Enhancing Biological LC-MS Analyses Using Ion Mobility Spectrometry

Comprehensive Analytical Chemistry

Volumn 79, Issue , 2018, Pages 205-240

  Purves, Randy W ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

DMS; FAIMS; Ion mobility; LC MS; T wave; TIMS; ultraFAIMS

Indexed keywords

EID: 85029595616     PISSN: 0166526X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.coac.2017.08.007     Document Type: Article

References (71)

1. Fenn, J.B., Mann, M., Meng, C.K., Wong, S.F., Whitehouse, C.M., Electrospray ionization for mass spectrometry of large biomolecules. Science 246 (1989), 64–71.
2. Baker, E.S., Clowers, B.H., Li, F., Tang, K., Tolmachev, A.V., Prior, D.C., Belov, M.E., Smith, R.D., Ion mobility spectrometry-mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures. J. Am. Soc. Mass Spectrom. 18 (2007), 1176–1187.
3. Hansen, S.H., General chromatographic theory and principles. Hansen, S.H., Pedersen-Bjergaard, S., (eds.) Bioanalysis of Pharmaceuticals: Sample Preparation, Chromatography and Mass Spectrometry, 2015, John Wiley & Sons, 31–60.
4. Mason, E.A., McDaniel, E.W., Transport Properties of Ions in Gases. 1988, John Wiley & Sons, Santa Fe.
5. Eiceman, G.A., Karpas, Z., Hill, H.H. Jr., Ion Mobility Spectrometry. third ed., 2014, CRC Press, Boca Raton.
6. Covington, J.A., van der Schee, M.P., Edge, A.S.L., Boyle, B., Savage, R.S., Arasaradnam, R.P., The application of FAIMS gas analysis in medical diagnostics. Analyst 140 (2015), 6775–6781.
7. Watson, J.T., Sparkman, O.D., Introduction to Mass Spectrometry: Instrumentation, Applications and Strategies for Data Interpretation. fourth ed., 2008, John Wiley & Sons, Chichester.
8. Kanu, A.B., Dwivedi, P., Tam, M., Matz, L., Hill, H.H. Jr., Ion mobility-mass spectrometry. J. Mass Spectrom. 43 (2008), 1–22.
9. Revercomb, H.E., Mason, E.A., Theory of plasma chromatography/gaseous electrophoresis-a review. Anal. Chem. 47 (1975), 970–983.
10. May, J.C., Goodwin, C.R., McLean, J.A., Ion mobility-mass spectrometry strategies for untargeted systems, synthetic, and chemical biology. Curr. Opin. Biotechnol. 31 (2015), 117–121.
11. Shvartsburg, A.A., Differential Ion Mobility Spectrometry: Non-linear Ion Transport and Fundamentals of FAIMS. 2009, CRC Press, Boca Raton.
12. Gorshkov, M.P., Method for Analysis of Impurities in Gases. USSR Inventor's Certificate No. 966583, 1982.
13. Buryakov, I.A., Krylov, E.V., Nazarov, E.G., Rasulev, U.K., A new method of separation of multi-atomic ions by mobility at atmospheric pressure using a high-frequency amplitude-asymmetric strong electric field. Int. J. Mass Spectrom. Ion Process. 128 (1993), 143–148.
14. Purves, R.W., Guevremont, R., Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer. Rev. Sci. Instrum. 69 (1998), 4094–4105.
15. Krylov, E.V., Nazarov, E.G., Electric field dependence of the ion mobility. Int. J. Mass Spectrom., 2009, 149–156.
16. Schneider, B.B., Nazarov, E.G., Londry, F., Vouros, P., Covey, T.R., Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications. Mass Spectrom. Rev. 35 (2016), 687–737.
17. Auerbach, D., Aspenleiter, J., Volmer, D.A., Description of gas-phase ion/neutral interactions in differential ion mobility spectrometry: CV prediction using calibration runs. J. Am. Soc. Mass Spectrom. 25 (2014), 1610–1621.
18. McDaniel, E.W., Martin, D.W., Barnes, W.S., Drift tube-mass spectrometer for studies of low-energy ion-molecule reactions. Rev. Sci. Instrum. 33 (1962), 2–7.
19. Hoaglund, C.S., Valentine, S.J., Sporleder, C.R., Reilly, J.P., Clemmer, D.E., Three-dimensional ion mobility/TOFMS analysis of electrosprayed biomolecules. Anal. Chem. 70 (1998), 2236–2242.
