Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

Cell Reports

Volumn 16, Issue 10, 2016, Pages 2605-2617

  Goldstein, Leonard D ^a   Lee, James ^a   Gnad, Florian ^a   Klijn, Christiaan ^a   Schaub, Annalisa ^a   Reeder, Jens ^a   Daemen, Anneleen ^a   Bakalarski, Corey E ^a   Holcomb, Thomas ^a   Shames, David S ^a   Hartmaier, Ryan J ^b   Chmielecki, Juliann ^b   Seshagiri, Somasekar ^a   Gentleman, Robert ^a   Stokoe, David ^a  

^a GENENTECH INC   (United States)

^b FOUNDATION MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; KEAP1 PROTEIN, HUMAN; MESSENGER RNA; PROTEIN BINDING;

ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; EXON; GENE DELETION; GENE EXPRESSION; GENE LOSS; GENETIC VARIABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; NON SMALL CELL LUNG CANCER; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN STABILITY; TRANSCRIPTION INITIATION; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN GENOME; METABOLISM; MUTATION; NEOPLASM; REPRODUCIBILITY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; EXONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MUTATION; NEOPLASMS; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

EID: 85006351788     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.08.010     Document Type: Article

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