Osteoblastic activation in the hematopoietic stem cell niche

Annals of the New York Academy of Sciences

Volumn 1068, Issue 1, 2006, Pages 477-488

  Calvi, Laura M ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Hematopoiesis; Jagged1; Notch; Osteoblast; Parathyroid hormone; Self renewal; Stem cell niche

Indexed keywords

JAGGED1; NOTCH1 RECEPTOR; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1;

BONE; BONE MARROW; BONE MARROW TRANSPLANTATION; CELL ACTIVATION; CELL INTERACTION; CELL SURVIVAL; CONFERENCE PAPER; HEMATOPOIETIC STEM CELL; HORMONE ACTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICROENVIRONMENT; NONHUMAN; OSTEOBLAST; PROTEIN ANALYSIS; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 33744765513     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1346.021     Document Type: Conference Paper

References (78)

1. Lovell-Badge, R. 2001. The future for stem cell research. Nature 414: 88 91.
2. Hackney, J.A. et al. 2002. A molecular profile of a hematopoietic stem cell niche. Proc. Natl. Acad. Sci. USA 99: 13061 13066.
3. Ivanova, N.B. et al. 2002. A stem cell molecular signature. Science 298: 601 604.
4. Ramalho-Santos, M. et al. 2002. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science 298: 597 600.
5. Schofield, R. 1978. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4: 7 25.
6. Xie, T. & A.C. Spradling. 2000. A niche maintaining germ line stem cells in the Drosophila ovary. Science 290: 328 330.
7. Kiger, A.A. et al. 2001. Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science 294: 2542 2545.
8. Tulina, N. & E. Matunis. 2001. Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science 294: 2546 2549.
9. Reya, T. et al. 2001. Stem cells, cancer, and cancer stem cells. Nature 414: 105 111.
10. Spangrude, G.J., S. Heimfeld & I.L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241: 58 62.
11. Baum, C.M. et al. 1992. Isolation of a candidate human hematopoietic stem-cell population. Proc. Natl. Acad. Sci. USA 89: 2804 2808.
12. Morrison, S.J. & I.L. Weissman. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1: 661 673.
13. Osawa, M. et al. 1996. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273: 242 245.
14. Sutherland, H.J. et al. 1989. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74: 1563 1570.
15. Sutherland, H.J. et al. 1990. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc. Natl. Acad. Sci. USA 87: 3584 3588.
16. Harrison, D.E. 1980. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood 55: 77 81.
17. Antin, J. &, N. Kernand 2003. Hematopoietic stem cell transplantation. In Blood Principles and Practice of Hematology. R.I. Handin, S.E. Lux & T.P. Stossel, Eds.: 2133 2190. Lippincott Williams and Wilkins. Philadelphia, PA.
18. Morrison, S.J. et al. 1997. Identification of a lineage of multipotent hematopoietic progenitors. Development 124: 1929 1939.
19. Bhardwaj, G. et al. 2001. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat. Immunol. 2: 172 180.
20. Yamane, T. et al. 2001. Wnt signaling regulates hemopoiesis through stromal cells. J. Immunol. 167: 765 772.
21. Murdoch, B. et al. 2003. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc. Natl. Acad. Sci. USA 100: 3422 3427.
22. Willert, K. et al. 2003. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423: 448 452.
23. Varnum-Finney, B. et al. 1998. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood 91: 4084 4091.
24. Varnum-Finney, B., C. Brashem-Stein & I.D. Bernstein. 2003. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 101: 1784 1789.
25. Karanu, F.N. et al. 2000. The Notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J. Exp. Med. 192: 1365 1372.
26. Burns, C.E. et al. 2005. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 19: 2331 2342.
27. Xie, T. & A.C. Spradling. 1998. Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94: 251 260.
28. Song, X. et al. 2002. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 296: 1855 1857.
29. Gong, J.K. 1978. Endosteal marrow: a rich source of hematopoietic stem cells. Science 199: 1443 1445.
30. Lord, B.I., N.G. Testa & J.H. Hendry. 1975. The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood 46: 65 72.
31. Nilsson, S.K., H.M. Johnston & J.A. Coverdale. 2001. Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood 97: 2293 2299.
32. Taichman, R.S. & S.G. Emerson. 1994. Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor. J. Exp. Med. 179: 1677 1682.
33. Taichman, R.S., M.J. Reilly & S.G. Emerson. 1996. Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures. Blood 87: 518 524.
34. Taichman, R.S., M.J. Reilly & S.G. Emerson. 2000. The hematopoietic microenvironment: osteoblasts and the hematopoietic microenvironment. Hematology 4: 421 426.
35. El-Badri, N.S. et al. 1998. Osteoblasts promote engraftment of allogeneic hematopoietic stem cells. Exp. Hematol. 26: 110 116.
36. Nilsson, S.K. et al. 1999. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J. Exp. Med. 189: 729 734.
