HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions

Journal of Infectious Diseases

Volumn 216, Issue 6, 2017, Pages 641-650

  Foldi, Julia ^a   Kozhaya, Lina ^d   McCarty, Bret ^a,b   Mwamzuka, Mussa ^c   Marshed, Fatma ^c   Ilmet, Tiina ^a,b   Kilberg, Max ^a,b   Kravietz, Adam ^a   Ahmed, Aabid ^c   Borkowsky, William ^a,b   Unutmaz, Derya ^a   Khaitan, Alka ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Infectious Diseases and Immunology   (United States)

^c Bomu Medical Centre   (Kenya)

^d JACKSON LABORATORY   (United States)

Author keywords

children; HIV infection; immune exhaustion; PD 1+ CD4 T cells; Th17

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; PROGRAMMED DEATH 1 RECEPTOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYTOKINE; PDCD1 PROTEIN, HUMAN; VIRUS RNA;

ADOLESCENT; ANTIRETROVIRAL THERAPY; CD4 LYMPHOCYTE PERCENTAGE; CD4+ T LYMPHOCYTE; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; DISEASE COURSE; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KENYAN; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VERTICAL TRANSMISSION; VIRUS LOAD; CELL PROLIFERATION; COHORT ANALYSIS; CYTOLOGY; GENETICS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; IMMUNOLOGY; KENYA; METABOLISM; PRESCHOOL CHILD;

ADOLESCENT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CYTOKINES; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; KENYA; MALE; PROGRAMMED CELL DEATH 1 RECEPTOR; RNA, VIRAL; VIRAL LOAD;

EID: 85030620604     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix341     Document Type: Conference Paper

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