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Volumn 19, Issue 12, 2017, Pages

Review of Cardiometabolic Effects of Prescription Omega-3 Fatty Acids

Author keywords

Alpha linolenic acid (ALA); Dietary supplement; Docosahexaenoic acid (DHA); Eicosapentaenoic acid (EPA); Ethyl ester (EE); Fatty acid (FA); Free FA (FFA); Linoleic acid (LA); Omega 3 FA (n 3FA); Triglycerides (TG)

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL; CORN OIL; DOCOSAPENTAENOIC ACID; FISH OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID ETHYL ESTER; LINOLEIC ACID; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; OMEGA 3 ACID ETHYL ESTER; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PLACEBO; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL;

EID: 85033502141     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-017-0700-z     Document Type: Review
Times cited : (30)

References (98)
  • 1
    • 79961054708 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events
    • COI: 1:CAS:528:DC%2BC3MXhs1eju7zE, PID: 22051327
    • Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011;58(20):2047–67. https://doi.org/10.1016/j.jacc.2011.06.063.
    • (2011) J Am Coll Cardiol , vol.58 , Issue.20 , pp. 2047-2067
    • Mozaffarian, D.1    Wu, J.H.2
  • 2
    • 84891710897 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: new developments and applications
    • PID: 24200766
    • Harris WS, Dayspring TD, Moran TJ. Omega-3 fatty acids and cardiovascular disease: new developments and applications. Postgrad Med. 2013;125(6):100–13. https://doi.org/10.3810/pgm.2013.11.2717.
    • (2013) Postgrad Med , vol.125 , Issue.6 , pp. 100-113
    • Harris, W.S.1    Dayspring, T.D.2    Moran, T.J.3
  • 4
    • 76349121984 scopus 로고    scopus 로고
    • Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's Strategic Impact Goal through 2020 and beyond
    • PID: 20089546
    • Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's Strategic Impact Goal through 2020 and beyond. Circulation. 2010;121:586–613. https://doi.org/10.1161/CIRCULATIONAHA.109.192703.
    • (2010) Circulation , vol.121 , pp. 586-613
    • Lloyd-Jones, D.M.1    Hong, Y.2    Labarthe, D.3    Mozaffarian, D.4    Appel, L.J.5    Van Horn, L.6
  • 5
    • 84922817862 scopus 로고    scopus 로고
    • Trends in the use of complementary health approaches among adults: United States, 2002–2012. National Health Statistics reports; no 79. Hyattsville, MD
    • Accessed August 5, 2017
    • Clark TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002–2012. National Health Statistics reports; no 79. Hyattsville, MD: National Center for Health Statistics. 2015. Available at https://nccih.nih.gov/research/statistics/NHIS/2012/natural-products/omega3. Accessed August 5, 2017.
    • (2015) National Center for Health Statistics
    • Clark, T.C.1    Black, L.I.2    Stussman, B.J.3    Barnes, P.M.4    Nahin, R.L.5
  • 6
    • 84978832830 scopus 로고    scopus 로고
    • The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
    • PID: 27444154
    • Backes J, Anzalone D, Hilleman D, Catini J. The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia. Lipids Health Dis. 2016;15:118–29. https://doi.org/10.1186/s12944-016-0286-4.
    • (2016) Lipids Health Dis , vol.15 , pp. 118-129
    • Backes, J.1    Anzalone, D.2    Hilleman, D.3    Catini, J.4
  • 7
    • 84955182988 scopus 로고    scopus 로고
    • History and future of omega-3 fatty acids in cardiovascular disease
    • COI: 1:CAS:528:DC%2BC2MXhvFOqsrjP, PID: 26566071
    • Sperling LS, Nelson JR. History and future of omega-3 fatty acids in cardiovascular disease. Curr Med Res Opin. 2016;32:301–11. https://doi.org/10.1185/03007995.2015.1120190.
    • (2016) Curr Med Res Opin , vol.32 , pp. 301-311
    • Sperling, L.S.1    Nelson, J.R.2
  • 9
    • 33746824712 scopus 로고    scopus 로고
    • n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
    • COI: 1:CAS:528:DC%2BD28XlvVOltrk%3D, PID: 16841863
    • Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. Am J Clin Nutr. 2006;83(suppl):1526S–35S.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1526S-1535S
    • Gebauer, S.K.1    Psota, T.L.2    Harris, W.S.3    Kris-Etherton, P.M.4
  • 10
    • 84890169034 scopus 로고    scopus 로고
    • Position of the Academy of Nutrition and Dietetics: dietary fatty acids for healthy adults
    • Academy of Nutrition and Dietetics. Position of the Academy of Nutrition and Dietetics: dietary fatty acids for healthy adults. J Acad Nutr Diet. 2014;114:136–53. https://doi.org/10.1016/j.jand.2013.11001.
    • (2014) J Acad Nutr Diet , vol.114 , pp. 136-153
  • 11
    • 84991454545 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: are there benefits?
    • PID: 27747477
    • Bowen KJ, Harris WS, Kris-Etherton PM. Omega-3 fatty acids and cardiovascular disease: are there benefits? Curr Treat Options Cardiovasc Med. 2016;18:69. https://doi.org/10.1007/s11936-016-0487-1.
    • (2016) Curr Treat Options Cardiovasc Med , vol.18 , pp. 69
    • Bowen, K.J.1    Harris, W.S.2    Kris-Etherton, P.M.3
  • 12
    • 84950277919 scopus 로고    scopus 로고
    • Emerging nutrition science on fatty acids and cardiovascular disease: nutritionists’ perspectives
    • COI: 1:CAS:528:DC%2BC2MXhtVyiur%2FN, PID: 25979506
    • Kris-Etherton PM, Fleming JA. Emerging nutrition science on fatty acids and cardiovascular disease: nutritionists’ perspectives. Adv Nutr. 2015;6:326S–37S. https://doi.org/10.3945/an.114.006981.
    • (2015) Adv Nutr , vol.6 , pp. 326S-337S
    • Kris-Etherton, P.M.1    Fleming, J.A.2
  • 13
    • 0015211669 scopus 로고
    • Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos
    • COI: 1:STN:280:DyaE3M3gtlaqtw%3D%3D, PID: 4102857, Landmark observational trial of the impact of n-3FA on reducing CV risk
    • • Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet. 1971;1:1143–5. Landmark observational trial of the impact of n-3FA on reducing CV risk.
