메뉴 건너뛰기




Volumn 3, Issue SEP, 2012, Pages

The danger theory: 20 years later

Author keywords

Cancer; Danger; Danger signals; Immunity; Inflammation; Innate immunity; Tolerance; Transplantation

Indexed keywords


EID: 84874208748     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00287     Document Type: Article
Times cited : (173)

References (92)
  • 2
    • 0034210009 scopus 로고    scopus 로고
    • Danger, the view from the bottom of the cliff
    • Anderson, C. C., and Matzinger, P. (2000a). Danger, the view from the bottom of the cliff. Semin. Immunol. 12, 231-238.
    • (2000) Semin. Immunol. , vol.12 , pp. 231-238
    • Anderson, C.C.1    Matzinger, P.2
  • 5
    • 0034113617 scopus 로고    scopus 로고
    • HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    • Asea, A., Kraeft, S. K., Kurt-Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R.W., Koo, G. C., and Calderwood, S. K. (2000). HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 6, 435-442.
    • (2000) Nat. Med. , vol.6 , pp. 435-442
    • Asea, A.1    Kraeft, S.K.2    Kurt-Jones, E.A.3    Stevenson, M.A.4    Chen, L.B.5    Finberg, R.W.6    Koo, G.C.7    Calderwood, S.K.8
  • 6
    • 0033747044 scopus 로고    scopus 로고
    • Necrotic but not apop-totic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
    • Basu, S., Binder, R. J., Suto, R., Anderson, K. M., and Srivastava, P. K. (2000). Necrotic but not apop-totic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int. Immunol. 12, 1539-1546.
    • (2000) Int. Immunol. , vol.12 , pp. 1539-1546
    • Basu, S.1    Binder, R.J.2    Suto, R.3    Anderson, K.M.4    Srivastava, P.K.5
  • 8
    • 63449101111 scopus 로고    scopus 로고
    • Dangers in and out
    • Bianchi, M. E., and Manfredi, A. A. (2009). Dangers in and out. Science 323, 1683-1684.
    • (2009) Science , vol.323 , pp. 1683-1684
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 11
    • 33749261659 scopus 로고    scopus 로고
    • Adenosine 5;-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    • Bours, M. J., Swennen, E. L., Di Virgilio, F., Cronstein, B. N., and Dagnelie, P. C. (2006). Adenosine 5;-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 112, 358-404.
    • (2006) Pharmacol Ther , vol.112 , pp. 358-404
    • Bours, M.J.1    Swennen, E.L.2    Di Virgilio, F.3    Cronstein, B.N.4    Dagnelie, P.C.5
  • 13
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • Bretscher, P., and Cohn, M. (1970). A theory of self-nonself discrimination. Science 169, 1042-1049.
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 14
    • 79960810171 scopus 로고    scopus 로고
    • Heat shock proteins are no DAMPs, rather 'DAMPERs'
    • Broere, F., van der Zee, R., and van Eden, W. (2011). Heat shock proteins are no DAMPs, rather 'DAMPERs'. Nat Rev. Immunol. 11, 565.
    • (2011) Nat Rev. Immunol. , vol.11 , pp. 565
    • Broere, F.1    van der Zee, R.2    van Eden, W.3
  • 15
    • 0037103167 scopus 로고    scopus 로고
    • Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy
    • Brown, B. D., and Lillicrap, D. (2002). Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy. Blood 100, 1133-1140.
    • (2002) Blood , vol.100 , pp. 1133-1140
    • Brown, B.D.1    Lillicrap, D.2
  • 18
    • 0003949266 scopus 로고
    • Self and Notself Cambridge: Cambridge University Press
    • Burnet, F. M. (1969). Cellular Immunology: Self and Notself Cambridge: Cambridge University Press.
    • (1969) Cellular Immunology
    • Burnet, F.M.1
  • 20
    • 69949105157 scopus 로고    scopus 로고
    • The NLRP3 inflam-masome: a sensor of immune danger signals
    • Cassel, S. L., Joly, S., and Sutterwala, F. S. (2009). The NLRP3 inflam-masome: a sensor of immune danger signals. Semin. Immunol. 21, 194-198.
