메뉴 건너뛰기




Volumn 12, Issue 9, 2017, Pages

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; DNA; POLYUNSATURATED FATTY ACID; DELTA-5 FATTY ACID DESATURASE; FADS2 PROTEIN, HUMAN;

EID: 85030032204     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0180903     Document Type: Article
Times cited : (23)

References (46)
  • 1
    • 84922479473 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and their metabolites in brain function and disease
    • PMID: 25387473
    • Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014; 15(12):771–85. https://doi.org/10.1038/nrn3820 PMID: 25387473.
    • (2014) Nat Rev Neurosci , vol.15 , Issue.12 , pp. 771-785
    • Bazinet, R.P.1    Laye, S.2
  • 2
    • 83855162786 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid metabolism in prostate cancer
    • PMID: 22015690; PubMed Central PMCID: PMCPMC3865857
    • Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011; 30(3–4):295–309. https://doi.org/10.1007/s10555-011-9299-7 PMID: 22015690; PubMed Central PMCID: PMCPMC3865857.
    • (2011) Cancer Metastasis Rev , vol.30 , Issue.3-4 , pp. 295-309
    • Berquin, I.M.1    Edwards, I.J.2    Kridel, S.J.3    Chen, Y.Q.4
  • 3
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • (Maywood). PMID: 18408140
    • Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 2008; 233(6):674–88. https://doi.org/10.3181/0711-MR-311 PMID: 18408140.
    • (2008) Exp Biol Med , vol.233 , Issue.6 , pp. 674-688
    • Simopoulos, A.P.1
  • 4
    • 79961054708 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: Effects on risk factors, molecular pathways, and clinical events
    • PMID: 22051327
    • Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011; 58(20):2047–67. https://doi.org/10.1016/j.jacc.2011.06.063 PMID: 22051327.
    • (2011) J Am Coll Cardiol , vol.58 , Issue.20 , pp. 2047-2067
    • Mozaffarian, D.1    Wu, J.H.2
  • 5
    • 46149088018 scopus 로고    scopus 로고
    • SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease
    • PMID: 18320251
    • Malerba G, Schaeffer L, Xumerle L, Klopp N, Trabetti E, Biscuola M, et al. SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids. 2008; 43(4):289–99. https://doi.org/10.1007/s11745-008-3158-5 PMID: 18320251.
    • (2008) Lipids , vol.43 , Issue.4 , pp. 289-299
    • Malerba, G.1    Schaeffer, L.2    Xumerle, L.3    Klopp, N.4    Trabetti, E.5    Biscuola, M.6
  • 6
    • 53849097341 scopus 로고    scopus 로고
    • FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    • PMID: 18842780
    • Martinelli N, Girelli D, Malerba G, Guarini P, Illig T, Trabetti E, et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr. 2008; 88(4):941–9. PMID: 18842780.
    • (2008) Am J Clin Nutr , vol.88 , Issue.4 , pp. 941-949
    • Martinelli, N.1    Girelli, D.2    Malerba, G.3    Guarini, P.4    Illig, T.5    Trabetti, E.6
  • 7
    • 57349126752 scopus 로고    scopus 로고
    • Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes
    • PMID: 18479586
    • Rzehak P, Heinrich J, Klopp N, Schaeffer L, Hoff S, Wolfram G, et al. Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. British Journal of Nutrition. 2009; 101 (1):20–6. https://doi.org/10.1017/S0007114508992564 PMID: 18479586
    • (2009) British Journal of Nutrition , vol.101 , Issue.1 , pp. 20-26
    • Rzehak, P.1    Heinrich, J.2    Klopp, N.3    Schaeffer, L.4    Hoff, S.5    Wolfram, G.6
  • 8
    • 33744736614 scopus 로고    scopus 로고
    • Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    • PMID: 16670158
    • Schaeffer L, Gohlke H, Muller M, Heid IM, Palmer LJ, Kompauer I, et al. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Human Molecular Genetics. 2006; 15(11):1745–56. https://doi.org/10.1093/hmg/ddl117 PMID: 16670158
    • (2006) Human Molecular Genetics , vol.15 , Issue.11 , pp. 1745-1756
    • Schaeffer, L.1    Gohlke, H.2    Muller, M.3    Heid, I.M.4    Palmer, L.J.5    Kompauer, I.6
  • 9
    • 79956194616 scopus 로고    scopus 로고
    • The impact of FADS genetic variants on omega6 polyunsaturated fatty acid metabolism in African Americans
    • PMID: 21599946; PubMed Central PMCID: PMCPMC3118962
    • Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, Kubala M, et al. The impact of FADS genetic variants on omega6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011; 12:50. https://doi.org/10.1186/1471-2156-12-50 PMID: 21599946; PubMed Central PMCID: PMCPMC3118962.
