-
1
-
-
84920837701
-
Cancer statistics, 2015
-
[CrossRef] [PubMed]
-
Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics, 2015. CA Cancer J. Clin. 2015, 65, 5-29. [CrossRef] [PubMed]
-
(2015)
CA Cancer J. Clin
, vol.65
, pp. 5-29
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
2
-
-
15744373791
-
-
3rd ed, WHO: Geneva, Switzerland
-
Travis, W., Brambilla, E., Mueller-Hermelink, H., Harris, C., Harris, C., Eds. Pathology and Genetics: Tumours of the Lung, Pleura, Thymus and Heart, 3rd ed.; World Health Organization Classification of Tumours, WHO: Geneva, Switzerland, 2004; Volume 10.
-
(2004)
Pathology and Genetics: Tumours of the Lung, Pleura, Thymus and Heart
, vol.10
-
-
Travis, W.1
Brambilla, E.2
Mueller-Hermelink, H.3
Harris, C.4
Harris, C.5
World Health Organization Classification of Tumours6
-
3
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
[CrossRef] [PubMed]
-
Paez, J.G.; Janne, P.A.; Lee, J.C.; Tracy, S.; Greulich, H.; Gabriel, S.; Herman, P.; Kaye, F.J.; Lindeman, N.; Boggon, T.J. et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004, 304, 1497-1500. [CrossRef] [PubMed]
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
4
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
[CrossRef] [PubMed]
-
Lynch, T.J.; Bell, D.W.; Sordella, R.; Gurubhagavatula, S.; Okimoto, R.A.; Brannigan, B.W.; Harris, P.L.; Haserlat, S.M.; Supko, J.G.; Haluska, F.G. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350, 2129-2139. [CrossRef] [PubMed]
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
5
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
[CrossRef] [PubMed]
-
Kwak, E.L.; Bang, Y.J.; Camidge, D.R.; Shaw, A.T.; Solomon, B.; Maki, R.G.; Ou, S.H.; Dezube, B.J.; Janne, P.A.; Costa, D.B. et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 2010, 363, 1693-1703. [CrossRef] [PubMed]
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
Maki, R.G.6
Ou, S.H.7
Dezube, B.J.8
Janne, P.A.9
Costa, D.B.10
-
6
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
[CrossRef] [PubMed]
-
Shaw, A.T.; Kim, D.W.; Nakagawa, K.; Seto, T.; Crino, L.; Ahn, M.J.; de Pas, T.; Besse, B.; Solomon, B.J.; Blackhall, F. et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med. 2013, 368, 2385-2394. [CrossRef] [PubMed]
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
Seto, T.4
Crino, L.5
Ahn, M.J.6
De Pas, T.7
Besse, B.8
Solomon, B.J.9
Blackhall, F.10
-
7
-
-
84900829967
-
Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
-
[CrossRef] [PubMed]
-
Kris, M.G.; Johnson, B.E.; Berry, L.D.; Kwiatkowski, D.J.; Iafrate, A.J.; Wistuba, I.I.; Varella-Garcia, M.; Franklin, W.A.; Aronson, S.L.; Su, P.-F. et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 2014, 311, 1998-2006. [CrossRef] [PubMed]
-
(2014)
JAMA
, vol.311
, pp. 1998-2006
-
-
Kris, M.G.1
Johnson, B.E.2
Berry, L.D.3
Kwiatkowski, D.J.4
Iafrate, A.J.5
Wistuba, I.I.6
Varella-Garcia, M.7
Franklin, W.A.8
Aronson, S.L.9
Su, P.-F.10
-
8
-
-
84875947292
-
New targetable oncogenes in non-small-cell lung cancer
-
[CrossRef] [PubMed]
-
Oxnard, G.R.; Binder, A.; Jänne, P.A. New targetable oncogenes in non-small-cell lung cancer. J. Clin. Oncol. 2013, 31, 1097-1104. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 1097-1104
-
-
Oxnard, G.R.1
Binder, A.2
Jänne, P.A.3
-
9
-
-
0025358375
-
Characterization of ROS1 cDNA from a human glioblastoma cell line
-
[CrossRef] [PubMed]
-
Birchmeier, C.; O’Neill, K.; Riggs, M.; Wigler, M. Characterization of ROS1 cDNA from a human glioblastoma cell line. Proc. Natl. Acad. Sci. USA 1990, 87, 4799-4803. [CrossRef] [PubMed]
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 4799-4803
-
-
Birchmeier, C.1
O’neill, K.2
Riggs, M.3
Wigler, M.4
-
10
-
-
0023477402
-
Expression and rearrangement of the ROS1 gene in human glioblastoma cells
-
[CrossRef] [PubMed]
-
Birchmeier, C.; Sharma, S.; Wigler, M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc. Natl. Acad. Sci. USA 1987, 84, 9270-9274. [CrossRef] [PubMed]
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 9270-9274
-
-
Birchmeier, C.1
Sharma, S.2
Wigler, M.3
-
11
-
-
33747887175
-
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
-
[CrossRef] [PubMed]
-
Charest, A.; Wilker, E.W.; McLaughlin, M.E.; Lane, K.; Gowda, R.; Coven, S.; McMahon, K.; Kovach, S.; Feng, Y.; Yaffe, M.B. et al. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006, 66, 7473-7481. [CrossRef] [PubMed]
-
(2006)
Cancer Res
, vol.66
, pp. 7473-7481
-
-
Charest, A.1
Wilker, E.W.2
McLaughlin, M.E.3
Lane, K.4
Gowda, R.5
Coven, S.6
McMahon, K.7
Kovach, S.8
Feng, Y.9
Yaffe, M.B.10
-
12
-
-
0037402509
-
Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
-
[CrossRef] [PubMed]
-
Charest, A.; Lane, K.; McMahon, K.; Park, J.; Preisinger, E.; Conroy, H.; Housman, D. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer 2003, 37, 58-71. [CrossRef] [PubMed]
-
(2003)
Genes Chromosomes Cancer
, vol.37
, pp. 58-71
-
-
Charest, A.1
Lane, K.2
McMahon, K.3
Park, J.4
Preisinger, E.5
Conroy, H.6
Housman, D.7
-
13
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
[CrossRef] [PubMed]
-
Rikova, K.; Guo, A.; Zeng, Q.; Possemato, A.; Yu, J.; Haack, H.; Nardone, J.; Lee, K.; Reeves, C.; Li, Y. et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007, 131, 1190-1203. [CrossRef] [PubMed]
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
-
14
-
-
84857985225
-
RET, ROS1 and ALK fusions in lung cancer
-
[CrossRef] [PubMed]
-
Takeuchi, K.; Soda, M.; Togashi, Y.; Suzuki, R.; Sakata, S.; Hatano, S.; Asaka, R.; Hamanaka, W.; Ninomiya, H.; Uehara, H. et al. RET, ROS1 and ALK fusions in lung cancer. Nat. Med. 2012, 18, 378-381. [CrossRef] [PubMed]
-
(2012)
Nat. Med
, vol.18
, pp. 378-381
-
-
Takeuchi, K.1
Soda, M.2
Togashi, Y.3
Suzuki, R.4
Sakata, S.5
Hatano, S.6
Asaka, R.7
Hamanaka, W.8
Ninomiya, H.9
Uehara, H.10
-
15
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
[CrossRef] [PubMed]
-
Bergethon, K.; Shaw, A.T.; Ou, S.H.; Katayama, R.; Lovly, C.M.; McDonald, N.T.; Massion, P.P.; Siwak-Tapp, C.; Gonzalez, A.; Fang, R. et al. ROS1 rearrangements define a unique molecular class of lung cancers. J. Clin. Oncol. 2012, 30, 863-870. [CrossRef] [PubMed]
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ou, S.H.3
Katayama, R.4
Lovly, C.M.5
McDonald, N.T.6
Massion, P.P.7
Siwak-Tapp, C.8
Gonzalez, A.9
Fang, R.10
-
16
-
-
84865441368
-
Identifying and targeting ROS1 gene fusions in non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Davies, K.D.; Le, A.T.; Theodoro, M.F.; Skokan, M.C.; Aisner, D.L.; Berge, E.M.; Terracciano, L.M.; Cappuzzo, F.; Incarbone, M.; Roncalli, M. et al. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin. Cancer Res. 2012, 18, 4570-4579. [CrossRef] [PubMed]
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 4570-4579
-
-
Davies, K.D.1
Le, A.T.2
Theodoro, M.F.3
Skokan, M.C.4
Aisner, D.L.5
Berge, E.M.6
Terracciano, L.M.7
Cappuzzo, F.8
Incarbone, M.9
Roncalli, M.10
-
17
-
-
84911372597
-
Crizotinib in ROS1-rearranged non-small-cell lung cancer
-
[CrossRef]
-
Shaw, A.T.; Ou, S.-H.I.; Bang, Y.-J.; Camidge, D.R.; Solomon, B.J.; Salgia, R.; Riely, G.J.; Varella-Garcia, M.; Shapiro, G.I.; Costa, D.B. et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N. Engl. J. Med. 2014. [CrossRef]
-
(2014)
N. Engl. J. Med
-
-
Shaw, A.T.1
Ou, S.-H.I.2
Bang, Y.-J.3
Camidge, D.R.4
Solomon, B.J.5
Salgia, R.6
Riely, G.J.7
Varella-Garcia, M.8
Shapiro, G.I.9
Costa, D.B.10
-
18
-
-
84927139647
-
Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: Results from the EUROS1 cohort
-
[CrossRef] [PubMed]
-
Mazieres, J.; Zalcman, G.; Crino, L.; Biondani, P.; Barlesi, F.; Filleron, T.; Dingemans, A.M.; Léna, H.; Monnet, I.; Rothschild, S.I. et al. Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: Results from the EUROS1 cohort. J. Clin. Oncol. 2015, 33, 992-999. [CrossRef] [PubMed]
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 992-999
-
-
Mazieres, J.1
Zalcman, G.2
Crino, L.3
Biondani, P.4
Barlesi, F.5
Filleron, T.6
Dingemans, A.M.7
Léna, H.8
Monnet, I.9
Rothschild, S.I.10
-
19
-
