A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists

Antiviral Research

Volumn 147, Issue , 2017, Pages 37-46

  Liu, Bowei ^a,b   Tang, Liudi ^c   Zhang, Xiaohui ^a,d   Ma, Julia ^a   Sehgal, Mohit ^a   Cheng, Junjun ^a   Zhang, Xuexiang ^a   Zhou, Yan ^e   Du, Yanming ^a   Kulp, John ^a   Guo, Ju Tao ^a   Chang, Jinhong ^a  

^a BARUCH S BLUMBERG INSTITUTE   (United States)

^b ZHENGZHOU UNIVERSITY   (China)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e FOX CHASE CANCER CENTER   (United States)

Author keywords

Antiviral; High throughput assay; Innate immune; STING

Indexed keywords

2,7,2'',2'' DISPIRO[INDENE 1'',3''DIONE] TETRAHYDRODITHIAZOLO[3,2 A:3',2' D]PYRAZINE 5,10(5AH,10AH) DIONE; 4 (2 CHLORO 6 FLUOROBENZYL) N (FURAN 2 YLMETHYL) 3 OXO 3,4 DIHYDRO 2H BENZO[B][1,4]THIAZINE 6 CARBOXAMIDE; AMIDE; ANTIVIRUS AGENT; FIREFLY LUCIFERASE; NUCLEOTIDE DERIVATIVE; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG; VADIMEZAN; INTERFERON INDUCING AGENT; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; PIPERAZINE DERIVATIVE; SPIRO COMPOUND; TRANSCRIPTION FACTOR;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; CYTOKINE RESPONSE; DENGUE VIRUS; DRUG MECHANISM; HEPAD38 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SKIN FIBROBLAST; VIRUS REPLICATION; YELLOW FEVER VIRUS; ZIKA VIRUS; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; FLAVIVIRUS; GENE EXPRESSION; GENETICS; INNATE IMMUNITY; LD50; MOUSE; MUTATION; PROCEDURES; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; DRUG DISCOVERY; FLAVIVIRUS; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNITY, INNATE; INTERFERON INDUCERS; LETHAL DOSE 50; MEMBRANE PROTEINS; MICE; MUTATION; NUCLEOTIDYLTRANSFERASES; PIPERAZINES; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; SPIRO COMPOUNDS; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

EID: 85030481650     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2017.10.001     Document Type: Article

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