By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

Immunity

Volumn 47, Issue 4, 2017, Pages 697-709.e3

  Zanoni, Ivan ^a,b   Tan, Yunhao ^a   Di Gioia, Marco ^a   Springstead, James R ^c   Kagan, Jonathan C ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c Parkview Campus   (United States)

Author keywords

dendritic cells; hyperactivation; inflammasome; innate immunity; interleukin 1; macrophages; oxPAPC; SMOC; Toll like Receptor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE 11; CD14 ANTIGEN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPID; PHOSPHORYLCHOLINE; TOLL LIKE RECEPTOR 4; LIPOPOLYSACCHARIDE; OXIDIZED-L-ALPHA-1-PALMITOYL-2-ARACHIDONOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE; PHOSPHATIDYLCHOLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL FATE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENDOCYTOSIS; ENDOSOME; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PYROPTOSIS; REGULATORY MECHANISM; SEPSIS; SIGNAL TRANSDUCTION; ADAPTIVE IMMUNITY; ANIMAL; C57BL MOUSE; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; FEMALE; FLOW CYTOMETRY; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; WESTERN BLOTTING;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, CD14; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; DENDRITIC CELLS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOCYTES; PHOSPHATIDYLCHOLINES;

EID: 85032828728     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.09.010     Document Type: Article

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