Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome

British Journal of Nutrition

Volumn 107, Issue 4, 2012, Pages 547-555

  Sergeant, Susan ^a   Hugenschmidt, Christina E ^a   Rudock, Megan E ^a   Ziegler, Julie T ^a   Ivester, Priscilla ^a   Ainsworth, Hannah C ^a   Vaidya, Dhananjay ^b   Douglas Case, L ^a   Langefeld, Carl D ^a   Freedman, Barry I ^a   Bowden, Donald W ^a   Mathias, Rasika A ^b   Chilton, Floyd H ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arachidonic acid synthesis; Fatty acid desaturase; SNP

Indexed keywords

ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; N 6 LONG CHAIN POLYUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ETHNIC DIFFERENCE; EUROPEAN AMERICAN; FATTY ACID BLOOD LEVEL; FATTY ACID DESATURASE GENE; FATTY ACID METABOLISM; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MUTATOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

8,11,14-EICOSATRIENOIC ACID; AFRICAN AMERICANS; AGED; ARACHIDONIC ACID; DIABETES MELLITUS, TYPE 2; EICOSAPENTAENOIC ACID; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAMILY HEALTH; FATTY ACID DESATURASES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIGENE FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE; SIBLINGS; UNITED STATES;

EID: 84856752552     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511003230     Document Type: Article

References (51)