    • (2009) Semin. Immunol. , vol.21 , pp. 194-198
    • Cassel, S.L.1    Joly, S.2    Sutterwala, F.S.3
  • 21
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: sensing and reacting to damage
    • Chen, G. Y., and Nuñez, G. (2010). Sterile inflammation: sensing and reacting to damage. Nat Rev. Immunol. 10, 826-837.
    • (2010) Nat Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nuñez, G.2
  • 22
    • 79960768302 scopus 로고    scopus 로고
    • Are heat shock proteins DAMPs Nat
    • Chen, G. Y, and Nuñez, G. (2011). Are heat shock proteins DAMPs? Nat. Rev. Immunol. 11, 565.
    • (2011) Rev. Immunol. , vol.11 , pp. 565
    • Chen, G.1    Nuñez, Y.G.2
  • 23
    • 63149171602 scopus 로고    scopus 로고
    • CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
    • Chen, G-Y, Tang, J., Zheng, P., and Liu, Y (2009). CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 323, 1722-1725.
    • (2009) Science , vol.323 , pp. 1722-1725
    • Chen, G.-Y.1    Tang, J.2    Zheng, P.3    Liu, Y.4
  • 24
    • 49449100696 scopus 로고    scopus 로고
    • From Darwin and Metchnik off to Burnet and beyond
    • 15th Edn. eds A. Egesten, A. Schmidt, and H. Herwald (Basel: Karger)
    • Cooper, E. L. (2008). "From Darwin and Metchnikoff to Burnet and beyond," in Trends in Innate Immunity. Contributions to Microbiology, 15th Edn. eds A. Egesten, A. Schmidt, and H. Herwald (Basel: Karger), 1-11.
    • Trends in Innate Immunity. Contributions to Microbiology , pp. 1-11
    • Cooper, E.L.1
  • 25
    • 77649178836 scopus 로고    scopus 로고
    • Self/not self, innate immunity, danger, cancer potential
    • Cooper, E. L. (2010). Self/not self, innate immunity, danger, cancer potential. Phys. Life Rev. 7, 85-87.
    • (2010) Phys. Life Rev. , vol.7 , pp. 85-87
    • Cooper, E.L.1
  • 26
    • 0036010595 scopus 로고    scopus 로고
    • Digging for innate immunity since Darwin and Metchnikoff
    • Cooper, E. L., Kauschke, E., and Cossarizza, A. (2002). Digging for innate immunity since Darwin and Metchnikoff. Bioessays 24, 319-333.
    • (2002) Bioessays , vol.24 , pp. 319-333
    • Cooper, E.L.1    Kauschke, E.2    Cossarizza, A.3
  • 27
    • 79958748545 scopus 로고    scopus 로고
    • Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage
    • De Maio, A. (2011). Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. Cell Stress Chaperones 16, 235-249.
    • (2011) Cell Stress Chaperones , vol.16 , pp. 235-249
    • De Maio, A.1
  • 28
    • 79960920271 scopus 로고    scopus 로고
    • NLRP3 inflammasomes link inflammation and metabolic disease
    • De Nardo, D., and Latz, E. (2011). NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 32, 373-379.
    • (2011) Trends Immunol , vol.32 , pp. 373-379
    • De Nardo, D.1    Latz, E.2
  • 30
    • 33750321707 scopus 로고    scopus 로고
    • Interferons, immunity and cancer immunoedit-ing
    • Dunn, G. P., Koebel, C. M., and Schreiber, R. D. (2006). Interferons, immunity and cancer immunoedit-ing. Nat. Rev. Immunol. 6, 836-848.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 836-848
    • Dunn, G.P.1    Koebel, C.M.2    Schreiber, R.D.3
  • 31
    • 77955652969 scopus 로고    scopus 로고
    • A new vision of immunity: homeostasis of the superorganism
    • Eberl, G. (2010). A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol. 3, 450-460.
    • (2010) Mucosal Immunol , vol.3 , pp. 450-460
    • Eberl, G.1
  • 32
    • 14444288166 scopus 로고
    • The assay of the activity of diphtheria-curative serum and its theoretical basis
    • ed F. Himmelweit, (1897) (Oxford: Pergamon)
    • Ehrlich, P. (1957). "The assay of the activity of diphtheria-curative serum and its theoretical basis," in The Collected Papers of Paul Ehrlich, Vol. 2, ed F. Himmelweit, (1897) (Oxford: Pergamon), 107-125.