    • (1971) Lancet , vol.1 , pp. 1143-1145
    • Bang, H.O.1    Dyerberg, J.2    Nielsen, A.B.3
  • 14
    • 0018581433 scopus 로고
    • Haemostatic function and platelet polyunsaturated fatty acids in Eskimos
    • COI: 1:CAS:528:DyaL3cXlsFymtQ%3D%3D, PID: 89498
    • Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet. 1979;2:433–5.
    • (1979) Lancet , vol.2 , pp. 433-435
    • Dyerberg, J.1    Bang, H.O.2
  • 15
    • 84878968839 scopus 로고    scopus 로고
    • Bioavailability of long-chain omega-3 fatty acids
    • COI: 1:CAS:528:DC%2BC3sXnslantLw%3D
    • Schuchardt JP, Hahn A. Bioavailability of long-chain omega-3 fatty acids. Prostaglandins, Leukot, Essent Fatty Acids. 2013;89(1):1–8. https://doi.org/10.1016/j.plefa.2013.03.010.
    • (2013) Prostaglandins, Leukot, Essent Fatty Acids , vol.89 , Issue.1 , pp. 1-8
    • Schuchardt, J.P.1    Hahn, A.2
  • 16
    • 84922553466 scopus 로고    scopus 로고
    • Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance
    • COI: 1:CAS:528:DC%2BC2cXhsVaktrbO, PID: 25149823, Excellent review of the ant-inflammatory effects of n-3FAs
    • •• Calder PC. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015;1851:469–84. https://doi.org/10.1016/j.bbalip.2014.08.010. Excellent review of the ant-inflammatory effects of n-3FAs.
    • (2015) Biochim Biophys Acta , vol.1851 , pp. 469-484
    • Calder, P.C.1
  • 17
    • 84965081917 scopus 로고    scopus 로고
    • Omega-3 fatty acid formulations in cardiovascular disease: dietary supplements are not substitutes for prescription products
    • COI: 1:CAS:528:DC%2BC28XnsVegt7Y%3D, PID: 27138439
    • Fialkow J. Omega-3 fatty acid formulations in cardiovascular disease: dietary supplements are not substitutes for prescription products. Am J Cardiovasc Drugs. 2016;16:229–39. https://doi.org/10.1007/s40256-016-0170-7.
    • (2016) Am J Cardiovasc Drugs , vol.16 , pp. 229-239
    • Fialkow, J.1
  • 18
    • 85033457533 scopus 로고    scopus 로고
    • Prescribing information for Lovaza. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021654s023lbl.pdf. Accessed July 21, 2017.
    • (2017) Prescribing information for Lovaza
  • 19
    • 85033449494 scopus 로고    scopus 로고
    • Accessed July 21, 2017
    • Prescribing information for Vascepa. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/202057s012lbl.pdf. Accessed July 21, 2017.
    • Prescribing information for Vascepa.
  • 20
    • 85033446420 scopus 로고    scopus 로고
    • Accessed July 21, 2017
    • Prescribing information for Omytrg. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204977s000lbl.pdf. Accessed July 21, 2017.
    • Prescribing information for Omytrg
  • 21
    • 85033501000 scopus 로고    scopus 로고
    • Accessed July 21, 2017
    • Prescribing information for Epanova. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205060s000lbl.pdf. Accessed July 21, 2017.
    • Prescribing information for Epanova
  • 22
    • 84914811260 scopus 로고    scopus 로고
    • Overview of prescription omega-3 fatty acid products for hypertriglyceridemia
    • PID: 25387209
    • Weintraub HS. Overview of prescription omega-3 fatty acid products for hypertriglyceridemia. Postgrad Med. 2014;126:7–18. https://doi.org/10.3810/pgm.2014.11.2828.
    • (2014) Postgrad Med , vol.126 , pp. 7-18
    • Weintraub, H.S.1
  • 23
    • 84961997813 scopus 로고    scopus 로고
    • A comparative overview of prescription omega-3 fatty acid products
    • PID: 26681905
    • Ito MK. A comparative overview of prescription omega-3 fatty acid products. Pharmacy and Therapeutics. 2015;40:826–57.
    • (2015) Pharmacy and Therapeutics , vol.40 , pp. 826-857
    • Ito, M.K.1
  • 24
    • 84870302077 scopus 로고    scopus 로고
    • A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3 acid ethyl esters: the ECLIPSE (Epanova® compared to Lovaza® in a pharmacokinetic single-dose evaluation) study
    • PID: 23312053
    • Davidson MH, Johnson J, Rooney MW, Kyle ML, Kling DF. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3 acid ethyl esters: the ECLIPSE (Epanova® compared to Lovaza® in a pharmacokinetic single-dose evaluation) study. J Clin Lipidol. 2012;6(6):573–84. https://doi.org/10.1016/j.jacl.2012.01.002.
    • (2012) J Clin Lipidol. , vol.6 , Issue.6 , pp. 573-584
    • Davidson, M.H.1    Johnson, J.2    Rooney, M.W.3    Kyle, M.L.4    Kling, D.F.5
  • 25
    • 84899955972 scopus 로고    scopus 로고
    • Fibrates and fish oil, but not corn oil, up-regulate the expression of the cholesterol ester transfer protein (CETP) gene
    • COI: 1:CAS:528:DC%2BC2cXmtlCntrY%3D, PID: 24746832
    • Raposo HF, Patricio PR, Simoes MC, Oliveira HC. Fibrates and fish oil, but not corn oil, up-regulate the expression of the cholesterol ester transfer protein (CETP) gene. J Nutr Biochem. 2014;25(6):669–74. https://doi.org/10.1016/j.jnutbio.2014.02.008.
    • (2014) J Nutr Biochem , vol.25 , Issue.6 , pp. 669-674
    • Raposo, H.F.1    Patricio, P.R.2    Simoes, M.C.3    Oliveira, H.C.4
  • 26
    • 84961138871 scopus 로고    scopus 로고
    • Marine n-3 polyunsaturated fatty acids lower plasma proprotein convertase subtilisin kexin type 9 in pre- and postmenopausal women: a randomised study
    • COI: 1:CAS:528:DC%2BC2MXhtFehsbzF
    • Graversen CB, Lundbye-Christensen S, Thomsen B, Christensen JH, Schmidt EB. Marine n-3 polyunsaturated fatty acids lower plasma proprotein convertase subtilisin kexin type 9 in pre- and postmenopausal women: a randomised study. Vasc Pharmacol. 2016;76:37–41. https://doi.org/10.1016/j.vph.2015.07.001.
