Gas exchange in acute respiratory distress syndrome

American Journal of Respiratory and Critical Care Medicine

Volumn 196, Issue 8, 2017, Pages 964-984

  Radermacher, Peter ^a   Maggiore, Salvatore Maurizio ^b   Mercat, Alain ^c  

^a UNIVERSITY OF ULM MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF CHIETI   (Italy)

^c ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

Carbon dioxide partial pressure; Cardiac output; Oxygen partial pressure; Positive end expiratory pressure; Ventilation perfusion ratios

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTIFICIAL VENTILATION; BLOOD VESSEL TONE; BREATHING; DISEASE SEVERITY ASSESSMENT; GRAVITY; HUMAN; LUNG BLOOD VESSEL; LUNG DEAD SPACE; LUNG GAS EXCHANGE; LUNG PERFUSION; MULTICENTER STUDY (TOPIC); NONHUMAN; PARALYSIS; PATHOPHYSIOLOGY; PATIENT POSITIONING; PERSONALIZED MEDICINE; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PULMONARY SHUNT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; ADULT; AGED; FEMALE; HISTORY; MALE; MEDICAL RESEARCH; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; RESPIRATORY DISTRESS SYNDROME, ADULT; UNITED STATES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMEDICAL RESEARCH; FEMALE; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; MALE; MIDDLE AGED; PULMONARY GAS EXCHANGE; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; UNITED STATES;

EID: 85031681375     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201610-2156SO     Document Type: Review

References (250)

1. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS; ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307: 2526-2533.
2. Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 2012;38: 1573-1582.
3. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet J-F, Eisner MD, Matthay MA. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 2002;346: 1281-1286.
4. Piiper J, Scheid P. Model for capillary-alveolar equilibration with special reference to O2 uptake in hypoxia. Respir Physiol 1981;46: 193-208.
5. Staub NC. Alveolar-arterial oxygen tension gradient due to diffusion. J Appl Physiol 1963;18:673-680.
6. Calzia E, Radermacher P. Alveolar ventilation and pulmonary blood flow: the V: A/Q: concept. Intensive Care Med 2003;29: 1229-1232.
7. West JB. State of the art: ventilation-perfusion relationships. Am Rev Respir Dis 1977;116:919-943.
8. West JB. Understanding pulmonary gas exchange: ventilation-perfusion relationships. Am J Physiol Lung Cell Mol Physiol 2004;287: L1071-L1072.
9. Riley RL, Cournand A. Ideal alveolar air and the analysis of ventilation-perfusion relationships in the lungs. J Appl Physiol 1949; 1:825-847.
10. Dantzker DR, Brook CJ, Dehart P, Lynch JP, Weg JG. Ventilation-perfusion distributions in the adult respiratory distress syndrome. Am Rev Respir Dis 1979;120:1039-1052.
11. Enghoff H. Volumen inefficax: bemerkungenzur frage des schädlichen raums [in German]. Upps Läkfor Förh 1938;44: 191-218.
12. Rossier PH, Bühlmann A. The respiratory dead space. Physiol Rev 1955;35:860-876.
13. Fowler WS. Lung function studies; the respiratory dead space. Am J Physiol 1948;154:405-416.
14. Fletcher R, Jonson B, Cumming G, Brew J. The concept of deadspace with special reference to the single breath test for carbon dioxide. Br J Anaesth 1981;53:77-88.
15. Martin L. Abbreviating the alveolar gas equation: an argument for simplicity. Respir Care 1986;31:40-44.
16. Berggren S. The oxygen deficit of arterial blood. Acta Physiol Scand Suppl 1942;II:1-92.
17. Quan SF, Kronberg GM, Schlobohm RM, Feeley TW, Don HF, Lister G. Changes in venous admixture with alterations of inspired oxygen concentration. Anesthesiology 1980;52: 477-482.
18. Shapiro BA, Cane RD, Harrison RA, Steiner MC. Changes in intrapulmonary shunting with administration of 100 percent oxygen. Chest 1980;77:138-141.
19. Aboab J, Jonson B, Kouatchet A, Taille S, Niklason L, Brochard L. Effect of inspired oxygen fraction on alveolar derecruitment in acute respiratory distress syndrome. Intensive Care Med 2006;32: 1979-1986.
20. Dantzker DR, Wagner PD, West JB. Instability of lung units with low V: A/Q: ratios during O2 breathing. J Appl Physiol 1975;38: 886-895.
21. Benumof JL, Pirlo AF, Johanson I, Trousdale FR. Interaction of Pv;-O2 with PAO2 on hypoxic pulmonary vasoconstriction. J Appl Physiol 1981;51:871-874.
22. Bishop MJ, Cheney FW. Effects of pulmonary blood flow and mixed venous O2 tension on gas exchange in dogs. Anesthesiology 1983; 58:130-135.
23. Domino KB, Wetstein L, Glasser SA, Lindgren L, Marshall C, Harken A, Marshall BE. Influence of mixed venous oxygen tension (Pv;-O2) on blood flow to atelectatic lung. Anesthesiology 1983;59:428-434.
24. Sandoval J, Long GR, Skoog C, Wood LD, Oppenheimer L. Independent influence of blood flow rate and mixed venous PO2 on shunt fraction. J Appl Physiol 1983;55:1128-1133.
25. Radermacher P, Herigault R, Teisseire B, Harf A, Lemaire F. Low V: A/Q: areas: arterial-alveolar N2 difference and multiple inert gas elimination technique. J Appl Physiol (1985) 1988;64:2224-2229.
26. Wagner PD. Causes of a high physiological dead space in critically ill patients. Crit Care 2008;12:148.
27. Niklason L, Eckerström J, Jonson B. The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling. Crit Care 2008; 12:R53.
28. Wagner PD, Saltzman HA, West JB. Measurement of continuous distributions of ventilation-perfusion ratios: theory. J Appl Physiol 1974;36:588-599.
29. Wagner PD. The multiple inert gas elimination technique (MIGET). Intensive Care Med 2008;34:994-1001.
30. Farhi LE. Elimination of inert gas by the lung. Respir Physiol 1967;3: 1-11.
31. Melot C, Naeije R, Mols P, Hallemans R, Lejeune P, Jaspar N. Pulmonary vascular tone improves pulmonary gas exchange in the adult respiratory distress syndrome. Am Rev Respir Dis 1987;136: 1232-1236.
32. Pappert D, Rossaint R, Slama K, Grüning T, Falke KJ. Influence of positioning on ventilation-perfusion relationships in severe adult respiratory distress syndrome. Chest 1994;106: 1511-1516.
