메뉴 건너뛰기




Volumn 153, Issue 1, 2017, Pages 87-97.e3

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

Author keywords

Metabolic Control; Microbial Obesity; Prebiotics; Short Chain Fatty Acids

Indexed keywords

GALACTOSE OLIGOSACCHARIDE; GASTROINTESTINAL HORMONE; INCRETIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; MALTODEXTRIN; PLACEBO; PREBIOTIC AGENT; SHORT CHAIN FATTY ACID; ACETIC ACID; ACUTE PHASE PROTEIN; BACTERIAL DNA; CARRIER PROTEIN; CYTOKINE; GALACTOSE; INSULIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN; OLIGOSACCHARIDE;

EID: 85019695782     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.03.051     Document Type: Article
Times cited : (149)

References (53)
  • 1
    • 84942191408 scopus 로고    scopus 로고
    • Gut microorganisms as promising targets for the management of type 2 diabetes
    • Delzenne, N.M., Cani, P.D., Everard, A., et al. Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia 58 (2015), 2206–2217.
    • (2015) Diabetologia , vol.58 , pp. 2206-2217
    • Delzenne, N.M.1    Cani, P.D.2    Everard, A.3
  • 2
    • 79952805978 scopus 로고    scopus 로고
    • Do nutrient–gut–microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
    • Diamant, M., Blaak, E., De Vos, W., Do nutrient–gut–microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?. Obes Rev 12 (2011), 272–281.
    • (2011) Obes Rev , vol.12 , pp. 272-281
    • Diamant, M.1    Blaak, E.2    De Vos, W.3
  • 3
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: an integrative view
    • Clemente, J.C., Ursell, L.K., Parfrey, L.W., et al. The impact of the gut microbiota on human health: an integrative view. Cell 148 (2012), 1258–1270.
    • (2012) Cell , vol.148 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3
  • 4
    • 27244434038 scopus 로고    scopus 로고
    • Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism
    • Robertson, M.D., Bickerton, A.S., Dennis, A.L., et al. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr 82 (2005), 559–567.
    • (2005) Am J Clin Nutr , vol.82 , pp. 559-567
    • Robertson, M.D.1    Bickerton, A.S.2    Dennis, A.L.3
  • 5
    • 84896401262 scopus 로고    scopus 로고
    • Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
    • Vrieze, A., Out, C., Fuentes, S., et al. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity. J Hepatol 60 (2014), 824–831.
    • (2014) J Hepatol , vol.60 , pp. 824-831
    • Vrieze, A.1    Out, C.2    Fuentes, S.3
  • 6
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze, A., Van Nood, E., Holleman, F., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143 (2012), 913–916.
    • (2012) Gastroenterology , vol.143 , pp. 913-916
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3
  • 7
    • 84923593959 scopus 로고    scopus 로고
    • Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects
    • Hulston, C.J., Churnside, A.A., Venables, M.C., Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects. Br J Nutr 113 (2015), 596–602.
    • (2015) Br J Nutr , vol.113 , pp. 596-602
    • Hulston, C.J.1    Churnside, A.A.2    Venables, M.C.3
  • 8
    • 84959512389 scopus 로고    scopus 로고
    • Effect of antibiotics on gut microbiota, glucose metabolism and bodyweight regulation-a review of the literature
    • Mikkelsen, K.H., Allin, K.H., Knop, F.K., Effect of antibiotics on gut microbiota, glucose metabolism and bodyweight regulation-a review of the literature. Diabetes Obes Metab 18 (2016), 444–453.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 444-453
    • Mikkelsen, K.H.1    Allin, K.H.2    Knop, F.K.3
  • 9
    • 84900509172 scopus 로고    scopus 로고
    • Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials
    • Kellow, N.J., Coughlan, M.T., Reid, C.M., Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr 111 (2014), 1147–1161.
    • (2014) Br J Nutr , vol.111 , pp. 1147-1161
    • Kellow, N.J.1    Coughlan, M.T.2    Reid, C.M.3
  • 10
    • 84941367190 scopus 로고    scopus 로고
    • Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials
    • Ruan, Y., Sun, J., He, J., et al. Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials. PLoS One, 10, 2015, e0132121.