20. Wu, C., Siems, W.F., Asbury, G.R., Hill, H.H. Jr., Electrospray ionization high-resolution ion mobility spectrometry-mass spectrometry. Anal. Chem. 70 (1998), 4929–4938.
21. Ewing, M.A., Glover, M.S., Clemmer, D.E., Hybrid ion mobility and mass spectrometry as a separation tool. J. Chromatogr. A 1439 (2016), 3–25.
22. Tolmachev, A.V., Kim, T., Udseth, H.R., Smith, R.D., Bailey, T.H., Futrell, J.H., Simulation-based optimization of the electrodynamic ion funnel for high sensitivity electrospray ionization mass spectrometry. Int. J. Mass Spectrom. 203 (2000), 31–47.
23. Kelly, R.T., Tolmachev, A.V., Page, J.S., Tang, K., Smith, R.D., The ion funnel: theory, implementations, and applications. Mass Spectrom. Rev. 29 (2010), 294–312.
24. Giles, K., Pringle, S.D., Worthington, K.R., Little, D., Wildgoose, J.L., Bateman, R.H., Applications of a travelling wave-based radio-frequency-only stacked ring ion guide. Rapid Commun. Mass Spectrom. 18 (2004), 2401–2414.
25. Giles, K., Williams, J.P., Campuzano, I., Enhancements in travelling wave ion mobility resolution. Rapid Commun. Mass Spectrom. 25 (2011), 1559–1566.
26. Michelmann, K., Silveira, J.A., Ridgeway, M.E., Park, M.A., Fundamentals of trapped ion mobility spectrometry. J. Am. Soc. Mass Spectrom. 26 (2015), 14–24.
27. Fernandez-Lima, F., Kaplan, D.A., Suetering, J., Park, M.A., Gas-phase separation using a trapped ion mobility spectrometer. Int. J. Ion Mobil. Spec., 2011, 93–98.
28. Silveira, J.A., Danielson, W., Ridgeway, M.E., Park, M.A., Altering the mobility-time continuum: nonlinear scan functions for targeted high resolution trapped ion mobility-mass spectrometry. Int. J. Ion Mobil. Spec. 19 (2016), 87–94.
29. Silveira, J.A., Ridgeway, M.E., Laukien, F.H., Mann, M., Park, M.A., Parallel accumulation for 100% duty cycle trapped ion mobility-mass spectrometry. Int. J. Mass Spectrom. 413 (2017), 168–175.
30. Shvartsburg, A.A., Tang, K., Smith, R.D., Understanding and designing field asymmetric waveform ion mobility spectrometry separations in gas mixtures. Anal. Chem. 76 (2004), 7366–7374.
31. McCooeye, M.A., Ells, B., Barnett, D.A., Purves, R.W., Guevremont, R., Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. J. Anal. Toxicol. 25 (2001), 81–87.
32. Ells, B., Barnett, D.A., Purves, R.W., Guevremont, R., Detection of nine chlorinated and brominated haloacetic acids at part-per-trillion levels using ESI-FAIMS-MS. Anal. Chem. 72 (2000), 4555–4559.
33. Guevremont, R., Purves, R., Barnett, D., Ells, B., FAIMS Apparatus and Method Using Carrier Gases that Contain a Trace Amount of a Dopant Species. US Patent 7,026,612, 2006.
34. Schneider, B.B., Nazarov, E.G., Covey, T.R., Peak capacity in differential mobility spectrometry: effects of transport gas and gas modifiers. Int. J. Ion Mobil. Spec. 15 (2012), 141–150.
35. Purves, R.W., Prasad, S., Belford, M., Vandenberg, A., Dunyach, J.J., Optimization of a new aerodynamic cylindrical FAIMS device for small molecule analysis. J. Am. Soc. Mass Spectrom. 28 (2017), 525–538.
36. Krylov, E.V., A method of reducing diffusion losses in a drift spectrometer. Tech. Phys. 44 (1999), 113–116.
37. Guevremont, R., Purves, R.W., Atmospheric pressure ion focusing in a high-field asymmetric waveform ion mobility spectrometer. Rev. Sci. Instrum. 70 (1999), 1370–1383.
38. Prasad, S., Belford, M.W., Dunyach, J.J., Purves, R.W., On an aerodynamic mechanism to enhance ion transmission and sensitivity of FAIMS for nano-electrospray ionization-mass spectrometry. J. Am. Soc. Mass Spectrom. 25 (2014), 2143–2153.
