The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans

BMC Genetics

Volumn 12, Issue , 2011, Pages

  Mathias, Rasika A ^a   Sergeant, Susan ^b   Ruczinski, Ingo ^c   Torgerson, Dara G ^d   Hugenschmidt, Christina E ^b   Kubala, Meghan ^a   Vaidya, Dhananjay ^a   Suktitipat, Bhoom ^a   Ziegler, Julie T ^b   Ivester, Priscilla ^b   Case, Douglas ^b   Yanek, Lisa R ^a   Freedman, Barry I ^b   Rudock, Megan E ^b   Barnes, Kathleen C ^a   Langefeld, Carl D ^b   Becker, Lewis C ^a   Bowden, Donald W ^b   Becker, Diane M ^a   Chilton, Floyd H ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; OMEGA 6 FATTY ACID;

ADULT; AFRICAN AMERICAN; ALLELE; ARTICLE; CHROMOSOME 11Q; FATTY ACID METABOLISM; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNITY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; CAUCASIAN; CHROMOSOME 11; GENETICS; METABOLISM;

8,11,14-EICOSATRIENOIC ACID; AFRICAN AMERICANS; ARACHIDONIC ACID; CHROMOSOMES, HUMAN, PAIR 11; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY ACIDS, OMEGA-6; GENE FREQUENCY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; STEAROYL-COA DESATURASE;

EID: 79956194616     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-12-50     Document Type: Article

References (36)

1. Burr GO, Burr MM, Miller ES. On the fatty acids essential in nutrition. III. J Biol Chem 1932, 97:1-9.
2. Steinberg G, Slaton WH, Howton DR, Mead JF. Metabolism of essential fatty acids: IV. Incorporation of linoleate into arachidonic acid. J Biol Chem 1956, 220:257-264.
3. Mead JF, Steinberg G, Howton DR. Metabolism of essential fatty acids: Incorporation of acetate into arachidonic acid. J Biol Chem 1953, 205:683-689.
4. Mead JF, Howton DR. Metabolism of essential fatty acids: VII. Conversion of γ-linolenic acid to arachidonic acid. J Biol Chem 1957,
5. Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004, 24:345-376. 10.1146/annurev.nutr.24.121803.063211, 15189125.
6. Das UN. Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006, 1(4):420-439. 10.1002/biot.200600012, 16892270.
7. Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008, 47(2):147-155. 10.1016/j.plipres.2007.12.004, 18198131.
8. Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 2008, 233(6):674-688.
9. Martinez M. Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 1992, 120(4 Pt 2):S129-138.
10. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 2005, 81(2):341-354.
11. Burdge GC. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids 2006, 75(3):161-168. 10.1016/j.plefa.2006.05.013, 16828546.
12. Pawlosky RJ, Lin YH, Llanos A, Mena P, Uauy R, Salem N. Compartmental analyses of plasma 13C- and 2H-labeled n-6 fatty acids arising from oral administrations of 13C-U-18:2n-6 and 2H5-20:3n-6 in newborn infants. Pediatr Res 2006, 60(3):327-333. 10.1203/01.pdr.0000232782.09352.ef, 16857777.
13. Emken EA, Adlof RO, Gulley RM. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim Biophys Acta 1994, 1213(3):277-288.
14. Malerba G, Schaeffer L, Xumerle L, Klopp N, Trabetti E, Biscuola M, Cavallari U, Galavotti R, Martinelli N, Guarini P, et al. SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids 2008, 43(4):289-299. 10.1007/s11745-008-3158-5, 18320251.
15. Xie L, Innis SM. Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr 2008, 138(11):2222-2228. 10.3945/jn.108.096156, 18936223.
16. Schaeffer L, Gohlke H, Muller M, Heid IM, Palmer LJ, Kompauer I, Demmelmair H, Illig T, Koletzko B, Heinrich J. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 2006, 15(11):1745-1756. 10.1093/hmg/ddl117, 16670158.
17. Martinelli N, Girelli D, Malerba G, Guarini P, Illig T, Trabetti E, Sandri M, Friso S, Pizzolo F, Schaeffer L, et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr 2008, 88(4):941-949.
18. Rzehak P, Heinrich J, Klopp N, Schaeffer L, Hoff S, Wolfram G, Illig T, Linseisen J. Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br J Nutr 2009, 101(1):20-26. 10.1017/S0007114508992564, 18479586.
19. Marquardt A, Stohr H, White K, Weber BH. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 2000, 66(2):175-183. 10.1006/geno.2000.6196, 10860662.
20. Lattka E, Illig T, Heinrich J, Koletzko B. FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics 2009, 2(3):119-128. 10.1159/000235559, 19776639.
21. Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, Guralnik JM, Singleton A, Bandinelli S, Cherubini A, Arnett D, et al. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet 2009, 5(1):e1000338. 10.1371/journal.pgen.1000338, 2613033, 19148276.
22. Horrobin DF, Ells K, Morse-Fisher N, Manku MS. Fatty acid distribution in plasma phospholipids in normal individuals from different geographical locations. J Nutr Environ Med 1991, 2:249-258.
23. Lattka E, Eggers S, Moeller G, Heim K, Weber M, Mehta D, Prokisch H, Illig T, Adamski J. A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. J Lipid Res 51(1):182-191.
24. Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with asthma: genetic insights. Proc Am Thorac Soc 2007, 4(1):58-68. 10.1513/pats.200607-146JG, 2647616, 17202293.
25. Khera A, McGuire DK, Murphy SA, Stanek HG, Das SR, Vongpatanasin W, Wians FH, Grundy SM, de Lemos JA. Race and gender differences in C-reactive protein levels. J Am Coll Cardiol 2005, 46(3):464-469. 10.1016/j.jacc.2005.04.051, 16053959.
26. Albert MA, Glynn RJ, Buring J, Ridker PM. C-reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study). Am J Cardiol 2004, 93(10):1238-1242. 10.1016/j.amjcard.2004.01.067, 15135696.
27. Bray PF, Mathias RA, Faraday N, Yanek LR, Fallin MD, Herrera-Galeano JE, Wilson AF, Becker LC, Becker DM. Heritability of platelet function in families with premature coronary artery disease. J Thromb Haemost 2007, 5(8):1617-1623. 10.1111/j.1538-7836.2007.02618.x, 17663734.
28. Bowden DW, Lehtinen AB, Ziegler JT, Rudock ME, Xu J, Wagenknecht LE, Herrington DM, Rich SS, Freedman BI, Carr JJ, et al. Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study. Ann Hum Genet 2008, 72(Pt 5):598-610.
29. Metcalfe LD, Schmitz AA, Pelka JR. Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal Chem 1966, 38:514-515.
30. Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem 2009, 284(23):15400-15407. 10.1074/jbc.M109.004861, 2708836, 19359242.
31. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81(3):559-575. 10.1086/519795, 1950838, 17701901.
32. Buetow KH, Edmonson M, MacDonald R, Clifford R, Yip P, Kelley J, Little DP, Strausberg R, Koester H, Cantor CR, et al. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci USA 2001, 98(2):581-584. 10.1073/pnas.021506298, 14630, 11136232.
33. Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986, 42(1):121-130. 10.2307/2531248, 3719049.
34. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006, 38(8):904-909. 10.1038/ng1847, 16862161.
35. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265. 10.1093/bioinformatics/bth457, 15297300.
36. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, et al. The structure of haplotype blocks in the human genome. Science 2002, 296(5576):2225-2229. 10.1126/science.1069424, 12029063.