1. Barnes KC, Grant AV, Hansel NN, et al. (2007) African Americans with asthma: genetic insights. Proc Am Thorac Soc 4, 58-68. (Pubitemid 46067564)
2. Olshansky SJ, Passaro DJ, Hershow RC, et al. (2005) A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 352, 1138-1145. (Pubitemid 40365358)
3. Vaidya D, Szklo M, Ding J, et al. (2007) Agreement of two metabolic syndrome definitions and their association with subclinical atherosclerosis: Multi-ethnic study of atherosclerosis cross sectional study. Metab Syndr Relat Disord 5, 343-352. (Pubitemid 350208900)
4. Burns SF, Lee SJ & Arslanian SA (2009) In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children. Diabetes Care 32, 2087-2093.
5. Bjorksten B, Clayton T, Ellwood P, et al. (2008) Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol 19, 110-124. (Pubitemid 351197288)
6. Khera A, McGuire DK, Murphy SA, et al. (2005) Race and gender differences in C-reactive protein levels. J Am Coll Cardiol 46, 464-469. (Pubitemid 41040287)
7. Albert MA, Glynn RJ, Buring J, et al. (2004) C-reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study). Am J Cardiol 93, 1238-1242. (Pubitemid 38595677)
8. Cordain L, Eaton SB, Sebastian A, et al. (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81, 341-354. (Pubitemid 43078368)
9. Flinn MV, Geary DC & Ward CV (2005) Ecological dominance, social competition, and coalitionary arms races: why humans evolved extraordinary intelligence. Evol Hum Behav 26, 10-46. (Pubitemid 40071325)
10. Innis SM (2003) Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr 143, Suppl. 4, S1-S8. (Pubitemid 37346688)
11. Innis SM (2008) Dietary omega 3 fatty acids and the developing brain. Brain Res 1237, 35-43.
12. Guillou H, Zadravec D, Martin PGP, et al. (2010) The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res 49, 186-199.
13. Blasbalg TL, Hibbeln JR, Ramsden CE, et al. (2011) Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr 93, 950-962.
14. Schmitz G & Ecker J.2008) The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 47, 147-155.
15. Simopoulos AP (2008) The importance of the omega-6/ omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exper Biol Med 233, 674-688.
16. Torrejon C, Jung UJ & Deckelbaum RJ (2007) n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms. Prostaglandins Leukot Essent Fatty Acids 77, 319-326 (Pubitemid 350198858)
17. Novak TE, Babcock TA, Jho DH, et al. (2003) NF-kB inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-a transcription. Am J Physiol Lung Cell Mol Physiol 284, L84-L89. (Pubitemid 35471261)
18. Soberman RJ & Christmas P (2003) The organization and consequences of eicosanoid signaling. J Clin Invest 111, 1107-1113. (Pubitemid 36519924)
19. Jump DB & Clarke SD (1999) Regulation of gene expression by dietary fat. Ann Rev Nutr 19, 63-90. (Pubitemid 29380597)
20. Xu J, Nakamura MT, Cho HP, et al. (1999) Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. J Biol Chem 274, 23577-23583.
21. Worgall TS, Sturley SL, Seo T, et al. (1998) Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem 273, 25537-25540. (Pubitemid 28475768)
22. Ghosh S & Karin M (2002) Missing pieces in the NF-kB puzzle. Cell 109, S81-S96.
23. Muskiet FAJ (2010) Pathophysiology and evolutionary aspects of dietary fats and long-chain polyunsaturated fatty acids across the life cycle. In Fat Detection: Taste, Texture, and Post Ingestive Effects [JP Montmayeur and J le Coutre, editors]. Boca Raton, FL: CRC Press. http://www.ncbi.nlm. nih.gov/books/NBK53557/.
24. Hussein N, Ah-Sing E, Wilkinson P, et al. (2005) Long-chain conversion of [13C]linoleic acid and a-linolenic acid in response to marked changes in their dietary intake in men. J Lipid Res 46, 269-280. (Pubitemid 40271091)
25. Vlaardingerbroek H, Hornstra G, de Koning TJ, et al. (2006) Essential polyunsaturated fatty acids in plasma and erythrocytes of children with inborn errors of amino acid metabolism. Mol Genet Metab 88, 159-165.
26. Harris WS, Mozaffarian D, Rimm E, et al. (2009) Omega-6 fatty acids and risk for cardiovascular disease: A science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 119, 902-907.
27. Friesen RW & Innis SM (2010) Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. Am J Clin Nutr 91, 23-31.
28. Malerba G, Schaeffer L, Xumerle L, et al. (2008) SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids 43, 289-299.
29. Xie L & Innis SM (2008) Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr 138, 2222-2228.
30. Schaeffer L, Gohlke H, Muller M, et al. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15, 1745-1756. (Pubitemid 43821765)
31. Martinelli N, Girelli D, Malerba G, et al. (2008) FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr 88, 941-949.
32. Rzehak P, Heinrich J, Klopp N, et al. (2009) Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br J Nutr 101, 20-26. (Pubitemid 352795577)
33. Bowden DW, Lehtinen AB, Ziegler JT, et al. (2008) Genetic epidemiology of subclinical cardiovascular disease in the Diabetes Heart Study. Ann Hum Genet 72, 598-610.
34. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). JAMA 285, 2486-2497.
35. Metcalfe LD, Schmitz AA & Pelka JR (1966) Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal Chem 38, 514-515.
36. Weaver KL, Ivester P, Seeds MC, et al. (2009) Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem 284, 15400-15407.
37. Tanaka T, Shen J, Abecasis GR, et al. (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI study. PLoS Genet 5, e1000338.
38. Allayee H, Baylin A, Hartiala J, et al. (2008) Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr 88, 934-940.
39. Buetow KH, Edmonson M, MacDonald R, et al. (2001) High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A 98, 581-584. (Pubitemid 32105085)
40. Barrett JC, Fry B, Maller J, et al. (2005) Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265. (Pubitemid 40202029)
41. Gabriel SB, Schaffner SF, Nguyen H, et al. (2002) The structure of haplotype blocks in the human genome. Science 296, 2225-2229. (Pubitemid 34680308)
42. Almasy L & Blangero J.1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62, 1198-1211. (Pubitemid 28199022)
43. Lattka E, Illig T, Heinrich J, et al. (2009) FADS gene cluster polymorphisms: Important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics 2, 119-128.
44. American Heart Association (2009) American Heart Association. Heart Disease and Stroke Statistics - 2008 Update. http://www.americanheartorg/ downloadable/heart/12000820 05246HS-Stats%202008.final.pdf (accessed November 2009).
45. World Health Organization (2009) Diabetes Programme: Facts and Figures. http://www.whoint/diabetes/facts/en/ index.html (accessed November 2009).
46. American Diabetes Association (2009) Diabetes Statistics - 2007. http://www.diabetes.org/diabetes-basics/diabetes-statistics/ (accessed November 2009).
47. Horrobin DF, Ells K, Morse-Fisher N, et al. (1991) Fatty acid distribution in plasma phospholipids in normal individuals from different geographical locations. J Nutr Environ Med 2, 249-258.
48. Mathias RA, Sergeant S, Ruczinski I, et al. (2011) The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet 12, 50.
49. Haldane JBS (1949) The rate of mutation of human genes. Proc Eighth Int Congr Genet Hered 35, 267-273.
50. Luca F, Perry GH & Di Rienzo A (2010) Evolutionary adaptations to dietary changes. Ann Rev Nutr 30, 291-314.
51. Ramsden CE, Hibbeln JR, Majchrzak SF, et al. (2010) n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: A meta-analysis of randomised controlled trials. Br J Nutr 104, 1586-1600.