    • (1957) The Collected Papers of Paul Ehrlich , vol.2 , pp. 107-125
    • Ehrlich, P.1
  • 33
    • 84866950457 scopus 로고    scopus 로고
    • Clear and present danger Engineered nanoparticles and the immune system
    • Fadeel, B. (2012). Clear and present danger? Engineered nanoparticles and the immune system. Swiss Med. Wkly. 142, w13609.
    • (2012) Swiss Med. Wkly. , vol.142
    • Fadeel, B.1
  • 35
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: endogenous activators of dendritic cells
    • Gallucci, S., Lolkema, M., and Matzinger, P. (1999). Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255.
    • (1999) Nat. Med. , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 36
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci, S., and Matzinger, P. (2001). Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13, 114-119.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 37
    • 33846942663 scopus 로고    scopus 로고
    • Conceptualizing immune responsiveness
    • Greenspan, N. S. (2007). Conceptualizing immune responsiveness. Nat. Immunol. 8, 5-7.
    • (2007) Nat. Immunol. , vol.8 , pp. 5-7
    • Greenspan, N.S.1
  • 38
    • 0034210015 scopus 로고    scopus 로고
    • Self-tolerance: context dependent tuning of T cell antigen recognition
    • Grossman, Z., and Paul, W. E. (2000). Self-tolerance: context dependent tuning of T cell antigen recognition. Semin. Immunol. 12, 197-203.
    • (2000) Semin. Immunol. , vol.12 , pp. 197-203
    • Grossman, Z.1    Paul, W.E.2
  • 39
    • 33747751590 scopus 로고    scopus 로고
    • Alarmin(g) news about danger: workshop on innate danger signals and HMGB1
    • Harris, H. E., and Raucci, A. (2006). Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep. 7, 774-778.
    • (2006) EMBO Rep , vol.7 , pp. 774-778
    • Harris, H.E.1    Raucci, A.2
  • 40
    • 0024955886 scopus 로고
    • Approaching the asymptote Evolution and revolution in immunology
    • Janeway, C. A. (1989). Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 41
    • 0026791975 scopus 로고
    • The immune system evolved to discriminate infectious nonself from noninfectious self
    • Janeway, C. A. (1992). The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13, 11-16.
    • (1992) Immunol. Today , vol.13 , pp. 11-16
    • Janeway, C.A.1
  • 42
    • 0030134246 scopus 로고    scopus 로고
    • Immunological tolerance: danger - pathogen on the premises! Curr
    • Janeway, J. A., Goodnow, C. C., and Medzhitov, R. (1996). Immunological tolerance: danger - pathogen on the premises! Curr. Biol. 6, 519-522.
    • (1996) Biol , vol.6 , pp. 519-522
    • Janeway, J.A.1    Goodnow, C.C.2    Medzhitov, R.3
  • 43
    • 58049209834 scopus 로고    scopus 로고
    • Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    • Joffre, O., Nolte, M. A., Spörri, R., and Reis e Sousa, C. (2009). Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol. Rev. 227, 234-247.
    • (2009) Immunol. Rev. , vol.227 , pp. 234-247
    • Joffre, O.1    Nolte, M.A.2    Spörri, R.3    Reis e Sousa, C.4
  • 45
    • 77953459979 scopus 로고    scopus 로고
    • Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proin-flammatory cytokines mediated by autocrine ATP
    • Kobayashi, T., Kouzaki, H., and Kita, H. (2010). Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proin-flammatory cytokines mediated by autocrine ATP. J. Immunol. 184, 6350-6358.
    • (2010) J. Immunol. , vol.184 , pp. 6350-6358
    • Kobayashi, T.1    Kouzaki, H.2    Kita, H.3
  • 46
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono, H., and Rock, K. L. (2008). How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8, 279-289.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 47
    • 79955040263 scopus 로고    scopus 로고
    • The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
    • Kouzaki, H., Iijima, K., Kobayashi, T., O'Grady, S. M., and Kita, H. (2011). The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J. Immunol. 186, 4375-4387.
