Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism

Critical Care Medicine

Volumn 40, Issue 9, 2012, Pages 2622-2630

  Contreras, Maya ^a,b   Ansari, Bilal ^a,b   Curley, Gerard ^b,c   Higgins, Brendan D ^a,b   Hassett, Patrick ^a,b   O'Toole, Daniel ^b,c   Laffey, John G ^a,b,c  

^a Clinical Sciences Institute   (Ireland)

^b National Centre for Biomedical Engineering Science   (Ireland)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

acidosis; acute lung injury; acute respiratory distress syndrome; hypercapnia; nuclear factor B; shock; ventilation induced lung injury

Indexed keywords

BICARBONATE; CARBON DIOXIDE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LACTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BICARBONATE BLOOD LEVEL; BLOOD CARBON DIOXIDE TENSION; BLOOD OXYGEN TENSION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL THERAPY; HISTOPATHOLOGY; HYPRECAPNIC ACIDOSIS (TREATMENT); IN VITRO STUDY; INJURY SEVERITY; LACTATE BLOOD LEVEL; LUNG ALVEOLUS EPITHELIUM; LUNG COMPLIANCE; LUNG LAVAGE; MALE; MEAN ARTERIAL PRESSURE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN SYNTHESIS INHIBITION; RAT; THERAPY EFFECT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VENTILATOR INDUCED LUNG INJURY;

ACIDOSIS, RESPIRATORY; ANIMALS; BIOPSY, NEEDLE; BLOOD GAS ANALYSIS; DISEASE MODELS, ANIMAL; HEMODYNAMICS; HYPERCAPNIA; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY SCORE; INTERLEUKIN-6; INTERLEUKIN-8; MALE; NF-KAPPA B; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE; VENTILATOR-INDUCED LUNG INJURY;

EID: 84865475718     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318258f8b4     Document Type: Article

References (35)

1. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308
2. Shibata K, Cregg N, Engelberts D, et al: Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase. Am J Respir Crit Care Med 1998; 158(5 Pt 1):1578-1584
3. Laffey JG, Honan D, Hopkins N, et al: Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. Am J Respir Crit Care Med 2004; 169:46-56
4. Laffey JG, Engelberts D, Kavanagh BP: Buffering hypercapnic acidosis worsens acute lung injury. Am J Respir Crit Care Med 2000; 161:141-146
5. Laffey JG, Tanaka M, Engelberts D, et al: Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000; 162:2287-2294
6. Laffey JG, Jankov RP, Engelberts D, et al: Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Am J Respir Crit Care Med 2003; 168:1383-1390
7. Doerr CH, Gajic O, Berrios JC, et al: Hypercapnic acidosis impairs plasma membrane wound resealing in ventilator-injured lungs. Am J Respir Crit Care Med 2005; 171:1371-1377
8. O'Toole D, Hassett P, Contreras M, et al: Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism. Thorax 2009; 64:976-982
9. Chonghaile MN, Higgins BD, Costello J, et al: Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia. Anesthesiology 2008; 109:837-848
10. Ni Chonghaile M, Higgins BD, Costello JF, et al: Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism. Crit Care Med 2008; 36:3135-3144
11. Costello J, Higgins B, Contreras M, et al: Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Crit Care Med 2009; 37:2412-2420
12. Higgins BD, Costello J, Contreras M, et al: Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis. Anesthesiology 2009; 111:1317-1326
13. Nichol AD, O'Cronin DF, Howell K, et al: Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis. Crit Care Med 2009; 37:2953-2961
14. O'Croinin DF, Nichol AD, Hopkins NO, et al: Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury. Crit Care Med 2008; 36: 2128-2135
15. Curley G, Contreras MM, Nichol AD, et al: Hypercapnia and acidosis in sepsis: A double-edged sword? Anesthesiology 2010; 112:462-472
16. Chen LW, Egan L, Li ZW, et al: The two faces of IKK and NF-kappaB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003; 9:575-581
17. Park GY, Christman JW: Nuclear factor kappa B is a promising therapeutic target in inflammatory lung disease. Curr Drug Targets 2006; 7:661-668
18. Takeshita K, Suzuki Y, Nishio K, et al: Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation. Am J Respir Cell Mol Biol 2003; 29:124-132
19. Broccard AF, Hotchkiss JR, Vannay C, et al: Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am J Respir Crit Care Med 2001; 164:802-806
20. Laffey JG, Engelberts D, Duggan M, et al: Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation. Crit Care Med 2003; 31:2634-2640
21. Sinclair SE, Kregenow DA, Lamm WJ, et al: Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med 2002; 166:403-408
22. Rai S, Engelberts D, Laffey JG, et al: Therapeutic hypercapnia is not protective in the in vivo surfactant-depleted rabbit lung. Pediatr Res 2004; 55:42-49
23. Strand M, Ikegami M, Jobe AH: Effects of high PCO2 on ventilated preterm lamb lungs. Pediatr Res 2003; 53:468-472
24. O'Croinin DF, Hopkins NO, Moore MM, et al: Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury. Crit Care Med 2005; 33:2606-2612
25. Kennedy MT, Higgins BD, Costello JF, et al: Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury. BMC Pulm Med 2008; 8:9
26. Howell K, Preston RJ, McLoughlin P: Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol (Lond) 2003; 547(Pt 1): 133-145
27. Hopkins N, Cadogan E, Giles S, et al: Chronic airway infection leads to angiogenesis in the pulmonary circulation. J Appl Physiol 2001; 91:919-928
28. Kregenow DA, Rubenfeld GD, Hudson LD, et al: Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med 2006; 34:1-7
29. Ning QM, Wang XR: Activations of mitogen-activated protein kinase and nuclear factor-kappaB by mechanical stretch result in ventilation-induced lung injury. Med Hypotheses 2007; 68:356-360
30. Prella M, Feihl F, Domenighetti G: Effects of short-term pressure-controlled ventilation on gas exchange, airway pressures, and gas distribution in patients with acute lung injury/ARDS: Comparison with volume-controlled ventilation. Chest 2002; 122:1382-1388
31. Laffey JG, Engelberts D, Kavanagh BP: Injurious effects of hypocapnic alkalosis in the isolated lung. Am J Respir Crit Care Med 2000; 162(2 Pt 1):399-405
32. Gattinoni L, Pesenti A: The concept of "baby lung". Intensive Care Med 2005; 31:776-784
33. Ishiyama T, Dharmarajan S, Hayama M, et al: Inhibition of nuclear factor kappaB by IkappaB superrepressor gene transfer ameliorates ischemia-reperfusion injury after experimental lung transplantation. J Thorac Cardiovasc Surg 2005; 130:194-201
34. Matsuda N, Hattori Y, Jesmin S, et al: Nuclear factor-kappaB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol Pharmacol 2005; 67:1018-1025
35. Sadikot RT, Zeng H, Joo M, et al: Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol 2006; 176:4923-4930