Rapid analysis of medically relevant compounds in faba bean seeds using FAIMS and mass spectrometry

International Journal for Ion Mobility Spectrometry

Volumn 20, Issue 3-4, 2017, Pages 125-135

  Purves, Randy W ^a   Zhang, Haixia ^a   Khazaei, Hamid ^a   Vandenberg, Albert ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

FAIMS; Favism; Ion mobility; Levodopa; Mass spectrometry; Vicine convicine

Indexed keywords

MASS SPECTROMETRY; NUTRITION; SPECTROMETRY;

FAIMS; FAVISM; ION MOBILITY; LEVODOPA; VICINE/CONVICINE;

DRUG PRODUCTS;

EID: 85032577375     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-017-0226-7     Document Type: Article

References (36)

1. Rabey JM, Vered Y, Shabtai H, Graff E, Harsat A, Korczyn AD (1993) Broad bean (Vicia faba) consumption and Parkinson's disease. Adv Neurol 60:681–684
2. Yarnall A, Archibald N, Burn D (2012) Parkinson’s disease. Medicine 40(10):529–535
3. Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368–376
4. Abbott A (2010) Levodopa: the story so far. Nature 66:S6–S7
5. Goyoaga C, Burbano C, Cuadrado C, Varela A, Guillamón E, Pedrosa MM, Muzquiz M (2008) Content and distribution of vicine, convicine and L-DOPA during germination and seedling growth of two Vicia faba L. varieties. Eur Food Res Technol 227(5):1537–1542
6. Burbano C, Cuadrado C, Muzquiz M, Cubero JI (1995) Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. Plant Foods Hum Nutr 47(3):265–274
7. Hill-Cottingham DG, Purves JV (1983) Changes during development in the free amino acid constituents of faba bean (Vicia faba L.) plants. Plant Soil 75(3):435–442
8. Crépon K, Marget P, Peyronnet C, Carrouée B, Arese P, Duc G (2010) Nutritional value of faba bean (Vicia faba L.) seeds for feed and food. Field Crops Res 115:329–339
9. Cappellini MD, Fiorelli G (2008) Glucose-6-phosphate dehydrogenase deficiency. Lancet 371:64–74
10. Khazaei H, Purves RW, Song M, Stonehouse R, Bett KE, Stoddard FL, Vandenberg A (2017) Development and validation of a robust, breeder-friendly molecular marker for the vc- locus in faba bean. Mol Breed. https://doi.org/10.1007/s11032-017-0742-5
11. Purves RW, Khazaei H, Vandenberg A (2018) Quantification of vicine and convicine in faba bean seeds using hydrophilic interaction liquid chromatography. Food Chem 240:1137–1145
12. Hegazy M, Marquardt RR (1983) Development of a simple procedure for the complete extraction of vicine and convicine from faba beans (Vicia faba L.). J Sci Food Agric 34:100–108
13. Singhal A, Karaca CA, Tyler R, Nickerson M (2016) Pulse proteins: from processing to structure-function relationships. In: Goyal A (ed) Grain Legumes. InTech. https://doi.org/10.5772/64020
14. Duc G, Sixdenier G, Lila M, Furstoss V (1989) Search of genetic variability for vicine and convicine content in Vicia faba L. A first report of a gene which codes for nearly zero-vicine and zero-convicine contents. Wageningen, The Netherlands (Pbs), pp 305–313
15. Sixdenier G, Cassecuelle F, Guillaumin L, Duc G (1996) Rapid spectrophotometric method for reduction of vicine and convicine in faba bean seed. FABIS Newslett 38/39:42–44
16. Chevion M, Novak T (1983) A novel method for quantitation of favism-inducing agents in legumes. Anal Biochem 128:152–158
17. Marquardt RR, Frohlich AA (1981) Rapid reversed-phase high-performance liquid chromatographic method for the quantitation of vicine, convicine and related compounds. J Chromatogr A 208:373–379