    • (2016) Vasc Pharmacol , vol.76 , pp. 37-41
    • Graversen, C.B.1    Lundbye-Christensen, S.2    Thomsen, B.3    Christensen, J.H.4    Schmidt, E.B.5
  • 27
    • 85006176245 scopus 로고    scopus 로고
    • A review of clinical practice guidelines for the management of hypertriglyceridemia: a focus on high dose omega-3 fatty acids
    • COI: 1:CAS:528:DC%2BC28XitFamtrzL, PID: 27981496, Excellent review on the management of hypertriglyceridemia
    • • Karalis DG. A review of clinical practice guidelines for the management of hypertriglyceridemia: a focus on high dose omega-3 fatty acids. Adv Ther. 2017;34:300–23. https://doi.org/10.1007/s12325-016-0462-y. Excellent review on the management of hypertriglyceridemia.
    • (2017) Adv Ther , vol.34 , pp. 300-323
    • Karalis, D.G.1
  • 29
    • 0032917836 scopus 로고    scopus 로고
    • Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins
    • COI: 1:CAS:528:DyaK1MXhsVWgtb4%3D, PID: 10217357
    • Pownall HJ, Brauchi D, Kilinc C, Osmundsen K, Pao Q, Payton-Ross C, et al. Correlation of serum triglyceride and its reduction by omega-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins. Atherosclerosis. 1999;143(2):285–97. https://doi.org/10.1016/S0021-9150(98)00301-3.
    • (1999) Atherosclerosis , vol.143 , Issue.2 , pp. 285-297
    • Pownall, H.J.1    Brauchi, D.2    Kilinc, C.3    Osmundsen, K.4    Pao, Q.5    Payton-Ross, C.6
  • 30
    • 34548319692 scopus 로고    scopus 로고
    • Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study
    • COI: 1:CAS:528:DC%2BD2sXhtVemurjN, PID: 17825687
    • Davidson MH, Stein EA, Bays HE, Maki KC, Doyle RT, Shalwitz RA, et al. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther. 2007;29(7):1354–67. https://doi.org/10.1016/j.clinthera.2007.07.018.
    • (2007) Clin Ther , vol.29 , Issue.7 , pp. 1354-1367
    • Davidson, M.H.1    Stein, E.A.2    Bays, H.E.3    Maki, K.C.4    Doyle, R.T.5    Shalwitz, R.A.6
  • 31
    • 80051784104 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the multi-center, placebo-controlled, randomized, double-blind, 12-week study with an open-label extension [MARINE] trial)
    • COI: 1:CAS:528:DC%2BC3MXhtVajtrbF, PID: 21683321
    • Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the multi-center, placebo-controlled, randomized, double-blind, 12-week study with an open-label extension [MARINE] trial). Am J Cardiol. 2011;108:682–90. https://doi.org/10.1016/j.amjcard.2011.04.015.
    • (2011) Am J Cardiol , vol.108 , pp. 682-690
    • Bays, H.E.1    Ballantyne, C.M.2    Kastelein, J.J.3    Isaacsohn, J.L.4    Braeckman, R.A.5    Soni, P.N.6
  • 32
    • 84866124338 scopus 로고    scopus 로고
    • Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)
    • COI: 1:CAS:528:DC%2BC38XhtVyktL7E, PID: 22819432
    • Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, et al. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). Am J Cardiol. 2012;110:984–92. https://doi.org/10.1016/j.amjcard.2012.05.031.
    • (2012) Am J Cardiol , vol.110 , pp. 984-992
    • Ballantyne, C.M.1    Bays, H.E.2    Kastelein, J.J.3    Stein, E.4    Isaacsohn, J.L.5    Braeckman, R.A.6    Soni, P.N.7
  • 33
    • 84893916503 scopus 로고    scopus 로고
    • Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial
    • PID: 24528690
    • Kastelein JJ, Maki KC, Susekov A, Ezhov M, Nordestgaard BG, Machielse BN, et al. Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial. J Clin Lipidol. 2014;8:94–106. https://doi.org/10.1016/j.jacl.2013.10.003.
    • (2014) J Clin Lipidol , vol.8 , pp. 94-106
    • Kastelein, J.J.1    Maki, K.C.2    Susekov, A.3    Ezhov, M.4    Nordestgaard, B.G.5    Machielse, B.N.6
  • 34
    • 84884355278 scopus 로고    scopus 로고
    • A highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk, statin-treated patients with residual hypertriglyceridemia (the ESPRIT trial)
    • COI: 1:CAS:528:DC%2BC3sXhtlKqs7%2FN, PID: 23998969
    • Maki KC, Orloff DG, Nicholls SJ, Dunbar RL, Roth EM, Curcio D, et al. A highly bioavailable omega-3 free fatty acid formulation improves the cardiovascular risk profile in high-risk, statin-treated patients with residual hypertriglyceridemia (the ESPRIT trial). Clin Ther. 2013;35:1400–11. https://doi.org/10.1016/j.clinthera.2013.07.420.
    • (2013) Clin Ther , vol.35 , pp. 1400-1411
    • Maki, K.C.1    Orloff, D.G.2    Nicholls, S.J.3    Dunbar, R.L.4    Roth, E.M.5    Curcio, D.6
  • 35
    • 84856179128 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review
    • PID: 22264569
    • Jacobson TA, Glickstein SB, Rowe JD, Soni PN. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. J Clin Lipidol. 2012;6(1):5–18. https://doi.org/10.1016/j.jacl.2011.10.018.
    • (2012) J Clin Lipidol. , vol.6 , Issue.1 , pp. 5-18
    • Jacobson, T.A.1    Glickstein, S.B.2    Rowe, J.D.3    Soni, P.N.4
  • 36
    • 33747188960 scopus 로고    scopus 로고
    • Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids
    • COI: 1:CAS:528:DC%2BD28XpslWitbc%3D, PID: 16919516
    • Robinson JG, Stone NJ. Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am J Cardiol. 2006;98(suppl):39i–49i. https://doi.org/10.1016/j.amjcard.2005.12.026.
    • (2006) Am J Cardiol , vol.98 , pp. 39i-49i
    • Robinson, J.G.1    Stone, N.J.2
  • 37
    • 0036075998 scopus 로고    scopus 로고
    • The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans
    • COI: 1:CAS:528:DC%2BD38XlslOltr4%3D, PID: 12145002
    • Nestel PJ, Shige H, Pomeroy SE, Cehun M, Abbey M, Raederstorff D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr. 2002;76:326–30.