-
84879088863
-
Acquired resistance to crizotinib from a mutation in CD74-ROS1
-
[CrossRef] [PubMed]
-
Awad, M.M.; Katayama, R.; McTigue, M.; Liu, W.; Deng, Y.-L.; Brooun, A.; Friboulet, L.; Huang, D.; Falk, M.D.; Timofeevski, S. et al. Acquired resistance to crizotinib from a mutation in CD74-ROS1. N. Engl. J. Med. 2013, 368, 2395-2401. [CrossRef] [PubMed]
-
(2013)
N. Engl. J. Med
, vol.368
, pp. 2395-2401
-
-
Awad, M.M.1
Katayama, R.2
McTigue, M.3
Liu, W.4
Deng, Y.-L.5
Brooun, A.6
Friboulet, L.7
Huang, D.8
Falk, M.D.9
Timofeevski, S.10
-
20
-
-
84892655145
-
Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Davies, K.D.; Mahale, S.; Astling, D.P.; Aisner, D.L.; Le, A.T.; Hinz, T.K.; Vaishnavi, A.; Bunn, P.A.; Heasley, L.E.; Tan, A.-C. et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE 2013, 8, e82236. [CrossRef] [PubMed]
-
(2013)
Plos ONE
, vol.8
-
-
Davies, K.D.1
Mahale, S.2
Astling, D.P.3
Aisner, D.L.4
Le, A.T.5
Hinz, T.K.6
Vaishnavi, A.7
Bunn, P.A.8
Heasley, L.E.9
Tan, A.-C.10
-
21
-
-
84930968377
-
Molecular changes associated with acquired resistance to crizotinib in ROS1-rearranged non-small cell lung cancer (NSCLC)
-
[CrossRef]
-
Song, A.; Kim, T.M.; Kim, D.-W.; Kim, S.; Keam, B.; Lee, S.-H.; Heo, D.S. Molecular changes associated with acquired resistance to crizotinib in ROS1-rearranged non-small cell lung cancer (NSCLC). Clin. Cancer Res. 2015. [CrossRef]
-
(2015)
Clin. Cancer Res
-
-
Song, A.1
Kim, T.M.2
Kim, D.-W.3
Kim, S.4
Keam, B.5
Lee, S.-H.6
Heo, D.S.7
-
22
-
-
84920548555
-
Cabozantinib overcomes crizotinib resistance in ROS1 fusion positive cancer
-
[CrossRef] [PubMed]
-
Katayama, R.; Kobayashi, Y.; Friboulet, L.; Lockerman, E.L.; Koike, S.; Shaw, A.T.; Engelman, J.A.; Fujita, N. Cabozantinib overcomes crizotinib resistance in ROS1 fusion positive cancer. Clin. Cancer Res. 2014, 21, 166-174. [CrossRef] [PubMed]
-
(2014)
Clin. Cancer Res
, vol.21
, pp. 166-174
-
-
Katayama, R.1
Kobayashi, Y.2
Friboulet, L.3
Lockerman, E.L.4
Koike, S.5
Shaw, A.T.6
Engelman, J.A.7
Fujita, N.8
-
23
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
[CrossRef] [PubMed]
-
Katayama, R.; Khan, T.M.; Benes, C.; Lifshits, E.; Ebi, H.; Rivera, V.M.; Shakespeare, W.C.; Iafrate, A.J.; Engelman, J.A.; Shaw, A.T. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc. Natl. Acad. Sci. USA 2011, 108, 7535-7540. [CrossRef] [PubMed]
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
Lifshits, E.4
Ebi, H.5
Rivera, V.M.6
Shakespeare, W.C.7
Iafrate, A.J.8
Engelman, J.A.9
Shaw, A.T.10
-
24
-
-
84888333580
-
Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins
-
[CrossRef] [PubMed]
-
Davare, M.A.; Saborowski, A.; Eide, C.A.; Tognon, C.; Smith, R.L.; Elferich, J.; Agarwal, A.; Tyner, J.W.; Shinde, U.P.; Lowe, S.W. et al. Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins. Proc. Natl. Acad. Sci. USA 2013, 110, 19519-19524. [CrossRef] [PubMed]
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 19519-19524
-
-
Davare, M.A.1
Saborowski, A.2
Eide, C.A.3
Tognon, C.4
Smith, R.L.5
Elferich, J.6
Agarwal, A.7
Tyner, J.W.8
Shinde, U.P.9
Lowe, S.W.10
-
25
-
-
84925307919
-
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
-
[CrossRef] [PubMed]
-
Zou, H.Y.; Li, Q.; Engstrom, L.D.; West, M.; Appleman, V.; Wong, K.A.; McTigue, M.; Deng, Y.-L.; Liu, W.; Brooun, A. et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Proc. Natl. Acad. Sci. USA 2015, 112, 3493-3498. [CrossRef] [PubMed]
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 3493-3498
-
-
Zou, H.Y.1
Li, Q.2
Engstrom, L.D.3
West, M.4
Appleman, V.5
Wong, K.A.6
McTigue, M.7
Deng, Y.-L.8
Liu, W.9
Brooun, A.10
-
26
-
-
84877679409
-
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Sang, J.; Acquaviva, J.; Friedland, J.C.; Smith, D.L.; Sequeira, M.; Zhang, C.; Jiang, Q.; Xue, L.; Lovly, C.M.; Jimenez, J.-P. et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov. 2013, 3, 430-443. [CrossRef] [PubMed]
-
(2013)
Cancer Discov
, vol.3
, pp. 430-443
-
-
Sang, J.1
Acquaviva, J.2
Friedland, J.C.3
Smith, D.L.4
Sequeira, M.5
Zhang, C.6
Jiang, Q.7
Xue, L.8
Lovly, C.M.9
Jimenez, J.-P.10
-
27
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
[CrossRef] [PubMed]
-
Davies, H.; Bignell, G.R.; Cox, C.; Stephens, P.; Edkins, S.; Clegg, S.; Teague, J.; Woffendin, H.; Garnett, M.J.; Bottomley, W. et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417, 949-954. [CrossRef] [PubMed]
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
28
-
-
0037112438
-
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
-
[PubMed]
-
Yuen, S.T.; Davies, H.; Chan, T.L.; Ho, J.W.; Bignell, G.R.; Cox, C.; Stephens, P.; Edkins, S.; Tsui, W.W.; Chan, A.S. et al. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res. 2002, 62, 6451-6455. [PubMed]
-
(2002)
Cancer Res
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
Davies, H.2
Chan, T.L.3
Ho, J.W.4
Bignell, G.R.5
Cox, C.6
Stephens, P.7
Edkins, S.8
Tsui, W.W.9
Chan, A.S.10
-
29
-
-
0037379904
-
High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
-
[PubMed]
-
Kimura, E.T.; Nikiforova, M.N.; Zhu, Z.; Knauf, J.A.; Nikiforov, Y.E.; Fagin, J.A. High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 2003, 63, 1454-1457. [PubMed]
-
(2003)
Cancer Res
, vol.63
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
Knauf, J.A.4
Nikiforov, Y.E.5
Fagin, J.A.6
-
30
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
[CrossRef] [PubMed]
-
Hauschild, A.; Grob, J.-J.; Demidov, L.V.; Jouary, T.; Gutzmer, R.; Millward, M.; Rutkowski, P.; Blank, C.U.; Miller, W.H.; Kaempgen, E. et al. Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012, 380, 358-365. [CrossRef] [PubMed]
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.-J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
Rutkowski, P.7
Blank, C.U.8
Miller, W.H.9
Kaempgen, E.10
-
31
-
-
84896714827
-
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study
-
[CrossRef] [PubMed]
-
McArthur, G.A.; Chapman, P.B.; Robert, C.; Larkin, J.; Haanen, J.B.; Dummer, R.; Ribas, A.; Hogg, D.; Hamid, O.; Ascierto, P.A. et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014, 15, 323-332. [CrossRef] [PubMed]
-
(2014)
Lancet Oncol
, vol.15
, pp. 323-332
-
-
McArthur, G.A.1
Chapman, P.B.2
Robert, C.3
Larkin, J.4
Haanen, J.B.5
Dummer, R.6
Ribas, A.7
Hogg, D.8
Hamid, O.9
Ascierto, P.A.10
-
32
-
-
0036895599
-
Missense mutations of the BRAF gene in human lung adenocarcinoma
-
[PubMed]
-
Naoki, K.; Chen, T.H.; Richards, W.G.; Sugarbaker, D.J.; Meyerson, M. Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res. 2002, 62, 7001-7003. [PubMed]
-
(2002)
Cancer Res
, vol.62
, pp. 7001-7003
-
-
Naoki, K.1
Chen, T.H.2
Richards, W.G.3
Sugarbaker, D.J.4
Meyerson, M.5
-
33
-
-
80053014471
-
Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
-
[CrossRef] [PubMed]
-
Marchetti, A.; Felicioni, L.; Malatesta, S.; Grazia Sciarrotta, M.; Guetti, L.; Chella, A.; Viola, P.; Pullara, C.; Mucilli, F.; Buttitta, F. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J. Clin. Oncol. 2011, 29, 3574-3579. [CrossRef] [PubMed]
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 3574-3579
-
-
Marchetti, A.1
Felicioni, L.2
Malatesta, S.3
Grazia Sciarrotta, M.4
Guetti, L.5
Chella, A.6
Viola, P.7
Pullara, C.8
Mucilli, F.9
Buttitta, F.10
-
34
-
-
79956316170
-
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
-
[CrossRef] [PubMed]
-
Paik, P.K.; Arcila, M.E.; Fara, M.; Sima, C.S.; Miller, V.A.; Kris, M.G.; Ladanyi, M.; Riely, G.J. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J. Clin. Oncol. 2011, 29, 2046-2051. [CrossRef] [PubMed]
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2046-2051
-
-
Paik, P.K.1
Arcila, M.E.2
Fara, M.3
Sima, C.S.4
Miller, V.A.5
Kris, M.G.6
Ladanyi, M.7
Riely, G.J.8
-
35
-
-
84884999688
-
Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients
-
Planchard, D.; Mazieres, J.; Riely, G.J.; Rudin, C.M.; Barlesi, F.; Quoix, E.A.; Souquet, P.J.; Socinski, M.A.; Switzky, J.; Ma, B. et al. Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients. J. Clin. Oncol. 2013, 31, 8009.