    • (2011) BMC Genet , vol.12 , pp. 50
    • Mathias, R.A.1    Sergeant, S.2    Ruczinski, I.3    Torgerson, D.G.4    Hugenschmidt, C.E.5    Kubala, M.6
  • 10
    • 77956820562 scopus 로고    scopus 로고
    • FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population
    • PMID: 20562440; PubMed Central PMCID: PMCPMC2918459
    • Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, et al. FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. J Lipid Res. 2010; 51(9):2766–74. https://doi.org/10.1194/jlr.M008359 PMID: 20562440; PubMed Central PMCID: PMCPMC2918459.
    • (2010) J Lipid Res , vol.51 , Issue.9 , pp. 2766-2774
    • Mathias, R.A.1    Vergara, C.2    Gao, L.3    Rafaels, N.4    Hand, T.5    Campbell, M.6
  • 11
    • 84856752552 scopus 로고    scopus 로고
    • Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome
    • PMID: 21733300; PubMed Central PMCID: PMCPMC3494092
    • Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, et al. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012; 107(4):547–55. https://doi.org/10.1017/S0007114511003230 PMID: 21733300; PubMed Central PMCID: PMCPMC3494092.
    • (2012) Br J Nutr , vol.107 , Issue.4 , pp. 547-555
    • Sergeant, S.1    Hugenschmidt, C.E.2    Rudock, M.E.3    Ziegler, J.T.4    Ivester, P.5    Ainsworth, H.C.6
  • 12
    • 55949102407 scopus 로고    scopus 로고
    • Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation
    • PMID: 18936223
    • Xie L, Innis SM. Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr. 2008; 138(11):2222–8. https://doi.org/10.3945/jn.108.096156 PMID: 18936223.
    • (2008) J Nutr , vol.138 , Issue.11 , pp. 2222-2228
    • Xie, L.1    Innis, S.M.2
  • 13
    • 77950814664 scopus 로고    scopus 로고
    • Association of Fatty Acid Desaturase Gene Polymorphisms with Blood Lipid Essential Fatty Acids and Perinatal Depression among Canadian Women: A Pilot Study
    • PMID: 20395685
    • Xie L, Innis SM. Association of Fatty Acid Desaturase Gene Polymorphisms with Blood Lipid Essential Fatty Acids and Perinatal Depression among Canadian Women: A Pilot Study. Journal of Nutrigenetics and Nutrigenomics. 2009; 2(4–5):243–50. https://doi.org/10.1159/000255636 PMID: 20395685
    • (2009) Journal of Nutrigenetics and Nutrigenomics , vol.2 , Issue.4-5 , pp. 243-250
    • Xie, L.1    Innis, S.M.2
  • 14
    • 84887872293 scopus 로고    scopus 로고
    • Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study
    • (Phila). PMID: 24022589; PubMed Central PMCID: PMCPMC3840911
    • Porenta SR, Ko YA, Gruber SB, Mukherjee B, Baylin A, Ren J, et al. Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study. Cancer Prev Res (Phila). 2013; 6(11):1212–21. https://doi.org/10.1158/1940-6207.CAPR-13-0131 PMID: 24022589; PubMed Central PMCID: PMCPMC3840911.
