Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: A prospective, randomized, controlled study

American Journal of Respiratory and Critical Care Medicine

Volumn 167, Issue 7, 2003, Pages 1008-1015

  Gerlach, Herwig ^a   Keh, Didier ^b   Semmerow, Alexander ^b   Busch, Thilo ^b   Lewandowski, Klaus ^b   Pappert, Dirk M ^b   Rossaint, Rolf ^b   Falke, Konrad J ^b  

^a VIVANTES KLINIKUM NEUKÖLLN   (Germany)

^b NONE

Author keywords

Acute respiratory distress syndrome; Dose response relationship, drug; Inhalation drug administration; Nitric oxide; Respiratory distress syndrome, adult

Indexed keywords

NITRIC OXIDE;

ADULT; AIR CONDITIONING; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENERAL CONDITION IMPROVEMENT; HUMAN; HUMAN EXPERIMENT; INTENSIVE CARE UNIT; LONG TERM CARE; MALE; MEASUREMENT; OXYGEN TENSION; OXYGENATION; PARAMETER; PATIENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEVERE ACUTE RESPIRATORY DISTRESS SYNDROME; SYNDROME; WEANING;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; BRONCHODILATOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PULMONARY VENTILATION; RESPIRATORY DISTRESS SYNDROME, ADULT; SEVERITY OF ILLNESS INDEX; TIME; TIME FACTORS; TREATMENT OUTCOME;

EID: 0037385202     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.2108121     Document Type: Article

References (48)