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Planchard, D.1
Mazieres, J.2
Riely, G.J.3
Rudin, C.M.4
Barlesi, F.5
Quoix, E.A.6
Souquet, P.J.7
Socinski, M.A.8
Switzky, J.9
Ma, B.10
-
36
-
-
84904098850
-
BRAF V600E-mutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib
-
[CrossRef] [PubMed]
-
Robinson, S.D.; O’Shaughnessy, J.A.; Cowey, C.L.; Konduri, K. BRAF V600E-mutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib. Lung Cancer 2014, 85, 326-330. [CrossRef] [PubMed]
-
(2014)
Lung Cancer
, vol.85
, pp. 326-330
-
-
Robinson, S.D.1
O’shaughnessy, J.A.2
Cowey, C.L.3
Konduri, K.4
-
37
-
-
84883879311
-
Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma
-
[CrossRef] [PubMed]
-
Peters, S.; Michielin, O.; Zimmermann, S. Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma. J. Clin. Oncol. 2013, 31, e341-e344. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Peters, S.1
Michielin, O.2
Zimmermann, S.3
-
38
-
-
84890512515
-
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma
-
[CrossRef] [PubMed]
-
Bahadoran, P.; Allegra, M.; Le Duff, F.; Long-Mira, E.; Hofman, P.; Giacchero, D.; Passeron, T.; Lacour, J.-P.; Ballotti, R. Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. J. Clin. Oncol. 2013, 31, e324-e326. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Bahadoran, P.1
Allegra, M.2
Le Duff, F.3
Long-Mira, E.4
Hofman, P.5
Giacchero, D.6
Passeron, T.7
Lacour, J.-P.8
Ballotti, R.9
-
39
-
-
84866595717
-
A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib
-
[CrossRef] [PubMed]
-
Gautschi, O.; Pauli, C.; Strobel, K.; Hirschmann, A.; Printzen, G.; Aebi, S.; Diebold, J. A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. J. Thorac. Oncol. 2012, 7, e23-e24. [CrossRef] [PubMed]
-
(2012)
J. Thorac. Oncol
, vol.7
-
-
Gautschi, O.1
Pauli, C.2
Strobel, K.3
Hirschmann, A.4
Printzen, G.5
Aebi, S.6
Diebold, J.7
-
40
-
-
77954376912
-
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models
-
[CrossRef] [PubMed]
-
Yang, H.; Higgins, B.; Kolinsky, K.; Packman, K.; Go, Z.; Iyer, R.; Kolis, S.; Zhao, S.; Lee, R.; Grippo, J.F. et al. RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res. 2010, 70, 5518-5527. [CrossRef] [PubMed]
-
(2010)
Cancer Res
, vol.70
, pp. 5518-5527
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
Packman, K.4
Go, Z.5
Iyer, R.6
Kolis, S.7
Zhao, S.8
Lee, R.9
Grippo, J.F.10
-
41
-
-
84887014975
-
Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib
-
[CrossRef] [PubMed]
-
Gautschi, O.; Peters, S.; Zoete, V.; Aebersold-Keller, F.; Strobel, K.; Schwizer, B.; Hirschmann, A.; Michielin, O.; Diebold, J. Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. Lung Cancer 2013, 82, 365-367. [CrossRef] [PubMed]
-
(2013)
Lung Cancer
, vol.82
, pp. 365-367
-
-
Gautschi, O.1
Peters, S.2
Zoete, V.3
Aebersold-Keller, F.4
Strobel, K.5
Schwizer, B.6
Hirschmann, A.7
Michielin, O.8
Diebold, J.9
-
42
-
-
84922235562
-
Response to dabrafenib after progression on vemurafenib in a patient with advanced BRAF V600E-mutant bronchial adenocarcinoma
-
[CrossRef] [PubMed]
-
Schmid, S.; Siano, M.; Joerger, M.; Rodriguez, R.; Müller, J.; Früh, M. Response to dabrafenib after progression on vemurafenib in a patient with advanced BRAF V600E-mutant bronchial adenocarcinoma. Lung Cancer 2015, 87, 85-87. [CrossRef] [PubMed]
-
(2015)
Lung Cancer
, vol.87
, pp. 85-87
-
-
Schmid, S.1
Siano, M.2
Joerger, M.3
Rodriguez, R.4
Müller, J.5
Früh, M.6
-
43
-
-
84863673204
-
Improved survival with MEK inhibition in BRAF-mutated melanoma
-
[CrossRef] [PubMed]
-
Flaherty, K.T.; Robert, C.; Hersey, P.; Nathan, P.; Garbe, C.; Milhem, M.; Demidov, L.V.; Hassel, J.C.; Rutkowski, P.; Mohr, P. et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N. Engl. J. Med. 2012, 367, 107-114. [CrossRef] [PubMed]
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
Nathan, P.4
Garbe, C.5
Milhem, M.6
Demidov, L.V.7
Hassel, J.C.8
Rutkowski, P.9
Mohr, P.10
-
44
-
-
55949097252
-
Genetic predictors of MEK dependence in non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Pratilas, C.A.; Hanrahan, A.J.; Halilovic, E.; Persaud, Y.; Soh, J.; Chitale, D.; Shigematsu, H.; Yamamoto, H.; Sawai, A.; Janakiraman, M. et al. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res. 2008, 68, 9375-9383. [CrossRef] [PubMed]
-
(2008)
Cancer Res
, vol.68
, pp. 9375-9383
-
-
Pratilas, C.A.1
Hanrahan, A.J.2
Halilovic, E.3
Persaud, Y.4
Soh, J.5
Chitale, D.6
Shigematsu, H.7
Yamamoto, H.8
Sawai, A.9
Janakiraman, M.10
-
45
-
-
84923295009
-
Trametinib with or without Vemurafenib in BRAF Mutated Non-Small Cell Lung Cancer
-
[CrossRef] [PubMed]
-
Joshi, M.; Rice, S.J.; Liu, X.; Miller, B.; Belani, C.P. Trametinib with or without Vemurafenib in BRAF Mutated Non-Small Cell Lung Cancer. PLoS ONE 2015, 10, e0118210. [CrossRef] [PubMed]
-
(2015)
Plos ONE
, vol.10
-
-
Joshi, M.1
Rice, S.J.2
Liu, X.3
Miller, B.4
Belani, C.P.5
-
46
-
-
0021362206
-
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient
-
[CrossRef] [PubMed]
-
Santos, E.; Martin-Zanca, D.; Reddy, E.P.; Pierotti, M.A.; Della Porta, G.; Barbacid, M. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science 1984, 223, 661-664. [CrossRef] [PubMed]
-
(1984)
Science
, vol.223
, pp. 661-664
-
-
Santos, E.1
Martin-Zanca, D.2
Reddy, E.P.3
Pierotti, M.A.4
Della Porta, G.5
Barbacid, M.6
-
47
-
-
82355191818
-
Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
-
[CrossRef] [PubMed]
-
Sequist, L.V.; Heist, R.S.; Shaw, A.T.; Fidias, P.; Rosovsky, R.; Temel, J.S.; Lennes, I.T.; Digumarthy, S.; Waltman, B.A.; Bast, E. et al. Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann. Oncol. 2011, 22, 2616-2624. [CrossRef] [PubMed]
-
(2011)
Ann. Oncol
, vol.22
, pp. 2616-2624
-
-
Sequist, L.V.1
Heist, R.S.2
Shaw, A.T.3
Fidias, P.4
Rosovsky, R.5
Temel, J.S.6
Lennes, I.T.7
Digumarthy, S.8
Waltman, B.A.9
Bast, E.10
-
48
-
-
53249145767
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
-
[CrossRef] [PubMed]
-
Riely, G.J.; Kris, M.G.; Rosenbaum, D.; Marks, J.; Li, A.; Chitale, D.A.; Nafa, K.; Riedel, E.R.; Hsu, M.; Pao, W. et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin. Cancer Res. 2008, 14, 5731-5734. [CrossRef] [PubMed]
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 5731-5734
-
-
Riely, G.J.1
Kris, M.G.2
Rosenbaum, D.3
Marks, J.4
Li, A.5
Chitale, D.A.6
Nafa, K.7
Riedel, E.R.8
Hsu, M.9
Pao, W.10
-
49
-
-
78049515002
-
Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases
-
[CrossRef] [PubMed]
-
Sun, Y.; Ren, Y.; Fang, Z.; Li, C.; Fang, R.; Gao, B.; Han, X.; Tian, W.; Pao, W.; Chen, H. et al. Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J. Clin. Oncol. 2010, 28, 4616-4620. [CrossRef] [PubMed]
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 4616-4620
-
-
Sun, Y.1
Ren, Y.2
Fang, Z.3
Li, C.4
Fang, R.5
Gao, B.6
Han, X.7
Tian, W.8
Pao, W.9
Chen, H.10
-
50
-
-
84881374148
-
Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy
-
[CrossRef] [PubMed]
-
Shepherd, F.A.; Domerg, C.; Hainaut, P.; Jänne, P.A.; Pignon, J.-P.; Graziano, S.; Douillard, J.-Y.; Brambilla, E.; Le Chevalier, T.; Seymour, L. et al. Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy. J. Clin. Oncol. 2013, 31, 2173-2181. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 2173-2181
-
-
Shepherd, F.A.1
Domerg, C.2
Hainaut, P.3
Jänne, P.A.4
Pignon, J.-P.5
Graziano, S.6
Douillard, J.-Y.7
Brambilla, E.8
Le Chevalier, T.9
Seymour, L.10
-
51
-
-
19944430434
-
The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis
-
[CrossRef] [PubMed]
-
Mascaux, C.; Iannino, N.; Martin, B.; Paesmans, M.; Berghmans, T.; Dusart, M.; Haller, A.; Lothaire, P.; Meert, A.-P.; Noel, S. et al. The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis. Br. J. Cancer 2005, 92, 131-139. [CrossRef] [PubMed]
-
(2005)
Br. J. Cancer
, vol.92
, pp. 131-139
-
-
Mascaux, C.1
Iannino, N.2
Martin, B.3
Paesmans, M.4
Berghmans, T.5
Dusart, M.6
Haller, A.7
Lothaire, P.8
Meert, A.-P.9
Noel, S.10
-
52
-
-
77953361374
-
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status
-
[CrossRef] [PubMed]
-
Kalikaki, A.; Koutsopoulos, A.; Hatzidaki, D.; Trypaki, M.; Kontopodis, E.; Stathopoulos, E.; Mavroudis, D.; Georgoulias, V.; Voutsina, A. Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status. Lung Cancer 2010, 69, 110-115. [CrossRef] [PubMed]
-
(2010)
Lung Cancer
, vol.69
, pp. 110-115
-
-
Kalikaki, A.1
Koutsopoulos, A.2
Hatzidaki, D.3
Trypaki, M.4
Kontopodis, E.5
Stathopoulos, E.6
Mavroudis, D.7
Georgoulias, V.8
Voutsina, A.9
-
53
-
-
79955483992