    • (2013) Cancer Prev Res , vol.6 , Issue.11 , pp. 1212-1221
    • Porenta, S.R.1    Ko, Y.A.2    Gruber, S.B.3    Mukherjee, B.4    Baylin, A.5    Ren, J.6
  • 15
    • 84878347413 scopus 로고    scopus 로고
    • Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
    • PMID: 23818766; PubMed Central PMCID: PMCPMC3693593
    • Hong SH, Kwak JH, Paik JK, Chae JS, Lee JH. Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men. Clin Interv Aging. 2013; 8:585–96. https://doi.org/10.2147/CIA.S42096 PMID: 23818766; PubMed Central PMCID: PMCPMC3693593.
    • (2013) Clin Interv Aging , vol.8 , pp. 585-596
    • Hong, S.H.1    Kwak, J.H.2    Paik, J.K.3    Chae, J.S.4    Lee, J.H.5
  • 16
    • 84878387779 scopus 로고    scopus 로고
    • FADS genotype and diet are important determinants of DHA status: A cross-sectional study in Danish infants
    • PMID: 23636240
    • Harslof LB, Larsen LH, Ritz C, Hellgren LI, Michaelsen KF, Vogel U, et al. FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. Am J Clin Nutr. 2013; 97(6):1403–10. https://doi.org/10.3945/ajcn.113.058685 PMID: 23636240.
    • (2013) Am J Clin Nutr , vol.97 , Issue.6 , pp. 1403-1410
    • Harslof, L.B.1    Larsen, L.H.2    Ritz, C.3    Hellgren, L.I.4    Michaelsen, K.F.5    Vogel, U.6
  • 17
    • 84873192744 scopus 로고    scopus 로고
    • FADS gene polymorphisms confer the risk of coronary artery disease in a Chinese Han population through the altered desaturase activities: Based on high-resolution melting analysis
    • PMID: 23383292; PubMed Central PMCID: PMCPMC3561316
    • Li SW, Lin K, Ma P, Zhang ZL, Zhou YD, Lu SY, et al. FADS gene polymorphisms confer the risk of coronary artery disease in a Chinese Han population through the altered desaturase activities: based on high-resolution melting analysis. PLoS One. 2013; 8(1):e55869. https://doi.org/10.1371/journal.pone. 0055869 PMID: 23383292; PubMed Central PMCID: PMCPMC3561316.
    • (2013) Plos One , vol.8 , Issue.1
    • Li, S.W.1    Lin, K.2    Ma, P.3    Zhang, Z.L.4    Zhou, Y.D.5    Lu, S.Y.6
  • 18
    • 79952010953 scopus 로고    scopus 로고
    • Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition
    • PMID: 21383846; PubMed Central PMCID: PMCPMC3044172
    • Morales E, Bustamante M, Gonzalez JR, Guxens M, Torrent M, Mendez M, et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS One. 2011; 6(2):e17181. https://doi.org/10.1371/journal.pone.0017181 PMID: 21383846; PubMed Central PMCID: PMCPMC3044172.
    • (2011) Plos One , vol.6 , Issue.2
    • Morales, E.1    Bustamante, M.2    Gonzalez, J.R.3    Guxens, M.4    Torrent, M.5    Mendez, M.6
  • 19
    • 84871987938 scopus 로고    scopus 로고
    • Dietary oils and FADS1-FADS2 genetic variants modulate [13C]alpha-linolenic acid metabolism and plasma fatty acid composition
    • PMID: 23221573
    • Gillingham LG, Harding SV, Rideout TC, Yurkova N, Cunnane SC, Eck PK, et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]alpha-linolenic acid metabolism and plasma fatty acid composition. Am J Clin Nutr. 2013; 97(1):195–207. https://doi.org/10.3945/ajcn.112.043117 PMID: 23221573.
    • (2013) Am J Clin Nutr , vol.97 , Issue.1 , pp. 195-207
    • Gillingham, L.G.1    Harding, S.V.2    Rideout, T.C.3    Yurkova, N.4    Cunnane, S.C.5    Eck, P.K.6
  • 20
    • 84865025293 scopus 로고    scopus 로고
    • Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human Male cortical brain tissue
    • PMID: 22900039; PubMed Central PMCID: PMCPMC3416866
    • Freemantle E, Lalovic A, Mechawar N, Turecki G. Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue. PLoS One. 2012; 7(8):e42696. https://doi.org/10.1371/journal.pone.0042696 PMID: 22900039; PubMed Central PMCID: PMCPMC3416866.
