Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome: A secondary analysis of the LOVS and express trials

American Journal of Respiratory and Critical Care Medicine

Volumn 190, Issue 1, 2014, Pages 70-76

  Goligher, Ewan C ^a,b   Kavanagh, Brian P ^a,c,d   Rubenfeld, Gordon D ^a,e   Adhikari, Neill K J ^a,e   Pinto, Ruxandra ^e   Fan, Eddy ^a,b   Brochard, Laurent J ^a,f   Granton, John T ^a,b   Mercat, Alain ^g   Richard, Jean Christophe Marie ^h   Chretien, Jean Marie ^g   Jones, Graham L ⁱ   Cook, Deborah J ⁱ   Stewart, Thomas E ^a,b   Slutsky, Arthur S ^a,b   Meade, Maureen O ⁱ   Ferguson, Niall D ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g ANGERS UNIVERSITY HOSPITAL   (France)

^h ROUEN UNIVERSITY HOSPITAL   (France)

ⁱ MCMASTER UNIVERSITY   (Canada)

Author keywords

Adult; Positive endexpiratory pressure; Respiratory distress syndrome; Ventilator induced lung injury

Indexed keywords

OXYGEN;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTERIAL PRESSURE; ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; FEMALE; HUMAN; LUNG DEAD SPACE; LUNG VENTILATION; MAJOR CLINICAL STUDY; MALE; OXYGEN TENSION; OXYGENATION; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; SECONDARY ANALYSIS;

POSITIVE END-EXPIRATORY PRESSURE; RESPIRATORY DISTRESS SYNDROME, ADULT; VENTILATOR-INDUCED LUNG INJURY;

FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; POSITIVE-PRESSURE RESPIRATION; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATORY DISTRESS SYNDROME, ADULT; SEVERITY OF ILLNESS INDEX; TIDAL VOLUME; TREATMENT OUTCOME; VENTILATOR-INDUCED LUNG INJURY;

EID: 84903831527     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201404-0688OC     Document Type: Article

References (31)

1. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342: 1301-1308.
2. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351: 327-336.
3. Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, et al.; Expiratory Pressure (ExPress) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008;299: 646-655.
4. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, et al.; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008;299: 637-645.
5. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-Analysis. JAMA 2010;303: 865-873.
6. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307: 2526-2533.
7. Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Peñuelas O, Abraira V, Raymondos K, Ŕios F, Nin N, Apeztegúia C, et al. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 2013;188: 220-230.
8. Rubenfeld GD. How much PEEP in acute lung injury. JAMA 2010;303: 883-884.
9. Gattinoni L, Caironi P, Cressoni M, Chiumello D, Ranieri VM, Quintel M, Russo S, Patroniti N, Cornejo R, Bugedo G. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 2006;354: 1775-1786.
10. Di Marco F, Devaquet J, Lyazidi A, Galia F, da Costa NP, Fumagalli R, Brochard L. Positive end-expiratory pressure-induced functional recruitment in patients with acute respiratory distress syndrome. Crit Care Med 2010;38: 127-132.
11. Caironi P, Cressoni M, Chiumello D, Ranieri M, Quintel M, Russo SG, Cornejo R, Bugedo G, Carlesso E, Russo R, et al. Lung opening and closing during ventilation of acute respiratory distress syndrome. Am J Respir Crit Care Med 2010;181: 578-586.
12. Maisch S, Reissmann H, Fuellekrug B, Weismann D, Rutkowski T, Tusman G, Böhm SH. Compliance and dead space fraction indicate an optimal level of positive end-expiratory pressure after recruitment in anesthetized patients. Anesth Analg 2008;106: 175-181, table of contents.
13. Fengmei G, Jin C, Songqiao L, Congshan Y, Yi Y. Dead space fraction changes during PEEP titration following lung recruitment in patients with ARDS. Respir Care 2012;57: 1578-1585.
14. Grasso S, Mascia L, Del Turco M, Malacarne P, Giunta F, Brochard L, Slutsky AS, Marco Ranieri V. Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy. Anesthesiology 2002;96: 795-802.
15. Goligher EC, Rubenfeld G, Adhikari NKJ, Pinto R, Kavanagh BP, Cook DJ, Guyatt GH, Jones GL, Granton J, Stewart TE, et al. Oxygenation response to increased PEEP predicts mortality in acute lung injury: a secondary analysis of the Lung Open Ventilation Study (LOVS) trial [abstract]. Am J Respir Crit Care Med 2012;185: A1158.
16. Papazian L, Forel J-M, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal J-M, Perez D, Seghboyan J-M, et al.; ACURASYS Study Investigators. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363: 1107-1116.
17. Gué rin C, Reignier J, Richard J-C, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, et al.; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013;368: 2159-2168.
18. Reske AW, Costa ELV, Reske AP, Rau A, Borges JB, Beraldo MA, Gottschaldt U, Seiwerts M, Schreiter D, Petroff D, et al. Bedside estimation of nonaerated lung tissue using blood gas analysis. Crit Care Med 2013;41: 732-743.
19. Borges JB, Okamoto VN, Matos GFJ, Caramez MPR, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CSV, et al. Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;174: 268-278.
20. Suarez-Sipmann F, Böhm SH, Tusman G, Pesch T, Thamm O, Reissmann H, Reske A, Magnusson A, Hedenstierna G. Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study. Crit Care Med 2007;35: 214-221.
21. Dantzker DR, Lynch JP, Weg JG. Depression of cardiac output is a mechanism of shunt reduction in the therapy of acute respiratory failure. Chest 1980;77: 636-642.
22. Mekontso Dessap A, Boissier F, Leon R, Carreira S, Campo FR, Lemaire F, Brochard L. Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome. Crit Care Med 2010;38: 1786-1792.
23. Gattinoni L, Carlesso E, Cressoni M. Assessing gas exchange in acute lung injury/acute respiratory distress syndrome: diagnostic techniques and prognostic relevance. Curr Opin Crit Care 2011;17: 18-23.
24. de Matos GFJ, Stanzani F, Passos RH, Fontana MF, Albaladejo R, Caserta RE, Santos DCB, Borges JB, Amato MBP, Barbas CSV. How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography. Crit Care 2012;16: R4.
25. Matamis D, Lemaire F, Harf A, Teisseire B, Brun-Buisson C. Redistribution of pulmonary blood flow induced by positive endexpiratory pressure and dopamine infusion in acute respiratory failure. Am Rev Respir Dis 1984;129: 39-44.
26. Mé lot C. Contribution of multiple inert gas elimination technique to pulmonary medicine. 5. Ventilation-perfusion relationships in acute respiratory failure. Thorax 1994;49: 1251-1258.
27. Puybasset L, Gusman P, Muller JC, Cluzel P, Coriat P, Rouby JJ; CT Scan ARDS Study Group. Regional distribution of gas and tissue in acute respiratory distress syndrome. III. Consequences for the effects of positive end-expiratory pressure. Intensive Care Med 2000; 26: 1215-1227.
28. Mancini M, Zavala E, Mancebo J, Fernandez C, BarberàJA, Rossi A, Roca J, Rodriguez-Roisin R. Mechanisms of pulmonary gas exchange improvement during a protective ventilatory strategy in acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164: 1448-1453.
29. Maggiore SM, Jonson B, Richard JC, Jaber S, Lemaire F, Brochard L. Alveolar derecruitment at decremental positive end-expiratory pressure levels in acute lung injury: comparison with the lower inflection point, oxygenation, and compliance. Am J Respir Crit Care Med 2001;164: 795-801.
30. Ranieri VM, Eissa NT, Corbeil C, Chassé M, Braidy J, Matar N, Milic-Emili J. Effects of positive end-expiratory pressure on alveolar recruitment and gas exchange in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1991;144: 544-551.
31. Lachmann B. Open up the lung and keep the lung open. Intensive Care Med 1992;18: 319-321.