    • (2015) PLoS One , vol.10 , pp. e0132121
    • Ruan, Y.1    Sun, J.2    He, J.3
  • 11
    • 78149272756 scopus 로고    scopus 로고
    • Prebiotic effects: metabolic and health benefits
    • Roberfroid, M., Gibson, G.R., Hoyles, L., et al. Prebiotic effects: metabolic and health benefits. Br J Nutr 104 (2010), S1–S63.
    • (2010) Br J Nutr , vol.104 , pp. S1-S63
    • Roberfroid, M.1    Gibson, G.R.2    Hoyles, L.3
  • 12
    • 84873805162 scopus 로고    scopus 로고
    • Gut microbiota and metabolic disorders: how prebiotic can work?
    • Delzenne, N.M., Neyrinck, A.M., Cani, P.D., Gut microbiota and metabolic disorders: how prebiotic can work?. Br J Nutr 109 (2013), S81–S85.
    • (2013) Br J Nutr , vol.109 , pp. S81-S85
    • Delzenne, N.M.1    Neyrinck, A.M.2    Cani, P.D.3
  • 13
    • 84874720592 scopus 로고    scopus 로고
    • A mixture of trans-galactooligosaccharides reduces markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults
    • Vulevic, J., Juric, A., Tzortzis, G., et al. A mixture of trans-galactooligosaccharides reduces markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults. J Nutr 143 (2013), 324–331.
    • (2013) J Nutr , vol.143 , pp. 324-331
    • Vulevic, J.1    Juric, A.2    Tzortzis, G.3
  • 14
    • 55849146633 scopus 로고    scopus 로고
    • Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers
    • Vulevic, J., Drakoularakou, A., Yaqoob, P., et al. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr 88 (2008), 1438–1446.
    • (2008) Am J Clin Nutr , vol.88 , pp. 1438-1446
    • Vulevic, J.1    Drakoularakou, A.2    Yaqoob, P.3
  • 15
    • 84941879755 scopus 로고    scopus 로고
    • Short-chain fatty acids in control of body weight and insulin sensitivity
    • Canfora, E.E., Jocken, J.W., Blaak, E.E., Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol 11 (2015), 577–591.
    • (2015) Nat Rev Endocrinol , vol.11 , pp. 577-591
    • Canfora, E.E.1    Jocken, J.W.2    Blaak, E.E.3
  • 16
    • 85014070812 scopus 로고    scopus 로고
    • Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men
    • van der Beek, C.M., Canfora, E.E., Lenaerts, K., et al. Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men. Clin Sci (Lond) 130 (2016), 2073–2082.
    • (2016) Clin Sci (Lond) , vol.130 , pp. 2073-2082
    • van der Beek, C.M.1    Canfora, E.E.2    Lenaerts, K.3
  • 17
    • 84863544278 scopus 로고    scopus 로고
    • Galacto-oligosaccharides have prebiotic activity in a dynamic in vitro colon model using a 13C-labeling technique
    • Maathuis, A.J., van den Heuvel, E.G., Schoterman, M.H., et al. Galacto-oligosaccharides have prebiotic activity in a dynamic in vitro colon model using a 13C-labeling technique. J Nutr 142 (2012), 1205–1212.
    • (2012) J Nutr , vol.142 , pp. 1205-1212
    • Maathuis, A.J.1    van den Heuvel, E.G.2    Schoterman, M.H.3
  • 18
    • 84860571162 scopus 로고    scopus 로고
    • Effects of prebiotic-containing infant formula on gastrointestinal tolerance and fecal microbiota in a randomized controlled trial
    • Holscher, H.D., Faust, K.L., Czerkies, L.A., et al. Effects of prebiotic-containing infant formula on gastrointestinal tolerance and fecal microbiota in a randomized controlled trial. JPEN J Parenter Enteral Nutr 36 (2012), 95S–105S.
    • (2012) JPEN J Parenter Enteral Nutr , vol.36 , pp. 95S-105S
    • Holscher, H.D.1    Faust, K.L.2    Czerkies, L.A.3
  • 19
    • 80053150201 scopus 로고    scopus 로고
    • Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans
    • Davis, L.M., Martínez, I., Walter, J., et al. Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLoS One, 6, 2011, e25200.
