Ginkgo biloba leaf extract reverses amyloid β-peptide-induced isoprostane production in rat brain in vitro

Planta Medica

Volumn 72, Issue 14, 2006, Pages 1296-1299

  Brunetti, Luigi ^a   Orlando, Giustino ^a   Menghini, Luigi ^a   Ferrante, Claudio ^a   Chiavaroli, Annalisa ^a   Vacca, Michele ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Aging; Amyloid peptide; Ginkgo biloba; Ginkgoaceae; Hydrogen peroxide; Isoprostane; Lipid peroxidation; Oxidative stress

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; AMYLOID BETA PROTEIN[25-35]; ARACHIDONIC ACID; FLAVANOID; GINKGO BILOBA EXTRACT; GINKGOLIDE B; GINKGOLIDE C; ISOPROSTANE; NEUROPROTECTIVE AGENT; PROSTAGLANDIN; REACTIVE OXYGEN METABOLITE; TERPENE DERIVATIVE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; GINKGO BILOBA; IC 50; IN VITRO STUDY; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PLANT LEAF; RAT; SYNAPSE;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; FREE RADICAL SCAVENGERS; GINKGO BILOBA; HYDROGEN PEROXIDE; ISOPROSTANES; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS;

GINKGO BILOBA; GINKGOACEAE;

EID: 33845270999     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-951688     Document Type: Article

References (16)

1. Floyd RA, Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002; 23: 795-807
2. nd. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase free radical-catalyzed mechanism. Proc Natl Acad Sci USA 1990; 87: 9383-7
3. 2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo. FASEB J 1998; 12: 1777-83
4. 2α in rat brain neuronal endings: a possible marker of membrane phospholipid peroxidation. Life Sci 2002; 71: 447-55
5. 2α release from rat brain. Neurobiol Aging 2004; 25: 125-9
6. Praticò D. Alzheimer's disease and oxygen radicals: new insights. Biochem Pharmacol 2002; 63: 563-7
7. Ivic L, Sands TT, Fishkin N, Nakanishi K, Sriegstein AR, Stromgaard K. Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. 2003; 278: 49279-85
8. Boles Ponto LL, Schultz SS. Ginkgo biloba extract: review of CNS effects. Ann Clin Psychiatry 2003; 15: 109-19
9. Gray EG, Whittaker VP. The isolation of nerve endings from brain: an electron microscope study of cell fragments derived by homogenization and centrifugation. J Anatomy 1962; 96: 79-87
10. 2α excretion in man. J Pharmacol Exp Ther 1995; 275: 94-100
11. Smith JV, Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 2004; 64: 465-72
12. Oyama Y, Chikahisa L, Ueha T, Kanemaru K, Noda K. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Res 1996; 712: 349-52
13. Wei T, Ni Y, Hou J, Chen C, Zhao B, Xin W. Hydrogen peroxide-induced oxidative damage and apoptosis in cerebellar granule cells: protection by Ginkgo biloba extract. Pharmacol Res 2000; 41: 427-33
14. Rottkamp CA, Raina AK, Zhu X, Gaier E, Bush Al, Atwood CS et al. Redox-active iron mediates amyloid-β toxicity. Free Radic Biol Med 2001; 30: 447-50
15. Pardon MC, Hanoun N, Perez-Diaz F, Joubert C, Launay JM, Christen Y et al. Long-term treatment with the antioxidant drug EGb 761 at senescence restored some neurobehavioral effects of chronic ultramild stress exposure seen in young mice. 2004; 25: 1067-83
16. Bastianetto S, Quirion R. Natural extracts as protective agents of brain aging. Neurobiol Aging 2002; 23: 891-7