    • (2002) Am J Clin Nutr , vol.76 , pp. 326-330
    • Nestel, P.J.1    Shige, H.2    Pomeroy, S.E.3    Cehun, M.4    Abbey, M.5    Raederstorff, D.6
  • 38
    • 0030923849 scopus 로고    scopus 로고
    • Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability
    • COI: 1:CAS:528:DyaK2sXksFWls7Y%3D, PID: 9194769
    • Nestel PJ, Pomeroy SE, Sasahara T, Yamashita T, Liang YL, Dart AM, et al. Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol. 1997;17:1163–70.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1163-1170
    • Nestel, P.J.1    Pomeroy, S.E.2    Sasahara, T.3    Yamashita, T.4    Liang, Y.L.5    Dart, A.M.6
  • 39
    • 84939559523 scopus 로고    scopus 로고
    • Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis
    • COI: 1:CAS:528:DC%2BC2MXhtlSisLzM, PID: 26253795
    • Borow KM, Nelson JR, Mason RP. Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis. Atherosclerosis. 2015;242:357–66. https://doi.org/10.1016/j.atherosclerosis.2015.07.035.
    • (2015) Atherosclerosis , vol.242 , pp. 357-366
    • Borow, K.M.1    Nelson, J.R.2    Mason, R.P.3
  • 40
    • 84874052886 scopus 로고    scopus 로고
    • Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies
    • COI: 1:CAS:528:DC%2BC3sXhsl2ntL%2FE, PID: 23325450
    • Bays HE, Ballantyne CM, Braeckman RA, Stirtan WG, Soni PN. Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies. Am J Cardiovasc Drugs. 2013;13(1):37–46. https://doi.org/10.1007/s40256-012-0002-3.
    • (2013) Am J Cardiovasc Drugs , vol.13 , Issue.1 , pp. 37-46
    • Bays, H.E.1    Ballantyne, C.M.2    Braeckman, R.A.3    Stirtan, W.G.4    Soni, P.N.5
  • 41
    • 84913568836 scopus 로고    scopus 로고
    • Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism
    • COI: 1:CAS:528:DC%2BC2cXhvVGgtbzM, PID: 25449996
    • Mason RP, Jacob RF. Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism. Biochim Biophys Acta. 2015;1848:502–9. https://doi.org/10.1016/j.bbamem.2014.10.016.
    • (2015) Biochim Biophys Acta , vol.1848 , pp. 502-509
    • Mason, R.P.1    Jacob, R.F.2
  • 42
    • 33749154105 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systemic review
    • COI: 1:CAS:528:DC%2BD28XhtVajsr3L, PID: 16530201
    • Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systemic review. Atherosclerosis. 2006;189:19–30. https://doi.org/10.1016/j.atherosclerosis.2006.02.012.
    • (2006) Atherosclerosis , vol.189 , pp. 19-30
    • Balk, E.M.1    Lichtenstein, A.H.2    Chung, M.3    Kupelnick, B.4    Chew, P.5    Lau, J.6
  • 43
    • 0038447923 scopus 로고    scopus 로고
    • Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women
    • COI: 1:CAS:528:DC%2BD3sXotFaht7s%3D, PID: 12821543
    • Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willet WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003;108:155–60. https://doi.org/10.1161/01.CIR.0000079224.46084.C2.
    • (2003) Circulation , vol.108 , pp. 155-160
    • Pischon, T.1    Hankinson, S.E.2    Hotamisligil, G.S.3    Rifai, N.4    Willet, W.C.5    Rimm, E.B.6
  • 44
    • 5744237842 scopus 로고    scopus 로고
    • Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects
    • COI: 1:CAS:528:DC%2BD2cXnslOru7Y%3D, PID: 15100717
    • Geelen A, Brouwer IA, Schouten EG, Kluft C, Katan MB, Zock PL. Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects. Eur J Clin Nutr. 2004;58:1440–2. https://doi.org/10.1038/sj.ejcn.1601986.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 1440-1442
    • Geelen, A.1    Brouwer, I.A.2    Schouten, E.G.3    Kluft, C.4    Katan, M.B.5    Zock, P.L.6
  • 45
    • 0038325709 scopus 로고    scopus 로고
    • The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study
    • COI: 1:CAS:528:DC%2BD3sXjtFGhtrk%3D, PID: 12654170
    • Madsen T, Christensen JH, Blom M, Schmidt EB. The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study. Br J Nutr. 2003;89:517–22. https://doi.org/10.1079/BJN2002815.
    • (2003) Br J Nutr , vol.89 , pp. 517-522
    • Madsen, T.1    Christensen, J.H.2    Blom, M.3    Schmidt, E.B.4
  • 46
    • 70249129428 scopus 로고    scopus 로고
    • An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals
    • COI: 1:CAS:528:DC%2BD1MXhtVKku7%2FF, PID: 19352379
    • Micallef MA, Munro IA, Garg ML. An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. Eur J Clin Nutr. 2009;63:1154–6. https://doi.org/10.1038/ejcn.2009.20.
    • (2009) Eur J Clin Nutr , vol.63 , pp. 1154-1156
    • Micallef, M.A.1    Munro, I.A.2    Garg, M.L.3
  • 47
    • 0024489402 scopus 로고
    • The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
    • COI: 1:CAS:528:DyaL1MXitlSmtr4%3D, PID: 2783477
    • Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med. 1989;320:265–71.
    • (1989) N Engl J Med , vol.320 , pp. 265-271
    • Endres, S.1    Ghorbani, R.2    Kelley, V.E.3    Georgilis, K.4    Lonnemann, G.5    van der Meer, J.W.6
  • 48
    • 0021861083 scopus 로고
    • Effects of dietary enrichment with eicosapentaenoic acid and docosahexaenoic acid on in vitro neutrophil and monocyte leukotriene generation and neutrophil function
    • COI: 1:CAS:528:DyaL2MXktlKmurw%3D, PID: 2985986
    • Lee TH, Hoover RL, Williams JD, et al. Effects of dietary enrichment with eicosapentaenoic acid and docosahexaenoic acid on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med. 1985;312:1217–24.
    • (1985) N Engl J Med , vol.312 , pp. 1217-1224
    • Lee, T.H.1    Hoover, R.L.2    Williams, J.D.3
  • 49
    • 0027458574 scopus 로고
    • Dietary n-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils
    • COI: 1:CAS:528:DyaK3sXitFWrtr8%3D, PID: 8381824
    • Sperling RI, Benincaso AI, Knoell CT, Larkin JK, Austen KF, Robinson DR, et al. Dietary n-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Investig. 1993;91:651–60.