    • (2011) PLoS One , vol.6 , pp. e25200
    • Davis, L.M.1    Martínez, I.2    Walter, J.3
  • 21
    • 0346219332 scopus 로고    scopus 로고
    • Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity
    • Wendel-Vos, G.W., Schuit, A.J., Saris, W.H., et al. Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. J Clin Epidemiol 56 (2003), 1163–1169.
    • (2003) J Clin Epidemiol , vol.56 , pp. 1163-1169
    • Wendel-Vos, G.W.1    Schuit, A.J.2    Saris, W.H.3
  • 22
    • 0018520840 scopus 로고
    • Glucose clamp technique: a method for quantifying insulin secretion and resistance
    • DeFronzo, R.A., Tobin, J.D., Andres, R., Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Gastrointest Liver Physiol 237 (1979), G214–G223.
    • (1979) Am J Physiol Gastrointest Liver Physiol , vol.237 , pp. G214-G223
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 23
    • 0034456325 scopus 로고    scopus 로고
    • Insulin resistance early in adulthood in subjects born with intrauterine growth retardation
    • Jaquet, D., Gaboriau, A., Czernichow, P., et al. Insulin resistance early in adulthood in subjects born with intrauterine growth retardation. J Clin Endocrinol Metab 85 (2000), 1401–1406.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1401-1406
    • Jaquet, D.1    Gaboriau, A.2    Czernichow, P.3
  • 24
    • 8944256349 scopus 로고
    • New methods for calculating metabolic rate with special reference to protein metabolism
    • Weir, J.B., New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109 (1949), 1–9.
    • (1949) J Physiol , vol.109 , pp. 1-9
    • Weir, J.B.1
  • 25
    • 0020576146 scopus 로고
    • Calculation of substrate oxidation rates in vivo from gaseous exchange
    • Frayn, K.N., Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55 (1983), 628–634.
    • (1983) J Appl Physiol , vol.55 , pp. 628-634
    • Frayn, K.N.1
  • 26
    • 0028281773 scopus 로고
    • Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans
    • Orskov, C., Rabenhoj, L., Wettergren, A., et al. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes 43 (1994), 535–539.
    • (1994) Diabetes , vol.43 , pp. 535-539
    • Orskov, C.1    Rabenhoj, L.2    Wettergren, A.3
  • 27
    • 84864577726 scopus 로고    scopus 로고
    • Alternative method for gas chromatography-mass spectrometry analysis of short-chain fatty acids in faecal samples
    • García-Villalba, R., Giménez-Bastida, J.A., García-Conesa, M.T., et al. Alternative method for gas chromatography-mass spectrometry analysis of short-chain fatty acids in faecal samples. J Sep Sci 35 (2012), 1906–1913.
    • (2012) J Sep Sci , vol.35 , pp. 1906-1913
    • García-Villalba, R.1    Giménez-Bastida, J.A.2    García-Conesa, M.T.3
  • 28
    • 61349112146 scopus 로고    scopus 로고
    • Application of liquid chromatography–mass spectrometry to measure short chain fatty acids in blood
    • van Eijk, H.M., Bloemen, J.G., Dejong, C.H., Application of liquid chromatography–mass spectrometry to measure short chain fatty acids in blood. J Chromatogr B Analyt Technol Biomed Life 877 (2009), 719–724.
    • (2009) J Chromatogr B Analyt Technol Biomed Life , vol.877 , pp. 719-724
    • van Eijk, H.M.1    Bloemen, J.G.2    Dejong, C.H.3
  • 29
    • 77951977802 scopus 로고    scopus 로고
    • Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis
    • Salonen, A., Nikkilä, J., Jalanka-Tuovinen, J., et al. Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis. J Microbiol Methods 81 (2010), 127–134.
    • (2010) J Microbiol Methods , vol.81 , pp. 127-134
    • Salonen, A.1    Nikkilä, J.2    Jalanka-Tuovinen, J.3
  • 30
    • 67649945513 scopus 로고    scopus 로고
    • Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults
    • Rajilić-Stojanović, M., Heilig, H.G., Molenaar, D., et al. Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Microbiol 11 (2009), 1736–1751.
    • (2009) Environ Microbiol , vol.11 , pp. 1736-1751
    • Rajilić-Stojanović, M.1    Heilig, H.G.2    Molenaar, D.3
  • 31
    • 78449287303 scopus 로고    scopus 로고
    • Probabilistic analysis of probe reliability in differential gene expression studies with short oligonucleotide arrays
    • Lahti, L., Elo, L.L., Aittokallio, T., et al. Probabilistic analysis of probe reliability in differential gene expression studies with short oligonucleotide arrays. IEEE/ACM Trans Comput Biol Bioinform 8 (2011), 217–225.
