Structure-Guided Screening for Functionally Selective D2 Dopamine Receptor Ligands from a Virtual Chemical Library

ACS Chemical Biology

Volumn 12, Issue 10, 2017, Pages 2652-2661

  Männel, Barbara ^a   Jaiteh, Mariama ^b   Zeifman, Alexey ^b   Randakova, Alena ^a   Möller, Dorothee ^a   Hübner, Harald ^a   Gmeiner, Peter ^a   Carlsson, Jens ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; QUINPIROLE; DOPAMINE; LIGAND; PROTEIN BINDING;

ALLOSTERIC SITE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; EC50; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; INTRACELLULAR SIGNALING; INTRINSIC ACTIVITY; MOLECULAR DOCKING; MOLECULAR LIBRARY; MOLECULAR WEIGHT; PREDICTIVE VALUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SYNTHESIS; CHEMISTRY; COMPUTER SIMULATION; MOLECULAR MODEL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; DOPAMINE; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85031298801     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.7b00493     Document Type: Article

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