Effects of central fibroblast growth factor 21 in energy balance

Journal of Biological Regulators and Homeostatic Agents

Volumn 31, Issue 3, 2017, Pages 603-613

  Recinella, L ^a   Leone, S ^a   Ferrante, C ^a   Chiavaroli, A ^a   Di Nisio, C ^a   Martinotti, S ^a   Vacca, M ^a   Brunetti, L ^a   Orlando, G ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

AgRP; CART; DA; Feeding; FGF21; NPY; POMC; UCP 1

Indexed keywords

AGOUTI RELATED PROTEIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; DOPAMINE; FIBROBLAST GROWTH FACTOR 21; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; SEROTONIN; UNCOUPLING PROTEIN 1; AGRP PROTEIN, RAT; FIBROBLAST GROWTH FACTOR; NERVE PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESITY; DOPAMINE BLOOD LEVEL; ENERGY BALANCE; ENERGY EXPENDITURE; FEEDING; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS; IN VIVO STUDY; INTERSCAPULAR BROWN ADIPOSE TISSUE; LOCOMOTION; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; NUCLEUS ACCUMBENS; POST HOC ANALYSIS; RAT; SEROTONIN BLOOD LEVEL; SPRAGUE DAWLEY RAT; ANIMAL; BLOOD; DRUG EFFECTS; ENERGY METABOLISM; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; METABOLISM;

AGOUTI-RELATED PROTEIN; ANIMALS; ENERGY METABOLISM; FEEDING BEHAVIOR; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; LOCOMOTION; MALE; NERVE TISSUE PROTEINS; NEUROPEPTIDE Y; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 85030563162     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 2000; 1492(1):203-6.
2. Fon Tacer K, Bookout AL, Ding X, et al. Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol 2010; 24(10):2050-64.
3. Kharitonenkov A, Shiyanova TL, Koester A, et al. FGF-21 as a novel metabolic regulator. J Clin Invest 2005; 115(6):1627-35.
4. Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 2008; 149(12):6018-27.
5. Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009; 58(1):250-9.
6. Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K, Schwartz MW. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 2010; 59(7):1817-24.
7. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999; 20(1):68-100.
8. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404(6778):661-71.
9. Kelley AE. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev 2004; 27:765-76.
10. Iodice P, Ferrante C, Brunetti L, Cabib S, Protasi F, Walton ME, Pezzulo G. Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making. Sci Rep 2017; 7(1):535.
11. Quarta D, Smolders I. Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission. Eur J Pharm Sci 2014; 57:2-10.
12. Castañeda TR, Jörgens H, Wiedmer P, et al. Obesity and the neuroendocrine control of energy homeostasis: The role of spontaneous locomotor activity. J Nutr 2005; 135(5):1314-19.
13. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000; 404(6778):652-60.
14. Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 1984; 64(1):1-64.
15. Brunetti L, Michelotto B, Orlando G, Recinella L, Di Nisio C, Ciabattoni G, Vacca M. Aging increases amyloid beta-peptide-induced 8-iso-prostaglandin F2alpha release from rat brain. Neurobiol Aging 2004; 25(1):125-29.
16. Leone S, Chiavaroli A, Orlando G, Mollica A, Di Nisio C, Brunetti L, Vacca M. The analgesic activity of biphalin and its analog AM 94 in rats. Eur J Pharmacol 2012; 685(1-3):70-73.
17. Brunetti L, Orlando G, Menghini L, Ferrante C, Chiavaroli A, Vacca M. Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro. Planta Med 2006; 72(14):1296-99.
18. Leone S, Chiavaroli A, Shohreh R, et al. Increased locomotor and thermogenic activity in mice with targeted ablation of the GHRH gene. Growth Horm IGF Res 2015; 25(2):80-84.
19. Brunetti L, Di Nisio C, Recinella L, et al. Obestatin inhibits dopamine release in rat hypothalamus. Eur J Pharmacol 2010; 641(2-3):142-47.
20. Brunetti L, Orlando G, Ferrante C, et al. Peripheral chemerin administration modulates hypothalamic control of feeding. Peptides 2014; 51:115-21.
21. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007; 5(6):426-37.
22. von Holstein-Rathlou S, BonDurant LD, Peltekian L, et al. FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver. Cell Metab 2016; 23(2):335-43.
23. Santoso P, Nakata M, Shiizaki K, et al. Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. Sci Rep 2017; 7:45819.
24. Sedbazar U, Maejima Y, Nakata M, Mori M, Yada T. Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats. Biochem Biophys Res Commun 2013; 434(3):434-38.
25. Brunetti L, Ferrante C, Orlando G, et al. Orexigenic effects of endomorphin-2 (EM-2) related to decreased CRH gene expression and increased dopamine and norepinephrine activity in the hypothalamus. Peptides 2013; 48:83-88.
26. Brunetti L, Recinella L, Di Nisio C, et al. Effects of visfatin/PBEF/NAMPT on feeding behaviour and hypothalamic neuromodulators in the rat. J Biol Regul Homeost Agents 2012; 26(2):295-302.
27. Puga L, Alcántara-Alonso V, Coffeen U, Jaimes O, de Gortari P. TRH injected into the nucleus accumbens shell releases dopamine and reduces feeding motivation in rats. Behav Brain Res 2016; 306:128-36.
28. Brunetti L, Cacciatore I, Di Stefano A, et al. Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue. Farmaco 2002; 57(6):479-86.
29. Bookout AL, de Groot MH, Owen BM, et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med 2013; 19(9):1147-52.
30. Whittle AJ, López M, Vidal-Puig A. Using brown adipose tissue to treat obesity-The central issue. Trends Mol Med 2011; 17(8):405-11.
31. Shi YC, Lau J, Lin Z, et al. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metab 2013; 17(2):236-48.
32. Bouillaud F, Ricquier D, Mory G, Thibault J. Increased level of mRNA for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or norepinephrine infusion. J Biol Chem 1984; 259(18):11583-86.
33. Commins SP, Marsh DJ, Thomas SA, Watson PM, Padgett MA, Palmiter R, Gettys TW. Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue. Endocrinology 1999; 140(10):4772-78.
34. Bartness TJ, Vaughan CH, Song CK. Sympathetic and sensory innervation of brown adipose tissue. Int J Obes (Lond) 2010; 34 (Suppl 1):S36-42.
35. Cornu M, Oppliger W, Albert V, et al. Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. Proc Natl Acad Sci USA 2014; 111(32):11592-99.