33. Pesenti A, Latini R, Riboni A, Gattinoni L. Simple estimate of the true right to left shunt (Qs/Qt) at maintenance FIO2 by sulphur hexafluoride retention. Intensive Care Med 1982;8:283-286.
34. Radermacher P, Huet Y, Pluskwa F, Herigault R, Mal H, Teisseire B, Lemaire F. Comparison of ketanserin and sodium nitroprusside in patients with severe ARDS. Anesthesiology 1988;68:152-157.
35. Radermacher P, Santak B, Becker H, Falke KJ. Prostaglandin E1 and nitroglycerin reduce pulmonary capillary pressure but worsen ventilation-perfusion distributions in patients with adult respiratory distress syndrome. Anesthesiology 1989;70:601-606.
36. Radermacher P, Santak B, Wüst HJ, Tarnow J, Falke KJ. Prostacyclin for the treatment of pulmonary hypertension in the adult respiratory distress syndrome: effects on pulmonary capillary pressure and ventilation-perfusion distributions. Anesthesiology 1990;72:238-244.
37. Ralph DD, Robertson HT, Weaver LJ, Hlastala MP, Carrico CJ, Hudson LD. Distribution of ventilation and perfusion during positive endexpiratory pressure in the adult respiratory distress syndrome. Am Rev Respir Dis 1985;131:54-60.
38. Reyes A, Roca J, Rodriguez-Roisin R, Torres A, Ussetti P, Wagner PD. Effect of almitrine on ventilation-perfusion distribution in adult respiratory distress syndrome. Am Rev Respir Dis 1988;137: 1062-1067.
39. Rossaint R, Falke KJ, López F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993;328:399-405.
40. Walmrath D, Schneider T, Schermuly R, Olschewski H, Grimminger F, Seeger W. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am J Respir Crit Care Med 1996;153:991-996.
41. Pappert D, Busch T, Gerlach H, Lewandowski K, Radermacher P, Rossaint R. Aerosolized prostacyclin versus inhaled nitric oxide in children with severe acute respiratory distress syndrome. Anesthesiology 1995;82:1507-1511.
42. Radermacher P, Cinotti L, Falke KJ. Grundlagen der methodischen erfassung von ventilations-perfusions-verteilungsstörungen [in German]. Anaesthesist 1988;37:36-42.
43. Harf A, Hughes JM. Topographical distribution of V: A/Q: in elderly subjects using Krypton-81m. Respir Physiol 1978;34: 319-327.
44. Meignan M, Harf A, Cinotti L. Regional distribution of ventilationperfusion ratios in acute pulmonary embolism. Intensive Care Med 1984;10:103-106.
45. Jalali A, Ishii M, Edvinsson JM, Guan L, Itkin M, Lipson DA, Baumgardner JE, Rizi RR. Detection of simulated pulmonary embolism in a porcine model using hyperpolarized 3He MRI. Magn Reson Med 2004;51:291-298.
46. Henderson AC, Sá RC, Theilmann RJ, Buxton RB, Prisk GK, Hopkins SR. The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung. J Appl Physiol (1985) 2013;115:313-324.
47. Kaushik SS, Freeman MS, Cleveland ZI, Davies J, Stiles J, Virgincar RS, Robertson SH, He M, Kelly KT, Foster WM, et al. Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging. J Appl Physiol (1985) 2013;115:850-860.
48. Vidal Melo MF, Layfield D, Harris RS, O'Neill K, Musch G, Richter T, Winkler T, Fischman AJ, Venegas JG. Quantification of regional ventilation-perfusion ratios with PET. J Nucl Med 2003;44: 1982-1991.
49. Richter T, Bellani G, Scott Harris R, Vidal Melo MF, Winkler T, Venegas JG, Musch G. Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med 2005;172:480-487.
50. Wellman TJ, de Prost N, Tucci M, Winkler T, Baron RM, Filipczak P, Raby B, Chu J-H, Harris RS, Musch G, et al. Lung metabolic activation as an early biomarker of acute respiratory distress syndrome and local gene expression heterogeneity. Anesthesiology 2016;125:992-1004.
51. Mauri T, Bellani G, Confalonieri A, Tagliabue P, Turella M, Coppadoro A, Citerio G, Patroniti N, Pesenti A. Topographic distribution of tidal ventilation in acute respiratory distress syndrome: effects of positive end-expiratory pressure and pressure support. Crit Care Med 2013;41:1664-1673.
52. Frerichs I, Becher T, Weiler N. Electrical impedance tomography imaging of the cardiopulmonary system. Curr Opin Crit Care 2014; 20:323-332.
53. Mauri T, Eronia N, Turrini C, Battistini M, Grasselli G, Rona R, Volta CA, Bellani G, Pesenti A. Bedside assessment of the effects of positive end-expiratory pressure on lung inflation and recruitment by the helium dilution technique and electrical impedance tomography. Intensive Care Med 2016;42:1576-1587.
54. Frerichs I, Amato MBP, van Kaam AH, Tingay DG, Zhao Z, Grychtol B, Bodenstein M, Gagnon H, Böhm SH, Teschner E, et al.; TREND study group. Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group. Thorax 2017;72:83-93.
55. Pesenti A, Musch G, Lichtenstein D, Mojoli F, Amato MBP, Cinnella G, Gattinoni L, Quintel M. Imaging in acute respiratory distress syndrome. Intensive Care Med 2016;42:686-698.
56. Baumgardner JE, Hedenstierna G. Ventilation/perfusion distributions revisited. Curr Opin Anaesthesiol 2016;29:2-7.
57. Bellani G, Rouby J-J, Constantin J-M, Pesenti A. Looking closer at acute respiratory distress syndrome: the role of advanced imaging techniques. Curr Opin Crit Care 2017;23:30-37.
58. West JB, Dollery CT, Naimark A. Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures. J Appl Physiol 1964;19:713-724.
59. Legras A, Dequin PF, Hazouard E, Doucet O, Tranquart F, Perrotin D. Right-to-left interatrial shunt in ARDS: dramatic improvement in prone position. Intensive Care Med 1999;25:412-414.
60. Voggenreiter G, Neudeck F, Aufmkolk M, Fassbinder J, Hirche H, Obertacke U, Schmit-Neuerburg KP. Intermittent prone positioning in the treatment of severe and moderate posttraumatic lung injury. Crit Care Med 1999;27:2375-2382.
61. Gillart T, Bazin JE, Cosserant B, Guelon D, Aigouy L, Mansoor O, Schoeffler P. Combined nitric oxide inhalation, prone positioning and almitrine infusion improve oxygenation in severe ARDS. Can J Anaesth 1998;45:402-409.
62. Borelli M, Lampati L, Vascotto E, Fumagalli R, Pesenti A. Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients. Crit Care Med 2000;28:2707-2712.
