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Volumn 7, Issue 6, 2017, Pages

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; FEMALE; HISTORY; HUMAN; MALE;

EID: 85030548518     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/BCJ.2017.53     Document Type: Review
Times cited : (849)

References (165)
  • 1
    • 0347492085 scopus 로고    scopus 로고
    • 1975-2013:Leukemia, annual incidence rates (acute lymphocytic leukemia)
    • National Cancer Institute. SEER cancer statistics review, 1975-2013:Leukemia, annual incidence rates (acute lymphocytic leukemia).
    • SEER Cancer Statistics Review
  • 3
    • 84937523007 scopus 로고    scopus 로고
    • New insights into the patho-physiology and therapy of adult acute lymphoblastic leukemia
    • Jabbour E, O'Brien S, Konopleva M, Kantarjian H. New insights into the patho-physiology and therapy of adult acute lymphoblastic leukemia. Cancer 2015; 121: 2517–2528.
    • (2015) Cancer , vol.121 , pp. 2517-2528
    • Jabbour, E.1    O'brien, S.2    Konopleva, M.3    Kantarjian, H.4
  • 4
    • 84879010315 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia with treatment--naive Fanconi anemia
    • Shah A, John BM, Sondhi V. Acute lymphoblastic leukemia with treatment--naive Fanconi anemia. Indian Pediatr 2013; 50: 508–510.
    • (2013) Indian Pediatr , vol.50 , pp. 508-510
    • Shah, A.1    John, B.M.2    Sondhi, V.3
  • 5
    • 0031052108 scopus 로고    scopus 로고
    • Bloom's syndrome. XX. The first 100 cancers
    • German J. Bloom's syndrome. XX. The first 100 cancers. Cancer Genet Cytogenet 1997; 93: 100–106.
    • (1997) Cancer Genet Cytogenet , vol.93 , pp. 100-106
    • German, J.1
  • 6
    • 84881504493 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia in early childhood as the presenting sign of ataxia-telangiectasia variant
    • Bielorai B, Fisher T, Waldman D, Lerenthal Y, Nissenkorn A, Tohami T et al. Acute lymphoblastic leukemia in early childhood as the presenting sign of ataxia-telangiectasia variant. Pediatr Hematol Oncol 2013; 30: 574–582.
    • (2013) Pediatr Hematol Oncol , vol.30 , pp. 574-582
    • Bielorai, B.1    Fisher, T.2    Waldman, D.3    Lerenthal, Y.4    Nissenkorn, A.5    Tohami, T.6
  • 7
    • 0034809324 scopus 로고    scopus 로고
    • Down's syndrome and acute lymphoblastic leukaemia: Clinical features and response to treatment
    • Chessells J, Harrison G, Richards S, Bailey C, Hill F, Gibson B et al. Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment. Arch Dis Child 2001; 85: 321–325.
    • (2001) Arch Dis Child , vol.85 , pp. 321-325
    • Chessells, J.1    Harrison, G.2    Richards, S.3    Bailey, C.4    Hill, F.5    Gibson, B.6
  • 9
    • 77749335598 scopus 로고    scopus 로고
    • High incidence of Epstein Barr virus infection in childhood acute lymphocytic leukemia: A preliminary study
    • Sehgal S, Mujtaba S, Gupta D, Aggarwal R, Marwaha RK. High incidence of Epstein Barr virus infection in childhood acute lymphocytic leukemia: a preliminary study. Indian J Pathol Microbiol 2010; 53: 63–67.
    • (2010) Indian J Pathol Microbiol , vol.53 , pp. 63-67
    • Sehgal, S.1    Mujtaba, S.2    Gupta, D.3    Aggarwal, R.4    Marwaha, R.K.5
  • 11
    • 70350680415 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 in B-progenitor and down syndrome associated acute lymphoblastic leukemia
    • Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin ML, Liu W, Zhang J et al. Rearrangement of CRLF2 in B-progenitor and down syndrome associated acute lymphoblastic leukemia. Nat Genet 2009; 41: 1243–1246.
    • (2009) Nat Genet , vol.41 , pp. 1243-1246
    • Mullighan, C.G.1    Collins-Underwood, J.R.2    Phillips, L.A.3    Loudin, M.L.4    Liu, W.5    Zhang, J.6
  • 13
    • 84865118132 scopus 로고    scopus 로고
    • Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lympho-blastic leukemia
    • Roberts KG, Morin RD, Zhang J, Hirst M, Zhao Y, Su X et al. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lympho-blastic leukemia. Cancer Cell 2012; 22: 153–166.
    • (2012) Cancer Cell , vol.22 , pp. 153-166
    • Roberts, K.G.1    Morin, R.D.2    Zhang, J.3    Hirst, M.4    Zhao, Y.5    Su, X.6
  • 14
    • 84907080295 scopus 로고    scopus 로고
    • Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
    • Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014; 371: 1005–1015.
    • (2014) N Engl J Med , vol.371 , pp. 1005-1015
    • Roberts, K.G.1    Li, Y.2    Payne-Turner, D.3    Harvey, R.C.4    Yang, Y.L.5    Pei, D.6
  • 15
  • 18
    • 0017162163 scopus 로고
    • Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group
    • Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol 1976; 33: 451–458.
    • (1976) Br J Haematol , vol.33 , pp. 451-458
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3    Flandrin, G.4    Galton, D.A.5    Gralnick, H.R.6
  • 19
    • 0032784783 scopus 로고    scopus 로고
    • World Health Organization classification of neoplastic diseases of the hemato-poietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997
    • Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J et al. World Health Organization classification of neoplastic diseases of the hemato-poietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999; 17: 3835–3849.
    • (1999) J Clin Oncol , vol.17 , pp. 3835-3849
    • Harris, N.L.1    Jaffe, E.S.2    Diebold, J.3    Flandrin, G.4    Muller-Hermelink, H.K.5    Vardiman, J.6
  • 20
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009; 114: 937–951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning, R.D.4    Borowitz, M.J.5    Porwit, A.6
  • 21
    • 84974560145 scopus 로고    scopus 로고
    • The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
    • Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127: 2391–2405.
    • (2016) Blood , vol.127 , pp. 2391-2405
    • Arber, D.A.1    Orazi, A.2    Hasserjian, R.3    Thiele, J.4    Borowitz, M.J.5    Le Beau, M.M.6
  • 22
    • 77955157595 scopus 로고    scopus 로고
    • Prognostic factors in adult acute lymphoblastic leukaemia
    • Rowe JM. Prognostic factors in adult acute lymphoblastic leukaemia. Br J Haematol 2010; 150: 389–405.
    • (2010) Br J Haematol , vol.150 , pp. 389-405
    • Rowe, J.M.1
  • 23
    • 28444490353 scopus 로고    scopus 로고
    • Induction therapy for adults with acute lymphoblastic leukemia: Results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
    • Rowe JM, Buck G, Burnett AK, Chopra R, Wiernik PH, Richards SM et al. Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood 2005; 106: 3760–3767.
    • (2005) Blood , vol.106 , pp. 3760-3767
    • Rowe, J.M.1    Buck, G.2    Burnett, A.K.3    Chopra, R.4    Wiernik, P.H.5    Richards, S.M.6
  • 24
    • 85136798600 scopus 로고    scopus 로고
    • T.U.o.T.M.D.A.C.C. Department of Leukemia, Houston, Texas, T.U.o.T.M.D.A.C.C. Department of Leukemia, P.O. Box 428, 1515 Holcombe Blvd., Houston, TX 77030, S. Jeha, T.U.o.T.M.D.A.C.C. Department of Leukemia, Houston, Texas, The biology and therapy of adult acute lymphoblastic leukemia
    • Faderl, S HM Kantarjian, et al, T.U.o.T.M.D.A.C.C. Department of Leukemia, Houston, Texas, T.U.o.T.M.D.A.C.C. Department of Leukemia, P.O. Box 428, 1515 Holcombe Blvd., Houston, TX 77030, S. Jeha, T.U.o.T.M.D.A.C.C. Department of Leukemia, Houston, Texas, The biology and therapy of adult acute lymphoblastic leukemia. Cancer, 2017; 98: 1337–1354.
    • (2017) Cancer , vol.98 , pp. 1337-1354
    • Faderl, S.H.M.K.1
  • 25
    • 34147135183 scopus 로고    scopus 로고
    • Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): Analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    • Moorman AV, Harrison CJ, Buck GA, Richards SM, Secker-Walker LM, Martineau M et al. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood 2007; 109: 3189–3197.
    • (2007) Blood , vol.109 , pp. 3189-3197
    • Moorman, A.V.1    Harrison, C.J.2    Buck, G.A.3    Richards, S.M.4    Secker-Walker, L.M.5    Martineau, M.6
  • 26
    • 41949083910 scopus 로고    scopus 로고
    • Impact of cyto-genetics on the outcome of adult acute lymphoblastic leukemia: Results of Southwest Oncology Group 9400 study
    • Pullarkat V, Slovak ML, Kopecky KJ, Forman SJ, Appelbaum FR. Impact of cyto-genetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study. Blood 2008; 111: 2563–2572.
    • (2008) Blood , vol.111 , pp. 2563-2572
    • Pullarkat, V.1    Slovak, M.L.2    Kopecky, K.J.3    Forman, S.J.4    Appelbaum, F.R.5
  • 27
    • 84933575478 scopus 로고    scopus 로고
    • Redefining ALL classification: Toward detecting high-risk ALL and implementing precision medicine
    • Hunger SP, Mullighan CG. Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine. Blood 2015; 125: 3977–3987.