-
The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients
-
[CrossRef] [PubMed]
-
Camps, C.; Jantus-Lewintre, E.; Cabrera, A.; Blasco, A.; Sanmartín, E.; Gallach, S.; Caballero, C.; del Pozo, N.; Rosell, R.; Guijarro, R. et al. The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients. Lung Cancer 2011, 72, 365-369. [CrossRef] [PubMed]
-
(2011)
Lung Cancer
, vol.72
, pp. 365-369
-
-
Camps, C.1
Jantus-Lewintre, E.2
Cabrera, A.3
Blasco, A.4
Sanmartín, E.5
Gallach, S.6
Caballero, C.7
Del Pozo, N.8
Rosell, R.9
Guijarro, R.10
-
54
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
[CrossRef] [PubMed]
-
Cappuzzo, F.; Ciuleanu, T.; Stelmakh, L.; Cicenas, S.; Szczesna, A.; Juhasz, E.; Esteban, E.; Molinier, O.; Brugger, W.; Melezinek, I. et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol. 2010, 11, 521-529. [CrossRef] [PubMed]
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
Cicenas, S.4
Szczesna, A.5
Juhasz, E.6
Esteban, E.7
Molinier, O.8
Brugger, W.9
Melezinek, I.10
-
55
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
[CrossRef] [PubMed]
-
Pao, W.; Wang, T.Y.; Riely, G.J.; Miller, V.A.; Pan, Q.; Ladanyi, M.; Zakowski, M.F.; Heelan, R.T.; Kris, M.G.; Varmus, H.E. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2005, 2, e17. [CrossRef] [PubMed]
-
(2005)
Plos Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
Miller, V.A.4
Pan, Q.5
Ladanyi, M.6
Zakowski, M.F.7
Heelan, R.T.8
Kris, M.G.9
Varmus, H.E.10
-
56
-
-
52749099497
-
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
[CrossRef] [PubMed]
-
Linardou, H.; Dahabreh, I.J.; Kanaloupiti, D.; Siannis, F.; Bafaloukos, D.; Kosmidis, P.; Papadimitriou, C.A.; Murray, S. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008, 9, 962-972. [CrossRef] [PubMed]
-
(2008)
Lancet Oncol
, vol.9
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
Siannis, F.4
Bafaloukos, D.5
Kosmidis, P.6
Papadimitriou, C.A.7
Murray, S.8
-
57
-
-
0038362742
-
Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer
-
[CrossRef] [PubMed]
-
Adjei, A.A.; Mauer, A.; Bruzek, L.; Marks, R.S.; Hillman, S.; Geyer, S.; Hanson, L.J.; Wright, J.J.; Erlichman, C.; Kaufmann, S.H. et al. Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 2003, 21, 1760-1766. [CrossRef] [PubMed]
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 1760-1766
-
-
Adjei, A.A.1
Mauer, A.2
Bruzek, L.3
Marks, R.S.4
Hillman, S.5
Geyer, S.6
Hanson, L.J.7
Wright, J.J.8
Erlichman, C.9
Kaufmann, S.H.10
-
58
-
-
84871720411
-
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
-
[CrossRef] [PubMed]
-
Jänne, P.A.; Shaw, A.T.; Pereira, J.R.; Jeannin, G.; Vansteenkiste, J.; Barrios, C.; Franke, F.A.; Grinsted, L.; Zazulina, V.; Smith, P. et al. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol. 2013, 14, 38-47. [CrossRef] [PubMed]
-
(2013)
Lancet Oncol
, vol.14
, pp. 38-47
-
-
Jänne, P.A.1
Shaw, A.T.2
Pereira, J.R.3
Jeannin, G.4
Vansteenkiste, J.5
Barrios, C.6
Franke, F.A.7
Grinsted, L.8
Zazulina, V.9
Smith, P.10
-
59
-
-
84894467946
-
Oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with docetaxel in KRAS-mutant and wild-type (WT) advanced non-small cell lung cancer (NSCLC): A phase I/Ib trial
-
Gandara, D.R.; Hiret, S.; Blumenschein, G.R.; Barlesi, F.; Delord, J.-P.; Madelaine, J.; Infante, J.R.; Reckamp, K.L.; Lara, P.; Audebert, C. et al. Oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with docetaxel in KRAS-mutant and wild-type (WT) advanced non-small cell lung cancer (NSCLC): A phase I/Ib trial. J. Clin. Oncol. 2013, 31, 8028.
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Gandara, D.R.1
Hiret, S.2
Blumenschein, G.R.3
Barlesi, F.4
Delord, J.-P.5
Madelaine, J.6
Infante, J.R.7
Reckamp, K.L.8
Lara, P.9
Audebert, C.10
-
60
-
-
84894491192
-
MEK114653, A randomized, multicenter, phase II study to assess efficacy and safety of trametinib (T) compared with docetaxel (D) in KRAS-mutant advanced non-small cell lung cancer (NSCLC)
-
Blumenschein, G.R.; Smit, E.F.; Planchard, D.; Kim, D.-W.; Cadranel, J.; de Pas, T.; Dunphy, F.; Udud, K.; Ahn, M.-J.; Hanna, N.H. et al. MEK114653, A randomized, multicenter, phase II study to assess efficacy and safety of trametinib (T) compared with docetaxel (D) in KRAS-mutant advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. 2013, 31, 8029.
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Blumenschein, G.R.1
Smit, E.F.2
Planchard, D.3
Kim, D.-W.4
Cadranel, J.5
De Pas, T.6
Dunphy, F.7
Udud, K.8
Ahn, M.-J.9
Hanna, N.H.10
-
61
-
-
70350228529
-
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations
-
[CrossRef] [PubMed]
-
Konstantinidou, G.; Bey, E.A.; Rabellino, A.; Schuster, K.; Maira, M.S.; Gazdar, A.F.; Amici, A.; Boothman, D.A.; Scaglioni, P.P. Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Res. 2009, 69, 7644-7652. [CrossRef] [PubMed]
-
(2009)
Cancer Res
, vol.69
, pp. 7644-7652
-
-
Konstantinidou, G.1
Bey, E.A.2
Rabellino, A.3
Schuster, K.4
Maira, M.S.5
Gazdar, A.F.6
Amici, A.7
Boothman, D.A.8
Scaglioni, P.P.9
-
62
-
-
84877666085
-
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas
-
[CrossRef] [PubMed]
-
Konstantinidou, G.; Ramadori, G.; Torti, F.; Kangasniemi, K.; Ramirez, R.E.; Cai, Y.; Behrens, C.; Dellinger, M.T.; Brekken, R.A.; Wistuba, I.I. et al. RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov. 2013, 3, 444-457. [CrossRef] [PubMed]
-
(2013)
Cancer Discov
, vol.3
, pp. 444-457
-
-
Konstantinidou, G.1
Ramadori, G.2
Torti, F.3
Kangasniemi, K.4
Ramirez, R.E.5
Cai, Y.6
Behrens, C.7
Dellinger, M.T.8
Brekken, R.A.9
Wistuba, I.I.10
-
63
-
-
84888639050
-
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
-
[CrossRef] [PubMed]
-
Ostrem, J.M.; Peters, U.; Sos, M.L.; Wells, J.A.; Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013, 503, 548-551. [CrossRef] [PubMed]
-
(2013)
Nature
, vol.503
, pp. 548-551
-
-
Ostrem, J.M.1
Peters, U.2
Sos, M.L.3
Wells, J.A.4
Shokat, K.M.5
-
64
-
-
84902603270
-
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
-
[CrossRef] [PubMed]
-
Hunter, J.C.; Gurbani, D.; Ficarro, S.B.; Carrasco, M.A.; Lim, S.M.; Choi, H.G.; Xie, T.; Marto, J.A.; Chen, Z.; Gray, N.S. et al. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc. Natl. Acad. Sci. USA 2014, 111, 8895-8900. [CrossRef] [PubMed]
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 8895-8900
-
-
Hunter, J.C.1
Gurbani, D.2
Ficarro, S.B.3
Carrasco, M.A.4
Lim, S.M.5
Choi, H.G.6
Xie, T.7
Marto, J.A.8
Chen, Z.9
Gray, N.S.10
-
65
-
-
84877097856
-
Characteristics of lung cancers harboring NRAS mutations
-
[CrossRef] [PubMed]
-
Ohashi, K.; Sequist L.V.; Arcila, M.E.; Lovly, C.M.; Chen, X.; Rudin, C.M.; Moran, T.; Camidge, D.R.; Vnencak-Jones, C.L.; Berry, L. et al. Characteristics of lung cancers harboring NRAS mutations. Clin. Cancer Res. 2013, 19, 2584-2591. [CrossRef] [PubMed]
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 2584-2591
-
-
Ohashi, K.1
Sequist, L.V.2
Arcila, M.E.3
Lovly, C.M.4
Chen, X.5
Rudin, C.M.6
Moran, T.7
Camidge, D.R.8
Vnencak-Jones, C.L.9
Berry, L.10
-
66
-
-
84876970810
-
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
-
[CrossRef] [PubMed]
-
Swain, S.M.; Kim, S.-B.; Cortés, J.; Ro, J.; Semiglazov, V.; Campone, M.; Ciruelos, E.; Ferrero, J.-.M.; Schneeweiss, A.; Knott, A. et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2013, 14, 461-471. [CrossRef] [PubMed]
-
(2013)
Lancet Oncol
, vol.14
, pp. 461-471
-
-
Swain, S.M.1
Kim, S.-B.2
Cortés, J.3
Ro, J.4
Semiglazov, V.5
Campone, M.6
Ciruelos, E.7
Ferrero, J.-M.8
Schneeweiss, A.9
Knott, A.10
-
67
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
[CrossRef] [PubMed]
-
Verma, S.; Miles, D.; Gianni, L.; Krop, I.E.; Welslau, M.; Baselga, J.; Pegram, M.; Oh, D.-Y.; Diéras, V.; Guardino, E. et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N. Engl. J. Med. 2012, 367, 1783-1791. [CrossRef] [PubMed]
-
(2012)
N. Engl. J. Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
Krop, I.E.4
Welslau, M.5
Baselga, J.6
Pegram, M.7
Oh, D.-Y.8
Diéras, V.9
Guardino, E.10
-
68
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
[CrossRef] [PubMed]
-
Geyer, C.E.; Forster, J.; Lindquist, D.; Chan, S.; Romieu, C.G.; Pienkowski, T.; Jagiello-Gruszfeld, A.; Crown, J.; Chan, A.; Kaufman, B. et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl. J. Med. 2006, 355, 2733-2743. [CrossRef] [PubMed]
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
-
69
-
-
0037029712
-
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas
-
[CrossRef] [PubMed]
-