63. Dupont H, Mentec H, Cheval C, Moine P, Fierobe L, Timsit JF. Shortterm effect of inhaled nitric oxide and prone positioning on gas exchange in patients with severe acute respiratory distress syndrome. Crit Care Med 2000;28:304-308.
64. Papazian L, Bregeon F, Gaillat F, Thirion X, Gainnier M, Gregoire R, Saux P, Gouin F, Jammes Y, Auffray JP. Respective and combined effects of prone position and inhaled nitric oxide in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1998;157:580-585.
65. Papazian L, Roch A, Bregeon F, Thirion X, Gaillat F, Saux P, Fulachier V, Jammes Y, Auffray JP. Inhaled nitric oxide and vasoconstrictors in acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;160:473-479.
66. Yang QH, Kaplowitz MR, Lai-Fook SJ. Regional variations in lung expansion in rabbits: prone vs. supine positions. J Appl Physiol (1985) 1989;67:1371-1376.
67. Guérin C, Baboi L, Richard JC. Mechanisms of the effects of prone positioning in acute respiratory distress syndrome. Intensive Care Med 2014;40:1634-1642.
68. Tawhai MH, Nash MP, Lin C-L, Hoffman EA. Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape. J Appl Physiol (1985) 2009;107: 912-920.
69. Gattinoni L, D'Andrea L, Pelosi P, Vitale G, Pesenti A, Fumagalli R. Regional effects and mechanism of positive end-expiratory pressure in early adult respiratory distress syndrome. JAMA 1993;269: 2122-2127.
70. Pelosi P, D'Andrea L, Vitale G, Pesenti A, Gattinoni L. Vertical gradient of regional lung inflation in adult respiratory distress syndrome. Am J Respir Crit Care Med 1994;149:8-13.
71. Albert RK, Hubmayr RD. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med 2000;161:1660-1665.
72. Hyatt RE, Bar-Yishay E, Abel MD. Influence of the heart on the vertical gradient of transpulmonary pressure in dogs. J Appl Physiol (1985) 1985;58:52-57.
73. Froese AB, Bryan AC. Effects of anesthesia and paralysis on diaphragmatic mechanics in man. Anesthesiology 1974;41:242-255.
74. Mutoh T, Lamm WJ, Embree LJ, Hildebrandt J, Albert RK. Abdominal distension alters regional pleural pressures and chest wall mechanics in pigs in vivo. J Appl Physiol (1985) 1991;70:2611-2618.
75. Galiatsou E, Kostanti E, Svarna E, Kitsakos A, Koulouras V, Efremidis SC, Nakos G. Prone position augments recruitment and prevents alveolar overinflation in acute lung injury. Am J Respir Crit Care Med 2006;174:187-197.
76. Glenny RW, Lamm WJ, Albert RK, Robertson HT. Gravity is a minor determinant of pulmonary blood flow distribution. J Appl Physiol (1985) 1991;71:620-629.
77. Lamm WJ, Graham MM, Albert RK. Mechanism by which the prone position improves oxygenation in acute lung injury. Am J Respir Crit Care Med 1994;150:184-193.
78. Nyrén S, Mure M, Jacobsson H, Larsson SA, Lindahl SG. Pulmonary perfusion is more uniform in the prone than in the supine position: scintigraphy in healthy humans. J Appl Physiol (1985) 1999;86: 1135-1141.
79. Richard JC, Janier M, Lavenne F, Berthier V, Lebars D, Annat G, Decailliot F, Guerin C. Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury. J Appl Physiol (1985) 2002;93:2181-2191.
80. Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL. Hypoxic pulmonary vasoconstriction: from molecular mechanisms to medicine. Chest 2017;151:181-192.
81. Roch A, Papazian L, Bregeon F, Gainnier M, Michelet P, Thirion X, Saux P, Thomas P, Jammes Y, Auffray JP. High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine? Intensive Care Med 2001;27:1737-1743.
82. Zwissler B, Kemming G, Habler O, Kleen M, Merkel M, Haller M, Briegel J, Welte M, Peter K. Inhaled prostacyclin (PGI2) versus inhaled nitric oxide in adult respiratory distress syndrome. Am J Respir Crit Care Med 1996;154:1671-1677.
83. Wysocki M, Delclaux C, Roupie E, Langeron O, Liu N, Herman B, Lemaire F, Brochard L. Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. Intensive Care Med 1994;20:254-259.
84. Gallart L, Lu Q, Puybasset L, Umamaheswara Rao GS, Coriat P, Rouby JJ; The NO Almitrine Study Group. Intravenous almitrine combined with inhaled nitric oxide for acute respiratory distress syndrome. Am J Respir Crit Care Med 1998;158:1770-1777.
85. Paven D, Muret J, Beloucif S, Gatecel C, Kermarrec N, Guinard N, Mateo J. Inhaled nitric oxide, almitrine infusion, or their coadministration as a treatment of severe hypoxemic focal lung lesions. Anesthesiology 1998;89:1157-1165.
86. Scheeren T, Radermacher P. Prostacyclin (PGI2): new aspects of an old substance in the treatment of critically ill patients. Intensive Care Med 1997;23:146-158.
87. Rodriguez-Roisin R. Nonpulmonary influences on gas exchange. Compr Physiol 2014;4:1455-1494.
88. Lemaire F, Harf A, Harari A, Teisseire B, Régnier B, Atlan G, Rapin M. La mesure du shunt intrapulmonaire en ránimation (utilisation d'un nomogramme). Bull Physiopathol Respir (Nancy) 1975;11:659-681.
89. Lemaire F, Teisseire B, Harf A. Evaluation de l'hematose dans l'insuffisance respiratoire aigue, Mesure de la difference alveoloarte rielle d'oxygene ou calcul du shunt? Ann Fr Anesth Reanim 1982; 1:59-64.
90. Rossaint R, Hahn SM, Pappert D, Falke KJ, Radermacher P. Influence of mixed venous PO2 and inspired O2 fraction on intrapulmonary shunt in patients with severe ARDS. J Appl Physiol (1985) 1995;78: 1531-1536.
91. Lemaire F, Harari A, Rapin M, Jardin F. Assessment of gas exchange during venoarterial bypass using the membrane lung. In: Zapol WM, Qvist J, editors. Artificial lungs for acute respiratory failure: theory and practice. New York: Academic Press; 1976. pp. 421-433.
92. Lemaire F, Gastine H, Regnier B, Teisseire B, Rapin M. Changes in intrapulmonary shunting with alterations in pulmonary vascular resistance. Anesthesiology 1977;47:315-316.