    • (2015) Blood , vol.125 , pp. 3977-3987
    • Hunger, S.P.1    Mullighan, C.G.2
  • 28
    • 84933505109 scopus 로고    scopus 로고
    • Minimal residual disease diagnostics in acute lymphoblastic leukemia: Need for sensitive, fast, and standardized technologies
    • Dongen JJMv, v.d. Velden VHJ, Brüggemann M, Orfao A. Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies. Blood 2015; 125: 3996–4009.
    • (2015) Blood , vol.125 , pp. 3996-4009
    • Dongen, J.1    Velden, V.H.J.2    Brüggemann, M.3    Orfao, A.4
  • 29
    • 31544467825 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia
    • Bruggemann M, Raff T, Flohr T, Gokbuget N, Nakao M, Droese J et al. Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood 2006; 107: 1116–1123.
    • (2006) Blood , vol.107 , pp. 1116-1123
    • Bruggemann, M.1    Raff, T.2    Flohr, T.3    Gokbuget, N.4    Nakao, M.5    Droese, J.6
  • 30
    • 0030793472 scopus 로고    scopus 로고
    • A prospective study of minimal residual disease in childhood B-lineage acute lymphoblastic leukaemia: MRD level at the end of induction is a strong predictive factor of relapse
    • Jacquy C, Delepaut B, Van Daele S, Vaerman JL, Zenebergh A, Brichard B et al. A prospective study of minimal residual disease in childhood B-lineage acute lymphoblastic leukaemia: MRD level at the end of induction is a strong predictive factor of relapse. Br J Haematol 1997; 98: 140–146.
    • (1997) Br J Haematol , vol.98 , pp. 140-146
    • Jacquy, C.1    Delepaut, B.2    van Daele, S.3    Vaerman, J.L.4    Zenebergh, A.5    Brichard, B.6
  • 31
    • 67650478894 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia
    • Sutton R, Venn NC, Tolisano J, Bahar AY, Giles JE, Ashton LJ et al. Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia. Br J Haematol 2009; 146: 292–299.
    • (2009) Br J Haematol , vol.146 , pp. 292-299
    • Sutton, R.1    Venn, N.C.2    Tolisano, J.3    Bahar, A.Y.4    Giles, J.E.5    Ashton, L.J.6
  • 32
    • 66149141393 scopus 로고    scopus 로고
    • Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL)
    • Bassan R, Spinelli O, Oldani E, Intermesoli T, Tosi M, Peruta B et al. Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL). Blood 2009; 113: 4153–4162.
    • (2009) Blood , vol.113 , pp. 4153-4162
    • Bassan, R.1    Spinelli, O.2    Oldani, E.3    Intermesoli, T.4    Tosi, M.5    Peruta, B.6
  • 33
    • 57549106619 scopus 로고    scopus 로고
    • Minimal residual disease in acute lymphoblastic leukemia
    • Campana D. Minimal residual disease in acute lymphoblastic leukemia. Semin Hematol 2009; 46: 100–106.
    • (2009) Semin Hematol , vol.46 , pp. 100-106
    • Campana, D.1
  • 34
    • 33846882622 scopus 로고    scopus 로고
    • Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: Data from the GMALL 06/99 and 07/03 trials
    • Raff T, Gökbuget N, Lüschen S, Reutzel R, Ritgen M, Irmer S et al. Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials. Blood 2007; 109: 910–915.
    • (2007) Blood , vol.109 , pp. 910-915
    • Raff, T.1    Gökbuget, N.2    Lüschen, S.3    Reutzel, R.4    Ritgen, M.5    Irmer, S.6
  • 35
    • 84903546885 scopus 로고    scopus 로고
    • Treatment of high-risk Philadelphia chromosome-negative acute lymphoblastic leukemia in adolescents and adults according to early cytologic response and minimal residual disease after consolidation assessed by flow cytometry: Final results of the PETHEMA ALL-AR-03 trial
    • Ribera JM, Oriol A, Morgades M, Montesinos P, Sarra J, Gonzalez-Campos J et al. Treatment of high-risk Philadelphia chromosome-negative acute lymphoblastic leukemia in adolescents and adults according to early cytologic response and minimal residual disease after consolidation assessed by flow cytometry: final results of the PETHEMA ALL-AR-03 trial. J Clin Oncol 2014; 32: 1595–1604.
    • (2014) J Clin Oncol , vol.32 , pp. 1595-1604
    • Ribera, J.M.1    Oriol, A.2    Morgades, M.3    Montesinos, P.4    Sarra, J.5    Gonzalez-Campos, J.6
  • 36
    • 60949101218 scopus 로고    scopus 로고
    • Pediatric-inspired therapy in adults with Philadelphia chromosome-negative acute lym-phoblastic leukemia: The GRAALL-2003 study
    • Huguet F, Leguay T, Raffoux E, Thomas X, Beldjord K, Delabesse E et al. Pediatric-inspired therapy in adults with Philadelphia chromosome-negative acute lym-phoblastic leukemia: the GRAALL-2003 study. J Clin Oncol 2009; 27: 911–918.
    • (2009) J Clin Oncol , vol.27 , pp. 911-918
    • Huguet, F.1    Leguay, T.2    Raffoux, E.3    Thomas, X.4    Beldjord, K.5    Delabesse, E.6
  • 37
    • 47849108085 scopus 로고    scopus 로고
    • What determines the outcomes for adolescents and young adults with acute lym-phoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies
    • Stock W, La M, Sanford B, Bloomfield CD, Vardiman JW, Gaynon P et al. What determines the outcomes for adolescents and young adults with acute lym-phoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies. Blood 2008; 112: 1646–1654.
    • (2008) Blood , vol.112 , pp. 1646-1654
    • Stock, W.1    La, M.2    Sanford, B.3    Bloomfield, C.D.4    Vardiman, J.W.5    Gaynon, P.6
  • 38
    • 0017078566 scopus 로고
    • Remission induction in adult acute lympho-cytic leukemia. Use of vincristine and prednisone alone
    • Scavino HF, George JN, Sears DA. Remission induction in adult acute lympho-cytic leukemia. Use of vincristine and prednisone alone. Cancer 1976; 38: 672–677.
    • (1976) Cancer , vol.38 , pp. 672-677
    • Scavino, H.F.1    George, J.N.2    Sears, D.A.3
  • 39
    • 0021265295 scopus 로고
    • Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: A prospective randomized trial by cancer and leukemia group B
    • Gottlieb A, Weinberg V, Ellison R, Henderson E, Terebelo H, Rafla S et al. Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B. Blood 1984; 64: 267–274.
    • (1984) Blood , vol.64 , pp. 267-274
    • Gottlieb, A.1    Weinberg, V.2    Ellison, R.3    Henderson, E.4    Terebelo, H.5    Rafla, S.6
  • 40
    • 0028938844 scopus 로고
    • A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and leukemia group B study 8811
    • Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P et al. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811. Blood 1995; 85: 2025–2037.
    • (1995) Blood , vol.85 , pp. 2025-2037
    • Larson, R.A.1    Dodge, R.K.2    Burns, C.P.3    Lee, E.J.4    Stone, R.M.5    Schulman, P.6
  • 41
    • 0028085149 scopus 로고
    • Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lympho-blastic leukemia
    • Nagura E, Kimura K, Yamada K, Ota K, Maekawa T, Takaku F et al. Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lympho-blastic leukemia. Cancer Chemother Pharmacol 1994; 33: 359–365.
    • (1994) Cancer Chemother Pharmacol , vol.33 , pp. 359-365
    • Nagura, E.1    Kimura, K.2    Yamada, K.3    Ota, K.4    Maekawa, T.5    Takaku, F.6
  • 42
    • 84979888012 scopus 로고    scopus 로고
    • Impact of complete molecular response on survival in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Short NJ, Jabbour E, Sasaki K, Patel K, O'Brien SM, Cortes JE et al. Impact of complete molecular response on survival in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2016; 128: 504–507.
    • (2016) Blood , vol.128 , pp. 504-507
    • Short, N.J.1    Jabbour, E.2    Sasaki, K.3    Patel, K.4    O'brien, S.M.5    Cortes, J.E.6
  • 44
    • 0033964380 scopus 로고    scopus 로고
    • Results of treatment with hyper-CVAD, a dose-intensive regimen, in s acute lympho-cytic leukemia
    • Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in s acute lympho-cytic leukemia. J Clin Oncol 2000; 18: 547–561.
    • (2000) J Clin Oncol , vol.18 , pp. 547-561
    • Kantarjian, H.M.1    O'brien, S.2    Smith, T.L.3    Cortes, J.4    Giles, F.J.5    Beran, M.6
  • 45
    • 0034655211 scopus 로고    scopus 로고
    • Substituting dexamethasone for prednisone complicates remission induction in children with acute lymphoblastic leukemia
    • Hurwitz CA, Silverman LB, Schorin MA, Clavell LA, Dalton VK, Glick KM et al. Substituting dexamethasone for prednisone complicates remission induction in children with acute lymphoblastic leukemia. Cancer 2000; 88: 1964–1969.