    • (2011) IEEE/ACM Trans Comput Biol Bioinform , vol.8 , pp. 217-225
    • Lahti, L.1    Elo, L.L.2    Aittokallio, T.3
  • 33
    • 84943645306 scopus 로고    scopus 로고
    • Fitting linear mixed-effects models using lme4
    • Bates, D., Mächler, M., Bolker, B., et al. Fitting linear mixed-effects models using lme4. J Stat Software 67 (2015), 1–48.
    • (2015) J Stat Software , vol.67 , pp. 1-48
    • Bates, D.1    Mächler, M.2    Bolker, B.3
  • 34
    • 85020914896 scopus 로고    scopus 로고
    • Package ‘vegan’. Community ecology package, version 2
    • Oksanen J, Blanchet FG, Kindt R, et al. Package ‘vegan’. Community ecology package, version 2, 2013.
    • (2013)
    • Oksanen, J.1    Blanchet, F.G.2    Kindt, R.3
  • 35
    • 40549138422 scopus 로고    scopus 로고
    • Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study
    • Depeint, F., Tzortzis, G., Vulevic, J., et al. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study. Am J Clin Nutr 87 (2008), 785–791.
    • (2008) Am J Clin Nutr , vol.87 , pp. 785-791
    • Depeint, F.1    Tzortzis, G.2    Vulevic, J.3
  • 36
    • 84896567979 scopus 로고    scopus 로고
    • Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: a multicentre, randomised, double-blind and placebo-controlled trial
    • Sierra, C., Bernal, M.-J., Blasco, J., et al. Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: a multicentre, randomised, double-blind and placebo-controlled trial. Eur J Nutr 54 (2015), 89–99.
    • (2015) Eur J Nutr , vol.54 , pp. 89-99
    • Sierra, C.1    Bernal, M.-J.2    Blasco, J.3
  • 37
    • 84939567027 scopus 로고    scopus 로고
    • Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons
    • Vulevic, J., Juric, A., Walton, G.E., et al. Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons. Br J Nutr 114 (2015), 586–595.
    • (2015) Br J Nutr , vol.114 , pp. 586-595
    • Vulevic, J.1    Juric, A.2    Walton, G.E.3
  • 38
    • 26844526519 scopus 로고    scopus 로고
    • Fermentation of fructooligosaccharides and inulin by bifidobacteria: a comparative study of pure and fecal cultures
    • Rossi, M., Corradini, C., Amaretti, A., et al. Fermentation of fructooligosaccharides and inulin by bifidobacteria: a comparative study of pure and fecal cultures. Appl Environ Microbiol 71 (2005), 6150–6158.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 6150-6158
    • Rossi, M.1    Corradini, C.2    Amaretti, A.3
  • 39
    • 84876708253 scopus 로고    scopus 로고
    • Fiber and prebiotics: mechanisms and health benefits
    • Slavin, J., Fiber and prebiotics: mechanisms and health benefits. Nutrients 5 (2013), 1417–1435.
    • (2013) Nutrients , vol.5 , pp. 1417-1435
    • Slavin, J.1
  • 40
    • 84988405277 scopus 로고    scopus 로고
    • Systemic availability and metabolism of colonic derived short chain fatty acids in healthy subjects: a stable isotope study
    • Boets, E., Gomand, S.V., Deroover, L., et al. Systemic availability and metabolism of colonic derived short chain fatty acids in healthy subjects: a stable isotope study. J Physiol 595 (2017), 541–555.
    • (2017) J Physiol , vol.595 , pp. 541-555
    • Boets, E.1    Gomand, S.V.2    Deroover, L.3
  • 41
    • 84863588844 scopus 로고    scopus 로고
    • A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age
    • Walton, G.E., van den Heuvel, E.G., Kosters, M.H., et al. A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age. Br J Nutr 107 (2012), 1466–1475.