    • (1993) J Clin Investig , vol.91 , pp. 651-660
    • Sperling, R.I.1    Benincaso, A.I.2    Knoell, C.T.3    Larkin, J.K.4    Austen, K.F.5    Robinson, D.R.6
  • 50
    • 0030038986 scopus 로고    scopus 로고
    • The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable or fish oil
    • COI: 1:CAS:528:DyaK28XhtF2it7s%3D, PID: 8604658
    • Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable or fish oil. Am J Clin Nutr. 1996;63:116–22.
    • (1996) Am J Clin Nutr , vol.63 , pp. 116-122
    • Caughey, G.E.1    Mantzioris, E.2    Gibson, R.A.3    Cleland, L.G.4    James, M.J.5
  • 51
    • 77957942833 scopus 로고    scopus 로고
    • Specialized pro-resolving lipid mediators in the inflammatory response: an update
    • COI: 1:CAS:528:DC%2BC3cXhtlShtLzP, PID: 20708099
    • Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: an update. Biochim Biophys Acta. 2010;1801:1260–73. https://doi.org/10.1016/j.bbalip.2010.08.002.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 1260-1273
    • Bannenberg, G.1    Serhan, C.N.2
  • 52
    • 85018464511 scopus 로고    scopus 로고
    • Treatment with high-dose n-3 PUFAS has no effect on platelet function, coagulation, metabolic status or inflammation in patients with atherosclerosis and type 2 diabetes
    • PID: 28410617
    • Poreba M, Mostowik M, Siniarski A, Golebiowska-Wiatrak R, Malinowski KP, Haberka M, et al. Treatment with high-dose n-3 PUFAS has no effect on platelet function, coagulation, metabolic status or inflammation in patients with atherosclerosis and type 2 diabetes. Cardiovasc Diabetol. 2017;16:50. https://doi.org/10.1186/s12933-017-0523-9.
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 50
    • Poreba, M.1    Mostowik, M.2    Siniarski, A.3    Golebiowska-Wiatrak, R.4    Malinowski, K.P.5    Haberka, M.6
  • 53
    • 84872823254 scopus 로고    scopus 로고
    • Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients
    • PID: 23326753
    • Yamakawa K, Shimabukuro M, Higa N, Asahi T, Ohba K, Arasaki O, et al. Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients. Cardiol Res Pract. 2012;2012:754181. https://doi.org/10.1155/2012/754181.
    • (2012) Cardiol Res Pract , vol.2012 , pp. 754181
    • Yamakawa, K.1    Shimabukuro, M.2    Higa, N.3    Asahi, T.4    Ohba, K.5    Arasaki, O.6
  • 54
    • 0037425770 scopus 로고    scopus 로고
    • Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial
    • COI: 1:CAS:528:DC%2BD3sXhtVahurw%3D, PID: 12583947
    • Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003;361(9356):477–85. https://doi.org/10.1016/S0140-6736(03)12468-3.
    • (2003) Lancet , vol.361 , Issue.9356 , pp. 477-485
    • Thies, F.1    Garry, J.M.2    Yaqoob, P.3    Rerkasem, K.4    Williams, J.5    Shearman, C.P.6
  • 55
    • 84897985527 scopus 로고    scopus 로고
    • Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma
    • COI: 1:CAS:528:DC%2BC2cXmtVGjtr8%3D, PID: 24637411
    • Nishio R, Shinke T, Otake H, Nakagawa M, Nagoshi R, Inoue T, et al. Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma. Atherosclerosis. 2014;234(1):114–9. https://doi.org/10.1016/j.atherosclerosis.2014.02.025.
    • (2014) Atherosclerosis , vol.234 , Issue.1 , pp. 114-119
    • Nishio, R.1    Shinke, T.2    Otake, H.3    Nakagawa, M.4    Nagoshi, R.5    Inoue, T.6    Kozuki, A.7    Hariki, H.8
  • 56
    • 84921866532 scopus 로고    scopus 로고
    • Impact of eicosapentaenoic acid treatment on the fibrous cap thickness in patients with coronary atherosclerotic plaque: an optical coherence tomography study
    • PID: 25132379
    • Yamano T, Kubo T, Shiono Y, Shimamura K, Orii M, Tanimoto T, et al. Impact of eicosapentaenoic acid treatment on the fibrous cap thickness in patients with coronary atherosclerotic plaque: an optical coherence tomography study. J Atheroscler Thromb. 2015;22(1):52–61. https://doi.org/10.5551/jat.25593.
    • (2015) J Atheroscler Thromb , vol.22 , Issue.1 , pp. 52-61
    • Yamano, T.1    Kubo, T.2    Shiono, Y.3    Shimamura, K.4    Orii, M.5    Tanimoto, T.6
  • 57
    • 0034622542 scopus 로고    scopus 로고
    • Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism
    • COI: 1:CAS:528:DC%2BD3cXlvFymsLs%3D, PID: 10931808
    • Doi H, Kugiyama K, Oka H, Sugiyama S, Ogata N, Koide SI, et al. Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism. Circulation. 2000;102(6):670–6. https://doi.org/10.1161/01.CIR.102.6.670.
    • (2000) Circulation , vol.102 , Issue.6 , pp. 670-676
    • Doi, H.1    Kugiyama, K.2    Oka, H.3    Sugiyama, S.4    Ogata, N.5    Koide, S.I.6
  • 58
    • 4444299083 scopus 로고    scopus 로고
    • Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation
    • COI: 1:CAS:528:DC%2BD2cXntVCrur8%3D, PID: 15217806
    • Vanschoonbeek K, Feijge MA, Paquay M, Rosing J, Saris W, Kluft C, et al. Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation. Arterioscler Thromb Vasc Biol. 2004;24:1734–40. https://doi.org/10.1161/01.ATV.0000137119.28893.0b.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1734-1740
    • Vanschoonbeek, K.1    Feijge, M.A.2    Paquay, M.3    Rosing, J.4    Saris, W.5    Kluft, C.6
  • 59
    • 84928014185 scopus 로고    scopus 로고
    • The effect of omega-3 polyunsaturated fatty acids on fibrin and thrombin generation in healthy subjects and subjects with cardiovascular disease
    • COI: 1:CAS:528:DC%2BC2MXjtFGlt7k%3D, PID: 25703517
    • McEwen BJ, Morel-Kopp MC, Tofler GH, Ward CM. The effect of omega-3 polyunsaturated fatty acids on fibrin and thrombin generation in healthy subjects and subjects with cardiovascular disease. Semin Thromb Hemost. 2015;41(3):315–22. https://doi.org/10.1055/s-0034-1395352.