93. Lynch JP, Mhyre JG, Dantzker DR. Influence of cardiac output on intrapulmonary shunt. J Appl Physiol 1979;46:315-321.
94. Dantzker DR, Lynch JP, Weg JG. Depression of cardiac output is a mechanism of shunt reduction in the therapy of acute respiratory failure. Chest 1980;77:636-642.
95. Marshall BE, Hanson CW, Frasch F, Marshall C. Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution. 2. Pathophysiology. Intensive Care Med 1994;20: 379-389.
96. Cheney FW, Colley PS. The effect of cardiac output on arterial blood oxygenation. Anesthesiology 1980;52:496-503.
97. Rodriguez-Roisin R, Roca J, Torres A. Interplay of intrapulmonary and extrapulmonary factors on pulmonary gas exchange during weaning. Intensive Care Med 1991;17:249-251.
98. Vieillard-Baron A, Schmitt JM, Augarde R, Fellahi JL, Prin S, Page B, Beauchet A, Jardin F. Acute cor pulmonale in acute respiratory distress syndrome submitted to protective ventilation: incidence, clinical implications, and prognosis. Crit Care Med 2001;29:1551-1555.
99. Osman D, Monnet X, Castelain V, Anguel N, Warszawski J, Teboul J-L, Richard C; French Pulmonary Artery Catheter Study Group. Incidence and prognostic value of right ventricular failure in acute respiratory distress syndrome. Intensive Care Med 2009;35:69-76.
100. Boissier F, Katsahian S, Razazi K, Thille AW, Roche-Campo F, Leon R, Vivier E, Brochard L, Vieillard-Baron A, Brun-Buisson C, et al. Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome. Intensive Care Med 2013;39:1725-1733.
101. Mekontso Dessap A, Boissier F, Leon R, Carreira S, Campo FR, Lemaire F, Brochard L. Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome. Crit Care Med 2010;38:1786-1792.
102. Legras A, Caille A, Begot E, Lhéritier G, Lherm T, Mathonnet A, Frat J-P, Courte A, Martin-Lefevre L, Gouëllo J-P, et al.; ARCO and CRICS network. Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study. Crit Care 2015;19:174.
103. Lemaire F, Richalet JP, Carlet J, Brun-Buisson C, MacLean C. Postoperative hypoxemia due to opening of a patent foramen ovale confirmed by a right atrium-left atrium pressure gradient during mechanical ventilation. Anesthesiology 1982;57:233-236.
104. Ravenscraft SA, Marinelli WA, Johnson T, Henke CA. Profound hypoxemia precipitated by positive end-expiratory pressure: induction of an intracardiac shunt. Crit Care Med 1992;20:434-436.
105. Aboab J, Louis B, Jonson B, Brochard L. Relation between PaO2/FIO2 ratio and FIO2: a mathematical description. Intensive Care Med 2006;32:1494-1497.
106. Feiner JR, Weiskopf RB. Evaluating pulmonary function: an assessment of PaO2/FIO2. Crit Care Med 2017;45:e40-e48.
107. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, et al.; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, patterns of pare, and portality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 2016;315:788-800.
108. Reske AW, Costa ELV, Reske AP, Rau A, Borges JB, Beraldo MA, Gottschaldt U, Seiwerts M, Schreiter D, Petroff D, et al. Bedside estimation of nonaerated lung tissue using blood gas analysis. Crit Care Med 2013;41:732-743.
109. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and metaanalysis. JAMA 2010;303:865-873.
110. Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NKJ, Latini R, Pesenti A, Guérin C, Mancebo J, Curley MAQ, et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med 2010;36:585-599.
111. Papazian L, Forel J-M, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal J-M, Perez D, Seghboyan J-M, et al.; ACURASYS Study Investigators. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116.
112. Villar J, Pérez-Méndez L, López J, Belda J, Blanco J, Saralegui I, Suárez-Sipmann F, López J, Lubillo S, Kacmarek RM; HELP Network. An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2007;176:795-804.
113. Villar J, Pérez-Méndez L, Blanco J, Añón JM, Blanch L, Belda J, Santos-Bouza A, Fernández RL, Kacmarek RM; Spanish Initiative for Epidemiology, Stratification, and Therapies for ARDS (SIESTA) Network. A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting-a prospective, multicenter validation study. Intensive Care Med 2013;39:583-592.
114. Chen W, Janz DR, Shaver CM, Bernard GR, Bastarache JA, Ware LB. Clinical characteristics and outcomes are similar in ARDS diagnosed by oxygen saturation/Fio2 ratio compared with Pao2/Fio2 ratio. Chest 2015;148:1477-1483.
115. Van de Louw A, Cracco C, Cerf C, Harf A, Duvaldestin P, Lemaire F, Brochard L. Accuracy of pulse oximetry in the intensive care unit. Intensive Care Med 2001;27:1606-1613.
116. Brown SM, Grissom CK, Moss M, Rice TW, Schoenfeld D, Hou PC, Thompson BT, Brower RG; NIH/NHLBI PETAL Network Collaborators. Nonlinear imputation of PaO2/FIO2 from SpO2/FIO2 among patients with acute respiratory distress syndrome. Chest 2016;150:307-313.
117. Cressoni M, Cadringher P, Chiurazzi C, Amini M, Gallazzi E, Marino A, Brioni M, Carlesso E, Chiumello D, Quintel M, et al. Lung inhomogeneity in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2014;189:149-158.
118. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA; National Heart Lung and Blood Institute ARDS Network Investigators. The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Respir Care 2014;59:1611-1618.
119. Wexler HR, Lok P. A simple formula for adjusting arterial carbon dioxide tension. Can Anaesth Soc J 1981;28:370-372.
120. Sinha P, Fauvel NJ, Singh S, Soni N. Ventilatory ratio: a simple bedside measure of ventilation. Br J Anaesth 2009;102:692-697.
121. Siddiki H, Kojicic M, Li G, Yilmaz M, Thompson TB, Hubmayr RD, Gajic O. Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials. Crit Care 2010;14:R141.
122. Sinha P, Sanders RD, Soni N, Vukoja MK, Gajic O. Acute respiratory distress syndrome: the prognostic value of ventilatory ratio-a simple bedside tool to monitor ventilatory efficiency. Am J Respir Crit Care Med 2013;187:1150-1153.
123. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med 2015;43:1026-1035.
124. Damiani E, Adrario E, Girardis M, Romano R, Pelaia P, Singer M, Donati A. Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Crit Care 2014;18:711.
125. Helmerhorst HJF, Roos-Blom M-J, van Westerloo DJ, de Jonge E. Association between arterial hyperoxia and outcome in subsets of critical illness: a systematic review, meta-analysis, and meta-regression of cohort studies. Crit Care Med 2015;43: 1508-1519.
126. Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A; Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-1308.
127. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351: 327-336.
128. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, et al.; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008;299:637-645.
129. Mercat A, Richard J-CM, Vielle B, Jaber S, Osman D, Diehl J-L, Lefrant J-Y, Prat G, Richecoeur J, Nieszkowska A, et al.; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008;299:646-655.
130. Guérin C, Reignier J, Richard J-C, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, et al.; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013;368:2159-2168.
131. Aggarwal NR, Brower RG. Targeting normoxemia in acute respiratory distress syndrome may cause worse short-term outcomes because of oxygen toxicity. Ann Am Thorac Soc 2014; 11:1449-1453.
132. Mikkelsen ME, Christie JD, Lanken PN, Biester RC, Thompson BT, Bellamy SL, Localio AR, Demissie E, Hopkins RO, Angus DC. The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med 2012;185:1307-1315.
133. Quinn DA, Moufarrej RK, Volokhov A, Hales CA. Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol (1985) 2002;93:517-525.
134. Kapanci Y, Tosco R, Eggermann J, Gould VE. Oxygen pneumonitis in man: light- and electron-microscopic morphometric studies. Chest 1972;62:162-169.
135. Six S, Jaffal K, Ledoux G, Jaillette E, Wallet F, Nseir S. Hyperoxemia as a risk factor for ventilator-associated pneumonia. Crit Care 2016; 20:195.
136. Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, Morelli A, Antonelli M, Singer M. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the Oxygen-ICU randomized clinical trial. JAMA 2016;316: 1583-1589.
137. Asfar P, Schortgen F, Boisramé -Helms J, Charpentier J, Guérot E, Megarbane B, Grimaldi D, Grelon F, Anguel N, Lasocki S, et al.; HYPER2S Investigators; REVA research network. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a twoby- two factorial, multicentre, randomised, clinical trial. Lancet Respir Med 2017;5:180-190.
138. Laffey JG, Tanaka M, Engelberts D, Luo X, Yuan S, Tanswell AK, Post M, Lindsay T, Kavanagh BP. Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000;162:2287-2294.
139. Sinclair SE, Kregenow DA, Lamm WJE, Starr IR, Chi EY, Hlastala MP. Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med 2002;166:403-408.
140. Contreras M, Ansari B, Curley G, Higgins BD, Hassett P, O'Toole D, Laffey JG. Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kB-dependent mechanism. Crit Care Med 2012;40:2622-2630.
141. Swenson ER, Robertson HT, Hlastala MP. Effects of inspired carbon dioxide on ventilation-perfusion matching in normoxia, hypoxia, and hyperoxia. Am J Respir Crit Care Med 1994;149: 1563-1569.
142. Kiiski R, Takala J, Kari A, Milic-Emili J. Effect of tidal volume on gas exchange and oxygen transport in the adult respiratory distress syndrome. Am Rev Respir Dis 1992;146:1131-1135.
143. Wang Z, Su F, Bruhn A, Yang X, Vincent J-L. Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock. Am J Respir Crit Care Med 2008; 177:178-183.
144. Komori M, Takada K, Tomizawa Y, Nishiyama K, Kawamata M, Ozaki M. Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits. Crit Care Med 2007; 35:2171-2175.
145. Turek Z, Kreuzer F. Effect of shifts of the O2 dissociation curve upon alveolar-arterial O2 gradients in computer models of the lung with ventilation-perfusion mismatching. Respir Physiol 1981;45: 133-139.
146. Briva A, Vadász I, Lecuona E, Welch LC, Chen J, Dada LA, Trejo HE, Dumasius V, Azzam ZS, Myrianthefs PM, et al. High CO2 levels impair alveolar epithelial function independently of pH. Plos One 2007;2:e1238.
147. O'Croinin DF, Nichol AD, Hopkins N, Boylan J, O'Brien S, O'Connor C, Laffey JG, McLoughlin P. Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury. Crit Care Med 2008;36:2128-2135.
148. Vadász I, Hubmayr RD, Nin N, Sporn PHS, Sznajder JI. Hypercapnia: a nonpermissive environment for the lung. Am J Respir Cell Mol Biol 2012;46:417-421.
149. Mekontso Dessap A, Charron C, Devaquet J, Aboab J, Jardin F, Brochard L, Vieillard-Baron A. Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med 2009;35:1850-1858.
150. Mekontso Dessap A, Boissier F, Charron C, Bégot E, Repessé X, Legras A, Brun-Buisson C, Vignon P, Vieillard-Baron A. Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. Intensive Care Med 2016;42:862-870.
151. Kregenow DA, Rubenfeld GD, Hudson LD, Swenson ER. Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med 2006;34: 1-7.
152. Nin N, Muriel A, Peñuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Ríos F, Violi DA, Thille AW, et al.; VENTILA Group. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Med 2017;43:200-208.
153. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967;2:319-323.
154. Santos C, Ferrer M, Roca J, Torres A, Hernández C, Rodriguez-Roisin R. Pulmonary gas exchange response to oxygen breathing in acute lung injury. Am J Respir Crit Care Med 2000;161:26-31.
155. Navalesi P, Maggiore SM. Positive end-expiratory pressure. In: Tobin MJ, editor. Principles and practice of mechanical ventilation, 3rd ed. New York: McGraw-Hill; 2012. pp. 253-302.
156. Suter PM, Fairley B, Isenberg MD. Optimum end-expiratory airway pressure in patients with acute pulmonary failure. N Engl J Med 1975;292:284-289.
157. Delclaux C, L'Her E, Alberti C, Mancebo J, Abroug F, Conti G, Guérin C, Schortgen F, Lefort Y, Antonelli M, et al. Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: a randomized controlled trial. JAMA 2000;284:2352-2360.
158. Lim C-M, Jung H, Koh Y, Lee JS, Shim T-S, Lee S-D, Kim W-S, Kim DS, Kim W-D. Effect of alveolar recruitment maneuver in early acute respiratory distress syndrome according to antiderecruitment strategy, etiological category of diffuse lung injury, and body position of the patient. Crit Care Med 2003;31: 411-418.
159. Maggiore SM, Jonson B, Richard JC, Jaber S, Lemaire F, Brochard L. Alveolar derecruitment at decremental positive end-expiratory pressure levels in acute lung injury: comparison with the lower inflection point, oxygenation, and compliance. Am J Respir Crit Care Med 2001;164:795-801.
160. Richard JC, Maggiore SM, Jonson B, Mancebo J, Lemaire F, Brochard L. Influence of tidal volume on alveolar recruitment: respective role of PEEP and a recruitment maneuver. Am J Respir Crit Care Med 2001;163:1609-1613.
