
, Issue.2
, pp. 123-129
-
-
Johung, K.L.1
Yeh, N.2
Desai, N.B.3
-
115
-
-
84996516736
-
Cumulative incidence rates for CNS and non-CNS progression by baseline CNS metastases status using data from two alectinib phase II studies
-
May
-
Gadgeel SM, Shaw AT, Barlesi F, et al. Cumulative incidence rates for CNS and non-CNS progression by baseline CNS metastases status using data from two alectinib phase II studies. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9063.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9063
-
-
Gadgeel, S.M.1
Shaw, A.T.2
Barlesi, F.3
-
116
-
-
85013017966
-
Pooled analysis of CNS response to alectinib in two studies of pre-treated ALK+ NSCLC
-
Gadgeel S, Shaw A, Ramaswamy G. Pooled analysis of CNS response to alectinib in two studies of pre-treated ALK+ NSCLC. J Thorac Oncol. 2015;10:S238.
-
(2015)
J Thorac Oncol
, vol.10
, pp. S238
-
-
Gadgeel, S.1
Shaw, A.2
Ramaswamy, G.3
-
117
-
-
78649973178
-
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
-
Dec
-
Chen Z, Sasaki T, Tan X, et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res. 2010 Dec 1;70(23):9827–9836.
-
(2010)
Cancer Res
, vol.70
, Issue.23
, pp. 9827-9836
-
-
Chen, Z.1
Sasaki, T.2
Tan, X.3
-
118
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
May
-
Katayama R, Khan TM, Benes C, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535–7540.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.18
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
-
119
-
-
84878971581
-
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
-
Jun
-
Socinski MA, Goldman J, El-Hariry I, et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res. 2013 Jun 1;19(11):3068–3077.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.11
, pp. 3068-3077
-
-
Socinski, M.A.1
Goldman, J.2
El-Hariry, I.3
-
120
-
-
84996477970
-
Addition of HSP90 inhibitor onalespib to crizotinib prior to progression in patients with ALK-pos NSCLC: results of a randomized phase 2 study
-
May
-
Lee J-S, Han J-Y, Ahn M-J, et al. Addition of HSP90 inhibitor onalespib to crizotinib prior to progression in patients with ALK-pos NSCLC:results of a randomized phase 2 study. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9059.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9059
-
-
Lee, J.-S.1
Han, J.-Y.2
Ahn, M.-J.3
-
121
-
-
79951885125
-
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
-
Nov
-
Sequist LV, Gettinger S, Senzer NN, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol. 2010 Nov 20;28(33):4953–4960.
-
(2010)
J Clin Oncol
, vol.28
, Issue.33
, pp. 4953-4960
-
-
Sequist, L.V.1
Gettinger, S.2
Senzer, N.N.3
-
122
-
-
84878358097
-
Phase II activity of the Hsp90 inhibitor AUY922 in patients with ALK-rearranged (ALK+) or EGFR-mutated advanced non-small cell lung cancer (NSCLC)
-
Felip E, Carcereny E, Barlesi F. Phase II activity of the Hsp90 inhibitor AUY922 in patients with ALK-rearranged (ALK+) or EGFR-mutated advanced non-small cell lung cancer (NSCLC). Ann Oncol. 2012;23(Suppl 9):ix152–ix174, 438.
-
(2012)
Ann Oncol
, vol.23
, pp. ix152-ix174, 438
-
-
Felip, E.1
Carcereny, E.2
Barlesi, F.3
-
123
-
-
79953029071
-
Anaplastic lymphoma kinase gene rearrangements in non-small cell lung cancer are associated with prolonged progression-free survival on pemetrexed
-
Apr
-
Camidge DR, Kono SA, Lu X, et al. Anaplastic lymphoma kinase gene rearrangements in non-small cell lung cancer are associated with prolonged progression-free survival on pemetrexed. J Thorac Oncol. 2011 Apr;6(4):774–780.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.4
, pp. 774-780
-
-
Camidge, D.R.1
Kono, S.A.2
Lu, X.3
-
124
-
-
80052261903
-
Anaplastic lymphoma kinase translocation: a predictive biomarker of pemetrexed in patients with non-small cell lung cancer
-
Sep
-
Lee JO, Kim TM, Lee SH, et al. Anaplastic lymphoma kinase translocation:a predictive biomarker of pemetrexed in patients with non-small cell lung cancer. J Thorac Oncol. 2011 Sep;6(9):1474–1480.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.9
, pp. 1474-1480
-
-
Lee, J.O.1
Kim, T.M.2
Lee, S.H.3
-
125
-
-
79955813242
-
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
-
May
-
Takezawa K, Okamoto I, Okamoto W, et al. Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer. Br J Cancer. 2011 May 10;104(10):1594–1601.
-
(2011)
Br J Cancer
, vol.104
, Issue.10
, pp. 1594-1601
-
-
Takezawa, K.1
Okamoto, I.2
Okamoto, W.3
-
126
-
-
85015856674
-
Resistance mechanisms to targeted therapies in ROS1+ and ALK+ non-small cell lung cancer
-
May
-
McCoach CE, Le AT, Aisner D, et al. Resistance mechanisms to targeted therapies in ROS1+ and ALK+ non-small cell lung cancer. ASCO Meet Abstr. 2016 May 31;34(15_suppl):9065.
-
(2016)
ASCO Meet Abstr
, vol.34
, Issue.15
, pp. 9065
-
-
McCoach, C.E.1
Le, A.T.2
Aisner, D.3
-
127
-
-
84962074480
-
Non-small cell lung cancer cells acquire resistance to the ALK inhibitor Alectinib by activating alternative receptor tyrosine kinases
-
Mar
-
Isozaki H, Ichihara E, Takigawa N, et al. Non-small cell lung cancer cells acquire resistance to the ALK inhibitor Alectinib by activating alternative receptor tyrosine kinases. Cancer Res. 2016 Mar 15;76(6):1506–1516.
-
(2016)
Cancer Res
, vol.76
, Issue.6
, pp. 1506-1516
-
-
Isozaki, H.1
Ichihara, E.2
Takigawa, N.3
-
128
-
-
84941013285
-
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer
-
Sep
-
Hrustanovic G, Olivas V, Pazarentzos E, et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat Med. 2015 Sep;21(9):1038–1047.
-
(2015)
Nat Med
, vol.21
, Issue.9
, pp. 1038-1047
-
-
Hrustanovic, G.1
Olivas, V.2
Pazarentzos, E.3
-
129
-
-
84944937210
-
Nivolumab versus Docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Oct
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus Docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015 Oct 22;373(17):1627–1639.
-
(2015)
N Engl J Med
, vol.373
, Issue.17
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
130
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
-
Apr
-
Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010):a randomised controlled trial. Lancet. 2016 Apr 9;387(10027):1540–1550.
-
(2016)
Lancet
, vol.387
, Issue.10027
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
-
131
-
-
84928761118
-
Cancer immunology. Mutational Landscape Determines Sensitivity to PD-1 Blockade in Non-Small Cell Lung Cancer
-
Apr
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational Landscape Determines Sensitivity to PD-1 Blockade in Non-Small Cell Lung Cancer. Science. 2015 Apr 3;348(6230):124–128.
-
(2015)
Science
, vol.348
, Issue.6230
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
132
-
-
84909988250
-
ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis
-
Nov
-
Martinengo C, Poggio T, Menotti M, et al. ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis. Cancer Res. 2014 Nov 1;74(21):6094–6106.
-
(2014)
Cancer Res
, vol.74
, Issue.21
, pp. 6094-6106
-
-
Martinengo, C.1
Poggio, T.2
Menotti, M.3
|