18. Quemener B (1988) Improvements in the high-pressure liquid chromatographic determination of amino sugars and alpha-galactosides in faba bean, lupine and pea. J Agric Food Chem 36:754–759
19. Pulkkinen M, Gautam M, Lampi AM, Ollilainen V, Stoddard FL, Sontag-Strohm T, Salovaara H, Piironen V (2015) Determination of vicine and convicine from faba bean with an optimized high-performance liquid chromatographic method. Food Res Int 76:168–177
20. McCooeye MA, Ells B, Barnett DA, Purves RW, Guevremont R (2001) Quantification of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. J Anal Toxicol 25:81–87
21. Eiceman GA, Karpas Z, Hill HH Jr (2014) Ion mobility spectrometry, 3rd edn. CRC Press, Boca Raton
22. Ewing MA, Glover MS, Clemmer DE (2016) Hybrid ion mobility and mass spectrometry as a separation tool. J Chromatogr A 1439:3–25
23. Purves RW (2017) Enhancing LC-MS biological analyses using ion mobility spectrometry, Chapter 9. In: Cappiello A, Palma P (eds) Advances in the use of liquid chromatography mass spectrometry (LC-MS): instrumentation developments and applications, vol 79. CAC Press, Boca Raton. https://doi.org/10.1016/bs.coac.2017.08.007
24. Buryakov IA, Krylov EV, Nazarov EG, Rasulev UK (1993) A new method of separation of multi-atomic ions by mobility at atmospheric pressure using a high-frequency amplitude-asymmetric strong electric field. Int J Mass Spectrom Ion Process 128:143–148
25. Purves RW, Guevremont R (1998) Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer. Rev Sci Instrum 69:4094–4105
26. Shvartsburg AA (2009) Differential ion mobility spectrometry: non-linear ion transport and fundamentals of FAIMS. CRC Press, Boca Raton
27. Schneider BB, Nazarov EG, Covey TR (2012) Peak capacity in differential mobility spectrometry: effects of transport gas and gas modifiers. Int J Ion Mobil Spectrom 15:141–150
28. Purves RW, Ozog A, Ambrose SJ, Prasad S, Belford M, Dunyach JJ (2014) Using gas modifiers to significantly improve sensitivity and selectivity in a cylindrical FAIMS. J Am Soc Mass Spectrom 25:1274–1284
29. Purves RW, Prasad S, Belford M, Vandenberg A (2017) Optimization of a new aerodynamic cylindrical FAIMS device for small molecule analysis. J Am Soc Mass Spectrom 28:525–538
30. Marquardt RR, Muduuli DS, Fröhlich AA (1983) Purification and some properties of vicine and convicine isolated from faba beans (Vicia faba L.) protein concentrate. J Agric Food Chem 31:839–844
31. Tan A, Boudreau N, Lévesque A (2012) Internal standards for quantitative LC-MS bioanalysis. Chapter 10. In: Xu QA, Madden TL (eds) LC-MS in drug analysis. Springer, Berlin
32. Prasad S, Belford MW, Dunyach JJ, Purves RW (2014) On an aerodynamic mechanism to enhance ion transmission and sensitivity of FAIMS for nano-electrospray ionization-mass spectrometry. J Am Soc Mass Spectrom 25:2143–2153
33. Barnett DA, Belford M, Dunyach JJ, Purves RW (2007) Characterization of a temperature-controlled FAIMS system. J Am Soc Mass Spectrom 18:1653–1663
34. Schneider BB, Covey TR, Nazarov EF (2013) DMS-MS separations with different transport gas modifiers. Int J Ion Mobil Spectrom 16:207–216
35. Griffiths DJ, Lawes DA (1978) Variation in the crude protein content of field beans (Vicia faba) in relation to the possible improvement of the protein content in the crop. Euphytica 27:487–449
36. Hu J, Kwon SJ, Park JJ, Landry E, Mattinson DS, Gang DR (2015) LC-MS determination of L-DOPA concentration in the leaf and flower tissues of six faba bean (Vicia faba L.) lines with common and rare flower colors. Func Foods Health Dis 5:243–250