161. Ranieri VM, Eissa NT, Corbeil C, Chassé M, Braidy J, Matar N, Milic- Emili J. Effects of positive end-expiratory pressure on alveolar recruitment and gas exchange in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1991;144: 544-551.
162. Ferrer M, Esquinas A, Leon M, Gonzalez G, Alarcon A, Torres A. Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial. Am J Respir Crit Care Med 2003;168: 1438-1444.
163. Cosentini R, Brambilla AM, Aliberti S, Bignamini A, Nava S, Maffei A, Martinotti R, Tarsia P, Monzani V, Pelosi P. Helmet continuous positive airway pressure vs oxygen therapy to improve oxygenation in community-acquired pneumonia: a randomized, controlled trial. Chest 2010;138:114-120.
164. Verbrugge SJ, Böhm SH, Gommers D, Zimmerman LJ, Lachmann B. Surfactant impairment after mechanical ventilation with large alveolar surface area changes and effects of positive end-expiratory pressure. Br J Anaesth 1998;80:360-364.
165. Chiumello D, Marino A, Brioni M, Cigada I, Menga F, Colombo A, Crimella F, Algieri I, Cressoni M, Carlesso E, et al. Lung recruitment assessed by respiratory mechanics and computed tomography in patients with acute respiratory distress syndrome. What is the relationship? Am J Respir Crit Care Med 2016;193:1254-1263.
166. Malbouisson LM, Muller JC, Constantin JM, Lu Q, Puybasset L, Rouby JJ; CT Scan ARDS Study Group. Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:1444-1450.
167. Crotti S, Mascheroni D, Caironi P, Pelosi P, Ronzoni G, Mondino M, Marini JJ, Gattinoni L. Recruitment and derecruitment during acute respiratory failure: a clinical study. Am J Respir Crit Care Med 2001; 164:131-140.
168. Webb HH, Tierney DF. Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures: protection by positive end-expiratory pressure. Am Rev Respir Dis 1974;110:556-565.
169. Corbridge TC, Wood LD, Crawford GP, ChudobaMJ, Yanos J, Sznajder JI. Adverse effects of large tidal volume and low PEEP in canine acid aspiration. Am Rev Respir Dis 1990;142:311-315.
170. Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema: respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988;137:1159-1164.
171. Dreyfuss D, Saumon G. Role of tidal volume, FRC, and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation. Am Rev Respir Dis 1993;148:1194-1203.
172. Malo J, Ali J, Wood LD. How does positive end-expiratory pressure reduce intrapulmonary shunt in canine pulmonary edema? J Appl Physiol 1984;57:1002-1010.
173. Paré PD, Warriner B, Baile EM, Hogg JC. Redistribution of pulmonary extravascular water with positive end-expiratory pressure in canine pulmonary edema. Am Rev Respir Dis 1983;127:590-593.
174. Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ; The CT Scan ARDS Study Group. A computed tomography scan assessment of regional lung volume in acute lung injury. Am J Respir Crit Care Med 1998;158:1644-1655.
175. Puybasset L, Gusman P, Muller JC, Cluzel P, Coriat P, Rouby JJ. Regional distribution of gas and tissue in acute respiratory distress syndrome. III. Consequences for the effects of positive end-expiratory pressure. CT Scan ARDS Study Group. Adult Respiratory Distress Syndrome. Intensive Care Med 2000;26: 1215-1227.
176. Gattinoni L, Pelosi P, Crotti S, Valenza F. Effects of positive endexpiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome. Am J Respir Crit Care Med 1995;151:1807-1814.
177. Dantzker DR. The influence of cardiovascular function on gas exchange. Clin Chest Med 1983;4:149-159.
178. Matamis D, Lemaire F, Harf A, Teisseire B, Brun-Buisson C. Redistribution of pulmonary blood flow induced by positive endexpiratory pressure and dopamine infusion in acute respiratory failure. Am Rev Respir Dis 1984;129:39-44.
179. Dueck R, Wagner PD, West JB. Effects of positive end-expiratory pressure on gas exchange in dogs with normal and edematous lungs. Anesthesiology 1977;47:359-366.
180. Gattinoni L, Caironi P, Cressoni M, Chiumello D, Ranieri VM, Quintel M, Russo S, Patroniti N, Cornejo R, Bugedo G. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 2006;354:1775-1786.
181. Beydon L, Uttman L, Rawal R, Jonson B. Effects of positive endexpiratory pressure on dead space and its partitions in acute lung injury. Intensive Care Med 2002;28:1239-1245.
182. Blanch L, Lucangelo U, Lopez-Aguilar J, Fernandez R, Romero PV. Volumetric capnography in patients with acute lung injury: effects of positive end-expiratory pressure. Eur Respir J 1999;13:1048-1054.
183. Fan E, Wilcox ME, Brower RG, Stewart TE, Mehta S, Lapinsky SE, Meade MO, Ferguson ND. Recruitment maneuvers for acute lung injury: a systematic review. Am J Respir Crit Care Med 2008;178: 1156-1163.
184. Kacmarek RM, Villar J, Sulemanji D, Montiel R, Ferrando C, Blanco J, Koh Y, Soler JA, Martínez D, Hernández M, et al.; Open Lung Approach Network. Open lung approach for the acute respiratory distress syndrome: a pilot, randomized controlled trial. Crit Care Med 2016;44:32-42.
185. Arnal JM, Paquet J, Wysocki M, Demory D, Donati S, Granier I, Corno G, Durand-Gasselin J. Optimal duration of a sustained inflation recruitment maneuver in ARDS patients. Intensive Care Med 2011; 37:1588-1594.
186. Al-Saady N, Bennett ED. Decelerating inspiratory flow waveform improves lung mechanics and gas exchange in patients on intermittent positive-pressure ventilation. Intensive Care Med 1985; 11:68-75.
187. Mercat A, Gräini L, Teboul JL, Lenique F, Richard C. Cardiorespiratory effects of pressure-controlled ventilation with and without inverse ratio in the adult respiratory distress syndrome. Chest 1993;104: 871-875.
188. Lessard MR, Guérot E, Lorino H, Lemaire F, Brochard L. Effects of pressure-controlled with different I:E ratios versus volumecontrolled ventilation on respiratory mechanics, gas exchange, and hemodynamics in patients with adult respiratory distress syndrome. Anesthesiology 1994;80:983-991.
189. Marcy TW, Marini JJ. Inverse ratio ventilation in ARDS: rationale and implementation. Chest 1991;100:494-504.
190. Chan K, Abraham E. Effects of inverse ratio ventilation on cardiorespiratory parameters in severe respiratory failure. Chest 1992;102:1556-1561.
