Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

Journal of Tissue Engineering and Regenerative Medicine

Volumn 12, Issue 2, 2018, Pages 479-489

  Sieber, Stefan ^a,b   Wirth, Lorenz ^a   Cavak, Nino ^a   Koenigsmark, Marielle ^a   Marx, Uwe ^c   Lauster, Roland ^a   Rosowski, Mark ^a  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c TISSUSE GMBH   (Germany)

Author keywords

alternative to animal testing; bone marrow on a chip; ceramic scaffold; haematopoietic stem cells; mesenchymal stem cells; stem cell niche

Indexed keywords

BONE; CELL CULTURE; ENZYME ACTIVITY; HYDROXYAPATITE; MICROFLUIDICS; SCAFFOLDS (BIOLOGY); STEM CELLS; ZIRCONIUM COMPOUNDS;

ALTERNATIVE TO ANIMAL TESTING; ANIMAL TESTING; BONE MARROW; BONE MARROW ON A CHIP; CERAMIC SCAFFOLDS; HAEMATOPOIETIC STEM CELLS; HEMATOPOIETIC PROGENITOR CELLS; LONG-TERM CULTURE; MESENCHYMAL STEM CELL; STEM-CELL NICHES;

BLOOD;

ADP RIBOSYL CYCLASE/CYCLIC ADP RIBOSE HYDROLASE 1; CD34 ANTIGEN; HYDROXYAPATITE; ZIRCONIUM OXIDE;

ARTICLE; BONE MARROW ON A CHIP; COLONY FORMATION; CONTROLLED STUDY; ERYTHROCYTE; EXTRACELLULAR MATRIX; GRANULOCYTE; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFORMED CONSENT; MACROPHAGE; MEGAKARYOCYTE; MESENCHYMAL STROMA CELL; MICROFLUIDICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CHEMISTRY; CYTOLOGY; PROCEDURES; STEM CELL NICHE; TIME FACTOR; TISSUE SCAFFOLD; ULTRASTRUCTURE;

BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; HEMATOPOIETIC STEM CELLS; HUMANS; MICROFLUIDICS; MODELS, BIOLOGICAL; STEM CELL NICHE; TIME FACTORS; TISSUE SCAFFOLDS;

EID: 85032948672     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.2507     Document Type: Article

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