39. Beach, D.G., Differential mobility spectrometry for improved selectivity in hydrophilic interaction liquid chromatography-tandem mass spectrometry analysis of paralytic shellfish toxins. J. Am. Soc. Mass Spectrom. 28 (2017), 1518–1530.
40. Sala, M., Lisa, M., Campbell, J.L., Holcapek, M., Determination of triacylglycerol regioisomers using differential mobility spectrometry. Rapid Commun. Mass Spectrom. 30 (2016), 256–264.
41. Wilks, A., Hart, M., Koehl, A., Somerville, J., Boyle, B., Ruiz-Alonso, D., Characterization of a miniature, ultra-high-field, ion mobility spectrometer. Int. J. Ion Mobil. Spec. 15 (2012), 199–222.
42. Clemmer, D.E., Hudgins, R.R., Jarrold, M.F., Naked protein conformations: cyctochrome c in the gas phase. J. Am. Chem. Soc. 117 (1995), 10141–10142.
43. Clemmer, D.E., Jarrold, M.F., Ion mobility measurements and their applications to clusters and biomolecules. J. Mass Spectrom. 32 (1997), 577–592.
44. Jarrold, M.F., Peptides and proteins in the vapor phase. Annu. Rev. Phys. Chem. 51 (2000), 179–207.
45. Purves, R.W., Barnett, D.A., Ells, B., Guevremont, R., Investigation of bovine ubiquitin conformers separated by high-field asymmetric waveform ion mobility spectrometry: cross section measurements using energy-loss experiments with a triple-quadrupole mass spectrometer. J. Am. Soc. Mass Spectrom. 11 (2000), 738–745.
46. Meier, F., Beck, S., Grassl, N., Lubeck, M., Park, M.A., Raether, O., Mann, M., Parallel accumulation – serial fragmentation (PASEF): multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device. J. Proteome Res. 14 (2015), 5378–5387.
47. Crowell, K.L., Slysz, G.W., Baker, E.S., LaMarche, B.L., Monroe, M.E., Ibrahim, Y.M., Payne, S.H., Anderson, G.A., Smith, R.D., LC-IMS-MS feature finder: detecting multidimensional liquid chromatorgraphy, ion mobility and mass spectrometry features in complex datasets. Bioinformatics 29 (2013), 2804–2805.
48. Paglia, G., Williams, J.P., Menikarachchi, L., Thompson, J.W., Tyldesley-Worster, R., Halldorsson, S., Rolfsson, O., Moseley, A., Grant, D., Langridge, J., Palsson, B.O., Astarita, G., Ion mobility-derived collision cross section to support metabolomics applications. Anal. Chem. 86 (2014), 3985–3993.
49. Ortmayr, K., Causon, T.J., Hann, S., Koellensperger, G., Increasing selectivity and coverage in LC-MS based metabolome analysis. Trends Anal. Chem. 82 (2016), 358–366.
50. Helm, D., Vissers, J.P.C., Hughes, C.J., Hahne, H., Ruprecht, B., Pachl, F., Grzyb, A., Richardson, K., Wildgoose, J., Maier, S.K., Marx, H., Wilhelm, M., Becher, I., Lemeer, S., Bantscheff, M., Langridge, J.I., Kuster, B., Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics. Mol. Cell. Proteom. 13 (2014), 3709–3715.
51. Paglia, G., Kliman, M., Claude, E., Geromanos, S., Astarita, G., Applications of ion-mobility mass spectrometry for lipid analysis. Anal. Bioanal. Chem. 407 (2015), 4995–5007.
52. Gray, C.J., Thomas, B., Upton, R., Migas, L.G., Eyers, C.E., Barran, P.E., Flitsch, S.L., Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis. Biochim. Biophys. Acta 1860 (2016), 1688–1709.
53. Tose, L.V., Santos, N.A., Rodrigues, R.R.T., Murgu, M., Gomes, A.F., Vasconcelos, G.A., Souza, P.C.T., Vaz, B.G., Romao, W., Isomeric separation of cannabinoids by UPLC combined with ionic mobility mass spectrometry (TWIM-MS)—Part I. Int. J. Mass Spectrom. 418 (2017), 112–121.
54. Barnett, D.A., Ells, B., Guevremont, R., Purves, R.W., Application of ESI-FAIMS-MS to the analysis of tryptic peptides. J. Am. Soc. Mass Spectrom. 13 (2002), 1282–1291.
55. Venne, K., Bonneil, E., Eng, K., Thibault, P., Improvement in peptide detection for proteomics analyses using nanoLC-MS and high-field asymmetry waveform ion mobility mass spectrometry. Anal. Chem. 77 (2005), 2176–2186.
