Acetate: A diet-derived key metabolite in energy metabolism: Good or bad in context of obesity and glucose homeostasis?

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 20, Issue 6, 2017, Pages 477-483

  Canfora, Emanuel E ^a   Blaak, Ellen E ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

body weight; energy metabolism; gut microbiota; insulin sensitivity; short chain fatty acids

Indexed keywords

ACETIC ACID; ACETIC ACID DERIVATIVE; GASTROINTESTINAL HORMONE; INSULIN;

ADIPOSE TISSUE; BODY WEIGHT; CALORIC INTAKE; CELL FUNCTION; DIET; ENERGY EXPENDITURE; ENERGY METABOLISM; GLUCOSE HOMEOSTASIS; HUMAN; IN VIVO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; METABOLITE; OBESITY; PANCREAS ISLET BETA CELL; PHENOTYPE; REVIEW; ANIMAL; BLOOD; BODY WEIGHT GAIN; DISEASE MODEL; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; INSULIN RESISTANCE; INTESTINE FLORA; METABOLISM; SATIETY;

ACETATES; ANIMALS; BLOOD GLUCOSE; DIET; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GASTROINTESTINAL HORMONES; GASTROINTESTINAL MICROBIOME; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; OBESITY; SATIATION; WEIGHT GAIN;

EID: 85030762475     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000408     Document Type: Review

References (36)

1. Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut 2016; 65:330-339.
2. Reijnders D, Goossens GH, Hermes GD, et al. Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial. Cell Metab 2016; 24:63-74.
3. Bindels LB, Delzenne NM, Cani PD, Walter J. Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 2015; 12: 303-310.
4. Canfora EE, Blaak EE. The role of polydextrose in body weight control and glucose regulation. Curr Opin Clin Nutr Metab Care 2015; 18: 395-400.
5. Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol 2015; 11:577-591.
6. Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 2016; 165:1332-1345.
7. Frost G, Sleeth ML, Sahuri-Arisoylu M, et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun 2014; 5:3611.
8. Sahuri-Arisoylu M, Brody L, Parkinson J, et al. Reprogramming of hepatic fat accumulation and 'browning'of adipose tissue by the short-chain fatty acid acetate. Int J Obes (Lond) 2016; 40:955-963.
9. Brooks L, Viardot A, Tsakmaki A, et al. Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Mol Metab 2017; 6:48-60.
10. den Besten G, Bleeker A, Gerding A, et al. Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARg-dependent switch from lipogenesis to fat oxidation. Diabetes 2015; 64:2398-2408.
11. Kimura I, Ozawa K, Inoue D, et al. The gut microbiota suppresses insulinmediated fat accumulation via the short-chain fatty acid receptor GPR43. Nature Commun 2013; 4:1829.
12. Li X, Chen H, Guan Y, et al. Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes. PloS One 2013; 8:e67880.
13. den Besten G, Gerding A, van Dijk TH, et al. Protection against the metabolic syndrome by guar gum-derived short-chain fatty acids depends on peroxisome proliferator-activated receptor g and glucagon-like peptide-1. PloS One 2015; 10:e0136364.
14. Everard A, Lazarevic V, Gaa N, et al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 2014; 8:2116-2130.
15. Lu Y, Fan C, Li P, et al. Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota. Sci Rep 2016; 6:37589.
16. McNelis JC, Lee YS, Mayoral R, et al. GPR43 potentiates b-cell function in obesity. Diabetes 2015; 64:3203-3217.
17. Fernandes J, Vogt J, Wolever TM. Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans. Eur J Clin Nutr 2012; 66:1029-1034.
18. van der Beek CM, Canfora EE, Lenaerts K, et al. Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men. Clin Sci (Lond) 2016; 130:2073-2082.
19. Priyadarshini M, Villa SR, Fuller M, et al. An acetate-specific GPCR, FFAR2, regulates insulin secretion. Mol Endocrinol 2015; 29:1055-1066.
20. Canfora EE, Beek CM, Jocken JW, et al. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Sci Rep 2017; 7:2360.
21. Lim J, Henry CJ, Haldar S. Vinegar as a functional ingredient to improve postprandial glycemic control: human intervention findings and molecular mechanisms. Mol Nutr Food Res 2016; 60:1837-1849.
22. Perry RJ, Peng L, Barry NA, et al. Acetate mediates a microbiome-brain-b-cell axis to promote metabolic syndrome. Nature 2016; 534:213-217.
23. Tang C, Ahmed K, Gille A, et al. Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med 2015; 21:173-177.
24. den Besten G, van Eunen K, Groen AK, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 2013; 54:2325.
25. Fernandes J, Su W, Rahat-Rozenbloom S, et al. Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans. Nutr Diabetes 2014; 4:e121.
26. Tolhurst G, Heffron H, Lam YS, et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 2012; 61:364-371.
27. Engelstoft M, Schwartz T. Opposite regulation of ghrelin and glucagon-like peptide-1 by metabolite G-protein-coupled receptors. Trends Endocrinol Metab 2016; 27:665-675.
28. Hanatani S, Motoshima H, Takaki Y, et al. Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice. J Clin Biochem Nutr 2016; 59:207-214.
29. Stinkens R, Goossens GH, Jocken JW, Blaak EE. Targeting fatty acid metabolism to improve glucose metabolism. Obes Rev 2015; 16:715-757.
30. Aberdein N, Schweizer M, Ball D. Sodium acetate decreases phosphorylation of hormone sensitive lipase in isoproterenol-stimulated 3T3-L1 mature adipocytes. Adipocyte 2014; 3:121.
31. Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569-573.
32. Soliman ML, Combs CK, Rosenberger TA. Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes. J Neuroimmune Pharmacol 2013; 8:287-300.
33. Kobayashi M, Mikami D, Kimura H, et al. Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-a-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells. Biochem Biophys Res Commun 2017; 486:499-505.
34. Halban PA, Polonsky KS, Bowden DW, et al. b-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care 2014; 37:1751-1758.
35. Canfora EE, van der Beek CM, Hermes GD, et al. Supplementation of diet with galacto-oligosaccharides increases Bifidobacteria, but not insulin sensitivity, in obese prediabetic individuals. Gastroenterology 2017; 153: 87.e3-97.e3.
36. Vulevic J, Juric A, Walton GE, et al. Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons. Br J Nutr 2015; 114:586-595.