    • (2011) J. Immunol. , vol.186 , pp. 4375-4387
    • Kouzaki, H.1    Iijima, K.2    Kobayashi, T.3    O'Grady, S.M.4    Kita, H.5
  • 49
    • 79953276805 scopus 로고    scopus 로고
    • Danger, Microbes, and Homeostasis
    • Lazzaro, B. P., and Rolff, J. (2011). Danger, Microbes, and Homeostasis. Science 332, 43-44.
    • (2011) Science , vol.332 , pp. 43-44
    • Lazzaro, B.P.1    Rolff, J.2
  • 50
    • 80052740181 scopus 로고    scopus 로고
    • Innate immune recognition receptors and damage associated molecular patterns in plaque inflammation
    • Lundberg, A. M., and Yan, Z. Q. (2011). Innate immune recognition receptors and damage associated molecular patterns in plaque inflammation. Curr. Opin. Lipidol. 22, 343-349.
    • (2011) Curr. Opin. Lipidol. , vol.22 , pp. 343-349
    • Lundberg, A.M.1    Yan, Z.Q.2
  • 52
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. (1994). Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 53
    • 0032191916 scopus 로고    scopus 로고
    • An innate sense of danger
    • Matzinger, P. (1998) An innate sense of danger. Semin. Immunol. 10, 399-415.
    • (1998) Semin. Immunol. , vol.10 , pp. 399-415
    • Matzinger, P.1
  • 54
    • 0034956209 scopus 로고    scopus 로고
    • The danger model in its historical context
    • Matzinger, P. (2001). The danger model in its historical context. Scand. J. Immunol. 54, 4-9.
    • (2001) Scand. J. Immunol. , vol.54 , pp. 4-9
    • Matzinger, P.1
  • 55
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • Matzinger, P. (2002). The danger model: a renewed sense of self. Science 296, 301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 56
    • 33846990935 scopus 로고    scopus 로고
    • Friendly and dangerous signals: is the tissue in control
    • Matzinger, P. (2007). Friendly and dangerous signals: is the tissue in control? Nat. Immunol. 8, 11-13.
    • (2007) Nat Immunol , vol.8 , pp. 11-13
    • Matzinger, P.1
  • 57
    • 84861368068 scopus 로고    scopus 로고
    • The evolution of the danger theory
    • Matzinger, P. (2012). The evolution of the danger theory. Expert Rev. Clin. Immunol. 8, 311-317.
    • (2012) Expert Rev. Clin. Immunol. , vol.8 , pp. 311-317
    • Matzinger, P.1
  • 58
    • 79952126441 scopus 로고    scopus 로고
    • Tissue-based class control: the other side of tolerance
    • Matzinger, P., and Kamala, T. (2011). Tissue-based class control: the other side of tolerance. Nat. Rev. Immunol. 11, 221-230.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 221-230
    • Matzinger, P.1    Kamala, T.2
  • 59
    • 0003509819 scopus 로고
    • Translated by F. A. Starling and E. H. Starling, (1892). London: Kegan, Pauls Trench Trubner
    • Metchnikoff, I. (1893). Lectures on the Comparative Pathology of Inflammation. Translated by F. A. Starling and E. H. Starling, (1892). London: Kegan, Pauls Trench Tr u b n e r.
    • (1893) Lectures on the Comparative Pathology of Inflammation
    • Metchnikoff, I.1
  • 60
    • 49849099795 scopus 로고    scopus 로고
    • Regulation of autoimmune arthritis by self-heat-shock proteins
    • Moudgil, K. D., and Durai, M. (2008). Regulation of autoimmune arthritis by self-heat-shock proteins. Tr e n d s Immunol. 29, 412-418.
    • (2008) Trends Immunol , vol.29 , pp. 412-418
    • Moudgil, K.D.1    Durai, M.2
  • 61
    • 36348964221 scopus 로고    scopus 로고
    • Heat shock proteins: linking danger and pathogen recognition
    • Osterloh, A., and Breloer, M. (2008). Heat shock proteins: linking danger and pathogen recognition. Med. Microbiol. Immunol. 197, 1-8.
    • (2008) Med. Microbiol. Immunol. , vol.197 , pp. 1-8
    • Osterloh, A.1    Breloer, M.2
  • 62
    • 60649118070 scopus 로고    scopus 로고
    • An innate immune response of blood cells to tumors and tissue damage in Drosophila
    • Pastor-Pareja, J., Wu, M., and Xu, T. (2008). An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis. Model Mech. 1, 144-154.
