Obestatin inhibits dopamine release in rat hypothalamus

European Journal of Pharmacology

Volumn 641, Issue 2-3, 2010, Pages 142-147

  Brunetti, Luigi ^a   Di Nisio, Chiara ^a   Recinella, Lucia ^a   Orlando, Giustino ^a   Ferrante, Claudio ^a   Chiavaroli, Annalisa ^a   Leone, Sheila ^a   Di Michele, Pierpaolo ^a   Shohreh, Rugia ^a   Vacca, Michele ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Dopamine; Feeding; Ghrelin; Hypothalamus; Obestatin

Indexed keywords

GHRELIN; OBESTATIN;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DEPOLARIZATION; DOPAMINE RELEASE; ENZYME INHIBITION; FEEDING BEHAVIOR; GENE EXPRESSION; HYPOTHALAMUS; IN VITRO STUDY; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SYNAPTOSOME; WEIGHT GAIN;

AGOUTI-RELATED PROTEIN; ANIMALS; ARCUATE NUCLEUS; BODY WEIGHT; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY INTAKE; GHRELIN; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDE Y; NEUROPEPTIDES; NOREPINEPHRINE; PEPTIDES; PRO-OPIOMELANOCORTIN; RATS; RATS, WISTAR; RNA, MESSENGER; SEROTONIN; SYNAPTOSOMES;

EID: 77954082796     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.059     Document Type: Article

References (34)

1. Annemie V.D., Debby V.D., Valentijn V., Bart, de S., Walter L., Liliane S., de D.Peter Paul Central administration of obestatin fails to show inhibitory effects on food and water intake in mice. Regul. Pept. 2009, 156:77-82.
2. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited: ingestive behavior. Neurosci. Biobehav. Rev. 1996, 20:189-287.
3. Bresciani E., Rapetti D., Donà F., Bulgarelli I., Tamiazzo L., Locatelli V., et al. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J. Endocrinol. Invest. 2006, 29:RC16-RC18.
4. Brunetti L., Michelotto B., Orlando G., Vacca M. Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings. Eur. J. Pharmacol. 1999, 372:237-240.
5. Brunetti L., Recinella L., Orlando G., Michelotto B., Di Nisio C., Vacca M. Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. Eur. J. Pharmacol. 2002, 454:189-192.
6. Brunetti L., Orlando G., Ferrante C., Chiavaroli A., Vacca M. Peptide YY (3-36) inhibits dopamine and norepinephrine release in the hypothalamus. Eur. J. Pharmacol. 2005, 519:48-51.
7. Brunetti L., Orlando G., Recinella L., Leone S., Ferrante C., Chiavaroli A., Lazzarin F., Vacca M. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Peptides 2008, 29:1377-1381.
8. Brunetti L., Leone S., Orlando G., Recinella L., Ferrante C., Chiavaroli A., Di Nisio C., Di Michele P., Vacca M. Effects of obestatin on feeding and body weight after standard or cafeteria diet in the rat. Peptides 2009, 30:1323-1327.
9. Carlini V.P., Schioth H.B., Debarioglio S.R. Obestatin improves memory performance and causes anxiolytic effects in rats. Biochem. Biophys. Res. Commun. 2007, 352:907-912.
10. Epelbaum J., Bedjaoui N., Dardennes R., Feng D.D., Gardette R., Grouselle D., Loudes C., Simon A., Tolle V., Yang S.K., Zizzari P. Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis. Mol. Cell. Endocrinol. 2010, 314:244-247.
11. Gillard E.R., Dang D.Q., Stanley B.G. Evidence that neuropeptide Y and dopamine in the perifornical hypothalamus interact antagonistically in the control of food intake. Brain Res. 1993, 628:128-136.
12. Granata R., Settanni F., Gallo D., Trovato L., Biancone L., Cantaluppi V., Nano R., Annunziata M., Campiglia P., Arnoletti E., Ghè C., Volante M., Papotti M., Muccioli G., Ghigo E. Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function. Diabetes 2008, 57:967-979.
13. Green B.D., Irwin N., Flatt P.R. Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice. Peptides 2007, 28:981-987.
14. Holst B., Egerod K.L., Schild E., Vickers S.P., Cheetham S., Gerlach L.O., Storjohann L., Stidsen C.E., Jones R., Beck-Sickinger A.G., Schwartz T.W. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 2007, 148:13-20.
15. Kageyama H., Takenoya F., Shiba K., Shioda S. Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding. Neuropeptides 2010, 44:133-138.
16. Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 1999, 20:68-100.
17. Kobelt P., Wisser A.S., Stengel A., Goebel M., Bannert N., Gourcerol G., Inhoff T., Noetzel S., Wiedenmann B., Klapp B.F., Taché Y., Mönnikes H. Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents. Peptides 2008, 29:1018-1027.
18. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
19. Lagaud G.J., Young A., Acena A., Morton M.F., Barrett T.D., Shankley N.P. Obestatin reduces food intake and suppresses body weight gain in rodents. Biochem. Biophys. Res. Commun. 2007, 35:264-269.
20. Lauwers E., Landuyt B., Arckens L., Schoofs L., Luyten W. Obestatin does not activate orphan G protein-coupled receptor GPR39. Biochem. Biophys. Res. Commun. 2006, 351:21-25.
21. -ΔΔCt method. Methods 2001, 25:402-408.
22. Orlando G., Brunetti L., Di Nisio C., Michelotto B., Recinella L., Ciabattoni G., Vacca M. Effects of cocaine- and amphetamine-regulated transcript peptide, leptin, and orexins on hypothalamic serotonin release. Eur. J. Pharmacol. 2001, 430:269-272.
23. Pan W., Tu H., Kastin A.J. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 2006, 27:911-916.
24. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2007, Academic Press, New York, NY. 6th ed.
25. Samanin R., Garattini S. Neurochemical mechanisms of action of anorectic drugs. Pharmacol. Toxicol. 1993, 73:63-68.
26. Shiraishi T. Noradrenergic neurons modulate lateral hypothalamic chemical and electrical stimulation-induced feeding by sated rats. Brain. Res. Bull. 1991, 27:347-351.
27. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985, 150:76-85.
28. Tang S.Q., Jiang Q.Y., Zhang Y.L., Zhu X.T., Shu G., Gao P., Feng D.Y., Wang X.Q., Dong X.Y. Obestatin: its physicochemical characteristics and physiological functions. Peptides 2008, 29:639-645.
29. Tecott L.H. Serotonin and the orchestration of energy balance. Cell Metab. 2007, 6:352-361.
30. Tremblay F., Perreault M., Klaman L.D., Tobin J.F., Smith E., Gimeno R.E. Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39. Endocrinology 2007, 148:501-506.
31. Vergote V., van Dorpe S., Peremans K., Burvenich C., De Spiegeleer B. In vitro metabolic stability of obestatin: kinetics and identification of cleavage products. Peptides 2008, 29:1740-1748.
32. Wellman P.J. Modulation of feeding by central cetecholamine systems. Curr. Drugs Targets 2005, 6:191-199.
33. Zhang J.V., Ren P.G., Avsian-Kretchmer O., Luo C.W., Rauch R., Klein C., Hsueh A.J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005, 310:996-999.
34. Zizzari P., Longchamps R., Epelbaum J., Bluet-Pajot M.T. Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 2007, 148:1648-1653.