    • (2012) Plos One , vol.7 , Issue.8
    • Freemantle, E.1    Lalovic, A.2    Mechawar, N.3    Turecki, G.4
  • 21
    • 84876115474 scopus 로고    scopus 로고
    • Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC)
    • PMID: 22877655; PubMed Central PMCID: PMCPMC3600399
    • Lattka E, Koletzko B, Zeilinger S, Hibbeln JR, Klopp N, Ring SM, et al. Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC). Br J Nutr. 2013; 109(7):1196–210. https://doi.org/10.1017/ S0007114512003108 PMID: 22877655; PubMed Central PMCID: PMCPMC3600399.
    • (2013) Br J Nutr , vol.109 , Issue.7 , pp. 1196-1210
    • Lattka, E.1    Koletzko, B.2    Zeilinger, S.3    Hibbeln, J.R.4    Klopp, N.5    Ring, S.M.6
  • 22
    • 79251469733 scopus 로고    scopus 로고
    • Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation
    • PMID: 21147856
    • Lattka E, Rzehak P, Szabo E, Jakobik V, Weck M, Weyermann M, et al. Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation. Am J Clin Nutr. 2011; 93(2):382–91. https://doi.org/10.3945/ajcn.110.004515 PMID: 21147856.
    • (2011) Am J Clin Nutr , vol.93 , Issue.2 , pp. 382-391
    • Lattka, E.1    Rzehak, P.2    Szabo, E.3    Jakobik, V.4    Weck, M.5    Weyermann, M.6
  • 23
    • 84858174171 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: Their associations with two common FADS2 polymorphisms
    • PMID: 22194195
    • Steer CD, Hibbeln JR, Golding J, Smith GD. Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. Human Molecular Genetics. 2012; 21(7):1504–12. https://doi.org/10.1093/hmg/ddr588 PMID: 22194195
    • (2012) Human Molecular Genetics , vol.21 , Issue.7 , pp. 1504-1512
    • Steer, C.D.1    Hibbeln, J.R.2    Golding, J.3    Smith, G.D.4
  • 24
    • 78651301789 scopus 로고    scopus 로고
    • Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: Findings from the Avon Longitudinal Study of Parents and Children
    • PMID: 21106917
    • Koletzko B, Lattka E, Zeilinger S, Illig T, Steer C. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr. 2011; 93 (1):211–9. https://doi.org/10.3945/ajcn.110.006189 PMID: 21106917.
    • (2011) Am J Clin Nutr , vol.93 , Issue.1 , pp. 211-219
    • Koletzko, B.1    Lattka, E.2    Zeilinger, S.3    Illig, T.4    Steer, C.5
  • 25
    • 78650842083 scopus 로고    scopus 로고
    • FADS gene polymorphisms in Koreans: Association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease
    • PMID: 21040914
    • Kwak JH, Paik JK, Kim OY, Jang Y, Lee SH, Ordovas JM, et al. FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. Atherosclerosis. 2011; 214(1):94–100. https://doi.org/10.1016/j.atherosclerosis.2010.10.004 PMID: 21040914.
    • (2011) Atherosclerosis , vol.214 , Issue.1 , pp. 94-100
    • Kwak, J.H.1    Paik, J.K.2    Kim, O.Y.3    Jang, Y.4    Lee, S.H.5    Ordovas, J.M.6
  • 26
    • 78149434189 scopus 로고    scopus 로고
    • Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life
    • ARTN e13261 PMID: 20948998
    • Rzehak P, Thijs C, Standl M, Mommers M, Glaser C, Jansen E, et al. Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life. Plos One. 2010; 5(10):e13261. ARTN e13261 https://doi.org/10.1371/journal.pone. 0013261 PMID: 20948998
    • (2010) Plos One , vol.5 , Issue.10
    • Rzehak, P.1    Thijs, C.2    Standl, M.3    Mommers, M.4    Glaser, C.5    Jansen, E.6
  • 27
    • 77955425717 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios
    • PMID: 20427696; PubMed Central PMCID: PMCPMC2903808
    • Bokor S, Dumont J, Spinneker A, Gonzalez-Gross M, Nova E, Widhalm K, et al. Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. J Lipid Res. 2010; 51(8):2325–33. https://doi.org/10.1194/jlr.M006205 PMID: 20427696; PubMed Central PMCID: PMCPMC2903808.