    • (2008) Dis. Model Mech. , vol.1 , pp. 144-154
    • Pastor-Pareja, J.1    Wu, M.2    Xu, T.3
  • 63
    • 64049096349 scopus 로고    scopus 로고
    • Sensing pathogens and danger signals by the inflammasome
    • Pedra, J. H. F., Cassel, S. L., and Sutterwala, F. S. (2009). Sensing pathogens and danger signals by the inflammasome. Curr. Opin. Immunol. 21, 10-16.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 10-16
    • Pedra, J.H.F.1    Cassel, S.L.2    Sutterwala, F.S.3
  • 65
    • 33845193274 scopus 로고    scopus 로고
    • On the definition of a criterion of immunogenicity
    • Pradeu, T., and Carosella, E. D. (2006). On the definition of a criterion of immunogenicity. Proc. Natl. Acad. Sci. U.S.A. 103, 17858-17861.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 17858-17861
    • Pradeu, T.1    Carosella, E.D.2
  • 66
    • 79751531096 scopus 로고    scopus 로고
    • The HSP60 immune system network
    • Quintana, F. J., and Cohen, I. R. (2011). The HSP60 immune system network. Trends Immunol. 32, 89-95.
    • (2011) Trends Immunol , vol.32 , pp. 89-95
    • Quintana, F.J.1    Cohen, I.R.2
  • 67
    • 33846990557 scopus 로고    scopus 로고
    • Organ-specific regulation of innate immunity
    • Raz, E. (2007). Organ-specific regulation of innate immunity. Nat. Immunol. 8, 3-4.
    • (2007) Nat. Immunol. , vol.8 , pp. 3-4
    • Raz, E.1
  • 69
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimula-tory dendritic cells
    • Sauter, B., Albert, M. L., Francisco, L., Larsson, M., Somersan, S., and Bhardwaj, N. (2000). Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimula-tory dendritic cells. J. Exp. Med. 191, 423-434.
    • (2000) J. Exp. Med. , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 70
    • 84866316867 scopus 로고    scopus 로고
    • LOX-1, A multili-gand receptor at the crossroads of response to danger signals
    • doi: 10.1097/MOL. 0b013e32835688e4. [Epub ahead of print].
    • Sawamura, T., Kakino, A., and Fujita, Y. (in press). LOX-1, A multili-gand receptor at the crossroads of response to danger signals. Curr. Opin. Lipidol. doi: 10.1097/MOL. 0b013e32835688e4. [Epub ahead of print].
    • Curr. Opin. Lipidol
    • Sawamura, T.1    Kakino, A.2    Fujita, Y.3
  • 71
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflamma-some: a sensor for metabolic danger
    • Schroder, K., Zhou, R., and Tschopp, J. (2010). The NLRP3 inflamma-some: a sensor for metabolic danger? Science 327, 296-300.
    • (2010) Science , vol.327 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 72
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: an ancient damage- associated molecular pattern that initiates innate immune responses
    • Seong, S.-Y., and Matzinger, P. (2004). Hydrophobicity: an ancient damage- associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4, 469-478.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 469-478
    • Seong, S.-Y.1    Matzinger, P.2
  • 73
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi, Y., Evans, J. E., and Rock, K. L. (2003). Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521.
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 74
    • 33646022583 scopus 로고    scopus 로고
    • Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model
    • Shi, Y., Galusha, S. A., and Rock, K. L. (2006). Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model. J. Immunol. 176, 3905-3908.
    • (2006) J. Immunol. , vol.176 , pp. 3905-3908
    • Shi, Y.1    Galusha, S.A.2    Rock, K.L.3
  • 75
    • 79960990849 scopus 로고    scopus 로고
    • Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis
    • Shields, A. M., Panayi, G. S., and Corrigall, V. M. (2011). Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis? Clin. Exp. Immunol. 165, 292-300.
    • (2011) Clin Exp. Immunol. , vol.165 , pp. 292-300
    • Shields, A.M.1    Panayi, G.S.2    Corrigall, V.M.3
  • 76
    • 0029664880 scopus 로고    scopus 로고
    • Immunological tolerance
    • Silverstein, A. M. (1996). Immunological tolerance. Science 272, 1405.
