Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury

Critical Care Medicine

Volumn 36, Issue 7, 2008, Pages 2128-2135

  O'Croinin, Donall F ^a   Nichol, Alistair D ^a   Hopkins, Natalie ^e   Boylan, John ^b   O'Brien, Sorca ^a   O'Connor, Clare ^a   Laffey, John G ^c,d   McLoughlin, Paul ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^d UNIVERSITY HOSPITAL GALWAY   (Ireland)

^e DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Chronic obstructive pulmonary disease; Escherichia coli; Hypercapnic acidosis; Immunosuppression; In vivo model; Infection; Lung; Pneumonia

Indexed keywords

CEFTRIAXONE;

AIR CONDITIONING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL INFECTION; BACTERIAL REPRODUCTION; BACTERIUM COLONY; CELL ISOLATION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; ESCHERICHIA COLI; EXPERIMENTAL MODEL; GENERAL ANESTHESIA; HYPERCAPNIA; HYPERCAPNIC ACIDOSIS; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LUNG COMPLIANCE; LUNG INFECTION; LUNG INJURY; MALE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RAT; RESPIRATORY ACIDOSIS; STEREOLOGY; WISTAR KYOTO RAT; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; ENTEROBACTER INFECTION; MICROBIOLOGY; PATHOPHYSIOLOGY;

ACIDOSIS, RESPIRATORY; ANIMALS; ESCHERICHIA COLI INFECTIONS; HYPERCAPNIA; MALE; PHAGOCYTOSIS; RATS; RATS, INBRED WKY; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 47249148480     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31817d1b59     Document Type: Article

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