    • (2015) Semin Thromb Hemost , vol.41 , Issue.3 , pp. 315-322
    • McEwen, B.J.1    Morel-Kopp, M.C.2    Tofler, G.H.3    Ward, C.M.4
  • 60
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    • COI: 1:CAS:528:DC%2BD2sXjs1Ohtro%3D, PID: 17398308
    • Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369(9567):1090–8. https://doi.org/10.1016/s0140-6736(07)60527-3.
    • (2007) Lancet , vol.369 , Issue.9567 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3    Matsuzawa, Y.4    Saito, Y.5    Ishikawa, Y.6
  • 61
    • 85020711549 scopus 로고    scopus 로고
    • No impact of fish oil supplements on bleeding risk: a systematic review
    • PID: 28552094
    • Begtrup KM, Krag AE, Hvas AM. No impact of fish oil supplements on bleeding risk: a systematic review. Dan Med J. 2017;64(5):A5366.
    • (2017) Dan Med J , vol.64 , Issue.5 , pp. A5366
    • Begtrup, K.M.1    Krag, A.E.2    Hvas, A.M.3
  • 62
    • 25444484216 scopus 로고    scopus 로고
    • Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BD2MXhtVWmurzJ, PID: 16172267
    • Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB. Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation. 2005;112(13):1945–52. https://doi.org/10.1161/CIRCULATIONAHA.105.556886.
    • (2005) Circulation , vol.112 , Issue.13 , pp. 1945-1952
    • Mozaffarian, D.1    Geelen, A.2    Brouwer, I.A.3    Geleijnse, J.M.4    Zock, P.L.5    Katan, M.B.6
  • 63
    • 84862829128 scopus 로고    scopus 로고
    • Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BC38XhvVOrtb8%3D, PID: 22317966
    • Wang Q, Liang X, Wang L, Lu X, Huang J, Cao J, et al. Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials. Atherosclerosis. 2012;221(2):536–43. https://doi.org/10.1016/j.atherosclerosis.2012.01.006.
    • (2012) Atherosclerosis , vol.221 , Issue.2 , pp. 536-543
    • Wang, Q.1    Liang, X.2    Wang, L.3    Lu, X.4    Huang, J.5    Cao, J.6
  • 64
    • 85021737650 scopus 로고    scopus 로고
    • Effect of supplemented intake of omega-3 fatty acids on arrhythmias in patients with ICD: fish oil therapy may reduce ventricular arrhythmia
    • PID: 28664342
    • Weisman D, Beinart R, Erez A, Koren-Morag N, Goldenberg I, Eldar M, et al. Effect of supplemented intake of omega-3 fatty acids on arrhythmias in patients with ICD: fish oil therapy may reduce ventricular arrhythmia. J Interv Card Electrophysiol. 2017;49(3):255–61. https://doi.org/10.1007/s10840-017-0267-1.
    • (2017) J Interv Card Electrophysiol , vol.49 , Issue.3 , pp. 255-261
    • Weisman, D.1    Beinart, R.2    Erez, A.3    Koren-Morag, N.4    Goldenberg, I.5    Eldar, M.6
  • 65
    • 58149401495 scopus 로고    scopus 로고
    • Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias
    • COI: 1:CAS:528:DC%2BD1cXhtlGitLbL, PID: 18838524
    • Jenkins DJ, Josse AR, Dorian P, Burr ML, LaBelle TR, Kendall CW, et al. Heterogeneity in randomized controlled trials of long chain (fish) omega-3 fatty acids in restenosis, secondary prevention and ventricular arrhythmias. J Am Coll Nutr. 2008;27(3):367–78.
    • (2008) J Am Coll Nutr , vol.27 , Issue.3 , pp. 367-378
    • Jenkins, D.J.1    Josse, A.R.2    Dorian, P.3    Burr, M.L.4    LaBelle, T.R.5    Kendall, C.W.6    Cunnane, S.C.7
  • 66
    • 84880038438 scopus 로고    scopus 로고
    • Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials
    • PID: 23714269
    • Khoueiry G, Abi Rafeh N, Sullivan E, Saiful F, Jaffery Z, Kenigsberg DN, et al. Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials. Heart Lung. 2013;42(4):251–6. https://doi.org/10.1016/j.hrtlng.2103.03.006.
    • (2013) Heart Lung , vol.42 , Issue.4 , pp. 251-256
    • Khoueiry, G.1    Abi Rafeh, N.2    Sullivan, E.3    Saiful, F.4    Jaffery, Z.5    Kenigsberg, D.N.6
  • 67
    • 84869170925 scopus 로고    scopus 로고
    • Fish oil and post-operative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial
    • COI: 1:CAS:528:DC%2BC38XhvVCmtrjM, PID: 23128104
    • Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, et al. Fish oil and post-operative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA. 2012;308:2001–11. https://doi.org/10.1001/jama2012.28733.
    • (2012) JAMA , vol.308 , pp. 2001-2011
    • Mozaffarian, D.1    Marchioli, R.2    Macchia, A.3    Silletta, M.G.4    Ferrazzi, P.5    Gardner, T.J.6
  • 68
    • 0036668195 scopus 로고    scopus 로고
    • Blood pressure response to fish oil supplementation: meta-regression analysis of randomized trials
    • COI: 1:CAS:528:DC%2BD38XmtFaqtLk%3D, PID: 12172309
    • Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ. Blood pressure response to fish oil supplementation: meta-regression analysis of randomized trials. J Hypertens. 2002;20(8):1493–9.
    • (2002) J Hypertens , vol.20 , Issue.8 , pp. 1493-1499
    • Geleijnse, J.M.1    Giltay, E.J.2    Grobbee, D.E.3    Donders, A.R.4    Kok, F.J.5
  • 69
    • 84902507382 scopus 로고    scopus 로고
    • Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BC2cXhtVajsL7N, PID: 24610882
    • Miller PE, Van Elswyk M, Alexander DD. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials. Am J Hypertens. 2014;27(7):885–96. https://doi.org/10.1093/ajh/hpu024.
    • (2014) Am J Hypertens , vol.27 , Issue.7 , pp. 885-896
    • Miller, P.E.1    Van Elswyk, M.2    Alexander, D.D.3
  • 70
    • 84960374620 scopus 로고    scopus 로고
    • Consumption of fish oil providing amounts of eicosapentaenoic acid and docosahexaenoic acid that can be obtained from the diet reduces blood pressure in adults with systolic hypertension: a retrospective analysis
    • COI: 1:CAS:528:DC%2BC28XhsFejs7zO, PID: 26817716
    • Minihane AM, Armah CK, Miles EA, et al. Consumption of fish oil providing amounts of eicosapentaenoic acid and docosahexaenoic acid that can be obtained from the diet reduces blood pressure in adults with systolic hypertension: a retrospective analysis. J Nutr. 2016;146(3):516–23. https://doi.org/10.3945/jn.115.220475.