    • (2010) J Lipid Res , vol.51 , Issue.8 , pp. 2325-2333
    • Bokor, S.1    Dumont, J.2    Spinneker, A.3    Gonzalez-Gross, M.4    Nova, E.5    Widhalm, K.6
  • 28
    • 77952849777 scopus 로고    scopus 로고
    • Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism
    • Epub 2010/01/05. PMID: 20045144
    • Glaser C, Heinrich J, Koletzko B. Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. Metabolism: clinical and experimental. 2010; 59(7):993–9. Epub 2010/01/05. https://doi.org/10.1016/j.metabol.2009.10.022 PMID: 20045144.
    • (2010) Metabolism: Clinical and Experimental , vol.59 , Issue.7 , pp. 993-999
    • Glaser, C.1    Heinrich, J.2    Koletzko, B.3
  • 29
    • 59249096217 scopus 로고    scopus 로고
    • Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    • PMID: 19148276; PubMed Central PMCID: PMCPMC2613033
    • Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, Guralnik JM, et al. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet. 2009; 5(1): e1000338. https://doi.org/10.1371/journal.pgen.1000338 PMID: 19148276; PubMed Central PMCID: PMCPMC2613033.
    • (2009) Plos Genet , vol.5 , Issue.1
    • Tanaka, T.1    Shen, J.2    Abecasis, G.R.3    Kisialiou, A.4    Ordovas, J.M.5    Guralnik, J.M.6
  • 30
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • PMID: 18193044; PubMed Central PMCID: PMCPMC2682493
    • Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008; 40(2):189–97. https://doi.org/10.1038/ng.75 PMID: 18193044; PubMed Central PMCID: PMCPMC2682493.
    • (2008) Nat Genet , vol.40 , Issue.2 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3    Surti, A.4    Burtt, N.P.5    Rieder, M.J.6
  • 31
    • 38649125868 scopus 로고    scopus 로고
    • Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    • PMID: 18193043
    • Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nature Genetics. 2008; 40(2):161–9. https://doi.org/10.1038/ng.76 PMID: 18193043
    • (2008) Nature Genetics , vol.40 , Issue.2 , pp. 161-169
    • Willer, C.J.1    Sanna, S.2    Jackson, A.U.3    Scuteri, A.4    Bonnycastle, L.L.5    Clarke, R.6
  • 32
    • 84864276423 scopus 로고    scopus 로고
    • Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study
    • PMID: 22911844; PubMed Central PMCID: PMCPMC3402436
    • Lu Y, Vaarhorst A, Merry AH, Dolle ME, Hovenier R, Imholz S, et al. Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS One. 2012; 7(7):e41681. https://doi.org/10.1371/journal.pone.0041681 PMID: 22911844; PubMed Central PMCID: PMCPMC3402436.
    • (2012) Plos One , vol.7 , Issue.7
    • Lu, Y.1    Vaarhorst, A.2    Merry, A.H.3    Dolle, M.E.4    Hovenier, R.5    Imholz, S.6
  • 33
    • 33749143454 scopus 로고    scopus 로고
    • Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder
    • Epub 2006/08/09. PMID: 16893529
    • Brookes KJ, Chen W, Xu X, Taylor E, Asherson P. Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biological psychiatry. 2006; 60(10):1053–61. Epub 2006/08/09. https://doi.org/10.1016/j.biopsych.2006.04.025 PMID: 16893529.
    • (2006) Biological Psychiatry , vol.60 , Issue.10 , pp. 1053-1061
    • Brookes, K.J.1    Chen, W.2    Xu, X.3    Taylor, E.4    Asherson, P.5
  • 34
    • 84901329540 scopus 로고    scopus 로고
    • DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver
    • PMID: 24842322; PubMed Central PMCID: PMCPMC4026313
    • Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, et al. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One. 2014; 9(5):e97510. https://doi.org/10.1371/journal.pone.0097510 PMID: 24842322; PubMed Central PMCID: PMCPMC4026313.