    • (2000) Cancer , vol.88 , pp. 1964-1969
    • Hurwitz, C.A.1    Silverman, L.B.2    Schorin, M.A.3    Clavell, L.A.4    Dalton, V.K.5    Glick, K.M.6
  • 46
    • 0025739294 scopus 로고
    • Lower incidence of meningeal leukemia when prednisone is replaced by dex-amethasone in the treatment of acute lymphocytic leukemia
    • Jones B, Freeman AI, Shuster JJ, Jacquillat C, Weil M, Pochedly C et al. Lower incidence of meningeal leukemia when prednisone is replaced by dex-amethasone in the treatment of acute lymphocytic leukemia. Med Pediatr Oncol 1991; 19: 269–275.
    • (1991) Med Pediatr Oncol , vol.19 , pp. 269-275
    • Jones, B.1    Freeman, A.I.2    Shuster, J.J.3    Jacquillat, C.4    Weil, M.5    Pochedly, C.6
  • 47
    • 84855972519 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia in adults
    • Narayanan S, Shami PJ. Treatment of acute lymphoblastic leukemia in adults. Crit Rev Oncol Hematol 2012; 81: 94–102.
    • (2012) Crit Rev Oncol Hematol , vol.81 , pp. 94-102
    • Narayanan, S.1    Shami, P.J.2
  • 49
    • 0036786909 scopus 로고    scopus 로고
    • Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trial
    • Dombret H, Gabert J, Boiron JM, Rigal-Huguet F, Blaise D, Thomas X et al. Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trial. Blood 2002; 100: 2357–2366.
    • (2002) Blood , vol.100 , pp. 2357-2366
    • Dombret, H.1    Gabert, J.2    Boiron, J.M.3    Rigal-Huguet, F.4    Blaise, D.5    Thomas, X.6
  • 50
    • 50949120904 scopus 로고    scopus 로고
    • Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: A 20-year experience with the fractionated total body irradiation-etoposide regimen
    • Laport GG, Alvarnas JC, Palmer JM, Snyder DS, Slovak ML, Cherry AM et al. Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen. Blood 2008; 112: 903–909.
    • (2008) Blood , vol.112 , pp. 903-909
    • Laport, G.G.1    Alvarnas, J.C.2    Palmer, J.M.3    Snyder, D.S.4    Slovak, M.L.5    Cherry, A.M.6
  • 51
    • 66549084080 scopus 로고    scopus 로고
    • Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: Results from the International ALL Trial MRC UKALLXII/ECOG2993
    • Fielding AK, Rowe JM, Richards SM, Buck G, Moorman AV, Durrant IJ et al. Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993. Blood 2009; 113: 4489–4496.
    • (2009) Blood , vol.113 , pp. 4489-4496
    • Fielding, A.K.1    Rowe, J.M.2    Richards, S.M.3    Buck, G.4    Moorman, A.V.5    Durrant, I.J.6
  • 53
    • 2942567555 scopus 로고    scopus 로고
    • Treatment of Philadelphia chromosome–positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate
    • Thomas DA, Faderl S, Cortes J, O'Brien S, Giles FJ, Kornblau SM et al. Treatment of Philadelphia chromosome–positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood 2004; 103: 4396–4407.
    • (2004) Blood , vol.103 , pp. 4396-4407
    • Thomas, D.A.1    Faderl, S.2    Cortes, J.3    O'brien, S.4    Giles, F.J.5    Kornblau, S.M.6
  • 54
    • 52049087410 scopus 로고    scopus 로고
    • Kinase domain point mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia emerge after therapy with BCR-ABL kinase inhibitors
    • Jones D, Thomas D, Yin CC, O'Brien S, Cortes JE, Jabbour E et al. Kinase domain point mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia emerge after therapy with BCR-ABL kinase inhibitors. Cancer 2008; 113: 985–994.
    • (2008) Cancer , vol.113 , pp. 985-994
    • Jones, D.1    Thomas, D.2    Yin, C.C.3    O'brien, S.4    Cortes, J.E.5    Jabbour, E.6
  • 55
    • 51649111035 scopus 로고    scopus 로고
    • Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia
    • Porkka K, Koskenvesa P, Lundan T, Rimpilainen J, Mustjoki S, Smykla R et al. Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. Blood 2008; 112: 1005–1012.
    • (2008) Blood , vol.112 , pp. 1005-1012
    • Porkka, K.1    Koskenvesa, P.2    Lundan, T.3    Rimpilainen, J.4    Mustjoki, S.5    Smykla, R.6
  • 56
    • 84948576141 scopus 로고    scopus 로고
    • Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lympho-blastic leukemia
    • Ravandi F, O'Brien SM, Cortes JE, Thomas DM, Garris R, Faderl S et al. Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lympho-blastic leukemia. Cancer 2015; 121: 4158–4164.
    • (2015) Cancer , vol.121 , pp. 4158-4164
    • Ravandi, F.1    O'brien, S.M.2    Cortes, J.E.3    Thomas, D.M.4    Garris, R.5    Faderl, S.6
  • 58
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
    • Ottmann O, Dombret H, Martinelli G, Simonsson B, Guilhot F, Larson RA et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007; 110: 2309–2315.
    • (2007) Blood , vol.110 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3    Simonsson, B.4    Guilhot, F.5    Larson, R.A.6
  • 59
    • 82155175738 scopus 로고    scopus 로고
    • Dasatinib as first-line treatment for adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia
    • Foà R, Vitale A, Vignetti M, Meloni G, Guarini A, Propris MSD et al. Dasatinib as first-line treatment for adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia. Blood 2011; 118: 6521–6528.
    • (2011) Blood , vol.118 , pp. 6521-6528
    • Foà, R.1    Vitale, A.2    Vignetti, M.3    Meloni, G.4    Guarini, A.5    Propris, M.S.D.6
  • 61
    • 84994427169 scopus 로고    scopus 로고
    • Hyper-CVAD plus ponatinib versus hyper-CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome-positive acute lympho-blastic leukemia: A propensity score analysis
    • Sasaki K, Jabbour EJ, Ravandi F, Short NJ, Thomas DA, Garcia-Manero G et al. Hyper-CVAD plus ponatinib versus hyper-CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome-positive acute lympho-blastic leukemia: A propensity score analysis. Cancer 2016; 122: 3650–3656.
    • (2016) Cancer , vol.122 , pp. 3650-3656
    • Sasaki, K.1    Jabbour, E.J.2    Ravandi, F.3    Short, N.J.4    Thomas, D.A.5    Garcia-Manero, G.6
  • 65
    • 84978224232 scopus 로고    scopus 로고
    • Final results of a single institution experience with a pediatric-based regimen, the augmented Berlin-Frankfurt-Munster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper-CVAD regimen
    • Rytting ME, Jabbour EJ, Jorgensen JL, Ravandi F, Franklin AR, Kadia TM et al. Final results of a single institution experience with a pediatric-based regimen, the augmented Berlin-Frankfurt-Munster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper-CVAD regimen. Am J Hematol 2016; 91: 819–823.
    • (2016) Am J Hematol , vol.91 , pp. 819-823
    • Rytting, M.E.1    Jabbour, E.J.2    Jorgensen, J.L.3    Ravandi, F.4    Franklin, A.R.5    Kadia, T.M.6
  • 66
    • 79953727884 scopus 로고    scopus 로고
    • Augmented hyper-CVAD based on dose-intensified vincristine, dexamethasone, and asparaginase in adult acute lymphoblastic leukemia salvage therapy
    • Faderl S, Thomas DA, O'Brien S, Ravandi F, Garcia-Manero G, Borthakur G et al. Augmented hyper-CVAD based on dose-intensified vincristine, dexamethasone, and asparaginase in adult acute lymphoblastic leukemia salvage therapy. Clin Lymphoma Myeloma Leuk 2011; 11: 54–59.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , pp. 54-59
    • Faderl, S.1    Thomas, D.A.2    O'brien, S.3    Ravandi, F.4    Garcia-Manero, G.5    Borthakur, G.6
  • 67
    • 58149394138 scopus 로고    scopus 로고
    • Outcome of Adults With Acute Lymphocytic Leukemia After Second Salvage Therapy
    • O’Brien S, Thomas D, Ravandi F, Faderl S, Cortes J, Borthakur G et al. Outcome of Adults With Acute Lymphocytic Leukemia After Second Salvage Therapy. Cancer 2008; 113: 3186–3191.
    • (2008) Cancer , vol.113 , pp. 3186-3191
    • O’Brien, S.1    Thomas, D.2    Ravandi, F.3    Faderl, S.4    Cortes, J.5    Borthakur, G.6
  • 69
    • 84875716409 scopus 로고    scopus 로고
    • High-Dose Vincristine Sulfate Liposome Injection for Advanced, Relapsed, and Refractory Adult Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia
    • O'Brien S, Schiller G, Lister J, Damon L, Goldberg S, Aulitzky W et al. High-Dose Vincristine Sulfate Liposome Injection for Advanced, Relapsed, and Refractory Adult Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia. in J Clin Oncol 2013; 31: 676–683.
    • (2013) In J Clin Oncol , vol.31 , pp. 676-683
    • O'brien, S.1    Schiller, G.2    Lister, J.3    Damon, L.4    Goldberg, S.5    Aulitzky, W.6
  • 71
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lympho-blastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp MS, Kufer P, Gokbuget N, Goebeler M, Klinger M, Neumann S et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lympho-blastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011; 29: 2493–2498.