    • (2016) J Nutr , vol.146 , Issue.3 , pp. 516-523
    • Minihane, A.M.1    Armah, C.K.2    Miles, E.A.3
  • 71
    • 0031897102 scopus 로고    scopus 로고
    • Fish oil and glycemic control in diabetes: a meta-analysis
    • COI: 1:STN:280:DyaK1c3jt1yhsw%3D%3D, PID: 9571330
    • Friedberg C, Janssen M, Heine R, Grobbee D. Fish oil and glycemic control in diabetes: a meta-analysis. Diabetes Care. 1998;21:494–500.
    • (1998) Diabetes Care , vol.21 , pp. 494-500
    • Friedberg, C.1    Janssen, M.2    Heine, R.3    Grobbee, D.4
  • 72
    • 5044223159 scopus 로고    scopus 로고
    • Effect of fish diets and weight loss on serum leptin concentration in overweight, treated hypertensive subjects
    • COI: 1:CAS:528:DC%2BD2cXnsV2kt7Y%3D, PID: 15361771
    • Mori T, Burke V, Puddey IB, Shaw JE, Berlin L. Effect of fish diets and weight loss on serum leptin concentration in overweight, treated hypertensive subjects. J Hypertens. 2004;22:1983–90.
    • (2004) J Hypertens , vol.22 , pp. 1983-1990
    • Mori, T.1    Burke, V.2    Puddey, I.B.3    Shaw, J.E.4    Berlin, L.5
  • 73
    • 85020695709 scopus 로고    scopus 로고
    • High intake of fatty fish, but not lean fish, improved postprandial glucose regulation and increased the n-PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial
    • COI: 1:CAS:528:DC%2BC2sXhtVOntLrN, PID: 28606215
    • Helland A, Bratlie M, Hagen IV, Mjos SA, Sornes S, Ingvar Halstensen A, et al. High intake of fatty fish, but not lean fish, improved postprandial glucose regulation and increased the n-PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial. Br J Nutr. 2017;117(10):1368–78. https://doi.org/10.1017/S0007114517001234.
    • (2017) Br J Nutr , vol.117 , Issue.10 , pp. 1368-1378
    • Helland, A.1    Bratlie, M.2    Hagen, I.V.3    Mjos, S.A.4    Sornes, S.5    Ingvar Halstensen, A.6
  • 75
    • 84855341899 scopus 로고    scopus 로고
    • The VITamin D and OmegA-3 Trial (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease
    • COI: 1:CAS:528:DC%2BC38XmtFaqug%3D%3D, PID: 21986389
    • Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, et al. The VITamin D and OmegA-3 Trial (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2012;33(1):159–71. https://doi.org/10.1016/j.cct.2011.09.009.
    • (2012) Contemp Clin Trials , vol.33 , Issue.1 , pp. 159-171
    • Manson, J.E.1    Bassuk, S.S.2    Lee, I.M.3    Cook, N.R.4    Albert, M.A.5    Gordon, D.6
  • 76
    • 84864219466 scopus 로고    scopus 로고
    • n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia
    • ORIGIN Trial Investigators, Bosch J, Gerstein HC, Dagenais GR, Diaz R, Dyal L, et al. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med. 2012;367:309–18. https://doi.org/10.1056/NEJMoa1203859.
    • (2012) N Engl J Med , vol.367 , pp. 309-318
    • Bosch, J.1    Gerstein, H.C.2    Dagenais, G.R.3    Diaz, R.4    Dyal, L.5    Jung, H.6
  • 77
    • 84877624255 scopus 로고    scopus 로고
    • n-3 fatty acids in patients with multiple cardiovascular risk factors [published correction appears in N Engl J Med. 2013;368:2146]
    • Risk and Prevention Study Collaborative Group, Roncaglioni MC, Tombesi M, Avanzini F, Barlera S, Caimi V, et al. n-3 fatty acids in patients with multiple cardiovascular risk factors [published correction appears in N Engl J Med. 2013;368:2146]. N Engl J Med. 2013;368:1800–8. https://doi.org/10.1056/NEJMoa1205409.
    • (2013) N Engl J Med , vol.368 , pp. 1800-1808
    • Roncaglioni, M.C.1    Tombesi, M.2    Avanzini, F.3    Barlera, S.4    Caimi, V.5    Longoni, P.6
  • 78
    • 84899869072 scopus 로고    scopus 로고
    • Effect of long-chain ω-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular disease outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial
    • Writing Group for the AREDS2 Research Group, Bonds DE, Harrington M, Worrall BB, Bertoni AG, Eaton CB, et al. Effect of long-chain ω-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular disease outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA Intern Med. 2014;174:763–71. https://doi.org/10.1001/jamainternmed.2014.328.
    • (2014) JAMA Intern Med , vol.174 , pp. 763-771
    • Bonds, D.E.1    Harrington, M.2    Worrall, B.B.3    Bertoni, A.G.4    Eaton, C.B.5    Hsia, J.6
  • 79
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
    • GISSI-Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico)
    • GISSI-Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 1999;354(9177):447–55.
    • (1999) Lancet , vol.354 , Issue.9177 , pp. 447-455
  • 80
    • 78549233384 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular events after myocardial infarction
    • COI: 1:CAS:528:DC%2BC3cXhsVykt7jI, PID: 20929341
    • Kromhout D, Giltay EJ, Geleijnse JM, for the Alpha Omega Trial Group. N-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med. 2010;363(21):2015–26. https://doi.org/10.1056/NEJMoa1003603.
    • (2010) N Engl J Med , vol.363 , Issue.21 , pp. 2015-2026
    • Kromhout, D.1    Giltay, E.J.2    Geleijnse, J.M.3
  • 81
    • 0024363690 scopus 로고
    • Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART)
    • COI: 1:STN:280:DyaL1MzotlOluw%3D%3D, PID: 2571009
    • Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART). Lancet. 1989;2:757–61.
    • (1989) Lancet , vol.2 , pp. 757-761
    • Burr, M.L.1    Fehily, A.M.2    Gilbert, J.F.3    Rogers, S.4    Holliday, R.M.5    Sweetnam, P.M.6
  • 82
    • 78650169331 scopus 로고    scopus 로고
    • OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction
    • COI: 1:CAS:528:DC%2BC3cXhsV2gu73K, PID: 21060071
    • Rauch B, Schiele R, Schneider S, Diller F, Victor N, Gohlke H, et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation. 2010;122:2152–9. https://doi.org/10.1161/CIRCULATIONAHA.110.948562.