Hirsch, F.R.; Varella-Garcia, M.; Franklin, W.A.; Veve, R.; Chen, L.; Helfrich, B.; Zeng, C.; Baron, A.; Bunn, P.A.; Bunn, P.A., Jr. Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. Br. J. Cancer 2002, 86, 1449-1456. [CrossRef] [PubMed]
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1449-1456
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Franklin, W.A.3
Veve, R.4
Chen, L.5
Helfrich, B.6
Zeng, C.7
Baron, A.8
Bunn, P.A.9
Bunn, P.A.10
-
70
-
-
0242442020
-
HER2 status in non-small cell lung cancer: Results from patient screening for enrollment to a phase II study of herceptin
-
[PubMed]
-
Heinmoller, P.; Gross, C.; Beyser, K.; Schmidtgen, C.; Maass, G.; Pedrocchi, M.; Ruschoff, J. HER2 status in non-small cell lung cancer: Results from patient screening for enrollment to a phase II study of herceptin. Clin. Cancer Res. 2003, 9, 5238-5243. [PubMed]
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 5238-5243
-
-
Heinmoller, P.1
Gross, C.2
Beyser, K.3
Schmidtgen, C.4
Maass, G.5
Pedrocchi, M.6
Ruschoff, J.7
-
71
-
-
78650459071
-
The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: A meta-analysis of published data
-
[CrossRef] [PubMed]
-
Liu, L.; Shao, X.; Gao, W.; Bai, J.; Wang, R.; Huang, P.; Yin, Y.; Liu, P.; Shu, Y. The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: A meta-analysis of published data. J. Thorac. Oncol. 2010, 5, 1922-1932. [CrossRef] [PubMed]
-
(2010)
J. Thorac. Oncol
, vol.5
, pp. 1922-1932
-
-
Liu, L.1
Shao, X.2
Gao, W.3
Bai, J.4
Wang, R.5
Huang, P.6
Yin, Y.7
Liu, P.8
Shu, Y.9
-
72
-
-
84866360342
-
Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
-
[CrossRef] [PubMed]
-
Arcila, M.E.; Chaft, J.E.; Nafa, K.L.; Roy-Chowdhuri, S.; Lau, C.; Zaidinski, M.; Paik, P.K.; Zakowski, M.F.; Kris, M.G.; Ladanyi, M. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin. Cancer Res. 2012, 18, 4910-4918. [CrossRef] [PubMed]
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 4910-4918
-
-
Arcila, M.E.1
Chaft, J.E.2
Nafa, K.L.3
Roy-Chowdhuri, S.4
Lau, C.5
Zaidinski, M.6
Paik, P.K.7
Zakowski, M.F.8
Kris, M.G.9
Ladanyi, M.10
-
73
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
[CrossRef] [PubMed]
-
Stephens, P.; Hunter, C.; Bignell, G.; Edkins, S.; Davies, H.; Teague, J.; Stevens, C.; O’Meara, S.; Smith, R.; Parker, A. et al. Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature 2004, 431, 525-526. [CrossRef] [PubMed]
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
Edkins, S.4
Davies, H.5
Teague, J.6
Stevens, C.7
O’meara, S.8
Smith, R.9
Parker, A.10
-
74
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
[CrossRef] [PubMed]
-
Shigematsu, H.; Takahashi, T.; Nomura, M.; Majmudar, K.; Suzuki, M.; Lee, H.; Wistuba, I.I.; Fong, K.M.; Toyooka, S.; Shimizu, N. et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res. 2005, 65, 1642-1646. [CrossRef] [PubMed]
-
(2005)
Cancer Res
, vol.65
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
Majmudar, K.4
Suzuki, M.5
Lee, H.6
Wistuba, I.I.7
Fong, K.M.8
Toyooka, S.9
Shimizu, N.10
-
75
-
-
0942287963
-
Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer
-
[CrossRef] [PubMed]
-
Gatzemeier, U.; Groth, G.; Butts, C.; van Zandwijk, N.; Shepherd, F.; Ardizzoni, A.; Barton, C.; Ghahramani, P.; Hirsh, V. Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann. Oncol. 2004, 15, 19-27. [CrossRef] [PubMed]
-
(2004)
Ann. Oncol
, vol.15
, pp. 19-27
-
-
Gatzemeier, U.1
Groth, G.2
Butts, C.3
Van Zandwijk, N.4
Shepherd, F.5
Ardizzoni, A.6
Barton, C.7
Ghahramani, P.8
Hirsh, V.9
-
76
-
-
12144290704
-
Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: Report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing d
-
[CrossRef] [PubMed]
-
Zinner, R.G.; Glisson, B.S.; Fossella, F.V.; Pisters, K.M.W.; Kies, M.S.; Lee, P.M.; Massarelli, E.; Sabloff, B.; Fritsche, H.A.; Ro, J.Y. et al. Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: Report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing d. Lung Cancer 2004, 44, 99-110. [CrossRef] [PubMed]
-
(2004)
Lung Cancer
, vol.44
, pp. 99-110
-
-
Zinner, R.G.1
Glisson, B.S.2
Fossella, F.V.3
Pisters, K.4
Kies, M.S.5
Lee, P.M.6
Massarelli, E.7
Sabloff, B.8
Fritsche, H.A.9
Ro, J.Y.10
-
77
-
-
77949694139
-
Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Ross, H.J.; Blumenschein, G.R.; Aisner, J.; Damjanov, N.; Dowlati, A.; Garst, J.; Rigas, J.R.; Smylie, M.; Hassani, H.; Allen, K.E. et al. Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer. Clin. Cancer Res. 2010, 16, 1938-1949. [CrossRef] [PubMed]
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 1938-1949
-
-
Ross, H.J.1
Blumenschein, G.R.2
Aisner, J.3
Damjanov, N.4
Dowlati, A.5
Garst, J.6
Rigas, J.R.7
Smylie, M.8
Hassani, H.9
Allen, K.E.10
-
78
-
-
84880661427
-
Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives
-
[CrossRef] [PubMed]
-
Mazières, J.; Peters, S.; Lepage, B.; Cortot, A.B.; Barlesi, F.; Beau-Faller, M.; Besse, B.; Blons, H.; Mansuet-Lupo, A.; Urban, T. et al. Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives. J. Clin. Oncol. 2013, 31, 1997-2003. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 1997-2003
-
-
Mazières, J.1
Peters, S.2
Lepage, B.3
Cortot, A.B.4
Barlesi, F.5
Beau-Faller, M.6
Besse, B.7
Blons, H.8
Mansuet-Lupo, A.9
Urban, T.10
-
79
-
-
84858002759
-
Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
-
[CrossRef] [PubMed]
-
De Grève, J.; Teugels, E.; Geers, C.; Decoster, L.; Galdermans, D.; de Mey, J.; Everaert, H.; Umelo, I.; In’t Veld, P.; Schallier, D. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer 2012, 76, 123-127. [CrossRef] [PubMed]
-
(2012)
Lung Cancer
, vol.76
, pp. 123-127
-
-
De Grève, J.1
Teugels, E.2
Geers, C.3
Decoster, L.4
Galdermans, D.5
De Mey, J.6
Everaert, H.7
Umelo, I.8
In’tveld, P.9
Schallier, D.10
-
80
-
-
84894807977
-
Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors
-
[CrossRef] [PubMed]
-
Gandhi, L.; Bahleda, R.; Tolaney, S.M.; Kwak, E.L.; Cleary, J.M.; Pandya, S.S.; Hollebecque, A.; Abbas, R.; Ananthakrishnan, R.; Berkenblit, A. et al. Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors. J. Clin. Oncol. 2013, 32, 68-75. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.32
, pp. 68-75
-
-
Gandhi, L.1
Bahleda, R.2
Tolaney, S.M.3
Kwak, E.L.4
Cleary, J.M.5
Pandya, S.S.6
Hollebecque, A.7
Abbas, R.8
Ananthakrishnan, R.9
Berkenblit, A.10
-
81
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
[CrossRef] [PubMed]
-
Onozato, R.; Kosaka, T.; Kuwano, H.; Sekido, Y.; Yatabe, Y.; Mitsudomi, T. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J. Thorac. Oncol. 2009, 4, 5-11. [CrossRef] [PubMed]
-
(2009)
J. Thorac. Oncol
, vol.4
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
Sekido, Y.4
Yatabe, Y.5
Mitsudomi, T.6
-
82
-
-
84868309107
-
The transcriptional landscape and mutational profile of lung adenocarcinoma
-
[CrossRef] [PubMed]
-
Seo, J.-S.; Ju, Y.S.; Lee, W.-C.; Shin, J.-Y.; Lee, J.K.; Bleazard, T.; Lee, J.; Jung, Y.J.; Kim, J.-O.; Shin, J.-Y. et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res. 2012, 22, 2109-2119. [CrossRef] [PubMed]
-
(2012)
Genome Res
, vol.22
, pp. 2109-2119
-
-
Seo, J.-S.1
Ju, Y.S.2
Lee, W.-C.3
Shin, J.-Y.4
Lee, J.K.5
Bleazard, T.6
Lee, J.7
Jung, Y.J.8
Kim, J.-O.9
Shin, J.-Y.10
-
83
-
-
41749097250
-
MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort
-
[CrossRef] [PubMed]
-
Beau-Faller, M.; Ruppert, A.-M.; Voegeli, A.-C.; Neuville, A.; Meyer, N.; Guerin, E.; Legrain, M.; Mennecier, B.; Wihlm, J.-M.; Massard, G. et al. MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort. J. Thorac. Oncol. 2008, 3, 331-339. [CrossRef] [PubMed]
-
(2008)
J. Thorac. Oncol
, vol.3
, pp. 331-339
-
-
Beau-Faller, M.1
Ruppert, A.-M.2
Voegeli, A.-C.3
Neuville, A.4
Meyer, N.5
Guerin, E.6
Legrain, M.7
Mennecier, B.8
Wihlm, J.-M.9
Massard, G.10
-
84
-
-
63849163410
-
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
-
[CrossRef] [PubMed]
-
Cappuzzo, F.; Marchetti, A.; Skokan, M.; Rossi, E.; Gajapathy, S.; Felicioni, L.; Del Grammastro, M.; Sciarrotta, M.G.; Buttitta, F.; Incarbone, M. et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J. Clin. Oncol. 2009, 27, 1667-1674. [CrossRef] [PubMed]
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 1667-1674
-
-
Cappuzzo, F.1
Marchetti, A.2
Skokan, M.3
Rossi, E.4
Gajapathy, S.5
Felicioni, L.6
Del Grammastro, M.7
Sciarrotta, M.G.8
Buttitta, F.9
Incarbone, M.10
-
85
-
-
0031667559
-
Differential expression of Met/hepatocyte growth factor receptor in subtypes of non-small cell lung cancers