    • (2011) J Clin Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6
  • 72
    • 85016750637 scopus 로고    scopus 로고
    • Long-Term Outcomes after Blinatumomab Treatment: Follow-up of a Phase 2 Study in Patients (Pts) with Minimal Residual Disease (MRD) Positive B-Cell Precursor Acute Lymphoblastic Leukemia (ALL)
    • Gökbuget N, Dombret H, Bonifacio M, Reichle A, Graux C, Faul C et al. Long-Term Outcomes after Blinatumomab Treatment: Follow-up of a Phase 2 Study in Patients (Pts) with Minimal Residual Disease (MRD) Positive B-Cell Precursor Acute Lymphoblastic Leukemia (ALL). Blood 2015; 126: 680–680.
    • (2015) Blood , vol.126 , pp. 680-680
    • Gökbuget, N.1    Dombret, H.2    Bonifacio, M.3    Reichle, A.4    Graux, C.5    Faul, C.6
  • 73
    • 84926099033 scopus 로고    scopus 로고
    • Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-arm, phase 2 study
    • Topp MS, Gokbuget N, Stein AS, Zugmaier G, O'Brien S, Bargou RC et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. Lancet Oncol 2015; 16: 57–66.
    • (2015) Lancet Oncol , vol.16 , pp. 57-66
    • Topp, M.S.1    Gokbuget, N.2    Stein, A.S.3    Zugmaier, G.4    O'brien, S.5    Bargou, R.C.6
  • 75
    • 84959542798 scopus 로고    scopus 로고
    • Complete Molecular and Hematologic Response in Adult Patients with Relapsed/ Refractory (R/R) Philadelphia Chromosome-Positive B-Precursor Acute Lympho-blastic Leukemia (ALL) Following Treatment with Blinatumomab: Results from a Phase 2 Single-Arm, Multicenter Study (ALCANTARA)[Abstract]
    • Martinelli G, Dombret H, Chevallier P, Ottmann OG, Goekbuget N, Topp MS et al. Complete Molecular and Hematologic Response in Adult Patients with Relapsed/ Refractory (R/R) Philadelphia Chromosome-Positive B-Precursor Acute Lympho-blastic Leukemia (ALL) Following Treatment with Blinatumomab: Results from a Phase 2 Single-Arm, Multicenter Study (ALCANTARA)[Abstract]. Blood 2015; 126: 679.
    • (2015) Blood , vol.126 , pp. 679
    • Martinelli, G.1    Dombret, H.2    Chevallier, P.3    Ottmann, O.G.4    Goekbuget, N.5    Topp, M.S.6
  • 77
    • 34250003760 scopus 로고    scopus 로고
    • Nelar-abine induces complete remissions in adults with relapsed or refractory T-line-age acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
    • DeAngelo DJ, Yu D, Johnson JL, Coutre SE, Stone RM, Stopeck AT et al. Nelar-abine induces complete remissions in adults with relapsed or refractory T-line-age acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. Blood 2007; 109: 5136–5142.
    • (2007) Blood , vol.109 , pp. 5136-5142
    • Deangelo, D.J.1    Yu, D.2    Johnson, J.L.3    Coutre, S.E.4    Stone, R.M.5    Stopeck, A.T.6
  • 79
    • 79551641737 scopus 로고    scopus 로고
    • Surface antigens analysis reveals significant expression of candidate targets for immu-notherapy in adult acute lymphoid leukemia
    • Piccaluga PP, Arpinati M, Candoni A, Laterza C, Paolini S, Gazzola A et al. Surface antigens analysis reveals significant expression of candidate targets for immu-notherapy in adult acute lymphoid leukemia. Leuk Lymphoma 2011; 52: 325–327.
    • (2011) Leuk Lymphoma , vol.52 , pp. 325-327
    • Piccaluga, P.P.1    Arpinati, M.2    Candoni, A.3    Laterza, C.4    Paolini, S.5    Gazzola, A.6
  • 80
    • 64849117882 scopus 로고    scopus 로고
    • Simultaneous study of five candidate target antigens (CD20, CD22, CD33, CD52, HER2) for antibody-based immunotherapy in B-ALL: A monocentric study of 44 cases
    • Chevallier P, Robillard N, Houille G, Ayari S, Guillaume T, Delaunay J et al. Simultaneous study of five candidate target antigens (CD20, CD22, CD33, CD52, HER2) for antibody-based immunotherapy in B-ALL: a monocentric study of 44 cases. in Leukemia 2009; England pp 806–807.
    • In Leukemia 2009; England , pp. 806-807
    • Chevallier, P.1    Robillard, N.2    Houille, G.3    Ayari, S.4    Guillaume, T.5    Delaunay, J.6
  • 81
    • 12444270688 scopus 로고    scopus 로고
    • Epratuzumab, a humanized monoclonal antibody targeting CD22: Characterization of in vitro properties
    • Carnahan J, Wang P, Kendall R, Chen C, Hu S, Boone T et al. Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties. Clin Cancer Res 2003; 9(10 Pt 2): 3982s–3990ss.
    • (2003) Clin Cancer Res , vol.9 , Issue.10 , pp. 3982s-3990ss
    • Carnahan, J.1    Wang, P.2    Kendall, R.3    Chen, C.4    Hu, S.5    Boone, T.6
  • 82
    • 49249109608 scopus 로고    scopus 로고
    • Che-moimmunotherapy reinduction with epratuzumab in children with acute lym-phoblastic leukemia in marrow relapse: A Children's Oncology Group Pilot Study
    • Raetz EA, Cairo MS, Borowitz MJ, Blaney SM, Krailo MD, Leil TA et al. Che-moimmunotherapy reinduction with epratuzumab in children with acute lym-phoblastic leukemia in marrow relapse: a Children's Oncology Group Pilot Study. J Clin Oncol 2008; 26: 3756–3762.
    • (2008) J Clin Oncol , vol.26 , pp. 3756-3762
    • Raetz, E.A.1    Cairo, M.S.2    Borowitz, M.J.3    Blaney, S.M.4    Krailo, M.D.5    Leil, T.A.6
  • 83
    • 84899493381 scopus 로고    scopus 로고
    • SWOG S0910: A phase 2 trial of clofarabine/cytarabine/epratuzumab for relapsed/ refractory acute lymphocytic leukaemia
    • Advani AS, McDonough S, Coutre S, Wood B, Radich J, Mims M et al. SWOG S0910: a phase 2 trial of clofarabine/cytarabine/epratuzumab for relapsed/ refractory acute lymphocytic leukaemia. Br J Haematol 2014; 165: 504–509.
    • (2014) Br J Haematol , vol.165 , pp. 504-509
    • Advani, A.S.1    McDonough, S.2    Coutre, S.3    Wood, B.4    Radich, J.5    Mims, M.6
  • 84
    • 84855675343 scopus 로고    scopus 로고
    • Epratuzumab–SN-38: A New Antibody–Drug Conjugate for the Therapy of Hematologic Malignancies
    • Sharkey RM, Govindan SV, Cardillo TM, Goldenberg DM. Epratuzumab–SN-38: A New Antibody–Drug Conjugate for the Therapy of Hematologic Malignancies. Mol Cancer Ther 2012; 11: 224–234.
    • (2012) Mol Cancer Ther , vol.11 , pp. 224-234
    • Sharkey, R.M.1    Govindan, S.V.2    Cardillo, T.M.3    Goldenberg, D.M.4
  • 85
    • 0027194197 scopus 로고
    • Pre-paration and characterization of monoclonal antibody conjugates of the cali-cheamicins: A novel and potent family of antitumor antibiotics
    • Hinman LM, Hamann PR, Wallace R, Menendez AT, Durr FE, Upeslacis J. Pre-paration and characterization of monoclonal antibody conjugates of the cali-cheamicins: a novel and potent family of antitumor antibiotics. Cancer Res 1993; 53: 3336–3342.
    • (1993) Cancer Res , vol.53 , pp. 3336-3342
    • Hinman, L.M.1    Hamann, P.R.2    Wallace, R.3    Menendez, A.T.4    Durr, F.E.5    Upeslacis, J.6
  • 86
    • 10744229449 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy with CMC-544: A CD22-targeted immu-noconjugate of calicheamicin for the treatment of B-lymphoid malignancies
    • DiJoseph JF, Armellino DC, Boghaert ER, Khandke K, Dougher MM, Sridharan L et al. Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immu-noconjugate of calicheamicin for the treatment of B-lymphoid malignancies. Blood 2004; 103: 1807–1814.
    • (2004) Blood , vol.103 , pp. 1807-1814
    • Dijoseph, J.F.1    Armellino, D.C.2    Boghaert, E.R.3    Khandke, K.4    Dougher, M.M.5    Sridharan, L.6
  • 87
    • 77951648118 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a phase I study
    • Advani A, Coiffier B, Czuczman MS, Dreyling M, Foran J, Gine E et al. Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. J Clin Oncol 2010; 28: 2085–2093.
    • (2010) J Clin Oncol , vol.28 , pp. 2085-2093
    • Advani, A.1    Coiffier, B.2    Czuczman, M.S.3    Dreyling, M.4    Foran, J.5    Gine, E.6
  • 88
    • 84862786326 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: A phase 2 study
    • Kantarjian H, Thomas D, Jorgensen J, Jabbour E, Kebriaei P, Rytting M et al. Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study. Lancet Oncol 2012; 13: 403–411.
