DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Nordlund, Jessica ^a   Milani, Lili ^a,b   Lundmark, Anders ^a   Lönnerholm, Gudmar ^a   Syvänen, Ann Christine ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; DNA; TUMOR MARKER;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; AMICA1 GENE; APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER DIAGNOSIS; CANCER REGRESSION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; CPNE7 GENE; CR1 GENE; DBC1 GENE; DNA METHYLATION; EYA4 GENE; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LGALS8 GENE; MALE; MONONUCLEAR CELL; PRESCHOOL CHILD; PROMOTER REGION; RYR3 GENE; SCHOOL CHILD; TUMOR GENE; UQCRFS1 GENE; WDR35 GENE; ALLELE; BIOSYNTHESIS; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETICS; INFANT; METABOLISM; PATHOLOGY; REMISSION;

ADOLESCENT; ALLELES; BONE MARROW CELLS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFANT; LEUKOCYTES, MONONUCLEAR; MALE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; REMISSION INDUCTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 84859516017     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034513     Document Type: Article

References (31)

1. Pui CH, Carroll WL, Meshinchi S, Arceci RJ, (2011) Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol 29: 551-565.
2. Pui CH, Relling MV, Downing JR, (2004) Acute lymphoblastic leukemia. N Engl J Med 350: 1535-1548.
3. Jaenisch R, Bird A, (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 (Suppl): 245-254.
4. Milani L, Lundmark A, Nordlund J, Kiialainen A, Flaegstad T, et al. (2009) Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. Genome Res 19: 1-11.
5. Broske A-M, Vockentanz L, Kharazi S, Huska MR, Mancini E, et al. (2009) DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 41: 1207-1215.
6. Issa JP, (2007) DNA methylation as a therapeutic target in cancer. Clin Cancer Res 13: 1634-1637.
7. Berdasco M, Esteller M, (2010) Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell 19: 698-711.
8. Jones PA, Baylin SB, (2007) The epigenomics of cancer. Cell 128: 683-692.
9. McCabe MT, Brandes JC, Vertino PM, (2009) Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 15: 3927-3937.
10. Narayan G, Freddy AJ, Xie D, Liyanage H, Clark L, et al. (2011) Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance. Genes Chromosomes Cancer.
11. Milani L, Lundmark A, Kiialainen A, Nordlund J, Flaegstad T, et al. (2010) DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood 115: 1214-1225.
12. Vilas-Zornoza A, Agirre X, Martin-Palanco V, Martin-Subero JI, San Jose-Eneriz E, et al. (2011) Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia. PLoS One 6: e17012.
13. Agrawal S, Unterberg M, Koschmieder S, zur Stadt U, Brunnberg U, et al. (2007) DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia. Cancer Res 67: 1370-1377.
14. Wang MX, Wang HY, Zhao X, Srilatha N, Zheng D, et al. (2010) Molecular detection of B-cell neoplasms by specific DNA methylation biomarkers. Int J Clin Exp Pathol 3: 265-279.
15. Schmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, et al. (2010) Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 24: 345-354.
16. Andersson A, Ritz C, Lindgren D, Eden P, Lassen C, et al. (2007) Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. Leukemia 21: 1198-1203.
17. Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, et al. (2010) Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 28: 2529-2537.
18. Li Y, Zhu J, Tian G, Li N, Li Q, et al. (2010) The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol 8: e1000533.
19. Zou H, Molina JR, Harrington JJ, Osborn NK, Klatt KK, et al. (2005) Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. Int J Cancer 116: 584-591.
20. Osborn NK, Zou H, Molina JR, Lesche R, Lewin J, et al. (2006) Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. Clin Gastroenterol Hepatol 4: 212-218.
21. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, et al. (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1: 133-143.
22. Cleaver AL, Beesley AH, Firth MJ, Sturges NC, O'Leary RA, et al. (2010) Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study. Mol Cancer 9: 105.
23. Hogan LE, Meyer JA, Yang J, Wang J, Wong N, et al. (2011) Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood.
24. San Jose-Eneriz E, Agirre X, Roman-Gomez J, Cordeu L, Garate L, et al. (2006) Downregulation of DBC1 expression in acute lymphoblastic leukaemia is mediated by aberrant methylation of its promoter. Br J Haematol 134: 137-144.
25. Taylor KH, Pena-Hernandez KE, Davis JW, Arthur GL, Duff DJ, et al. (2007) Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia. Cancer Res 67: 2617-2625.
26. Cerveira N, Meyer C, Santos J, Torres L, Lisboa S, et al. (2010) A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. BMC Cancer 10: 518.
27. Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, et al. (2009) New insights to the MLL recombinome of acute leukemias. Leukemia 23: 1490-1499.
28. Chung W, Bondaruk J, Jelinek J, Lotan Y, Liang S, et al. (2011) Detection of bladder cancer using novel DNA methylation biomarkers in urine sediments. Cancer Epidemiol Biomarkers Prev 20: 1483-1491.
29. Hansen KD, Timp W, Bravo HC, Sabunciyan S, Langmead B, et al. (2011) Increased methylation variation in epigenetic domains across cancer types. Nat Genet.
30. Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, et al. (2005) Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Hum Mol Genet 14: 997-1007.
31. Testa U, (2011) Leukemia stem cells. Ann Hematol 90: 245-271.