191. Tharratt RS, Allen RP, Albertson TE. Pressure controlled inverse ratio ventilation in severe adult respiratory failure. Chest 1988;94:755-762.
192. Abraham E, Yoshihara G. Cardiorespiratory effects of pressure controlled inverse ratio ventilation in severe respiratory failure. Chest 1989;96:1356-1359.
193. Mercat A, Titiriga M, Anguel N, Richard C, Teboul JL. Inverse ratio ventilation (I/E = 2/1) in acute respiratory distress syndrome: a six-hour controlled study. Am J Respir Crit Care Med 1997;155: 1637-1642.
194. Mercat A, Diehl JL, Michard F, Anguel N, Teboul JL, Labrousse J, Richard C. Extending inspiratory time in acute respiratory distress syndrome. Crit Care Med 2001;29:40-44.
195. Devaquet J, Jonson B, Niklason L, Si Larbi A-G, Uttman L, Aboab J, Brochard L. Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury. J Appl Physiol (1985) 2008;105: 1944-1949.
196. Aguirre-Bermeo H, Morán I, Bottiroli M, Italiano S, Parrilla FJ, Plazolles E, Roche-Campo F, Mancebo J. End-inspiratory pause prolongation in acute respiratory distress syndrome patients: effects on gas exchange and mechanics. Ann Intensive Care 2016;6:81.
197. Krishnan JA, Brower RG. High-frequency ventilation for acute lung injury and ARDS. Chest 2000;118:795-807.
198. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, et al.; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 2013;368:795-805.
199. Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH; OSCAR Study Group. High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 2013;368:806-813.
200. Guervilly C, Forel JM, Hraiech S, Demory D, Allardet-Servent J, Adda M, Barreau-Baumstark K, Castanier M, Papazian L, Roch A. Right ventricular function during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care Med 2012;40:1539-1545.
201. Feihl F, Eckert P, Brimioulle S, Jacobs O, Schaller MD, Mélot C, Naeije R. Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome. Am J Respir Crit Care Med 2000;162:209-215.
202. Prat G, Renault A, Tonnelier J-M, Goetghebeur D, Oger E, Boles J-M, L'Her E. Influence of the humidification device during acute respiratory distress syndrome. Intensive Care Med 2003;29:2211-2215.
203. Morán I, Bellapart J, Vari A, Mancebo J. Heat and moisture exchangers and heated humidifiers in acute lung injury/acute respiratory distress syndrome patients. Effects on respiratory mechanics and gas exchange. Intensive Care Med 2006;32: 524-531.
204. Lucangelo U, Nahum A, Blanch L. Transtracheal gas insufflation, transtracheal oxygen therapy, emergency transtracheal ventilation. In: Tobin MJ, editor. Principles and practice of mechanical ventilation, 3rd ed. New York: McGraw-Hill; 2012. pp. 555-570.
205. Kuo PH, Wu HD, Yu CJ, Yang SC, Lai YL, Yang PC. Efficacy of tracheal gas insufflation in acute respiratory distress syndrome with permissive hypercapnia. Am J Respir Crit Care Med 1996;154: 612-616.
206. Richecoeur J, Lu Q, Vieira SR, Puybasset L, Kalfon P, Coriat P, Rouby JJ. Expiratory washout versus optimization of mechanical ventilation during permissive hypercapnia in patients with severe acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;160:77-85.
207. De Robertis E, Sigurdsson SE, Drefeldt B, Jonson B. Aspiration of airway dead space: a new method to enhance CO2 elimination. Am J Respir Crit Care Med 1999;159:728-732.
208. De Robertis E, Servillo G, Tufano R, Jonson B. Aspiration of dead space allows isocapnic low tidal volume ventilation in acute lung injury: relationships to gas exchange and mechanics. Intensive Care Med 2001;27:1496-1503.
209. Putensen C, Räsänen J, López FA, Downs JB. Effect of interfacing between spontaneous breathing and mechanical cycles on the ventilation-perfusion distribution in canine lung injury. Anesthesiology 1994;81:921-930.
210. Wrigge H, Zinserling J, Neumann P, Defosse J, Magnusson A, Putensen C, Hedenstierna G. Spontaneous breathing improves lung aeration in oleic acid-induced lung injury. Anesthesiology 2003;99:376-384.
211. Neumann P, Wrigge H, Zinserling J, Hinz J, Maripuu E, Andersson LG, Putensen C, Hedenstierna G. Spontaneous breathing affects the spatial ventilation and perfusion distribution during mechanical ventilatory support. Crit Care Med 2005;33: 1090-1095.
212. Henzler D, Pelosi P, Bensberg R, Dembinski R, Quintel M, Pielen V, Rossaint R, Kuhlen R. Effects of partial ventilatory support modalities on respiratory function in severe hypoxemic lung injury. Crit Care Med 2006;34:1738-1745.
213. Güldner A, Braune A, Carvalho N, Beda A, Zeidler S, Wiedemann B, Wunderlich G, Andreeff M, Uhlig C, Spieth PM, et al. Higher levels of spontaneous breathing induce lung recruitment and reduce global stress/strain in experimental lung injury. Anesthesiology 2014;120:673-682.
214. Groeger JS, Levinson MR, Carlon GC. Assist control versus synchronized intermittent mandatory ventilation during acute respiratory failure. Crit Care Med 1989;17:607-612.
215. Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling J. Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;159: 1241-1248.
216. Putensen C, Zech S, Wrigge H, Zinserling J, Stüber F, Von Spiegel T, Mutz N. Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med 2001;164:43-49.
217. Yoshida T, Rinka H, Kaji A, Yoshimoto A, Arimoto H, Miyaichi T, Kan M. The impact of spontaneous ventilation on distribution of lung aeration in patients with acute respiratory distress syndrome: airway pressure release ventilation versus pressure support ventilation. Anesth Analg 2009;109:1892-1900.
218. Putensen C, Räsänen J, López FA. Ventilation-perfusion distributions during mechanical ventilation with superimposed spontaneous breathing in canine lung injury. Am J Respir Crit Care Med 1994; 150:101-108.
219. Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y. Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury. Crit Care Med 2012;40:1578-1585.
220. Brochard L, Slutsky A, Pesenti A. Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Am J Respir Crit Care Med 2017;195:438-442.
221. Yoshida T, Torsani V, Gomes S, De Santis RR, Beraldo MA, Costa ELV, Tucci MR, Zin WA, Kavanagh BP, Amato MBP. Spontaneous effort causes occult pendelluft during mechanical ventilation. Am J Respir Crit Care Med 2013;188:1420-1427.