-
[CrossRef] [PubMed]
-
Tsao, M.S.; Liu, N.; Chen, J.R.; Pappas, J.; Ho, J.; To, C.; Viallet, J.; Park, M.; Zhu, H. Differential expression of Met/hepatocyte growth factor receptor in subtypes of non-small cell lung cancers. Lung Cancer 1998, 20, 1-16. [CrossRef] [PubMed]
-
(1998)
Lung Cancer
, vol.20
, pp. 1-16
-
-
Tsao, M.S.1
Liu, N.2
Chen, J.R.3
Pappas, J.4
Ho, J.5
To, C.6
Viallet, J.7
Park, M.8
Zhu, H.9
-
86
-
-
0029803612
-
Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance
-
[CrossRef] [PubMed]
-
Ichimura, E.; Maeshima, A.; Nakajima, T.; Nakamura, T. Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. Jpn. J. Cancer Res. 1996, 87, 1063-1069. [CrossRef] [PubMed]
-
(1996)
Jpn. J. Cancer Res
, vol.87
, pp. 1063-1069
-
-
Ichimura, E.1
Maeshima, A.2
Nakajima, T.3
Nakamura, T.4
-
87
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
[CrossRef] [PubMed]
-
Engelman, J.A.; Zejnullahu, K.; Mitsudomi, T.; Song, Y.; Hyland, C.; Park, J.O.; Lindeman, N.; Gale, C.-M.M.; Zhao, X.; Christensen, J. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316, 1039-1043. [CrossRef] [PubMed]
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.-M.M.8
Zhao, X.9
Christensen, J.10
-
88
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
[CrossRef] [PubMed]
-
Bean, J.; Brennan, C.; Shih, J.-Y.; Riely, G.; Viale, A.; Wang, L.; Chitale, D.; Motoi, N.; Szoke, J.; Broderick, S. et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl. Acad. Sci. USA 2007, 104, 20932-20937. [CrossRef] [PubMed]
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.-Y.3
Riely, G.4
Viale, A.5
Wang, L.6
Chitale, D.7
Motoi, N.8
Szoke, J.9
Broderick, S.10
-
89
-
-
84890108571
-
Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
-
[CrossRef]
-
Spigel, D.R.; Ervin, T.J.; Ramlau, R.A.; Daniel, D.B.; Goldschmidt, J.H., Jr.; Blumenschein, G.R., Jr.; Krzakowski, M.J.; Robinet, G.; Godbert, B.; Barlesi, F. et al. Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 2013. [CrossRef]
-
(2013)
J. Clin. Oncol
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.A.3
Daniel, D.B.4
Goldschmidt, J.H.5
Blumenschein, G.R.6
Krzakowski, M.J.7
Robinet, G.8
Godbert, B.9
Barlesi, F.10
-
90
-
-
84904679830
-
Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global trial
-
[CrossRef]
-
Spigel, D.R.; Edelman, M.J.; O’Byrne, K.; Paz-Ares, L.; Shames, D.S.; Yu, W.; Paton, V.E.; Mok, T.; Sarah Cannon Research Institute; Nashville, T.N. et al. Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global trial. J. Clin. Oncol. 2014, 32, 8000. [CrossRef]
-
(2014)
J. Clin. Oncol
, vol.32
, pp. 8000
-
-
Spigel, D.R.1
Edelman, M.J.2
O’byrne, K.3
Paz-Ares, L.4
Shames, D.S.5
Yu, W.6
Paton, V.E.7
Mok, T.8
Nashville, T.N.9
Sarah Cannon Research Institute10
-
91
-
-
84904542906
-
Phase I ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma
-
[CrossRef] [PubMed]
-
Patnaik, A.; Weiss, G.J.; Papadopoulos, K.P.; Hofmeister, C.C.; Tibes, R.; Tolcher, A.; Isaacs, R.; Jac, J.; Han, M.; Payumo, F.C. et al. Phase I ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma. Br. J. Cancer 2014, 111, 272-280. [CrossRef] [PubMed]
-
(2014)
Br. J. Cancer
, vol.111
, pp. 272-280
-
-
Patnaik, A.1
Weiss, G.J.2
Papadopoulos, K.P.3
Hofmeister, C.C.4
Tibes, R.5
Tolcher, A.6
Isaacs, R.7
Jac, J.8
Han, M.9
Payumo, F.C.10
-
92
-
-
74549174584
-
Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors
-
[CrossRef] [PubMed]
-
Gordon, M.S.; Sweeney, C.S.; Mendelson, D.S.; Eckhardt, S.G.; Anderson, A.; Beaupre, D.M.; Branstetter, D.; Burgess, T.L.; Coxon, A.; Deng, H. et al. Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors. Clin. Cancer Res. 2010, 16, 699-710. [CrossRef] [PubMed]
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 699-710
-
-
Gordon, M.S.1
Sweeney, C.S.2
Mendelson, D.S.3
Eckhardt, S.G.4
Anderson, A.5
Beaupre, D.M.6
Branstetter, D.7
Burgess, T.L.8
Coxon, A.9
Deng, H.10
-
93
-
-
80051974548
-
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
-
[CrossRef] [PubMed]
-
Sequist, L.V.; von Pawel, J.; Garmey, E.G.; Akerley, W.L.; Brugger, W.; Ferrari, D.; Chen, Y.; Costa, D.B.; Gerber, D.E.; Orlov, S. et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J. Clin. Oncol. 2011, 29, 3307-3315. [CrossRef] [PubMed]
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 3307-3315
-
-
Sequist, L.V.1
Von Pawel, J.2
Garmey, E.G.3
Akerley, W.L.4
Brugger, W.5
Ferrari, D.6
Chen, Y.7
Costa, D.B.8
Gerber, D.E.9
Orlov, S.10
-
94
-
-
84899122597
-
MARQUEE: A randomized, double-blind, placebo-controlled, phase 3 trial of tivantinib (ARQ 197) plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, non-squamous, non-small-cell lung cancer (NSCLC)
-
Amsterdam, The Netherlands, 27 September-1 October
-
Scagliotti, G.; Novello, S.; Ramlau, R.; Favaretto, A.; Barlesi, F.; Akerley, W.; von Pawel, J.; Shuster, D.; Schwartz, B.; Sandler, A. MARQUEE: A randomized, double-blind, placebo-controlled, phase 3 trial of tivantinib (ARQ 197) plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, non-squamous, non-small-cell lung cancer (NSCLC). In Proceedings of the 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress 2013, Amsterdam, The Netherlands, 27 September-1 October 2013.
-
(2013)
Proceedings of the 17Th Ecco-38Th Esmo-32Nd ESTRO European Cancer Congress 2013
-
-
Scagliotti, G.1
Novello, S.2
Ramlau, R.3
Favaretto, A.4
Barlesi, F.5
Akerley, W.6
Von Pawel, J.7
Shuster, D.8
Schwartz, B.9
Sandler, A.10
-
95
-
-
84920424119
-
Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines
-
[CrossRef] [PubMed]
-
Calles, A.; Kwiatkowski, N.; Cammarata, B.K.; Ercan, D.; Gray, N.S.; Jänne, P.A. Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines. Mol. Oncol. 2015, 9, 260-269. [CrossRef] [PubMed]
-
(2015)
Mol. Oncol
, vol.9
, pp. 260-269
-
-
Calles, A.1
Kwiatkowski, N.2
Cammarata, B.K.3
Ercan, D.4
Gray, N.S.5
Jänne, P.A.6
-
96
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
[CrossRef] [PubMed]
-
Zou, H.Y.; Li, Q.; Lee, J.H.; Arango, M.E.; McDonnell, S.R.; Yamazaki, S.; Koudriakova, T.B.; Alton, G.; Cui, J.J.; Kung, P.P. et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007, 67, 4408-4417. [CrossRef] [PubMed]
-
(2007)
Cancer Res
, vol.67
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
Arango, M.E.4
McDonnell, S.R.5
Yamazaki, S.6
Koudriakova, T.B.7
Alton, G.8
Cui, J.J.9
Kung, P.P.10
-
97
-
-
79955458487
-
Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
-
[CrossRef] [PubMed]
-
Ou, S.H.; Kwak, E.L.; Siwak-Tapp, C.; Dy, J.; Bergethon, K.; Clark, J.W.; Camidge, D.R.; Solomon, B.J.; Maki, R.G.; Bang, Y.J. et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J. Thorac. Oncol. 2011, 6, 942-946. [CrossRef] [PubMed]
-
(2011)
J. Thorac. Oncol
, vol.6
, pp. 942-946
-
-
Ou, S.H.1
Kwak, E.L.2
Siwak-Tapp, C.3
Dy, J.4
Bergethon, K.5
Clark, J.W.6
Camidge, D.R.7
Solomon, B.J.8
Maki, R.G.9
Bang, Y.J.10
-
98
-
-
73149115248
-
Targeting the RET pathway in thyroid cancer
-
[CrossRef] [PubMed]
-
Wells, S.A., Jr.; Santoro, M. Targeting the RET pathway in thyroid cancer. Clin. Cancer Res. 2009, 15, 7119-7123. [CrossRef] [PubMed]
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 7119-7123
-
-
Wells, S.A.1
Santoro, M.2
-
99
-
-
9244255770
-
Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice
-
[PubMed]
-
Santoro, M.; Chiappetta, G.; Cerrato, A.; Salvatore, D.; Zhang, L.; Manzo, G.; Picone, A.; Portella, G.; Santelli, G.; Vecchio, G. et al. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice. Oncogene 1996, 12, 1821-1826. [PubMed]
-
(1996)
Oncogene
, vol.12
, pp. 1821-1826
-
-
Santoro, M.1
Chiappetta, G.2
Cerrato, A.3
Salvatore, D.4
Zhang, L.5
Manzo, G.6
Picone, A.7
Portella, G.8
Santelli, G.9
Vecchio, G.10
-
100
-
-
84870748688
-
RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
-
[CrossRef] [PubMed]
-
Wang, R.; Hu, H.; Pan, Y.; Li, Y.; Ye, T.; Li, C.; Luo, X.; Wang, L.; Li, H.; Zhang, Y. et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J. Clin. Oncol. 2012, 30, 4352-4359. [CrossRef] [PubMed]
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 4352-4359
-
-
Wang, R.1
Hu, H.2
Pan, Y.3
Li, Y.4
Ye, T.5
Li, C.6
Luo, X.7
Wang, L.8
Li, H.9
Zhang, Y.10
-
101
-
-
84880709088
-
RET rearrangements detected by FISH in “pan-negative” lung adenocarcinoma
-
Varella-Garcia, M.; Xu, L.G.; Mahale, S.; Berge, E.M.; Bennati, C.; Le, A.T.; Aisner, D.; Crinò, L.; Bunn, P.A.; Camidge, D.R. et al. RET rearrangements detected by FISH in “pan-negative” lung adenocarcinoma. J. Clin. Oncol. 2013, 31, 8024.
