MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3

Cancer Letters

Volumn 289, Issue 2, 2010, Pages 195-207

  Revet, Ingrid ^a   Huizenga, Gerda ^a   Koster, Jan ^a   Volckmann, Richard ^a   van Sluis, Peter ^a   Versteeg, Rogier ^a   Geerts, Dirk ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

DKK; MSX1; Neuroblastoma; SFRP; Wnt

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; DICKKOPF 2 PROTEIN; DICKKOPF 3 PROTEIN; DISHEVELLED PROTEIN; DISHEVELLED PROTEIN 3; GLYCOPROTEIN; SECRETED FRIZZLED RELATED PROTEIN 1; TRANSCRIPTION FACTOR MSX1; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3 PROTEIN; WNT5A PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NEURAL CREST; NEUROBLASTOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSGENE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BETA CATENIN; BLOTTING, NORTHERN; BLOTTING, WESTERN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; MEMBRANE PROTEINS; MSX1 TRANSCRIPTION FACTOR; NEUROBLASTOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; T CELL TRANSCRIPTION FACTOR 1; TUMOR CELLS, CULTURED; WNT PROTEINS;

EID: 76849085038     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.08.019     Document Type: Article

References (54)

1. Brodeur G.M. Neuroblastoma: biological insights into a clinical enigma. Nat. Rev. Cancer 3 (2003) 203-216
2. Molenaar J.J., Van Sluis P., Boon K., Versteeg R., and Caron H.N. Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma. Genes Chromosomes Cancer 36 (2003) 242-249
3. van Limpt V., Schramm A., Lakeman A., van Sluis P., Chan A., van Noesel M., Baas F., Caron H., Eggert A., and Versteeg R. The Phox2B homeobox gene is mutated in sporadic neuroblastomas. Oncogene 23 (2004) 9280-9288
4. Trochet D., Bourdeaut F., Janoueix-Lerosey I., Deville A., de Pontual L., Schleiermacher G., Coze C., Philip N., Frebourg T., Munnich A., Lyonnet S., Delattre O., and Amiel J. Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. Am. J. Hum. Genet. 74 (2004) 761-764
5. Mossé Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., and Maris J.M. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455 (2008) 930-935
6. Shimada H., Umehara S., Monobe Y., Hachitanda Y., Nakagawa A., Goto S., Gerbing R.B., Stram D.O., Lukens J.N., and Matthay K.K. International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer 92 (2001) 2451-2461
7. Joshi V.V. Peripheral neuroblastic tumors: pathologic classification based on recommendations of international neuroblastoma pathology committee (modification of shimada classification). Pediatr. Devel. Pathol. 3 (2000) 184-199
8. Koppen A., Ait-Aissa R., Koster J., Ora I., Bras J., Van Sluis P.G., Caron H., Versteeg R., and Valentijn L.J. Dickkopf-3 expression is a marker for neuroblastic tumour maturation and is down-regulated by MYCN. Int. J. Cancer 122 (2008) 1455-1464
9. Barembaum M., and Bronner-Fraser M. Early steps in neural crest specification. Semin. Cell Dev. Biol. 16 (2005) 642-646
10. Sauka-Spengler T., and Bronner-Fraser M. A gene regulatory network orchestrates neural crest formation. Nat. Rev. Mol. Cell Biol. 9 (2008) 557-568
11. Crane J.F., and Trainor P.A. Neural crest stem and progenitor cells. Annu. Rev. Cell. Dev. Biol. 22 (2006) 267-286
12. Ramos C., and Robert B. Msh/Msx gene family in neural development. Trends Genet. 21 (2005) 624-632
13. Bach A., Lallemand Y., Nicola M.A., Ramos C., Mathis L., Maufras M., and Robert B. Msx1 is required for dorsal diencephalon patterning. Development 130 (2003) 4025-4036
14. Raible D.W. Development of the neural crest: achieving specificity in regulatory pathways. Curr. Opin. Cell. Biol. 18 (2006) 698-703
15. Bendall A.J., and Abate-Shen C. Roles for Msx and Dlx homeoproteins in vertebrate development. Gene 247 (2000) 17-31
16. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 127 (2006) 469-480
17. Koesters R., and von Knebel Doeberitz M. The Wnt signaling pathway in solid childhood tumors. Cancer Lett. 198 (2003) 123-138
18. Aster J.C., Pear W.S., and Blacklow S.C. Notch signaling in leukemia. Annu. Rev. Pathol. 3 (2008) 587-613
19. Van Limpt V.A., Chan A.J., Van Sluis P.G., Caron H.N., Van Noesel C.J., and Versteeg R. High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type. Int. J. Cancer 105 (2003) 61-69
20. Påhlman S., Stockhausen M.T., Fredlund E., and Axelson H. Notch signaling in neuroblastoma. Semin. Cancer Biol. 14 (2004) 365-373
21. van Limpt V., Chan A., Schramm A., Eggert A., and Versteeg R. Phox2B mutations and the Delta-Notch pathway in neuroblastoma. Cancer Lett. 228 (2005) 59-63
22. Revet I., Huizenga G., Chan A., Koster J., Volckmann R., Van Sluis P., Øra I., Versteeg R., and Geerts D. The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp. Cell Res. 314 (2008) 707-719
23. Funahashi Y., Hernandez S.L., Das I., Ahn A., Huang J., Vorontchikhina M., Sharma A., Kanamaru E., Borisenko V., Desilva D.M., Suzuki A., Wang X., Shawber C.J., Kandel J.J., Yamashiro D.J., and Kitajewski J. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 68 (2008) 4727-4735
