Age and Haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Freemantle, Erika ^a,b   Lalovic, Aleksandra ^b   Mechawar, Naguib ^a,b   Turecki, Gustavo ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; DNA; FATTY ACID;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CLINICAL ARTICLE; DNA SEQUENCE; ENZYME ACTIVITY; FADS1 GENE; FADS2 GENE; FATTY ACID SYNTHESIS; GAS CHROMATOGRAPHY; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC VARIABILITY; HAPLOTYPE; HAPLOTYPE MAP; HUMAN; HUMAN TISSUE; LIPID BRAIN LEVEL; LIPID COMPOSITION; MALE; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGE FACTORS; CEREBELLAR CORTEX; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY ACID DESATURASES; FATTY ACIDS; GENE EXPRESSION; GENE ORDER; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84865025293     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042696     Document Type: Article

References (47)

1. Conklin SM, Runyan CA, Leonard S, Reddy RD, Muldoon MF, et al. (2010) Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder. Prostaglandins Leukot Essent Fatty Acids 82: 111-119.
2. Conklin SM, Manuck SB, Yao JK, Flory JD, Hibbeln JR, et al. (2007) High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom Med 69: 932-934.
3. Conklin SM, Harris JI, Manuck SB, Yao JK, Hibbeln JR, et al. (2007) Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. Psychiatry Res 152: 1-10.
4. Muldoon MF, Ryan CM, Sheu L, Yao JK, Conklin SM, et al. (2010) Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood. J Nutr 140: 848-853.
5. Fraser T, Tayler H, Love S, (2010) Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochem Res 35: 503-513.
6. Milte CM, Sinn N, Howe PR, (2009) Polyunsaturated fatty acid status in attention deficit hyperactivity disorder, depression, and Alzheimer's disease: towards an omega-3 index for mental health? Nutr Rev 67: 573-590.
7. McNamara RK, Liu Y, Jandacek R, Rider T, Tso P, (2008) The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins Leukot Essent Fatty Acids 78: 293-304.
8. Liu Y, Jandacek R, Rider T, Tso P, McNamara RK, (2009) Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. Schizophrenia research 109: 113-120.
9. Lassek WD, Gaulin SJ, (2011) Sex differences in the relationship of dietary Fatty acids to cognitive measures in american children. Front Evol Neurosci 3: 5.
10. Rao JS, Ertley RN, DeMar JC Jr, Rapoport SI, Bazinet RP, et al. (2007) Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry 12: 151-157.
11. Spector AA (2001) Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J Mol Neurosci 16: 159-165; discussion 215-121.
12. Rapoport SI, Rao JS, Igarashi M, (2007) Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot Essent Fatty Acids 77: 251-261.
13. Hsieh AT, Brenna JT, (2009) Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonates. Prostaglandins Leukot Essent Fatty Acids 81: 105-110.
14. Schaeffer L, Gohlke H, Muller M, Heid IM, Palmer LJ, et al. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15: 1745-1756.
15. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, et al. (2009) Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41: 56-65.
16. Kwak JH, Paik JK, Kim OY, Jang Y, Lee SH, et al. (2011) FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. Atherosclerosis 214: 94-100.
17. Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, et al. (2010) FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. J Lipid Res 51: 2766-2774.
18. Lattka E, Rzehak P, Szabo E, Jakobik V, Weck M, et al. (2011) Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation. Am J Clin Nutr 93: 382-391.
19. Lattka E, Illig T, Koletzko B, Heinrich J, (2010) Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism. Curr Opin Lipidol 21: 64-69.
20. Koletzko B, Lattka E, Zeilinger S, Illig T, Steer C, (2011) Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr 93: 211-219.
21. Tanaka T, Shen J, Abecasis GR, Kisialiou A, Ordovas JM, et al. (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet 5: e1000338.
22. Bokor S, Dumont J, Spinneker A, Gonzalez-Gross M, Nova E, et al. (2010) Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. J Lipid Res 51: 2325-2333.
23. Warensjo E, Rosell M, Hellenius ML, Vessby B, De Faire U, et al. (2009) Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. Lipids Health Dis 8: 37.
24. Marquardt A, Stohr H, White K, Weber BH, (2000) cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66: 175-183.
25. Stohr H, Marquardt A, White K, Weber BH, (2000) cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12->q13.1 which encodes a highly conserved, potential membrane-associated protein. Cytogenet Cell Genet 88: 211-216.
26. Nakamura MT, Nara TY, (2002) Gene regulation of mammalian desaturases. Biochem Soc Trans 30: 1076-1079.
27. Park WJ, Reardon HT, Tyburczy C, Kothapalli KS, Brenna JT, (2010) Alternative splicing generates a novel FADS2 alternative transcript in baboons. Mol Biol Rep 37: 2403-2406.
28. Brenna JT, Kothapalli KS, Park WJ, (2010) Alternative transcripts of fatty acid desaturase (FADS) genes. Prostaglandins Leukot Essent Fatty Acids 82: 281-285.
29. Park WJ, Kothapalli KS, Reardon HT, Kim LY, Brenna JT, (2009) Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing. Gene 446: 28-34.
30. Reardon HT, Park WJ, Zhang J, Lawrence P, Kothapalli KS, et al. (2011) The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition. J Lipid Res 52: 2279-2286.
31. Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer CP, et al. (2012) FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies. Allergy 67: 83-90.
32. Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer CP, et al. (2011) FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children. Clin Exp Allergy 41: 1757-1766.
33. Xie L, Innis SM, (2009) Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study. J Nutrigenet Nutrigenomics 2: 243-250.
34. Lattka E, Illig T, Heinrich J, Koletzko B, (2009) FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics 2: 119-128.
35. Glaser C, Lattka E, Rzehak P, Steer C, Koletzko B, (2011) Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. Matern Child Nutr 7 Suppl 2: 27-40.
36. Morales E, Bustamante M, Gonzalez JR, Guxens M, Torrent M, et al. (2011) Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS One 6: e17181.
37. Diau GY, Hsieh AT, Sarkadi-Nagy EA, Wijendran V, Nathanielsz PW, et al. (2005) The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. BMC Med 3: 11.
38. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
39. Haiman CA, Stram DO, (2008) Utilizing HapMap and tagging SNPs. Methods Mol Med 141: 37-54.
40. Lalovic A, Levy E, Canetti L, Sequeira A, Montoudis A, et al. (2007) Fatty acid composition in postmortem brains of people who completed suicide. J Psychiatry Neurosci 32: 363-370.
41. Folch J, Ascoli I, Lees M, Meath JA, Le BN, (1951) Preparation of lipide extracts from brain tissue. J Biol Chem 191: 833-841.
42. Folch J, Lees M, Sloane Stanley GH, (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509.
43. Lattka E, Eggers S, Moeller G, Heim K, Weber M, et al. (2010) A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. J Lipid Res 51: 182-191.
44. Park WJ, Kothapalli KS, Reardon HT, Lawrence P, Qian SB, et al. (2012) A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. J Lipid Res.
45. Tang B, Capitao C, Dean B, Thomas EA (2012) Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia. Psychiatry Res.
46. Basselin M, Ramadan E, Rapoport SI (2011) Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. Brain Res Bull.
47. Umeda-Sawada R, Fujiwara Y, Ushiyama I, Sagawa S, Morimitsu Y, et al. (2006) Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats. Biosci Biotechnol Biochem 70: 2121-2130.