    • (2014) Plos One , vol.9 , Issue.5
    • Howard, T.D.1    Mathias, R.A.2    Seeds, M.C.3    Herrington, D.M.4    Hixson, J.E.5    Shimmin, L.C.6
  • 35
    • 84901313698 scopus 로고    scopus 로고
    • Diet-gene interactions and PUFA metabolism: A potential contributor to health disparities and human diseases
    • PMID: 24853887; PubMed Central PMCID: PMCPMC4042578
    • Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, et al. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients. 2014; 6(5):1993–2022. https://doi.org/10.3390/nu6051993 PMID: 24853887; PubMed Central PMCID: PMCPMC4042578.
    • (2014) Nutrients , vol.6 , Issue.5 , pp. 1993-2022
    • Chilton, F.H.1    Murphy, R.C.2    Wilson, B.A.3    Sergeant, S.4    Ainsworth, H.5    Seeds, M.C.6
  • 36
    • 85030028660 scopus 로고    scopus 로고
    • Racial Differences in Plasma Omega-3 Long Chain Fatty Acid Levels in a Cohort of African Americans and European Americans with Diabetes and Metabolic Syndrome
    • WOS:000310711305363
    • Wilson BA, Sergeant S, Ainsworth H, Mathias R, Chilton FH. Racial Differences in Plasma Omega-3 Long Chain Fatty Acid Levels in a Cohort of African Americans and European Americans with Diabetes and Metabolic Syndrome. Faseb Journal. 2012; 26. WOS:000310711305363.
    • (2012) Faseb Journal , vol.26
    • Wilson, B.A.1    Sergeant, S.2    Ainsworth, H.3    Mathias, R.4    Chilton, F.H.5
  • 37
    • 0030836750 scopus 로고    scopus 로고
    • The PDAY Study: Natural history, risk factors, and pathobiology. Pathobiological Determinants of Atherosclerosis in Youth
    • discussion 35–7. PMID: 9186600
    • Strong JP, Malcom GT, Oalmann MC, Wissler RW. The PDAY Study: natural history, risk factors, and pathobiology. Pathobiological Determinants of Atherosclerosis in Youth. Ann N Y Acad Sci. 1997; 811:226–35; discussion 35–7. PMID: 9186600.
    • (1997) Ann N Y Acad Sci , vol.811 , pp. 226-235
    • Strong, J.P.1    Malcom, G.T.2    Oalmann, M.C.3    Wissler, R.W.4
  • 38
    • 77955894071 scopus 로고    scopus 로고
    • METAL: Fast and efficient meta-analysis of genomewide association scans
    • PMID: 20616382; PubMed Central PMCID: PMCPMC2922887
    • Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010; 26(17):2190–1. https://doi.org/10.1093/bioinformatics/btq340 PMID: 20616382; PubMed Central PMCID: PMCPMC2922887.
    • (2010) Bioinformatics , vol.26 , Issue.17 , pp. 2190-2191
    • Willer, C.J.1    Li, Y.2    Abecasis, G.R.3
  • 39
    • 84905833501 scopus 로고    scopus 로고
    • Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans
    • Epub 2014/06/26. PMID: 24962583; PubMed Central PMCID: PMCPMC4139254
    • Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, et al. Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. J Biol Chem. 2014; 289(32):22482–9. Epub 2014/06/26. https://doi.org/10.1074/jbc.M114.579557 PMID: 24962583; PubMed Central PMCID: PMCPMC4139254.
    • (2014) J Biol Chem , vol.289 , Issue.32 , pp. 22482-22489
    • Hester, A.G.1    Murphy, R.C.2    Uhlson, C.J.3    Ivester, P.4    Lee, T.C.5    Sergeant, S.6
  • 40
    • 84865504765 scopus 로고    scopus 로고
    • Fueling the flame: Bioenergy couples metabolism and inflammation
    • PMID: 22571857; PubMed Central PMCID: PMCPMC3427613
    • Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, et al. Fueling the flame: bioenergy couples metabolism and inflammation. Journal of leukocyte biology. 2012; 92(3):499–507. https://doi.org/10.1189/jlb.0212078 PMID: 22571857; PubMed Central PMCID: PMCPMC3427613.