222. Yoshida T, Fujino Y, Amato MB, Kavanagh BP. Fifty years of research in ARDS: spontaneous breathing during mechanical ventilation: risks, mechanisms, and management. Am J Respir Crit Care Med 2017;195:985-992.
223. Douglas WW, Rehder K, Beynen FM, Sessler AD, Marsh HM. Improved oxygenation in patients with acute respiratory failure: the prone position. Am Rev Respir Dis 1977;115:559-566.
224. Piehl MA, Brown RS. Use of extreme position changes in acute respiratory failure. Crit Care Med 1976;4:13-14.
225. Gattinoni L, Pelosi P, Valenza F, Mascheroni D. Patient positioning in acute respiratory failure. In: Tobin MJ, editor. Principles and practice of mechanical ventilation. New York: McGraw-Hill; 1994. pp. 1067-1076.
226. Ward NS. Effects of prone position ventilation in ARDS: an evidencebased review of the literature. Crit Care Clin 2002;18:35-44.
227. Guérin C. Prone ventilation in acute respiratory distress syndrome. Eur Respir Rev 2014;23:249-257.
228. Charron C, Repesse X, Bouferrache K, Bodson L, Castro S, Page B, Jardin F, Vieillard-Baron A. PaCO2 and alveolar dead space are more relevant than PaO2/FiO2 ratio in monitoring the respiratory response to prone position in ARDS patients: a physiological study. Crit Care 2011;15:R175.
229. Lemasson S, Ayzac L, Girard R, Gaillard S, Pavaday K, Guérin C. Does gas exchange response to prone position predict mortality in hypoxemic acute respiratory failure? Intensive Care Med 2006;32: 1987-1993.
230. Gattinoni L, Vagginelli F, Carlesso E, Taccone P, Conte V, Chiumello D, Valenza F, Caironi P, Pesenti A; Prone-Supine Study Group. Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome. Crit Care Med 2003;31:2727-2733.
231. Protti A, Chiumello D, Cressoni M, Carlesso E, Mietto C, Berto V, Lazzerini M, Quintel M, Gattinoni L. Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure. Intensive Care Med 2009;35: 1011-1017.
232. Broccard A, Shapiro RS, Schmitz LL, Adams AB, Nahum A, Marini JJ. Prone positioning attenuates and redistributes ventilator-induced lung injury in dogs. Crit Care Med 2000;28:295-303.
233. Papazian L, Gainnier M, Marin V, Donati S, Arnal J-M, Demory D, Roch A, Forel J-M, Bongrand P, Brégeon F, et al. Comparison of prone positioning and high-frequency oscillatory ventilation in patients with acute respiratory distress syndrome. Crit Care Med 2005;33: 2162-2171.
234. Valenza F, Guglielmi M, Maffioletti M, Tedesco C, Maccagni P, Fossali T, Aletti G, Porro GA, Irace M, Carlesso E, et al. Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role? Crit Care Med 2005;33:361-367.
235. Sud S, Friedrich JO, Adhikari NKJ, Taccone P, Mancebo J, Polli F, Latini R, Pesenti A, Curley MAQ, Fernandez R, et al. Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis. CMAJ 2014;186:E381-E390.
236. Gattinoni L, Taccone P, Carlesso E, Marini JJ. Prone position in acute respiratory distress syndrome: rationale, indications, and limits. Am J Respir Crit Care Med 2013;188:1286-1293.
237. Richard J-CM, Maggiore SM, Mancebo J, Lemaire F, Jonson B, Brochard L. Effects of vertical positioning on gas exchange and lung volumes in acute respiratory distress syndrome. Intensive Care Med 2006;32:1623-1626.
238. Dellamonica J, Lerolle N, Sargentini C, Hubert S, Beduneau G, Di Marco F, Mercat A, Diehl JL, Richard JCM, Bernardin G, et al. Effect of different seated positions on lung volume and oxygenation in acute respiratory distress syndrome. Intensive Care Med 2013;39: 1121-1127.
239. Gerlach H, Keh D, Semmerow A, Busch T, Lewandowski K, Pappert DM, Rossaint R, Falke KJ. Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study. Am J Respir Crit Care Med 2003;167:1008-1015.
240. Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis K Jr, Kelly KM, Smith TC, Small RJ; Inhaled Nitric Oxide in ARDS Study Group. Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 2004;291: 1603-1609.
241. Christenson J, Lavoie A, O'Connor M, Bhorade S, Pohlman A, Hall JB. The incidence and pathogenesis of cardiopulmonary deterioration after abrupt withdrawal of inhaled nitric oxide. Am J Respir Crit Care Med 2000;161:1443-1449.
242. Adhikari NKJ, Dellinger RP, Lundin S, Payen D, Vallet B, Gerlach H, Park KJ, Mehta S, Slutsky AS, Friedrich JO. Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med 2014; 42:404-412.
243. Kiiski R, Kaitainen S, Karppi R, Takala J. Physiological effects of reduced tidal volume at constant minute ventilation and inspiratory flow rate in acute respiratory distress syndrome. Intensive Care Med 1996;22:192-198.
244. Leatherman JW, Lari RL, Iber C, Ney AL. Tidal volume reduction in ARDS: effect on cardiac output and arterial oxygenation. Chest 1991;99:1227-1231.
245. Thorens JB, Jolliet P, Ritz M, Chevrolet JC. Effects of rapid permissive hypercapnia on hemodynamics, gas exchange, and oxygen transport and consumption during mechanical ventilation for the acute respiratory distress syndrome. Intensive Care Med 1996;22:182-191.
246. Goligher EC, Kavanagh BP, Rubenfeld GD, Adhikari NKJ, Pinto R, Fan E, Brochard LJ, Granton JT, Mercat A, Marie Richard J-C, et al. Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome: a secondary analysis of the LOVS and ExPress trials. Am J Respir Crit Care Med 2014;190: 70-76.
247. Caironi P, Carlesso E, Cressoni M, Chiumello D, Moerer O, Chiurazzi C, Brioni M, Bottino N, Lazzerini M, Bugedo G, et al. Lung recruitability is better estimated according to the Berlin definition of acute respiratory distress syndrome at standard 5 cm H2O rather than higher positive end-expiratory pressure: a retrospective cohort study. Crit Care Med 2015;43:781-790.
248. Lucangelo U, Blanch L. Dead space. Intensive Care Med 2004;30: 576-579.
249. Radermacher P, Falke KJ. Pulmonary ventilation and gas exchange. In: Tinker J, Zapol WM, editors. Care of the critically ill patient, 2nd ed. New York: Springer; 1992. pp. 59-67.
250. Benatar SR, Hewlett AM, Nunn JF. The use of iso-shunt lines for control of oxygen therapy. Br J Anaesth 1973;45:711-718.