Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns

Cell

Volumn 171, Issue 2, 2017, Pages 321-330.e14

  Enge, Martin ^a,f   Arda, H Efsun ^b   Mignardi, Marco ^a,e   Beausang, John ^a   Bottino, Rita ^d   Kim, Seung K ^b   Quake, Stephen R ^a,c,d  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHAN ZUCKERBERG BIOHUB   (United States)

^d ALLEGHENY HEALTH NETWORK   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

glucagon; human aging; human pancreas; insulin; islet; mutational signatures; single cell RNA seq; somatic variation; transcriptional instability

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GENOMIC DNA; HORMONE; MESSENGER RNA; TRANSCRIPTOME;

ADULT; AGE; AGING; ARTICLE; CELL AGING; CELL FATE; CELL STRESS; CHILD; CONTROLLED STUDY; FITNESS; GENE EXPRESSION; GENETIC STABILITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INFANT; MIDDLE AGED; MUTATIONAL ANALYSIS; MUTATIONAL LOAD; NORMAL HUMAN; OXIDATIVE STRESS; PANCREAS; PANCREAS ISLET CELL; PRESCHOOL CHILD; PRIMARY CELL; PRIORITY JOURNAL; RNA ANALYSIS; RNA EDITING; RNA SEQUENCE; SINGLE CELL ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; YOUNG ADULT; CYTOLOGY; MUTATION; PATHOLOGY; PHYSIOLOGY; SEQUENCE ANALYSIS;

ADULT; AGING; CELL AGING; CHILD; CHILD, PRESCHOOL; HUMANS; INFANT; MIDDLE AGED; MUTATION; PANCREAS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 85030543594     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.09.004     Document Type: Article

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