    • (2012) Lancet Oncol , vol.13 , pp. 403-411
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3    Jabbour, E.4    Kebriaei, P.5    Rytting, M.6
  • 89
    • 84880574025 scopus 로고    scopus 로고
    • Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia
    • Kantarjian H, Thomas D, Jorgensen J, Kebriaei P, Jabbour E, Rytting M et al. Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. Cancer 2013; 119: 2728–2736.
    • (2013) Cancer , vol.119 , pp. 2728-2736
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3    Kebriaei, P.4    Jabbour, E.5    Rytting, M.6
  • 90
    • 84982898563 scopus 로고    scopus 로고
    • A Phase II Study of Weekly Inotuzumab Ozogamicin (InO) in Adult Patients with CD22-Positive Acute Lymphoblastic Leukemia (ALL) in Second or Later Salvage
    • Advani AS, Stein AS, Kantarjian HM, Shustov AR, DeAngelo DJ, Ananthakrishnan R et al. A Phase II Study of Weekly Inotuzumab Ozogamicin (InO) in Adult Patients with CD22-Positive Acute Lymphoblastic Leukemia (ALL) in Second or Later Salvage. Blood 2014; 124: 2255.
    • (2014) Blood , vol.124 , pp. 2255
    • Advani, A.S.1    Stein, A.S.2    Kantarjian, H.M.3    Shustov, A.R.4    Deangelo, D.J.5    Ananthakrishnan, R.6
  • 92
    • 85136789884 scopus 로고    scopus 로고
    • Inotuzumab Ozogamicin (IO) in Combination with Low-Intensity Chemotherapy (mini-hyper-CVD) as Frontline Therapy for Older Patients (pts) and as Salvage Therapy for Adult with Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)
    • Jabbour E, O’Brien S, Thomas D, Sasaki K, Garcia-Manero G, Ravandi F et al. Inotuzumab Ozogamicin (IO) in Combination with Low-Intensity Chemotherapy (mini-hyper-CVD) as Frontline Therapy for Older Patients (pts) and as Salvage Therapy for Adult with Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL). Clin Lymphoma Myeloma Leuk 2015, 15.
    • (2015) Clin Lymphoma Myeloma Leuk , pp. 15
    • Jabbour, E.1    O’Brien, S.2    Thomas, D.3    Sasaki, K.4    Garcia-Manero, G.5    Ravandi, F.6
  • 93
    • 80054118081 scopus 로고    scopus 로고
    • Antibody Fusion Proteins: Anti-CD22 Recombi-nant Immunotoxin Moxetumomab Pasudotox
    • Kreitman RJ, Pastan I. Antibody Fusion Proteins: Anti-CD22 Recombi-nant Immunotoxin Moxetumomab Pasudotox. Clin Cancer Res 2011; 17: 6398–6405.
    • (2011) Clin Cancer Res , vol.17 , pp. 6398-6405
    • Kreitman, R.J.1    Pastan, I.2
  • 95
    • 77949679970 scopus 로고    scopus 로고
    • Anti-CD22 Immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-Positive Hematologic Malignancies of Childhood: Preclinical Studies and Phase I Clinical Trial
    • Wayne AS, Kreitman RJ, Findley HW, Lew G, Delbrook C, Steinberg SM et al. Anti-CD22 Immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-Positive Hematologic Malignancies of Childhood: Preclinical Studies and Phase I Clinical Trial. Clin Cancer Res 2010; 16: 1894–1903.
    • (2010) Clin Cancer Res , vol.16 , pp. 1894-1903
    • Wayne, A.S.1    Kreitman, R.J.2    Findley, H.W.3    Lew, G.4    Delbrook, C.5    Steinberg, S.M.6
  • 96
    • 84859156821 scopus 로고    scopus 로고
    • A Novel Anti-CD22 Immunotoxin, Moxetumomab Pasudotox: Phase I Study in Pediatric Acute Lymphoblastic Leukemia (ALL)
    • Wayne AS, Bhojwani D, Silverman LB, Richards K, Stetler-Stevenson M, Shah NN et al. A Novel Anti-CD22 Immunotoxin, Moxetumomab Pasudotox: Phase I Study in Pediatric Acute Lymphoblastic Leukemia (ALL). Blood 2011; 118: 248.
    • (2011) Blood , vol.118 , pp. 248
    • Wayne, A.S.1    Bhojwani, D.2    Silverman, L.B.3    Richards, K.4    Stetler-Stevenson, M.5    Shah, N.N.6
  • 97
    • 84902331864 scopus 로고    scopus 로고
    • Design Of a Phase 1/2 Study Of Moxetumomab Pasudotox In Adult Patients With Relapsed and/Or Refractory Acute Lymphoblastic Leukemia (ALL)
    • Ravandi F, Kantarjian HM, Goswami T, Wang F, Ibrahim R. Design Of a Phase 1/2 Study Of Moxetumomab Pasudotox In Adult Patients With Relapsed and/Or Refractory Acute Lymphoblastic Leukemia (ALL). Blood 2013; 122: 5021.
    • (2013) Blood , vol.122 , pp. 5021
    • Ravandi, F.1    Kantarjian, H.M.2    Goswami, T.3    Wang, F.4    Ibrahim, R.5
  • 98
    • 73949122603 scopus 로고    scopus 로고
    • A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia
    • Herrera L, Bostrom B, Gore L, Sandler E, Lew G, Schlegel PG et al. A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009; 31: 936–941.
    • (2009) J Pediatr Hematol Oncol , vol.31 , pp. 936-941
    • Herrera, L.1    Bostrom, B.2    Gore, L.3    Sandler, E.4    Lew, G.5    Schlegel, P.G.6
  • 100
    • 67650594764 scopus 로고    scopus 로고
    • Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia
    • Thomas DA, O'Brien S, Jorgensen JL, Cortes J, Faderl S, Garcia-Manero G et al. Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia. Blood 13: 6330–6337.
    • Blood , vol.13 , pp. 6330-6337
    • Thomas, D.A.1    O'brien, S.2    Jorgensen, J.L.3    Cortes, J.4    Faderl, S.5    Garcia-Manero, G.6
  • 101
    • 81055148076 scopus 로고    scopus 로고
    • Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: Results from the phase 2 international study
    • Wierda WG, Padmanabhan S, Chan GW, Gupta IV, Lisby S, Österborg A et al. Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase 2 international study. Blood 2011; 118: 5126–5129.
    • (2011) Blood , vol.118 , pp. 5126-5129
    • Wierda, W.G.1    Padmanabhan, S.2    Chan, G.W.3    Gupta, I.V.4    Lisby, S.5    Österborg, A.6
  • 102
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
    • Teeling JL, French RR, Cragg MS, v.d. Brakel J, Pluyter M, Huang H et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 2004; 104: 1793–1800.
    • (2004) Blood , vol.104 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3    V.D.Brakel, J.4    Pluyter, M.5    Huang, H.6
  • 103
    • 68949129063 scopus 로고    scopus 로고
    • Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofa-tumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX
    • Pawluczkowycz AW, Beurskens FJ, Beum PV, Lindorfer MA, v.d. Winkel JGJ, Parren PWHI et al. Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofa-tumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX. J Immunol 2009; 183: 749–758.
    • (2009) J Immunol , vol.183 , pp. 749-758
    • Pawluczkowycz, A.W.1    Beurskens, F.J.2    Beum, P.V.3    Lindorfer, M.A.4    Winkel, J.G.J.5    Parren, P.W.H.I.6
  • 104
    • 84916596316 scopus 로고    scopus 로고
    • Phase II Study Of The Hyper-CVAD Regimen In Combination With Ofatumumab As Frontline Therapy For Adults With CD-20 Positive Acute Lymphoblastic Leukemia (ALL)
    • Jabbour E, Hagop K, Thomas D, Garcia-Manero G, Hoehn D, Garris R et al. Phase II Study Of The Hyper-CVAD Regimen In Combination With Ofatumumab As Frontline Therapy For Adults With CD-20 Positive Acute Lymphoblastic Leukemia (ALL). Blood 2013; 122: 2664.
    • (2013) Blood , vol.122 , pp. 2664
    • Jabbour, E.1    Hagop, K.2    Thomas, D.3    Garcia-Manero, G.4    Hoehn, D.5    Garris, R.6
  • 106
    • 77956240944 scopus 로고    scopus 로고
    • Chemoimmunotherapy With a Modified Hyper-CVAD and Rituximab Regimen Improves Outcome in De Novo Philadelphia Chromosome–Negative Precursor B-Lineage Acute Lymphoblastic Leukemia
    • Thomas DA, O'Brien S, Faderl S, Garcia-Manero G, Ferrajoli A, Wierda W et al. Chemoimmunotherapy With a Modified Hyper-CVAD and Rituximab Regimen Improves Outcome in De Novo Philadelphia Chromosome–Negative Precursor B-Lineage Acute Lymphoblastic Leukemia. J Clin Oncol 2010; 28: 3880–3889.
