Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue

Farmaco

Volumn 57, Issue 6, 2002, Pages 479-486

  Brunetti, L ^a   Cacciatore, I ^a   Di Stefano, A ^a   Dupre S ^b   Giorgi, A ^b   Luisi, G ^a   Michelotto, B ^a   Orlando, G ^a   Pinnen, F ^a,b   Recinella, L ^a   Sozio, P ^a   Spirito, A ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Pyroglutamic acid; Pyroglutamyl peptidases; Sulphonamidopeptides; Synaptosomes; Thyrotropin releasing hormone

Indexed keywords

5 OXOPROLYL PEPTIDASE; GLUTAMIC ACID DERIVATIVE; ISOTHIAZOLIDINE 1,1 DIOXIDE 3 CARBOXYLIC ACID; N (ISOTHIAZOLIDINE 1,1 DIOXIDE 3 CARBONYL)HISTIDYLPROLINAMIDE; PROLACTIN; PROTIRELIN DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG; DOPAMINE; DRUG DERIVATIVE; PROTIRELIN; PYROGLUTAMIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HYDROLYSIS; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROLACTIN RELEASE; RAT; STRUCTURE ACTIVITY RELATION; ADENOHYPOPHYSIS; ANIMAL; CATTLE; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; SECRETION; SYNTHESIS; WISTAR RAT;

ANIMAL; CATTLE; CELLS, CULTURED; COMPARATIVE STUDY; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PITUITARY GLAND, ANTERIOR; PROLACTIN; PROTIRELIN; PYROGLUTAMYL-PEPTIDASE I; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUPPORT, NON-U.S. GOV'T; ANIMALS; THYROTROPIN-RELEASING HORMONE;

EID: 0036594026     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01232-6     Document Type: Article

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