Metalloprotease-mediated GH receptor proteolysis and GHBP shedding: Determination of extracellular domain stem region cleavage site

Journal of Biological Chemistry

Volumn 277, Issue 52, 2002, Pages 50510-50519

  Wang, Xiangdong ^a   He, Kai ^a   Gerhart, Mary ^b   Huang, Yao ^a   Jiang, Jing ^a   Paxton, Raymond J ^b   Yang, Shaohua ^c   Lu, Chunxia ^c   Menon, Ram K ^c   Black, Roy A ^b   Baumann, Gerhard ^d   Frank, Stuart J ^a,e,f  

^a University of Alabama at Birmingham   (United States)

^b AMGEN INC   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e BIRMINGHAM VA MEDICAL CENTER   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL MEMBRANES; ESTERS; MUTAGENESIS; PROTEINS; SUBSTRATES;

GROWTH HORMONE RECEPTOR;

HORMONES;

GROWTH HORMONE BINDING PROTEIN; GROWTH HORMONE RECEPTOR; METALLOPROTEINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL LINE; CULTURE MEDIA, SERUM-FREE; EXTRACELLULAR SPACE; HUMANS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLASMIDS; RECEPTORS, SOMATOTROPIN; RECOMBINANT PROTEINS; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 0037184959     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208738200     Document Type: Article

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