    • (2010) Circulation , vol.122 , pp. 2152-2159
    • Rauch, B.1    Schiele, R.2    Schneider, S.3    Diller, F.4    Victor, N.5    Gohlke, H.6
  • 83
    • 79551499975 scopus 로고    scopus 로고
    • Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial
    • PID: 21115589
    • Galan P, Kesse-Guyot E, Czemichow S, Briancon S, Blacher J, Hercberg S, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ. 2010;341:c6273. https://doi.org/10.1136/bmj.c6273.
    • (2010) BMJ , vol.341 , pp. c6273
    • Galan, P.1    Kesse-Guyot, E.2    Czemichow, S.3    Briancon, S.4    Blacher, J.5    Hercberg, S.6
  • 84
    • 84866070612 scopus 로고    scopus 로고
    • Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systemic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC38XhsFentbnM, PID: 22968891
    • Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systemic review and meta-analysis. JAMA. 2012;308:1024–33. https://doi.org/10.1001/2012.jama.11374.
    • (2012) JAMA , vol.308 , pp. 1024-1033
    • Rizos, E.C.1    Ntzani, E.E.2    Bika, E.3    Kostapanos, M.S.4    Elisaf, M.S.5
  • 86
    • 53049110571 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
    • PID: 18757090
    • Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372(9645):1223–30. https://doi.org/10.1016/S0140-6736(08)61239-8.
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1223-1230
    • Tavazzi, L.1    Maggioni, A.P.2    Marchioli, R.3    Barlera, S.4    Franzosi, M.G.5    Latini, R.6    Gissi-HF Investigators7
  • 87
    • 85009141814 scopus 로고    scopus 로고
    • A meta-analysis of randomized controlled trials and prospective cohort studies of eicosapentaenoic and docosahexaenoic long-chain omega-3 fatty acids and coronary heart disease risk
    • COI: 1:CAS:528:DC%2BC28XhvVeqt7vJ, PID: 28062061
    • Alexander DD, Miller PE, Van Elswyk ME, Kuratko CN, Bylsma LC. A meta-analysis of randomized controlled trials and prospective cohort studies of eicosapentaenoic and docosahexaenoic long-chain omega-3 fatty acids and coronary heart disease risk. Mayo Clin Proc. 2017;92(1):15–29. https://doi.org/10.1016/j.mayocp.2016.10.018.
    • (2017) Mayo Clin Proc , vol.92 , Issue.1 , pp. 15-29
    • Alexander, D.D.1    Miller, P.E.2    Van Elswyk, M.E.3    Kuratko, C.N.4    Bylsma, L.C.5
  • 88
    • 84881638790 scopus 로고    scopus 로고
    • Long-term effect of high dose omega-3 fatty acid supplementation for secondary prevention of cardiovascular outcomes: a meta-analysis of randomized, placebo controlled trials [corrected]
    • PID: 23958480
    • Casula M, Soranna D, Catapano AL, Corrao G. Long-term effect of high dose omega-3 fatty acid supplementation for secondary prevention of cardiovascular outcomes: a meta-analysis of randomized, placebo controlled trials [corrected]. Atheroscler Suppl. 2013;14(2):243–51.
    • (2013) Atheroscler Suppl , vol.14 , Issue.2 , pp. 243-251
    • Casula, M.1    Soranna, D.2    Catapano, A.L.3    Corrao, G.4
  • 89
    • 85015187606 scopus 로고    scopus 로고
    • Rationale and design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial
    • Bhatt DL, Steg PG, Brinton EA, Jacobson TA, Miller M, Tardif JC, et al. Rationale and design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial. Clin Cardiology. 2017;40:138–48. https://doi.org/10.1002/clc.22692.
    • (2017) Clin Cardiology , vol.40 , pp. 138-148
    • Bhatt, D.L.1    Steg, P.G.2    Brinton, E.A.3    Jacobson, T.A.4    Miller, M.5    Tardif, J.C.6
  • 92
    • 0037137299 scopus 로고    scopus 로고
    • Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    • PID: 12438303
    • Kris-Etherton PM, Harris WS, Appel LJ, for the American Heart Association, Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106(21):2747–57. https://doi.org/10.1161/01.CIR.0000038493.65177.94.
    • (2002) Circulation , vol.106 , Issue.21 , pp. 2747-2757
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 93
    • 85027956925 scopus 로고    scopus 로고
    • Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association
    • PID: 21502576
    • Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123:2292–333. https://doi.org/10.1161/CIR.0b013e3182160726.
    • (2011) Circulation , vol.123 , pp. 2292-2333
    • Miller, M.1    Stone, N.J.2    Ballantyne, C.3    Bittner, V.4    Criqui, M.H.5    Ginsberg, H.N.6
  • 94
    • 84928823445 scopus 로고    scopus 로고
    • National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1—full report
    • PID: 25911072
    • Jacobson TA, Ito MK, Maki KC, Orringer CE, Bays HE, Jones PH, et al. National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1—full report. J Clin Lipidol. 2015;9(2):129–69. https://doi.org/10.1016/j.jacl.2015.02.003.
    • (2015) J Clin Lipidol , vol.9 , Issue.2 , pp. 129-169
    • Jacobson, T.A.1    Ito, M.K.2    Maki, K.C.3    Orringer, C.E.4    Bays, H.E.5    Jones, P.H.6
  • 95
    • 84957953328 scopus 로고    scopus 로고
    • National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2
    • PID: 26699442
    • Jacobson TA, Maki KC, Orringer CE, Jones PH, Kris-Etherton PM, Sikand G, et al. National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2. J Clin Lipidol. 2015;9(6 Suppl):S1–122.e1. https://doi.org/10.1016/j.jacl.2015.09.002.
    • (2015) J Clin Lipidol , vol.9 , pp. S1-122.e1
    • Jacobson, T.A.1    Maki, K.C.2    Orringer, C.E.3    Jones, P.H.4    Kris-Etherton, P.M.5    Sikand, G.6
  • 97
    • 84994296486 scopus 로고    scopus 로고
    • 2016 ESC/EAS guidelines for the management of dyslipidaemias
    • The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)
    • The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37:2999–3058. https://doi.org/10.1093/eurheartj/ehw272.
    • (2016) Eur Heart J , vol.37 , pp. 2999-3058


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