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Varella-Garcia, M.1
Xu, L.G.2
Mahale, S.3
Berge, E.M.4
Bennati, C.5
Le, A.T.6
Aisner, D.7
Crinò, L.8
Bunn, P.A.9
Camidge, D.R.10
-
102
-
-
84862776857
-
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
-
[CrossRef] [PubMed]
-
Lipson, D.; Capelletti, M.; Yelensky, R.; Otto, G.; Parker, A.; Jarosz, M.; Curran, J.A.; Balasubramanian, S.; Bloom, T.; Brennan, K.W. et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat. Med. 2012, 18, 382-384. [CrossRef] [PubMed]
-
(2012)
Nat. Med
, vol.18
, pp. 382-384
-
-
Lipson, D.1
Capelletti, M.2
Yelensky, R.3
Otto, G.4
Parker, A.5
Jarosz, M.6
Curran, J.A.7
Balasubramanian, S.8
Bloom, T.9
Brennan, K.W.10
-
103
-
-
84857929267
-
KIF5B-RET fusions in lung adenocarcinoma
-
[CrossRef] [PubMed]
-
Kohno, T.; Ichikawa, H.; Totoki, Y.; Yasuda, K.; Hiramoto, M.; Nammo, T.; Sakamoto, H.; Tsuta, K.; Furuta, K.; Shimada, Y. et al. KIF5B-RET fusions in lung adenocarcinoma. Nat. Med. 2012, 18, 375-377. [CrossRef] [PubMed]
-
(2012)
Nat. Med
, vol.18
, pp. 375-377
-
-
Kohno, T.1
Ichikawa, H.2
Totoki, Y.3
Yasuda, K.4
Hiramoto, M.5
Nammo, T.6
Sakamoto, H.7
Tsuta, K.8
Furuta, K.9
Shimada, Y.10
-
104
-
-
84878858856
-
Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas
-
[CrossRef] [PubMed]
-
Drilon, A.; Wang, L.; Hasanovic, A.; Suehara, Y.; Lipson, D.; Stephens, P.; Ross, J.; Miller, V.; Ginsberg, M.; Zakowski, M.F. et al. Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer Discov. 2013, 3, 630-635. [CrossRef] [PubMed]
-
(2013)
Cancer Discov
, vol.3
, pp. 630-635
-
-
Drilon, A.1
Wang, L.2
Hasanovic, A.3
Suehara, Y.4
Lipson, D.5
Stephens, P.6
Ross, J.7
Miller, V.8
Ginsberg, M.9
Zakowski, M.F.10
-
105
-
-
84880749878
-
Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo
-
[CrossRef] [PubMed]
-
Suzuki, M.; Makinoshima, H.; Matsumoto, S.; Suzuki, A.; Mimaki, S.; Matsushima, K.; Yoh, K.; Goto, K.; Suzuki, Y.; Ishii, G. et al. Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo. Cancer Sci. 2013, 104, 896-903. [CrossRef] [PubMed]
-
(2013)
Cancer Sci
, vol.104
, pp. 896-903
-
-
Suzuki, M.1
Makinoshima, H.2
Matsumoto, S.3
Suzuki, A.4
Mimaki, S.5
Matsushima, K.6
Yoh, K.7
Goto, K.8
Suzuki, Y.9
Ishii, G.10
-
106
-
-
84918504885
-
Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Kodama, T.; Tsukaguchi, T.; Satoh, Y.; Yoshida, M.; Watanabe, Y.; Kondoh, O.; Sakamoto, H. Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer. Mol. Cancer Ther. 2014, 13, 2910-2918. [CrossRef] [PubMed]
-
(2014)
Mol. Cancer Ther
, vol.13
, pp. 2910-2918
-
-
Kodama, T.1
Tsukaguchi, T.2
Satoh, Y.3
Yoshida, M.4
Watanabe, Y.5
Kondoh, O.6
Sakamoto, H.7
-
107
-
-
84925876884
-
Effect of the RET inhibitor vandetanib in a patient with RET fusion-positive metastatic non-small-cell lung cancer
-
[CrossRef]
-
Falchook, G.S.; Ordóñez, N.G.; Bastida, C.C.; Stephens, P.J.; Miller, V.A.; Gaido, L.; Jackson, T.; Karp, D.D. Effect of the RET inhibitor vandetanib in a patient with RET fusion-positive metastatic non-small-cell lung cancer. J. Clin. Oncol. 2014. [CrossRef]
-
(2014)
J. Clin. Oncol
-
-
Falchook, G.S.1
Ordóñez, N.G.2
Bastida, C.C.3
Stephens, P.J.4
Miller, V.A.5
Gaido, L.6
Jackson, T.7
Karp, D.D.8
-
108
-
-
84876383602
-
A patient with lung adenocarcinoma and RET fusion treated with vandetanib
-
[CrossRef] [PubMed]
-
Gautschi, O.; Zander, T.; Keller, F.A.; Strobel, K.; Hirschmann, A.; Aebi, S.; Diebold, J. A patient with lung adenocarcinoma and RET fusion treated with vandetanib. J. Thorac. Oncol. 2013, 8, e43-e44. [CrossRef] [PubMed]
-
(2013)
J. Thorac. Oncol
, vol.8
-
-
Gautschi, O.1
Zander, T.2
Keller, F.A.3
Strobel, K.4
Hirschmann, A.5
Aebi, S.6
Diebold, J.7
-
109
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
[CrossRef] [PubMed]
-
Kawano, O.; Sasaki, H.; Endo, K.; Suzuki, E.; Haneda, H.; Yukiue, H.; Kobayashi, Y.; Yano, M.; Fujii, Y. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 2006, 54, 209-215. [CrossRef] [PubMed]
-
(2006)
Lung Cancer
, vol.54
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
Suzuki, E.4
Haneda, H.5
Yukiue, H.6
Kobayashi, Y.7
Yano, M.8
Fujii, Y.9
-
110
-
-
34548485621
-
PIK3CA gene amplification in Japanese non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Kawano, O.; Sasaki, H.; Okuda, K.; Yukiue, H.; Yokoyama, T.; Yano, M.; Fujii, Y. PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer 2007, 58, 159-160. [CrossRef] [PubMed]
-
(2007)
Lung Cancer
, vol.58
, pp. 159-160
-
-
Kawano, O.1
Sasaki, H.2
Okuda, K.3
Yukiue, H.4
Yokoyama, T.5
Yano, M.6
Fujii, Y.7
-
111
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
The Cancer Genome Atlas Research Network, [CrossRef] [PubMed]
-
The Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012, 489, 519-525. [CrossRef] [PubMed]
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
112
-
-
84856823963
-
Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling
-
[CrossRef] [PubMed]
-
Chaft, J.E.; Arcila, M.E.; Paik, P.K.; Lau, C.; Riely, G.J.; Pietanza, M.C.; Zakowski, M.F.; Rusch, V.; Sima, C.S.; Ladanyi, M. et al. Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling. Mol. Cancer Ther. 2012, 11, 485-491. [CrossRef] [PubMed]
-
(2012)
Mol. Cancer Ther
, vol.11
, pp. 485-491
-
-
Chaft, J.E.1
Arcila, M.E.2
Paik, P.K.3
Lau, C.4
Riely, G.J.5
Pietanza, M.C.6
Zakowski, M.F.7
Rusch, V.8
Sima, C.S.9
Ladanyi, M.10
-
113
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
[CrossRef] [PubMed]
-
Sequist, L.V.; Waltman, B.A.; Dias-Santagata, D.; Digumarthy, S.; Turke, A.B.; Fidias, P.; Bergethon, K.; Shaw, A.T.; Gettinger, S.; Cosper, A.K. et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 2011, 3, 75ra26. [CrossRef] [PubMed]
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
Digumarthy, S.4
Turke, A.B.5
Fidias, P.6
Bergethon, K.7
Shaw, A.T.8
Gettinger, S.9
Cosper, A.K.10
-
114
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
[CrossRef] [PubMed]
-
Engelman, J.A.; Chen, L.; Tan, X.; Crosby, K.; Guimaraes, A.R.; Upadhyay, R.; Maira, M.; McNamara, K.; Perera, S.A.; Song, Y. et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat. Med. 2008, 14, 1351-1356. [CrossRef] [PubMed]
-
(2008)
Nat. Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
Maira, M.7
McNamara, K.8
Perera, S.A.9
Song, Y.10
-
115
-
-
79958112619
-
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
-
[CrossRef] [PubMed]
-
Dutt, A.; Ramos, A.H.; Hammerman, P.S.; Mermel, C.; Cho, J.; Sharifnia, T.; Chande, A.; Tanaka, K.E.; Stransky, N.; Greulich, H. et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS ONE 2011, 6, e20351. [CrossRef] [PubMed]
-
(2011)
Plos ONE
, vol.6
-
-
Dutt, A.1
Ramos, A.H.2
Hammerman, P.S.3
Mermel, C.4
Cho, J.5
Sharifnia, T.6
Chande, A.7
Tanaka, K.E.8
Stransky, N.9
Greulich, H.10
-
116
-
-
78650451788
-
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
-
[CrossRef] [PubMed]
-
Weiss, J.; Sos, M.L.; Seidel, D.; Peifer, M.; Zander, T.; Heuckmann, J.M.; Ullrich, R.T.; Menon, R.; Maier, S.; Soltermann, A. et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci. Transl. Med. 2010, 2, 62ra93. [CrossRef] [PubMed]
-
(2010)
Sci. Transl. Med
, vol.2
-
-
Weiss, J.1
Sos, M.L.2
Seidel, D.3
Peifer, M.4
Zander, T.5
Heuckmann, J.M.6
Ullrich, R.T.7
Menon, R.8