37. Calvi, L.M. et al. 2003. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841 846.
38. Zhang, J. et al. 2003. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425: 836 841.
39. Visnjic, D. et al. 2004. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood 103: 3258 3264.
40. Arai, F. et al. 2004. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149 161.
41. Wilson, A. et al. 2004. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 18: 2747 2763.
42. Nilsson, S.K. et al. 2005. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 106: 1232 1239.
43. Stier, S. et al. 2005. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J. Exp. Med. 201: 1781 1791.
44. Calvi, L.M. et al. 2001. Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J. Clin. Invest. 107: 277 286.
45. Rossert, J.A. et al. 1996. Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc. Natl. Acad. Sci. USA 93: 1027 1031.
46. Rossert, J., & B. De Crombrugghe. 1996. Type I collagen: structure, synthesis and regulation. In Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, G.A. Rodan, Eds.: 127 142. Academic Press. San Diego.
47. Rossert, J., H. Eberspaecher & B. de Crombrugghe. 1995. Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J. Cell Biol. 129: 1421 1432.
48. Pavlin, D. et al. 1992. Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells. J. Cell Biol. 116: 227 236.
49. Juppner, H. et al. 1991. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254: 1024 1026.
50. Abou-Samra, A.B. et al. 1992. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. USA 89: 2732 2736.
51. Schipani, E., K. Kruse & H. Juppner. 1995. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268: 98 100.
52. Schipani, E. et al. 1996. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia [see comments]. N. Engl. J. Med. 335: 708 714.
53. Milner, L.A. & A. Bigas. 1999. Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation. Blood 93: 2431 2448.
54. Li, L. et al. 1998. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity 8: 43 55.
55. Aubin, J., & J.T. Triffitt. 2002. Mesenchymal stem cells and osteoblast differentiation. In Principles of Bone Biology, Vol. 1. J.P. Bilezikian, L.G. Raisz, G.A. Rodan, Eds.: 59 81. Academic Press. San Diego, CA.
56. Malaval, L. et al. 1994. Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures. J. Cell Physiol. 158: 555 572.
57. Otto, F. et al. 1997. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development [see comments]. Cell 89: 765 771.
58. Banerjee, C. et al. 1997. Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J. Cell Biochem. 66: 1 8.
59. Stein, G.S. & J.B. Lian. 1993. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr. Rev. 14: 424 442.
60. Bellows, C.G. et al. 1990. Parathyroid hormone reversibly suppresses the differentiation of osteoprogenitor cells into functional osteoblasts. Endocrinology 127: 3111 3116.
61. Onyia, J.E. et al. 1995. In vivo, human parathyroid hormone fragment (hPTH 1-34) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats. Bone 17: 479 484.
62. Carpio, L. et al. 2001. Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways. Am. J. Physiol. Endocrinol. Metab. 281: E489 E499.
63. Isogai, Y. et al. 1996. Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages. J. Bone Miner. Res. 11: 1384 1393.
64. Pereira, R.M. et al. 2002. Cortisol regulates the expression of Notch in osteoblasts. J. Cell. Biochem. 85: 252 258.
65. Qin, L. et al. 2003. Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics. J. Biol. Chem. 278: 19723 19731.
66. Stier, S. et al. 2002. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 99: 2369 2378.
67. Varnum-Finney, B. et al. 2000. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat. Med. 6: 1278 1281.
68. Karanu, F.N. et al. 2001. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. Blood 97: 1960 1967.
69. Mancini, S.J. et al. 2005. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 105: 2340 2342.
70. Sciaudone, M. et al. 2003. Notch 1 impairs osteoblastic cell differentiation. Endocrinology 144: 5631 5639.
71. Nobta, M. et al. 2005. Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J. Biol. Chem. 280: 15842 15848.
72. Shindo, K. et al. 2003. Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling. Exp. Cell Res. 290: 370 380.
73. Watanabe, N. et al. 2003. Suppression of differentiation and proliferation of early chondrogenic cells by Notch. J. Bone Miner. Metab. 21: 344 352.
74. Nishida, S. et al. 1994. Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow. Bone 15: 717 723.
75. Chan, G.K. et al. 2003. Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology 144: 5511 5520.
76. MacDonald, B.R., J.A. Gallagher & R.G. Russell. 1986. Parathyroid hormone stimulates the proliferation of cells derived from human bone. Endocrinology 118: 2445 2449.
77. Miao, D. et al. 2001. Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 276: 32204 32213.
78. Jilka, R.L. et al. 1999. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J. Clin. Invest. 104: 439 446.