56. Swearingen, K.E., Winget, J.M., Hoopmann, M.R., Kusebauch, U., Moritz, R.L., Decreased gap width in a cylindrical high-field asymmetric waveform ion mobility spectrometry device improves protein discovery. Anal. Chem. 87 (2015), 12230–12237.
57. Cooper, H.J., To what extent is FAIMS beneficial in the analysis of proteins?. J. Am. Soc. Mass Spectrom. 27 (2016), 566–577.
58. Pfammatter, S., Bonneil, E., Thibault, P., Improvement of quantitative measurements in multiplex proteomics using high-field asymmetric waveform spectrometry. J. Proteome Res. 15 (2016), 4653–4665.
59. Baker, P.R.S., Armando, A.M., Campbell, J.L., Quehenberger, O., Dennis, E.A., Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies. J. Lipid Res. 55 (2014), 2432–2442.
60. Lintonen, T.P.I., Baker, P.R.S., Suoniemi, M., Ubhi, B.K., Koistinen, K.M., Duchoslav, E., Campbell, J.L., Ekroos, K., Differential mobility spectrometry-driven shotgun lipidomics. Anal. Chem. 86 (2014), 9662–9669.
61. Arthur, K.L., Turner, M.A., Reynolds, J.C., Creaser, C.S., Increasing peak capacity in nontargeted omics applications by combining full scan field asymmetric waveform ion mobility spectrometry with liquid chromatography-mass spectrometry. Anal. Chem. 89 (2017), 3452–3459.
62. Stephan, S., Jakob, C., Hippler, J., Schmitz, O.J., A novel four-dimensional approach for analysis of complex samples. Anal. Bioanal. Chem. 408 (2016), 3751–3759.
63. Zhang, X., Ibrahim, Y.M., Chen, T., Kyle, J.E., Norheim, R.V., Monroe, M.E., Smith, R.D., Baker, E.S., Enhancing biological analyses with three dimensional field asymmetric ion mobility, low field drift tube ion mobility and mass spectrometry (μFAIMS/IMS-MS) separations. Analyst 140 (2015), 6955–6963.
64. Goscinny, S., Joly, L., De Pauw, E., Hanot, V., Eppe, G., Travelling-wave ion mobility time-of-flight mass spectrometry as an alternative strategy for screening of multi-class pesticides in fruits and vegetables. J. Chromatogr. A 1405 (2015), 85–93.
65. Regueiro, J., Negreira, N., Hannisdal, R., Berntssen, M.H.G., Targeted approach for qualitative screening of pesticides in salmon feed by liquid chromatography coupled to traveling-wave ion mobility/quadrupole time-of-flight mass spectrometry. Food Control 78 (2017), 116–125.
66. Kolakowski, B.M., Mester, Z., Review of applications of high-field asymmetric waveform ion mobility spectrometry (FAIMS) and differential mobility spectrometry (DMS). Analyst 132 (2007), 842–864.
67. Beach, D.G., Melanson, J.E., Purves, R.W., Analysis of paralytic shellfish toxins using high-field asymmetric waveform ion mobility spectrometry with liquid chromatography-mass spectrometry. Anal. Bioanal. Chem. 407 (2015), 2473–2484.
68. Ray, J.A., Kushnir, M.M., Yost, R.A., Rockwood, A.L., Meikle, A.W., Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry. Clin. Chim. Acta 438 (2015), 330–336.
69. Chen, P.S., Chen, S.H., Chen, J.H., Huang, W.Y., Liu, H.T., Kong, P.H., Yang, O.H.Y., Modifier-assisted differential mobility-tandem mass spectrometry method for detection and quantification of amphetamine-type stimulants in urine. Anal. Chim. Acta 946 (2016), 1–8.
70. Young, L.M., Saunders, J.C., Mahood, R.A., Revill, C.H., Foster, R.J., Tu, L., Raleigh, D.P., Radford, S.E., Ashcroft, A.E., Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry. Nat. Chem. 7 (2015), 73–81.
71. Beach, D.G., Gabryelski, W., Nontarget analysis of urine by electrospray ionization-high field asymmetric waveform ion mobility-tandem mass spectrometry. Anal. Chem. 83 (2011), 9107–9113.