    • (2010) J Clin Oncol , vol.28 , pp. 3880-3889
    • Thomas, D.A.1    O'brien, S.2    Faderl, S.3    Garcia-Manero, G.4    Ferrajoli, A.5    Wierda, W.6
  • 107
    • 84885671483 scopus 로고    scopus 로고
    • Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
    • Herter S, Herting F, Mundigl O, Waldhauer I, Weinzierl T, Fauti T et al. Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models. Mol Cancer Ther 2013; 12: 2031–2042.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2031-2042
    • Herter, S.1    Herting, F.2    Mundigl, O.3    Waldhauer, I.4    Weinzierl, T.5    Fauti, T.6
  • 108
    • 84955331603 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) compared to rituximab significantly enhances cell death and antibody-dependent cytotoxicity and improves overall survival against CD20(+) rituximab-sensitive/-resistant Burkitt lymphoma (BL) and precursor B-acute lymphoblastic leukaemia (pre-B-ALL): Potential targeted therapy in patients with poor risk CD20(+) BL and pre-B-ALL
    • Awasthi A, Ayello J, Van de Ven C, Elmacken M, Sabulski A, Barth MJ et al. Obinutuzumab (GA101) compared to rituximab significantly enhances cell death and antibody-dependent cytotoxicity and improves overall survival against CD20(+) rituximab-sensitive/-resistant Burkitt lymphoma (BL) and precursor B-acute lymphoblastic leukaemia (pre-B-ALL): potential targeted therapy in patients with poor risk CD20(+) BL and pre-B-ALL. Br J Haematol 2015; 171: 763–775.
    • (2015) Br J Haematol , vol.171 , pp. 763-775
    • Awasthi, A.1    Ayello, J.2    van de Ven, C.3    Elmacken, M.4    Sabulski, A.5    Barth, M.J.6
  • 109
    • 84894552888 scopus 로고    scopus 로고
    • Obi-nutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions
    • Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM et al. Obi-nutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions. N Engl J Med 2014; 370: 1101–1110.
    • (2014) N Engl J Med , vol.370 , pp. 1101-1110
    • Goede, V.1    Fischer, K.2    Busch, R.3    Engelke, A.4    Eichhorst, B.5    Wendtner, C.M.6
  • 110
    • 84949681670 scopus 로고    scopus 로고
    • A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys. Scientific Reports
    • Smith EJ, Olson K, Haber LJ, Varghese B, Duramad P, Tustian AD et al. A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys. Scientific Reports, Published online 2015; 5: 17943, 2015.
    • (2015) Published Online , vol.2015 , Issue.5
    • Smith, E.J.1    Olson, K.2    Haber, L.J.3    Varghese, B.4    Duramad, P.5    Tustian, A.D.6
  • 111
    • 85028701354 scopus 로고    scopus 로고
    • Phase 1 Study of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Monoclonal Antibody, in Patients with CD20+ B-Cell Malignancies Previously Treated with CD20-Directed Antibody Therapy
    • Bannerji R, Brown JR, Advani RH, Arnason J, O'Brien SM, Allan JN et al. Phase 1 Study of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Monoclonal Antibody, in Patients with CD20+ B-Cell Malignancies Previously Treated with CD20-Directed Antibody Therapy. Blood 2016; 128: 621.
    • (2016) Blood , vol.128 , pp. 621
    • Bannerji, R.1    Brown, J.R.2    Advani, R.H.3    Arnason, J.4    O'brien, S.M.5    Allan, J.N.6
  • 112
    • 0033564251 scopus 로고    scopus 로고
    • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation
    • Fujimoto M, Poe JC, Jansen PJ, Sato S, Tedder TF. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. J Immunol 1999; 162: 7088–7094.
    • (1999) J Immunol , vol.162 , pp. 7088-7094
    • Fujimoto, M.1    Poe, J.C.2    Jansen, P.J.3    Sato, S.4    Tedder, T.F.5
  • 113
    • 0035846955 scopus 로고    scopus 로고
    • CD19-dependent Activation of Akt Kinase in B-lymphocytes
    • Otero DC, Omori SA, Rickert RC. CD19-dependent Activation of Akt Kinase in B-lymphocytes. J Biol Chem 2001; 276: 1474–1478.
    • (2001) J Biol Chem , vol.276 , pp. 1474-1478
    • Otero, D.C.1    Omori, S.A.2    Rickert, R.C.3
  • 114
    • 84861815445 scopus 로고    scopus 로고
    • CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis
    • Chung EY, Psathas JN, Yu D, Li Y, Weiss MJ, Thomas-Tikhonenko A. CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest 2012; 122: 2257–2266.
    • (2012) J Clin Invest , vol.122 , pp. 2257-2266
    • Chung, E.Y.1    Psathas, J.N.2    Yu, D.3    Li, Y.4    Weiss, M.J.5    Thomas-Tikhonenko, A.6
  • 117
    • 84877100125 scopus 로고    scopus 로고
    • The Anti-CD19 Antibody–Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia
    • Carol H, Szymanska B, Evans K, Boehm I, Houghton PJ, Smith MA et al. The Anti-CD19 Antibody–Drug Conjugate SAR3419 Prevents Hematolymphoid Relapse Postinduction Therapy in Preclinical Models of Pediatric Acute Lymphoblastic Leukemia. Clin Cancer Res 2013; 19: 1795–1805.
    • (2013) Clin Cancer Res , vol.19 , pp. 1795-1805
    • Carol, H.1    Szymanska, B.2    Evans, K.3    Boehm, I.4    Houghton, P.J.5    Smith, M.A.6
  • 118
    • 78650279693 scopus 로고    scopus 로고
    • Phase I Multidose-Escalation Study of the Anti-CD19 Maytansinoid Immunoconjugate SAR3419 Administered by Intravenous Infusion Every 3 Weeks to Patients With Relapsed/Refractory B-Cell Lymphoma
    • Younes A, Kim S, Romaguera J, Copeland A, Farial Sdc, Kwak LW et al. Phase I Multidose-Escalation Study of the Anti-CD19 Maytansinoid Immunoconjugate SAR3419 Administered by Intravenous Infusion Every 3 Weeks to Patients With Relapsed/Refractory B-Cell Lymphoma. Blood 2009; 114: 585.
    • (2009) Blood , vol.114 , pp. 585
    • Younes, A.1    Kim, S.2    Romaguera, J.3    Copeland, A.4    Farial, S.5    Kwak, L.W.6
  • 119
    • 84958922276 scopus 로고    scopus 로고
    • A Phase II Study of Coltuximab Ravtansine (SAR3419) Monotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
    • Kantarjian HM, Lioure B, Kim SK, Atallah E, Leguay T, Kelly K et al. A Phase II Study of Coltuximab Ravtansine (SAR3419) Monotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk 2016; 16: 139–145.
    • (2016) Clin Lymphoma Myeloma Leuk , vol.16 , pp. 139-145
    • Kantarjian, H.M.1    Lioure, B.2    Kim, S.K.3    Atallah, E.4    Leguay, T.5    Kelly, K.6
  • 120
    • 84976299178 scopus 로고    scopus 로고
    • A Phase 1 Study of Denintuzumab Mafodotin (SGN-CD19A) in Adults with Relapsed or Refractory B-Lineage Acute Leukemia (B-ALL) and Highly Aggressive Lymphoma
    • Fathi AT, Borate U, DeAngelo DJ, O'Brien MM, Trippett T, Shah BD et al. A Phase 1 Study of Denintuzumab Mafodotin (SGN-CD19A) in Adults with Relapsed or Refractory B-Lineage Acute Leukemia (B-ALL) and Highly Aggressive Lymphoma. Blood 2015; 126: 1328.
    • (2015) Blood , vol.126 , pp. 1328
    • Fathi, A.T.1    Borate, U.2    Deangelo, D.J.3    O'brien, M.M.4    Trippett, T.5    Shah, B.D.6
  • 121
    • 84982932963 scopus 로고    scopus 로고
    • Pre-Clinical Development of Adct-402, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate (ADC) Targeting CD19-Expressing B-Cell Malignancies
    • Zammarchi F, Williams DG, Adams L, Havenith K, Chivers S, D'Hooge F et al. Pre-Clinical Development of Adct-402, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate (ADC) Targeting CD19-Expressing B-Cell Malignancies. Blood 2015; 126: 1564.
    • (2015) Blood , vol.126 , pp. 1564
    • Zammarchi, F.1    Williams, D.G.2    Adams, L.3    Havenith, K.4    Chivers, S.5    D'hooge, F.6
  • 122
    • 84978530027 scopus 로고    scopus 로고
    • Pre-Clinical Activity of Adct-301, a Novel Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hema-tological Malignancies
    • Flynn MJ, Pv Berkel, Zammarchi F, Levy J-N, Tiberghien A, Masterson LA et al. Pre-Clinical Activity of Adct-301, a Novel Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hema-tological Malignancies. Blood 2014; 124: 4491.
    • (2014) Blood , vol.124 , pp. 4491
    • Flynn, M.J.1    Berkel, P.2    Zammarchi, F.3    Levy, J.-N.4    Tiberghien, A.5    Masterson, L.A.6
  • 123
    • 84978530027 scopus 로고    scopus 로고
    • Pre-Clinical Activity of Adct-301, a Novel Pyrrolobenzodiazepine (PBD) Dimer-Con-taining Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hematolo-gical Malignancies
    • Flynn MJ, Berkel PHv, Zammarchi F, Tyrer PC, Akarca AU, Janghra N et al. Pre-Clinical Activity of Adct-301, a Novel Pyrrolobenzodiazepine (PBD) Dimer-Con-taining Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hematolo-gical Malignancies. Blood 2014; 124: 4491.