    • (1996) Science , vol.272 , pp. 1405
    • Silverstein, A.M.1
  • 77
    • 0030717434 scopus 로고    scopus 로고
    • On the mystique of the immunological self
    • Silverstein, A. M., and Rose, N. R. (1997). On the mystique of the immunological self. Immunol. Rev. 159, 197.
    • (1997) Immunol. Rev. , vol.159 , pp. 197
    • Silverstein, A.M.1    Rose, N.R.2
  • 78
    • 0034210011 scopus 로고    scopus 로고
    • There is only one immune system! The view from immunopathology
    • Silverstein, A. M., and Rose, N. R. (2000). There is only one immune system! The view from immunopathology. Semin. Immunol. 12, 173-178.
    • (2000) Semin. Immunol. , vol.12 , pp. 173-178
    • Silverstein, A.M.1    Rose, N.R.2
  • 79
    • 0036512171 scopus 로고    scopus 로고
    • Roles of heat-shock proteins in innate and adaptive immunity
    • Srivastava, P. (2002). Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2, 185-194.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 185-194
    • Srivastava, P.1
  • 80
    • 4444328615 scopus 로고    scopus 로고
    • Intravital microscopy: visualizing immunity in context
    • Sumen, C., Mempel, T. R., Mazo, I. B., and von Andrian, U. H. (2004). Intravital microscopy: visualizing immunity in context. Immunity 21, 315-329.
    • (2004) Immunity , vol.21 , pp. 315-329
    • Sumen, C.1    Mempel, T.R.2    Mazo, I.B.3    von Andrian, U.H.4
  • 81
    • 4043068462 scopus 로고    scopus 로고
    • Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils
    • Stenfeldt, A. L., and Wennerås, C. (2004). Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils. Immunology 112, 605-14.
    • (2004) Immunology , vol.112 , pp. 605-614
    • Stenfeldt, A.L.1    Wennerås, C.2
  • 84
    • 2042528695 scopus 로고
    • Injury and immunity in insects: Studies with Hyalophora cecropia fat body hemocytes in vivo and in vitro
    • eds F. Sehnal, A. Zabza, and D. L. Denlinger (Wroclaw: Wroclaw Technical University Press)
    • Trenczek, T. (1988). "Injury and immunity in insects: Studies with Hyalophora cecropia fat body hemocytes in vivo and in vitro," in Endocrinological Frontiers in Physiological Insect Ecology, eds F. Sehnal, A. Zabza, and D. L. Denlinger (Wroclaw: Wroclaw Technical University Press), 369-378.
    • (1988) Endocrinological Frontiers in Physiological Insect Ecology , pp. 369-378
    • Trenczek, T.1
  • 85
    • 0034662687 scopus 로고    scopus 로고
    • A Copernician revolution Doubts about the danger theory
    • Vance, R. E. (2000). A Copernician revolution? Doubts about the danger theory. J. Immunol. 165, 1725-1728.
    • (2000) J. Immunol , vol.165 , pp. 1725-1728
    • Vance, R.E.1
  • 87
    • 17144417382 scopus 로고    scopus 로고
    • Heat-shock proteins induce T-cell regulation of chronic inflammation
    • van Eden, W., van der Zee, R., and Prakken, B. (2005). Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat. Rev. Immunol. 5, 318-330.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 318-330
    • van Eden, W.1    van der Zee, R.2    Prakken, B.3
  • 90
    • 80052493237 scopus 로고    scopus 로고
    • Danger signals activating innate immunity in graft-versus-host disease
    • Zeiser, R., Penack, O., Holler, E., and Idzko, M. (2011). Danger signals activating innate immunity in graft-versus-host disease. J. Mol. Med. (Berl.) 89, 833-845.
    • (2011) J. Mol. Med. (Berl. ) , vol.89 , pp. 833-845
    • Zeiser, R.1    Penack, O.2    Holler, E.3    Idzko, M.4
  • 92
    • 0034210006 scopus 로고    scopus 로고
    • Localization dose and time of antigens determine immune reactivity
    • Zinkernagel, R. M. (2000). Localization dose and time of antigens determine immune reactivity. Semin. Immunol. 12, 163-171.
    • (2000) Semin. Immunol. , vol.12 , pp. 163-171
    • Zinkernagel, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.