Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells

Biochemical and Biophysical Research Communications

Volumn 486, Issue 2, 2017, Pages 499-505

  Kobayashi, Mamiko ^a   Mikami, Daisuke ^a   Kimura, Hideki ^a,b   Kamiyama, Kazuko ^a   Morikawa, Yukie ^a   Yokoi, Seiji ^a   Kasuno, Kenji ^a   Takahashi, Naoki ^a   Taniguchi, Takanobu ^c   Iwano, Masayuki ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b UNIVERSITY OF FUKUI HOSPITAL   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

GPR41; GPR43; JNK; Monocyte chemoattractant protein 1; p38; SCFA

Indexed keywords

ANTIINFLAMMATORY AGENT; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 41; G PROTEIN COUPLED RECEPTOR 43; MITOGEN ACTIVATED PROTEIN KINASE 14; MONOCYTE CHEMOTACTIC PROTEIN 1; PROPIONIC ACID; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CCL2 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; FFAR3 PROTEIN, HUMAN; G-PROTEIN COUPLED RECEPTOR 43, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; VOLATILE FATTY ACID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY COLLECTING TUBULE; KIDNEY CORTEX; KIDNEY DISTAL TUBULE; KIDNEY EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GLOMERULONEPHRITIS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CELL LINE; CHEMOKINE CCL2; EPITHELIAL CELLS; FATTY ACIDS, VOLATILE; GENE EXPRESSION REGULATION; GLOMERULONEPHRITIS; HUMANS; KIDNEY CORTEX; KIDNEY TUBULES, COLLECTING; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85015754658     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2017.03.071     Document Type: Article

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