1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967;2:319-323.
2. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide in adult respiratory distress syndrome. N Engl J Med 1993;328:399-405.
3. Rossaint R, Gerlach H, Schmidt-Ruhnke H, Pappert D, Lewandowski K, Steudel W, Falke KJ. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest 1995;107:1107-1115.
4. Gerlach H, Rossaint R, Pappert D, Falke KJ. Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 1993;23:499-502.
5. Puybasset L, Rouby JJ, Mourgeon E, Stewart TE, Cluzel P, Arthaud M, Poete P, Bodin L, Korinek AM, Viars P. Inhaled nitric oxide in acute respiratory failure: dose-response curves. Intensive Care Med 1994;20:319-327.
6. Lu Q, Mourgeon E, Law-Koune JD, Roche S, Vezinet C, Abdennour L, Vicaut E, Puybasset L, Diaby M, Coriat P, et al. Dose-response curves of inhaled nitric oxide with and without intravenous almitrine in nitric oxide-responding patients with acute respiratory distress syndrome. Anesthesiology 1995;83:929-943.
7. Lowson SM, Rich GF, McArdle PA, Jaidev J, Morris GN. The response to varying concentrations of inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesth Analg 1996;82:574-581.
8. Lundin S, Westfelt UN, Stenqvist O, Blomqvist H, Lindh A, Berggren L, Arvidsson S, Rudberg U, Frostell CG. Response to nitric oxide inhalation in early acute lung injury. Intensive Care Med 1996;22:728-734.
9. Mourgeon E, Puybasset L, Law-Koune JD, Lu Q, Abdennour L, Gallart L, Malassine P, Rao GSU, Cluzel P, Bennani A, et al. Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose-response study. Crit Care 1997;1:25-39.
10. Krafft P, Fridrich P, Fitzgerald RD, Koc D, Steltzer H. Effectiveness of nitric oxide inhalation in septic ARDS. Chest 1996;109:486-493.
11. Manktelow C, Bigatello LM, Hess D, Hurford WE. Physiologic determinants of the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 1997;87:297-307.
12. Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ. Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 1993;19:443-449.
13. Dellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ, Davis K Jr, Flyers TM, Papadakos P. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial: inhaled nitric oxide in ARDS Study Group. Crit Care Med 1998;26:15-23.
14. Lundin S, Mang H, Smithies M, Stenquist O, Frostell C. Inhalation of nitric oxide in acute lung injury: results of a European multicenter study. Intensive Care Med 1999;25:911-919.
15. Michael JR, Barton RG, Saffle JR, Mone M, Markewitz BA, Hillier K, Elstad MR, Campbell EJ, Troyer BE, Whatley RE, et al. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med 1998;157:1372-1380.
16. Troncy E, Collet JP, Shapiro S, Guimond JG, Blair L, Ducruet T, Francoeur M, Charbonneau M, Blaise G. Inhaled nitric oxide in acute respiratory distress syndrome: a pilot randomized controlled study. Am J Respir Crit Care Med 1998;157:1483-1488.
17. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke KJ, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-824.
18. Finer NN, Etches PC, Kamstra B, Tierney AJ, Peliowski A, Ryan CA. Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose response. J Pediatr 1994;124:302-308.
19. Rassaf T, Preik M, Kleinbongard P, Lauer T, Heiss C, Strauer BE, Feelisch M, Kelm M. Evidence for in vivo transport of bioactive nitric oxide in human plasma. J Clin Invest 2002;109:1241-1248.
20. Schechter AN, Gladwin MT, Cannon RO III. NO solutions? J Clin Invest 2002;109:1149-1151.
21. Kiff RJ, Moss DW, Moncada S. Effect of nitric oxide gas on the generation of nitric oxide by isolated blood vessels: implications for inhalation therapy. Br J Pharmacol 1994;113:496-498.
22. Holzmann A, Manktelow C, Taut FJH, Bloch KD, Zapol WM. Inhibition of nitric oxide synthase prevents hyporesponsiveness to inhaled nitric oxide in lungs from endotoxin-challenged rats. Anesthesiology 1999;91:215-221.
23. Denninger JW, Marletta MA. Guanylate cyclase and the NO/cGMP signalling pathway. Biochim Biophys Acta 1999;1411:334-350.
24. Behrends S, Kempfert J, Mietens A, Koglin M, Scholz H, Middendorff R. Developmental changes of nitric oxide-sensitive guanylyl cyclase expression in pulmonary arteries. Biochem Biophys Res Commun 2001;283:883-887.
25. Holzmann A, Manktelow C, Weimann J, Bloch KD, Zapol WM. Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin. Intensive Care Med 2001;27:251-257.
26. Pearl JM, Nelson DP, Raake JL, Manning PB, Schwartz SM, Koons L, Shanley TP, Wong HR, Duffy JY. Inhaled nitric oxide increases endothelin-1 levels: a potential cause of rebound pulmonary hypertension. Crit Care Med 2002;30:89-93.
27. Chen L, He H, Fernandez-Mondejar E, Freden F, Wiklund P, Alving K, Hedenstierna G. Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide. Am J Physiol Heart Circ Physiol 2001;281:H124-H131.
28. Bucher M, Taeger K. Endothelin-receptor gene-expression in rat endotoxemia. Intensive Care Med 2002;28:642-647.
29. Hambraeus-Jonzon K, Chen L, Freden F, Wiklund P, Hedenstierna G. Pulmonary vasoconstriction during regional nitric oxide inhalation: evidence of a blood-borne regulator of nitric oxide synthase activity. Anesthesiology 2001;95:102-112.
30. Johns RA. New mechanisms for inhaled NO: release of an endogenous NO inhibitor? Anesthesiology 2001;95:3-5.
31. Gust R, McCarthy TJ, Kozlowski J, Stephenson AH, Schuster DP. Response to inhaled nitric oxide in acute lung injury depends on distribution of pulmonary blood flow prior to its administration. Am J Respir Crit Care Med 1999;159:563-570.
32. Freden F, Berglund JE, Hedenstierna G. Pulmonary blood flow distribution in lobar hypoxia: influence of cardiac output and nitric oxide inhalation. Scand Cardiovasc J 1999;33:215-221.
33. Lamb NJ, Quinlan GJ, Westerman ST, Gutteridge JMC, Evans TW. Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide. Am J Respir Crit Care Med 1999;160:1031-1034.
34. Lang JD, Chumley P, Eiserich JP, Estevez A, Bamberg T, Adhami A, Crow J, Freeman BA. Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway. Am J Physiol Lung Cell Mol Physiol 2000;279:L994-L1002.
35. Chollet-Martin S, Gatecel C, Kermarrec N, Gougerot-Pocidalo MA, Payen D. Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Am J Respir Crit Care Med 1996;153:985-990.
36. Maurenbrecher H, Lamy M, Deby-Dupont G, Frascarolo P, Hedenstierna G. An animal model of response and nonresponse to inhaled nitric oxide in endotoxin-induced lung injury. Chest 2001;120:573-581.
37. Razavi HM, Werhun R, Scott JA, Weicker S, Wang LF, McCormack DG, Mehta S. Effects of inhaled nitric oxide in a mouse model of sepsis-induced acute lung injury. Crit Care Med 2002;30:868-873.
38. Lum LC, Tan PS, Saville A, Venkataraman ST, Pinsky MR. Occult nitric oxide inhalation improves oxygenation in mechanically ventilated children. J Pediatr 1998;133:613-616.
39. Cornfield DN, Maynard RC, deRegnier RC, Guiang SF, Barbato JE, Milla CE. Randomized, controlled trial of low-dose inhaled nitric oxide in the treatment of term and near-term infants with respiratory failure and pulmonary hypertension. Pediatrics 1999;104:1089-1094.
40. Rialp G, Betbese AJ, Perez-Marquez M, Mancebo J. Short-term effects of inhaled nitric oxide and prone position in pulmonary and extrapulmonary acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164:243-249.
41. Lewandowski K, Rossaint R, Pappert D, Gerlach H, Slama KJ, Weidemann H, Frey DJM, Hoffmann O, Keske U, Falke KJ. High survival rate in 122 ARDS patients managed according to a clinical algorithm including extracorporeal membrane oxygenation. Intensive Care Med 1997;23:819-835.
42. Finer N, Solimano A, Germain F, Walker R, Ramirez AM, Singhal N, Bourcier L, Fajardo C, Cook V, Kirpalani H, et al. Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. Pediatrics 1997;99:838-845.
43. Kinsella JP, Truog WE, Walsh WF, Goldberg RN, Bancalari E, Mayock DE, Redding GJ, Delemos RA, Sardesai S, McCurnin DC, et al. Randomized, multicenter trial of inhaled nitric oxide and high frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 1997;131:55-62.
44. Stork E, Gorjanc E, Verter J, Younes N, Stenzel BA, Powers T, Sokol G, Wright LL, Yaffe SJ, Catz C, et al. Inhaled nitric oxide in full term and nearly full term infants with hypoxic respiratory failure. N Engl J Med 1997;336:597-604.
45. Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S, Walsh-Sukys MC, McCaffrey MJ, Cornfield DN, Bhutani VK, et al. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 1999;354:1061-1065.
46. The Franco-Belgium Collaborative NO Trial Group. Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial. Lancet 1999;354:1065-1071.
47. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1988;138:720-723.
48. Goris RJA, te Boekhorst TPA, Nuytinck JKS, Gimbrère JSF. Multiple organ failure: generalized autodestructive inflammation. Arch Surg 1985;120:1109-1115.