24. Blanc E., Roux G.L., Benard J., and Raguenez G. Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene 24 (2005) 1277-1283
25. Koppen A., Ait-Aissa R., Hopman S., Koster J., Haneveld F., Versteeg R., and Valentijn L.J. Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation. Cancer Lett. 256 (2007) 218-228
26. Liu X., Mazanek P., Dam V., Wang Q., Zhao H., Guo R., Jagannathan J., Cnaan A., Maris J.M., and Hogarty M.D. Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification. Oncogene 27 (2008) 1478-1488
27. Orme M.H., Giannini A.L., Vivanco M.D., and Kypta R.M. Glycogen synthase kinase-3 and axin function in a beta-catenin-independent pathway that regulates neurite outgrowth in neuroblastoma cells. Mol. Cell. Neurosci. 24 (2003) 673-686
28. Fan S., Ramirez S.H., Garcia T.M., and Dewhurst S. Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. Brain Res. Mol. Brain Res. 132 (2004) 38-50
29. Bell E., Lunec J., and Tweddle D.A. Cell cycle regulation targets of MYCN identified by gene expression microarrays. Cell cycle 6 (2007) 1249-1256
30. Unsicker K., Huber K., Schütz G., and Kalcheim C. The chromaffin cell and its development. Neurochem. Res. 30 (2005) 921-925
31. Huber K. The sympathoadrenal cell lineage: specification, diversification, and new perspectives. Dev. Biol. 298 (2006) 335-343
32. Ritke M.K., Shah R., Valentine M., Douglass E.C., and Tereba A. Molecular analysis of chromosome 1 abnormalities in neuroblastoma. Cytogenet. Cell. Genet. 50 (1989) 84-90
33. Shapiro D.N., Valentine M.B., Rowe S.T., Sinclair A.E., Sublett J.E., Roberts W.M., and Look A.T. Detection of N-myc gene amplification by fluorescence in situ hybridization: diagnostic utility for neuroblastoma. Am. J. Pathol. 142 (1993) 1339-1346
34. Barrett T., Troup D.B., Wilhite S.E., Ledoux P., Rudnev D., Evangelista C., Kim I.F., Soboleva A., Tomashevsky M., Marshall K.A., Phillippy K.H., Sherman P.M., Muertter R.N., and Edgar R. NCBI GEO: archive for high-throughput functional genomic data. Nucleic Acids Res. 37 (2009) D885-890
35. Kawano Y., and Kypta R. Secreted antagonists of the Wnt signalling pathway. J. Cell Sci. 116 (2003) 2627-2634
36. Bryja V., Schulte G., Rawal N., Grahn A., and Arenas E. Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell Sci. 120 (2007) 586-595
37. Kikuchi A., Yamamoto H., and Sato A. Selective activation mechanisms of Wnt signaling pathways. Trends Cell. Biol. 19 (2009) 119-129
38. Korinek V., Barker N., Morin P.J., van Wichen D., de Weger R., Kinzler K., Vogelstein B., and Clevers H. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275 (1997) 1784-1787
39. Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., and Kinzler K.W. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275 (1997) 1787-1790
40. Tetsu O., and McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398 (1999) 422-426
41. Essers M.A., Vries-Smits L.M., Barker N., Polderman P.E., Burgering B.M., and Korswagen H.C. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 (2005) 1181-1184
42. Sinner D., Rankin S., Lee M., and Zorn A.M. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development 131 (2004) 3069-3080
43. Veeman M.T., Axelrod J.D., and Moon R.T. A second canon, functions and mechanisms of beta-catenin-independent Wnt signaling. Dev. Cell 5 (2003) 367-377
44. Varga A.C., and Wrana J.L. The disparate role of BMP in stem cell biology. Oncogene 24 (2005) 5713-5721
45. Garcia-Castro M.I., Marcelle C., and Bronner-Fraser M. Ectodermal Wnt function as a neural crest inducer. Science 297 (2002) 848-851
46. Chenn A., and Walsh C.A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297 (2002) 365-369
47. Zechner D., Fujita Y., Hulsken J., Muller T., Walther I., Taketo M.M., Crenshaw III E.B., Birchmeier W., and Birchmeier C. Beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258 (2003) 406-418
48. Aguilera O., Fraga M.F., Ballestar E., Paz M.F., Herranz M., Espada J., García J.M., Muñoz A., Esteller M., and González-Sancho J.M. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 25 (2006) 4116-4121
49. Nojima M., Suzuki H., Toyota M., Watanabe Y., Maruyama R., Sasaki S., Sasaki Y., Mita H., Nishikawa N., Yamaguchi K., Hirata K., Itoh F., Tokino T., Mori M., Imai K., and Shinomura Y. Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 26 (2007) 4699-4713
50. Yue W., Sun Q., Dacic S., Landreneau R.J., Siegfried J.M., Yu J., and Zhang L. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis 29 (2008) 84-92
51. Gumz M.L., Zou H., Kreinest P.A., Childs A.C., Belmonte L.S., LeGrand S.N., Wu K.J., Luxon B.A., Sinha M., Parker A.S., Sun L.Z., Ahlquist D.A., Wood C.G., and Copland J.A. Secreted frizzled-related protein 1 loss contributes to tumour phenotype of clear cell renal cell carcinoma. Clin. Cancer Res. 13 (2007) 4740-4749
52. Cowling V.H., D'Cruz C.M., Chodosh L.A., and Cole M.D. C-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol. Cell Biol. 27 (2007) 5135-5146
53. Semenov M.V., Habas R., Macdonald B.T., and He X. SnapShot: noncanonical Wnt Signaling Pathways. Cell 131 (2007) 1378
54. Bewick V., Cheek L., and Ball J. Statistics review 12: survival analysis. Crit. Care 8 (2004) 389-394