    • (2012) Journal of Leukocyte Biology , vol.92 , Issue.3 , pp. 499-507
    • Liu, T.F.1    Brown, C.M.2    El Gazzar, M.3    McPhail, L.4    Millet, P.5    Rao, A.6
  • 41
    • 67650156460 scopus 로고    scopus 로고
    • Effect of dietary fatty acids on inflammatory gene expression in healthy humans
    • Epub 2009/04/11. PMID: 19359242; PubMed Central PMCID: PMCPMC2708836
    • Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009; 284(23):15400–7. Epub 2009/04/11. https://doi.org/10.1074/jbc.M109.004861 PMID: 19359242; PubMed Central PMCID: PMCPMC2708836.
    • (2009) J Biol Chem , vol.284 , Issue.23 , pp. 15400-15407
    • Weaver, K.L.1    Ivester, P.2    Seeds, M.3    Case, L.D.4    Arm, J.P.5    Chilton, F.H.6
  • 42
    • 84908125109 scopus 로고    scopus 로고
    • Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells
    • PMID: 25329159; PubMed Central PMCID: PMCPMC4201459
    • Hoile SP, Clarke-Harris R, Huang RC, Calder PC, Mori TA, Beilin LJ, et al. Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells. PLoS One. 2014; 9(10):e109896. https://doi.org/10.1371/journal.pone.0109896 PMID: 25329159; PubMed Central PMCID: PMCPMC4201459.
    • (2014) Plos One , vol.9 , Issue.10
    • Hoile, S.P.1    Clarke-Harris, R.2    Huang, R.C.3    Calder, P.C.4    Mori, T.A.5    Beilin, L.J.6
  • 43
    • 84952638942 scopus 로고    scopus 로고
    • Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance
    • PMID: 26455892
    • Cheatham CL, Lupu DS, Niculescu MD. Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance. Nutr Res. 2015; 35(11):948–55. https://doi.org/10.1016/j.nutres.2015.09. 005 PMID: 26455892.
    • (2015) Nutr Res , vol.35 , Issue.11 , pp. 948-955
    • Cheatham, C.L.1    Lupu, D.S.2    Niculescu, M.D.3
  • 44
    • 84952639014 scopus 로고    scopus 로고
    • Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: Maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: An exploratory analysis
    • PMID: 26439440
    • Lupu DS, Cheatham CL, Corbin KD, Niculescu MD. Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis. Nutr Res. 2015; 35(11):939–47. https://doi.org/10.1016/j.nutres.2015.09.004 PMID: 26439440.
    • (2015) Nutr Res , vol.35 , Issue.11 , pp. 939-947
    • Lupu, D.S.1    Cheatham, C.L.2    Corbin, K.D.3    Niculescu, M.D.4
  • 45
    • 84982798856 scopus 로고    scopus 로고
    • Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer
    • PMID: 27197070
    • Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, et al. Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer. Prostate. 2016; 76(13):1182–91. https://doi.org/10.1002/pros.23205 PMID: 27197070.
    • (2016) Prostate , vol.76 , Issue.13 , pp. 1182-1191
    • Cui, T.1    Hester, A.G.2    Seeds, M.C.3    Rahbar, E.4    Howard, T.D.5    Sergeant, S.6
  • 46
    • 84979907627 scopus 로고    scopus 로고
    • Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake
    • Epub 2014/07/01. PMID: 24977108; PubMed Central PMCID: PMCPMC4070521
    • Mathias RA, Pani V, Chilton FH. Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake. Current nutrition reports. 2014; 3(2):139–48. Epub 2014/07/01. https://doi.org/10.1007/s13668-014-0079-1 PMID: 24977108; PubMed Central PMCID: PMCPMC4070521.
    • (2014) Current Nutrition Reports , vol.3 , Issue.2 , pp. 139-148
    • Mathias, R.A.1    Pani, V.2    Chilton, F.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.