PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling

Journal of Bone and Mineral Research

Volumn 30, Issue 11, 2015, Pages 1959-1968

  Esen, Emel ^a   Lee, Seung Yon ^a   Wice, Burton M ^a   Long, Fanxin ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AEROBIC GLYCOLYSIS; BONE ANABOLISM; IGF; PARATHYROID HORMONE; PTH

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; FORSKOLIN; GLUCOSE; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; OXYGEN; PARATHYROID HORMONE[1-34]; SOMATOMEDIN; TRICARBOXYLIC ACID; CARBON; CARBON DIOXIDE; CYCLIC AMP; IMMEDIATE EARLY PROTEIN; MULTIPROTEIN COMPLEX; PARATHYROID HORMONE; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

AEROBIC GLYCOLYSIS; AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE METABOLISM; BONE MINERALIZATION; CELL LINEAGE; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG MECHANISM; GLUCOSE INTAKE; GLYCOLYSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR MODEL; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; SIGNAL TRANSDUCTION; WARBURG EFFECT; WILD TYPE; ANIMAL; BONE; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DIAGNOSTIC IMAGING; DRUG EFFECTS; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; TIBIA;

AEROBIOSIS; ANIMALS; ANIMALS, NEWBORN; BONE AND BONES; CARBON DIOXIDE; CARBON ISOTOPES; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CYCLIC AMP; GLUCOSE; GLYCOLYSIS; IMMEDIATE-EARLY PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; OSTEOBLASTS; PARATHYROID HORMONE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TIBIA; TOR SERINE-THREONINE KINASES; X-RAY MICROTOMOGRAPHY;

EID: 84944722257     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2556     Document Type: Article

References (34)

1. Hodsman AB, Bauer DC, Dempster DW, et al., Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr Rev. 2005; 26 (5): 688-703.
2. Jilka RL., Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007; 40 (6): 1434-46.
3. Bellido T, Ali AA, Plotkin LI, et al., Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003; 278 (50): 50259-72.
4. Kim SW, Pajevic PD, Selig M, et al., Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts. J Bone Miner Res. 2012; 27 (10): 2075-84.
5. Dobnig H, Turner RT., Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology. 1995; 136 (8): 3632-8.
6. Potts JT., Parathyroid hormone: past and present. J Endocrinol. 2005; 187 (3): 311-25.
7. Gesty-Palmer D, Chen M, Reiter E, et al., Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem. 2006; 281 (16): 10856-64.
8. Li X, Liu H, Qin L, et al., Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem. 2007; 282 (45): 33086-97.
9. Wan M, Yang C, Li J, et al., Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev. 2008; 22 (21): 2968-79.
10. Wan M, Li J, Herbst K, et al., LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Galpha(s). Sci Signal. 2011; 4 (164): ra15.
11. Qiu T, Wu X, Zhang F, Clemens TL, Wan M, Cao X., TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling. Nat Cell Biol. 2010; 12 (3): 224-34.
12. McCarthy TL, Centrella M, Canalis E., Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology. 1989; 124 (3): 1247-53.
13. Linkhart TA, Mohan S., Parathyroid hormone stimulates release of insulin-like growth factor-I (IGF-I) and IGF-II from neonatal mouse calvaria in organ culture. Endocrinology. 1989; 125 (3): 1484-91.
14. McCarthy TL, Centrella M, Canalis E., Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures. J Biol Chem. 1990; 265 (26): 15353-6.
15. Bikle DD, Sakata T, Leary C, et al., Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res. 2002; 17 (9): 1570-8.
16. Miyakoshi N, Kasukawa Y, Linkhart TA, Baylink DJ, Mohan S., Evidence that anabolic effects of PTH on bone require IGF-I in growing mice. Endocrinology. 2001; 142 (10): 4349-56.
17. Wang Y, Nishida S, Boudignon BM, et al., IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007; 22 (9): 1329-37.
18. Esen E, Long F., Aerobic glycolysis in osteoblasts. Curr Osteoporos Rep. 2014; 12 (4): 433-8.
19. Regan JN, Lim J, Shi Y, et al., Up-regulation of glycolytic metabolism is required for HIF1alpha-driven bone formation. Proc Natl Acad Sci U S A. 2014; 111 (23): 8673-8.
20. Esen E, Chen J, Karner CM, Okunade AL, Patterson BW, Long F., WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab. 2013; 17 (5): 745-55.
21. Borle AB, Nichols N, Nichols G Jr., Metabolic studies of bone in vitro. II. The metabolic patterns of accretion and resorption. J Biol Chem. 1960; 235: 1211-4.
22. Neuman WF, Neuman MW, Brommage R., Aerobic glycolysis in bone: lactate production and gradients in calvaria. Am J Physiol. 1978; 234 (1): C41-50.
23. Rodan GA, Rodan SB, Marks SC Jr., Parathyroid hormone stimulation of adenylate cyclase activity and lactic acid accumulation in calvaria of osteopetrotic (ia) rats. Endocrinology. 1978; 102 (5): 1501-5.
24. Long F, Joeng KS, Xuan S, Efstratiadis A, McMahon AP., Independent regulation of skeletal growth by Ihh and IGF signaling. Dev Biol. 2006; 298 (1): 327-33.
25. Chen J, Long F., beta-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice. J Bone Miner Res. 2013; 28 (5): 1160-9.
26. Chen J, Holguin N, Shi Y, Silva MJ, Long F., mTORC2 signaling promotes skeletal growth and bone formation in mice. J Bone Miner Res. 2015 Feb; 30 (2): 369-78.
27. Reitzer LJ, Wice BM, Kennell D., Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem. 1979; 254 (8): 2669-76.
28. McCauley LK, Koh AJ, Beecher CA, Cui Y, Rosol TJ, Franceschi RT., PTH/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis. J Cell Biochem. 1996; 61 (4): 638-47.
29. Tahimic CG, Wang Y, Bikle DD., Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol. 2013; 4: 6.
30. Hernandez-Sanchez C, Blakesley V, Kalebic T, Helman L, LeRoith D., The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis. J Biol Chem. 1995; 270 (49): 29176-81.
31. Garcia-Martinez JM, Alessi DR,. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J. 2008; 416 (3): 375-85.
32. Pfeilschifter J, Laukhuf F, Muller-Beckmann B, Blum WF, Pfister T, Ziegler R., Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. J Clin Invest. 1995; 96 (2): 767-74.
33. Xian L, Wu X, Pang L, et al., Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012; 18 (7): 1095-101.
34. Karner CM, Esen E, Okunade AL, Patterson BW, Long F., Increased glutamine catabolism mediates bone anabolism in response to Wnt signaling. J Clin Invest. 2015 Feb; 125 (2): 551-62.