    • (2014) Blood , vol.124 , pp. 4491
    • Flynn, M.J.1    Berkel, P.2    Zammarchi, F.3    Tyrer, P.C.4    Akarca, A.U.5    Janghra, N.6
  • 124
    • 75749118583 scopus 로고    scopus 로고
    • Expression of CD66c and CD25 in acute lymphoblastic leukemia as a predictor of the presence of BCR/ABL rearrangement
    • Owaidah TM, Rawas FI, Al Khayatt MF, Elkum NB. Expression of CD66c and CD25 in acute lymphoblastic leukemia as a predictor of the presence of BCR/ABL rearrangement. Hematol Oncol Stem Cell Ther 2008; 1: 34–37.
    • (2008) Hematol Oncol Stem Cell Ther , vol.1 , pp. 34-37
    • Owaidah, T.M.1    Rawas, F.I.2    Al Khayatt, M.F.3    Elkum, N.B.4
  • 126
    • 2542481724 scopus 로고    scopus 로고
    • Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias
    • Cortes J, Thomas D, Koller C, Giles F, Estey E, Faderl S et al. Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias. Clin Cancer Res 2004; 10: 3371–3376.
    • (2004) Clin Cancer Res , vol.10 , pp. 3371-3376
    • Cortes, J.1    Thomas, D.2    Koller, C.3    Giles, F.4    Estey, E.5    Faderl, S.6
  • 127
    • 84864045203 scopus 로고    scopus 로고
    • Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
    • Messinger YH, Gaynon PS, Sposto R, v.d. Giessen J, Eckroth E, Malvar J et al. Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. Blood 2012; 120: 285–290.
    • (2012) Blood , vol.120 , pp. 285-290
    • Messinger, Y.H.1    Gaynon, P.S.2    Sposto, R.3    Giessen, J.4    Eckroth, E.5    Malvar, J.6
  • 129
    • 84868528389 scopus 로고    scopus 로고
    • Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
    • Maude SL, Tasian SK, Vincent T, Hall JW, Sheen C, Roberts KG et al. Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 2012; 120: 3510–3518.
    • (2012) Blood , vol.120 , pp. 3510-3518
    • Maude, S.L.1    Tasian, S.K.2    Vincent, T.3    Hall, J.W.4    Sheen, C.5    Roberts, K.G.6
  • 130
    • 84864440264 scopus 로고    scopus 로고
    • Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia
    • Tasian SK, Doral MY, Borowitz MJ, Wood BL, Chen IM, Harvey RC et al. Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. Blood 2012; 120: 833–842.
    • (2012) Blood , vol.120 , pp. 833-842
    • Tasian, S.K.1    Doral, M.Y.2    Borowitz, M.J.3    Wood, B.L.4    Chen, I.M.5    Harvey, R.C.6
  • 131
    • 85132600854 scopus 로고    scopus 로고
    • The JAK Inhibitor Ruxolitinib Is Effective in Treating T Cell Acute Lymphoblastic Leukemia with Gain of Function Mutations in IL-7R Alpha
    • Senkevitch E, Hixon J, Andrews C, Barata JT, Li W, Durum S. The JAK Inhibitor Ruxolitinib Is Effective in Treating T Cell Acute Lymphoblastic Leukemia with Gain of Function Mutations in IL-7R Alpha. Blood 2015; 126: 1330.
    • (2015) Blood , vol.126 , pp. 1330
    • Senkevitch, E.1    Hixon, J.2    Andrews, C.3    Barata, J.T.4    Li, W.5    Durum, S.6
  • 132
    • 84859516017 scopus 로고    scopus 로고
    • DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission
    • Nordlund J, Milani L, Lundmark A, Lonnerholm G, Syvanen AC. DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission. PLoS One 2012; 7: e34513.
    • (2012) Plos One , vol.7
    • Nordlund, J.1    Milani, L.2    Lundmark, A.3    Lonnerholm, G.4    Syvanen, A.C.5
  • 135
    • 77949536178 scopus 로고    scopus 로고
    • DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
    • Milani L, Lundmark A, Kiialainen A, Nordlund J, Flaegstad T, Forestier E et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood 2010; 115: 1214–1225.
    • (2010) Blood , vol.115 , pp. 1214-1225
    • Milani, L.1    Lundmark, A.2    Kiialainen, A.3    Nordlund, J.4    Flaegstad, T.5    Forestier, E.6
  • 136
    • 34250213859 scopus 로고    scopus 로고
    • DNA Methylation as a Therapeutic Target in Cancer
    • Issa J-PJ. DNA Methylation as a Therapeutic Target in Cancer. Clin Cancer Res 2007; 13: 1634–1637.
    • (2007) Clin Cancer Res , vol.13 , pp. 1634-1637
    • Issa, J.-P.1
  • 137
    • 67650930106 scopus 로고    scopus 로고
    • Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia
    • Yánez L, Bermúdez A, Richard C, Bureo E, Iriondo A. Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia. Leukemia 2009; 23: 1342–1343.
    • (2009) Leukemia , vol.23 , pp. 1342-1343
    • Yánez, L.1    Bermúdez, A.2    Richard, C.3    Bureo, E.4    Iriondo, A.5
  • 138
    • 84911995813 scopus 로고    scopus 로고
    • Safety and clinical activity of 5-aza-2’-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia
    • Benton CB, Thomas DA, Yang H, Ravandi F, Rytting M, O’Brien S et al. Safety and clinical activity of 5-aza-2’-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia. Br J Haematol 2014; 167: 356–365.
    • (2014) Br J Haematol , vol.167 , pp. 356-365
    • Benton, C.B.1    Thomas, D.A.2    Yang, H.3    Ravandi, F.4    Rytting, M.5    O’Brien, S.6
  • 139
    • 84906100499 scopus 로고    scopus 로고
    • A therapeutic trial of decitabine and vorinostat in combination with chemotherapy for relapsed/refractory acute lymphoblastic leukemia
    • Burke MJ, Lamba JK, Pounds S, Cao X, Ghodke-Puranik Y, Lindgren BR et al. A therapeutic trial of decitabine and vorinostat in combination with chemotherapy for relapsed/refractory acute lymphoblastic leukemia. Am J Hematol 2014; 89: 889–895.
    • (2014) Am J Hematol , vol.89 , pp. 889-895
    • Burke, M.J.1    Lamba, J.K.2    Pounds, S.3    Cao, X.4    Ghodke-Puranik, Y.5    Lindgren, B.R.6
  • 140
    • 84953223472 scopus 로고    scopus 로고
    • Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples
    • Lu BY, Thanawala SU, Zochowski KC, Burke MJ, Carroll WL, Bhatla T. Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples. Leuk Lymphoma 2016; 57: 1938–1941.
    • (2016) Leuk Lymphoma , vol.57 , pp. 1938-1941
    • Lu, B.Y.1    Thanawala, S.U.2    Zochowski, K.C.3    Burke, M.J.4    Carroll, W.L.5    Bhatla, T.6
  • 141
    • 74249106880 scopus 로고    scopus 로고
    • Targeted therapy in T-cell malignancies: Dysregulation of the cellular signaling pathways
    • Zhao WL. Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways. Leukemia 2010; 24: 13–21.
    • (2010) Leukemia , vol.24 , pp. 13-21
    • Zhao, W.L.1
  • 142
    • 65949088837 scopus 로고    scopus 로고
    • Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
    • Chiarini F, Fala F, Tazzari PL, Ricci F, Astolfi A, Pession A et al. Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. Cancer Res 2009; 69: 3520–3528.
    • (2009) Cancer Res , vol.69 , pp. 3520-3528
    • Chiarini, F.1    Fala, F.2    Tazzari, P.L.3    Ricci, F.4    Astolfi, A.5    Pession, A.6
  • 143
    • 84868614691 scopus 로고    scopus 로고
    • Har-nessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels
    • Bressanin D, Evangelisti C, Ricci F, Tabellini G, Chiarini F, Tazzari PL et al. Har-nessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels. Oncotarget 2012; 3: 811–823.
    • (2012) Oncotarget , vol.3 , pp. 811-823
    • Bressanin, D.1    Evangelisti, C.2    Ricci, F.3    Tabellini, G.4    Chiarini, F.5    Tazzari, P.L.6
  • 144
    • 84856819520 scopus 로고    scopus 로고
    • The dual kinase inhibitor NVP-BEZ235 in combination with cytotoxic drugs exerts anti-proliferative activity towards acute lymphoblastic leukemia cells
    • Schult C, Dahlhaus M, Glass A, Fischer K, Lange S, Freund M et al. The dual kinase inhibitor NVP-BEZ235 in combination with cytotoxic drugs exerts anti-proliferative activity towards acute lymphoblastic leukemia cells. Anticancer Res 2012; 32: 463–474.
    • (2012) Anticancer Res , vol.32 , pp. 463-474
    • Schult, C.1    Dahlhaus, M.2    Glass, A.3    Fischer, K.4    Lange, S.5    Freund, M.6
  • 145
    • 78650992280 scopus 로고    scopus 로고
    • The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia
    • Saunders P, Cisterne A, Weiss J, Bradstock KF, Bendall LJ. The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia. Haematologica 2011; 96: 69–77.