Maier, S.9
Soltermann, A.10
-
117
-
-
84874888512
-
Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer
-
[CrossRef] [PubMed]
-
Kim, H.R.; Kim, D.J.; Kang, D.R.; Lee, J.G.; Lim, S.M.; Lee, C.Y.; Rha, S.Y.; Bae, M.K.; Lee, Y.J.; Kim, S.H. et al. Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. J. Clin. Oncol. 2013, 31, 731-737. [CrossRef] [PubMed]
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 731-737
-
-
Kim, H.R.1
Kim, D.J.2
Kang, D.R.3
Lee, J.G.4
Lim, S.M.5
Lee, C.Y.6
Rha, S.Y.7
Bae, M.K.8
Lee, Y.J.9
Kim, S.H.10
-
118
-
-
84870336531
-
FGFR1 amplification in squamous cell carcinoma of the lung
-
[CrossRef] [PubMed]
-
Heist, R.S.; Mino-Kenudson, M.; Sequist, L.V.; Tammireddy, S.; Morrissey, L.; Christiani, D.C.; Engelman, J.A.; Iafrate, A.J. FGFR1 amplification in squamous cell carcinoma of the lung. J. Thorac. Oncol. 2012, 7, 1775-1780. [CrossRef] [PubMed]
-
(2012)
J. Thorac. Oncol
, vol.7
, pp. 1775-1780
-
-
Heist, R.S.1
Mino-Kenudson, M.2
Sequist, L.V.3
Tammireddy, S.4
Morrissey, L.5
Christiani, D.C.6
Engelman, J.A.7
Iafrate, A.J.8
-
119
-
-
84882709305
-
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma
-
[CrossRef] [PubMed]
-
Liao, R.G.; Jung, J.; Tchaicha, J.; Wilkerson, M.D.; Sivachenko, A.; Beauchamp, E.M.; Liu, Q.; Pugh, T.J.; Pedamallu, C.S.; Hayes, D.N. et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 2013, 73, 5195-5205. [CrossRef] [PubMed]
-
(2013)
Cancer Res
, vol.73
, pp. 5195-5205
-
-
Liao, R.G.1
Jung, J.2
Tchaicha, J.3
Wilkerson, M.D.4
Sivachenko, A.5
Beauchamp, E.M.6
Liu, Q.7
Pugh, T.J.8
Pedamallu, C.S.9
Hayes, D.N.10
-
120
-
-
0032921366
-
Discoidin domain receptors: Structural relations and functional implications
-
[PubMed]
-
Vogel, W. Discoidin domain receptors: structural relations and functional implications. FASEB J. 1999, 13, S77-S82. [PubMed]
-
(1999)
FASEB J
, vol.13
-
-
Vogel, W.1
-
121
-
-
84866709500
-
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
-
[CrossRef] [PubMed]
-
Hammerman, P.S.; Sos, M.L.; Ramos, A.H.; Xu, C.; Dutt, A.; Zhou, W.; Brace, L.E.; Woods, B.A.; Lin, W.; Zhang, J. et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011, 1, 78-89. [CrossRef] [PubMed]
-
(2011)
Cancer Discov
, vol.1
, pp. 78-89
-
-
Hammerman, P.S.1
Sos, M.L.2
Ramos, A.H.3
Xu, C.4
Dutt, A.5
Zhou, W.6
Brace, L.E.7
Woods, B.A.8
Lin, W.9
Zhang, J.10
-
122
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
[CrossRef] [PubMed]
-
Marks, J.L.; Gong, Y.; Chitale, D.; Golas, B.; McLellan, M.D.; Kasai, Y.; Ding, L.; Mardis, E.R.; Wilson, R.K.; Solit, D. et al. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res. 2008, 68, 5524-5528. [CrossRef] [PubMed]
-
(2008)
Cancer Res
, vol.68
, pp. 5524-5528
-
-
Marks, J.L.1
Gong, Y.2
Chitale, D.3
Golas, B.4
McLellan, M.D.5
Kasai, Y.6
Ding, L.7
Mardis, E.R.8
Wilson, R.K.9
Solit, D.10
-
123
-
-
84887445619
-
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
-
[CrossRef] [PubMed]
-
Vaishnavi, A.; Capelletti, M.; Le, A.T.; Kako, S.; Butaney, M.; Ercan, D.; Mahale, S.; Davies, K.D.; Aisner, D.L.; Pilling, A.B. et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat. Med. 2013, 19, 1469-1472. [CrossRef] [PubMed]
-
(2013)
Nat. Med
, vol.19
, pp. 1469-1472
-
-
Vaishnavi, A.1
Capelletti, M.2
Le, A.T.3
Kako, S.4
Butaney, M.5
Ercan, D.6
Mahale, S.7
Davies, K.D.8
Aisner, D.L.9
Pilling, A.B.10
-
124
-
-
84915784462
-
Phase 1 open label, dose escalation study of RXDX101, an oral pan-trk, ROS1, and ALK inhibitor, in patients with advanced solid tumors with relevant molecular alterations
-
De Braud, F.G.; Pilla, L.; Niger, M.; Damian, S.; Bardazza, B.; Martinetti, A.; Pelosi, G.; Marrapese, G.; Palmeri, L.; Cerea, G. et al. Phase 1 open label, dose escalation study of RXDX101, an oral pan-trk, ROS1, and ALK inhibitor, in patients with advanced solid tumors with relevant molecular alterations. J. Clin. Oncol. 2014, 32, 2502.
-
(2014)
J. Clin. Oncol
, vol.2014
, pp. 2502
-
-
De Braud, F.G.1
Pilla, L.2
Niger, M.3
Damian, S.4
Bardazza, B.5
Martinetti, A.6
Pelosi, G.7
Marrapese, G.8
Palmeri, L.9
Cerea, G.10
-
125
-
-
31344479312
-
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
-
[CrossRef] [PubMed]
-
Tang, J.-M.; He, Q.-Y.; Guo, R.-X.; Chang, X.-J. Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer 2006, 51, 181-191. [CrossRef] [PubMed]
-
(2006)
Lung Cancer
, vol.51
, pp. 181-191
-
-
Tang, J.-M.1
He, Q.-Y.2
Guo, R.-X.3
Chang, X.-J.4
-
126
-
-
77955092315
-
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
-
[CrossRef] [PubMed]
-
Jin, G.; Kim, M.J.; Jeon, H.-S.; Choi, J.E.; Kim, D.S.; Lee, E.B.; Cha, S.I.; Yoon, G.S.; Kim, C.H.; Jung, T.H. et al. PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers. Lung Cancer 2010, 69, 279-283. [CrossRef] [PubMed]
-
(2010)
Lung Cancer
, vol.69
, pp. 279-283
-
-
Jin, G.1
Kim, M.J.2
Jeon, H.-S.3
Choi, J.E.4
Kim, D.S.5
Lee, E.B.6
Cha, S.I.7
Yoon, G.S.8
Kim, C.H.9
Jung, T.H.10
-
127
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
[CrossRef] [PubMed]
-
Ding, L.; Getz, G.; Wheeler, D.A.; Mardis, E.R.; McLellan, M.D.; Cibulskis, K.; Sougnez, C.; Greulich, H.; Muzny, D.M.; Morgan, M.B. et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008, 455, 1069-1075. [CrossRef] [PubMed]
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
Cibulskis, K.6
Sougnez, C.7
Greulich, H.8
Muzny, D.M.9
Morgan, M.B.10
-
128
-
-
84873529736
-
A high-dimensional, deep-sequencing study of lung adenocarcinoma in female never-smokers
-
[CrossRef] [PubMed]
-
Kim, S.C.; Jung, Y.; Park, J.; Cho, S.; Seo, C.; Kim, J.; Kim, P.; Park, J.; Seo, J.; Kim, J. et al. A high-dimensional, deep-sequencing study of lung adenocarcinoma in female never-smokers. PLoS ONE 2013, 8, e55596. [CrossRef] [PubMed]
-
(2013)
Plos ONE
, vol.8
-
-
Kim, S.C.1
Jung, Y.2
Park, J.3
Cho, S.4
Seo, C.5
Kim, J.6
Kim, P.7
Park, J.8
Seo, J.9
Kim, J.10
-
129
-
-
84890046280
-
A genomics-based classification of human lung tumors
-
The Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM), [PubMed]
-
The Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM). A genomics-based classification of human lung tumors. Sci. Transl. Med. 2013, 5, 209ra153. [PubMed]
-
(2013)
Sci. Transl. Med
, vol.5
-
-
-
131
-
-
84927154472
-
Basket trials and the evolution of clinical trial design in an era of genomic medicine
-
[CrossRef]
-
Redig, A.J.; Jänne, P.A. Basket trials and the evolution of clinical trial design in an era of genomic medicine. J. Clin. Oncol. 2015. [CrossRef]
-
(2015)
J. Clin. Oncol
-
-
Redig, A.J.1
Jänne, P.A.2
-
132
-
-
84927164071
-
Molecular profiling and targeted therapy for advanced thoracic malignancies: A Biomarker-derived, multiarm, multihistology phase II basket trial
-
[CrossRef] [PubMed]
-
Lopez-Chavez, A.; Thomas, A.; Rajan, A.; Raffeld, M.; Morrow, B.; Kelly, R.; Carter, C.A.; Guha, U.; Killian, K.; Lau, C.C. et al. Molecular profiling and targeted therapy for advanced thoracic malignancies: A Biomarker-derived, multiarm, multihistology phase II basket trial. J. Clin. Oncol. 2015, 33, 1000-1007. [CrossRef] [PubMed]
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 1000-1007
-
-
Lopez-Chavez, A.1
Thomas, A.2
Rajan, A.3
Raffeld, M.4
Morrow, B.5
Kelly, R.6
Carter, C.A.7
Guha, U.8
Killian, K.9
Lau, C.C.10
|