    • (2012) Br J Nutr , vol.107 , pp. 1466-1475
    • Walton, G.E.1    van den Heuvel, E.G.2    Kosters, M.H.3
  • 42
    • 79957884644 scopus 로고    scopus 로고
    • In vitro batch fecal fermentation comparison of gas and short-chain fatty acid production using “slowly fermentable” dietary fibers
    • Kaur, A., Rose, D.J., Rumpagaporn, P., et al. In vitro batch fecal fermentation comparison of gas and short-chain fatty acid production using “slowly fermentable” dietary fibers. J Food Sci 76 (2011), H137–H142.
    • (2011) J Food Sci , vol.76 , pp. H137-H142
    • Kaur, A.1    Rose, D.J.2    Rumpagaporn, P.3
  • 43
    • 66849129539 scopus 로고    scopus 로고
    • Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
    • Parnell, J.A., Reimer, R.A., Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 89 (2009), 1751–1759.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1751-1759
    • Parnell, J.A.1    Reimer, R.A.2
  • 44
    • 84880270337 scopus 로고    scopus 로고
    • Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
    • Dewulf, E., Cani, P., Claus, S., et al. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut 62 (2013), 1112–1121.
    • (2013) Gut , vol.62 , pp. 1112-1121
    • Dewulf, E.1    Cani, P.2    Claus, S.3
  • 45
    • 84948992933 scopus 로고    scopus 로고
    • Gut microbiota and aging
    • O'Toole, P.W., Jeffery, I.B., Gut microbiota and aging. Science 350 (2015), 1214–1215.
    • (2015) Science , vol.350 , pp. 1214-1215
    • O'Toole, P.W.1    Jeffery, I.B.2
  • 46
    • 74249119678 scopus 로고    scopus 로고
    • Obesity and the human microbiome
    • Ley, R.E., Obesity and the human microbiome. Curr Opin Gastroenterol 26 (2010), 5–11.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 5-11
    • Ley, R.E.1
  • 47
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli, V., Bäckhed, F., Functional interactions between the gut microbiota and host metabolism. Nature 489 (2012), 242–249.
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 48
    • 84920690371 scopus 로고    scopus 로고
    • Aging and the human gut microbiota—from correlation to causality
    • Saraswati, S., Sitaraman, R., Aging and the human gut microbiota—from correlation to causality. Front Microbiol, 5, 2015, 764.
    • (2015) Front Microbiol , vol.5 , pp. 764
    • Saraswati, S.1    Sitaraman, R.2
  • 49
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura, V.K., Faith, J.J., Rey, F.E., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 341, 2013, 1241214.
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1    Faith, J.J.2    Rey, F.E.3
  • 50
    • 84910131419 scopus 로고    scopus 로고
    • Microbial modulation of insulin sensitivity
    • Khan, M.T., Nieuwdorp, M., Bäckhed, F., Microbial modulation of insulin sensitivity. Cell Metab 20 (2014), 753–760.
    • (2014) Cell Metab , vol.20 , pp. 753-760
    • Khan, M.T.1    Nieuwdorp, M.2    Bäckhed, F.3
  • 51
    • 84908348194 scopus 로고    scopus 로고
    • Meta-analyses of human gut microbes associated with obesity and IBD
    • Walters, W.A., Xu, Z., Knight, R., Meta-analyses of human gut microbes associated with obesity and IBD. FEBS Lett 588 (2014), 4223–4233.
    • (2014) FEBS Lett , vol.588 , pp. 4223-4233
    • Walters, W.A.1    Xu, Z.2    Knight, R.3
  • 52
    • 84920971125 scopus 로고    scopus 로고
    • Molecular ecological tools to decipher the role of our microbial mass in obesity
    • Hermes, G., Zoetendal, E., Smidt, H., Molecular ecological tools to decipher the role of our microbial mass in obesity. Benef Microbes 6 (2014), 61–81.
    • (2014) Benef Microbes , vol.6 , pp. 61-81
    • Hermes, G.1    Zoetendal, E.2    Smidt, H.3
  • 53
    • 85009729394 scopus 로고    scopus 로고
    • Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals
    • Azcarate-Peril, M.A., Ritter, A.J., Savaiano, D., et al. Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals. Proc Natl Acad Sci U S A 114 (2017), E367–E375.
    • (2017) Proc Natl Acad Sci U S A , vol.114 , pp. E367-E375
    • Azcarate-Peril, M.A.1    Ritter, A.J.2    Savaiano, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.