    • (2011) Haematologica , vol.96 , pp. 69-77
    • Saunders, P.1    Cisterne, A.2    Weiss, J.3    Bradstock, K.F.4    Bendall, L.J.5
  • 146
    • 84979268324 scopus 로고    scopus 로고
    • Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy
    • pii djv439
    • Dai H, Wang Y, Lu X, Han W. Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy. Natl Cancer Inst 2016; 108: pii djv439.
    • (2016) Natl Cancer Inst , vol.108
    • Dai, H.1    Wang, Y.2    Lu, X.3    Han, W.4
  • 147
    • 84933510694 scopus 로고    scopus 로고
    • CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
    • Maude SL, Teachey DT, Porter DL, Grupp SA. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood 2015; 125: 4017–4023.
    • (2015) Blood , vol.125 , pp. 4017-4023
    • Maude, S.L.1    Teachey, D.T.2    Porter, D.L.3    Grupp, S.A.4
  • 148
    • 84867746760 scopus 로고    scopus 로고
    • Genetic modification of lymphocytes by retrovirus-based vectors
    • Suerth JD, Schambach A, Baum C. Genetic modification of lymphocytes by retrovirus-based vectors. Curr Opin Immunol 2012; 24: 598–608.
    • (2012) Curr Opin Immunol , vol.24 , pp. 598-608
    • Suerth, J.D.1    Schambach, A.2    Baum, C.3
  • 149
    • 84878631475 scopus 로고    scopus 로고
    • Nonviral RNA trans-fection to transiently modify T cells with chimeric antigen receptors for adoptive therapy
    • Riet T, Holzinger A, Dorrie J, Schaft N, Schuler G, Abken H. Nonviral RNA trans-fection to transiently modify T cells with chimeric antigen receptors for adoptive therapy. Methods Mol Biol 2013; 969: 187–201.
    • (2013) Methods Mol Biol , vol.969 , pp. 187-201
    • Riet, T.1    Holzinger, A.2    Dorrie, J.3    Schaft, N.4    Schuler, G.5    Abken, H.6
  • 150
    • 84882410441 scopus 로고    scopus 로고
    • Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia
    • Barrett DM, Liu X, Jiang S, June CH, Grupp SA, Zhao Y. Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia. Hum Gene Ther 2013; 24: 717–727.
    • (2013) Hum Gene Ther , vol.24 , pp. 717-727
    • Barrett, D.M.1    Liu, X.2    Jiang, S.3    June, C.H.4    Grupp, S.A.5    Zhao, Y.6
  • 151
    • 84975172606 scopus 로고    scopus 로고
    • Durable Remissions in Children with Relapsed/Refractory ALL Treated with T Cells Engi-neered with a CD19-Targeted Chimeric Antigen Receptor (CTL019)
    • Grupp SA, Maude SL, Shaw PA, Aplenc R, Barrett DM, Callahan C et al. Durable Remissions in Children with Relapsed/Refractory ALL Treated with T Cells Engi-neered with a CD19-Targeted Chimeric Antigen Receptor (CTL019). Blood 2015; 126: 681–681.
    • (2015) Blood , vol.126 , pp. 681-681
    • Grupp, S.A.1    Maude, S.L.2    Shaw, P.A.3    Aplenc, R.4    Barrett, D.M.5    Callahan, C.6
  • 153
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leu-kemia
    • Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K et al. Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leu-kemia. Sci Transl Med 2014; 6: 224ra25.
    • (2014) Sci Transl Med , vol.6 , pp. 224ra25
    • Davila, M.L.1    Riviere, I.2    Wang, X.3    Bartido, S.4    Park, J.5    Curran, K.6
  • 154
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 2015; 385: 517–528.
    • (2015) Lancet , vol.385 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3    Cui, Y.K.4    Delbrook, C.5    Feldman, S.A.6
  • 155
    • 84897568616 scopus 로고    scopus 로고
    • Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies
    • Maude SL, Barrett D, Teachey DT, Grupp. SA. Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies. Cancer J 2014; 20: 119–122.
    • (2014) Cancer J , vol.20 , pp. 119-122
    • Maude, S.L.1    Barrett, D.2    Teachey, D.T.3    Grupp, S.A.4
  • 156
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, Louis CU, Ahmed N, Jensen M et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood 2014; 124: 188–195.
    • (2014) Blood , vol.124 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3    Louis, C.U.4    Ahmed, N.5    Jensen, M.6
  • 157
    • 84874027123 scopus 로고    scopus 로고
    • Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
    • Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH et al. Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood 2013; 1165–1174.
    • (2013) Blood , pp. 1165-1174
    • Haso, W.1    Lee, D.W.2    Shah, N.N.3    Stetler-Stevenson, M.4    Yuan, C.M.5    Pastan, I.H.6
  • 158
    • 85017333976 scopus 로고    scopus 로고
    • Minimal Residual Disease Negative Complete Remissions Following Anti-CD22 Chimeric Antigen Receptor (CAR) in Children and Young Adults with Relapsed/ Refractory Acute Lymphoblastic Leukemia (ALL)
    • Shah NN, Stetler-Stevenson M, Yuan CM, Shalabi H, Yates B, Delbrook C et al. Minimal Residual Disease Negative Complete Remissions Following Anti-CD22 Chimeric Antigen Receptor (CAR) in Children and Young Adults with Relapsed/ Refractory Acute Lymphoblastic Leukemia (ALL). Blood 2016; 128: 650.
    • (2016) Blood , vol.128 , pp. 650
    • Shah, N.N.1    Stetler-Stevenson, M.2    Yuan, C.M.3    Shalabi, H.4    Yates, B.5    Delbrook, C.6
  • 159
    • 0141707820 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for patients with high-risk acute lymphoblastic leukemia in first or second complete remission using fractionated total-body irradiation and high-dose etoposide: A 15-year experience
    • Jamieson CH, Amylon MD, Wong RM, Blume KG. Allogeneic hematopoietic cell transplantation for patients with high-risk acute lymphoblastic leukemia in first or second complete remission using fractionated total-body irradiation and high-dose etoposide: a 15-year experience. Exp Hematol 2003; 31: 981–986.
    • (2003) Exp Hematol , vol.31 , pp. 981-986
    • Jamieson, C.H.1    Amylon, M.D.2    Wong, R.M.3    Blume, K.G.4
  • 160
    • 7044263031 scopus 로고    scopus 로고
    • Outcome of treatment in adults with acute lymphoblastic leukemia: Analysis of the LALA-94 trial
    • Thomas X, Boiron JM, Huguet F, Dombret H, Bradstock K, Vey N et al. Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial. J Clin Oncol 2004; 22: 4075–4086.
    • (2004) J Clin Oncol , vol.22 , pp. 4075-4086
    • Thomas, X.1    Boiron, J.M.2    Huguet, F.3    Dombret, H.4    Bradstock, K.5    Vey, N.6
  • 161
    • 84963757742 scopus 로고    scopus 로고
    • Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/ LBL) in adolescents and adults: A high-risk subtype
    • Jain N, Lamb AV, O'Brien S, Ravandi F, Konopleva M, Jabbour E et al. Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/ LBL) in adolescents and adults: a high-risk subtype. Blood 2016; 127: 1863–1869.
    • (2016) Blood , vol.127 , pp. 1863-1869
    • Jain, N.1    Lamb, A.V.2    O'brien, S.3    Ravandi, F.4    Konopleva, M.5    Jabbour, E.6
  • 162
    • 84865709936 scopus 로고    scopus 로고
    • Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted thera-pies
    • Gokbuget N, Kneba M, Raff T, Trautmann H, Bartram CR, Arnold R et al. Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted thera-pies. Blood 2012; 120: 1868–1876.
    • (2012) Blood , vol.120 , pp. 1868-1876
    • Gokbuget, N.1    Kneba, M.2    Raff, T.3    Trautmann, H.4    Bartram, C.R.5    Arnold, R.6
  • 163
    • 84927760952 scopus 로고    scopus 로고
    • Role of allo-geneic stem cell transplantation in adult patients with Ph-negative acute lym-phoblastic leukemia
    • quiz 2586
    • Dhedin N, Huynh A, Maury S, Tabrizi R, Beldjord K, Asnafi V et al. Role of allo-geneic stem cell transplantation in adult patients with Ph-negative acute lym-phoblastic leukemia. Blood 2015; 125: 2486–2496, quiz 2586.
    • (2015) Blood , vol.125 , pp. 2486-2496
    • Dhedin, N.1    Huynh, A.2    Maury, S.3    Tabrizi, R.4    Beldjord, K.5    Asnafi, V.6
  • 164
    • 34548136113 scopus 로고    scopus 로고
    • Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial
    • Tavernier E, Boiron JM, Huguet F, Bradstock K, Vey N, Kovacsovics T et al. Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial. Leukemia 2007; 21: 1907–1914.
    • (2007) Leukemia , vol.21 , pp. 1907-1914
    • Tavernier, E.1    Boiron, J.M.2    Huguet, F.3    Bradstock, K.4    Vey, N.5    Kovacsovics, T.6
  • 165
    • 33846869976 scopus 로고    scopus 로고
    • Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study
    • Fielding AK, Richards SM, Chopra R, Lazarus HM, Litzow MR, Buck G et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 2007; 109: 944–950.
    • (2007) Blood , vol.109 , pp. 944-950
    • Fielding, A.K.1    Richards, S.M.2    Chopra, R.3    Lazarus, H.M.4    Litzow, M.R.5    Buck, G.6


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