Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study

Biological Psychiatry

Volumn 83, Issue 1, 2018, Pages 61-69

  Holmes, Sophie E ^a   Hinz, Rainer ^a   Conen, Silke ^a   Gregory, Catherine J ^a   Matthews, Julian C ^a   Anton Rodriguez, Jose M ^a   Gerhard, Alexander ^a,b   Talbot, Peter S ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

^c GREATER MANCHESTER MENTAL HEALTH NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Anterior cingulate; Depression; Inflammation; Microglia; PET; Suicide

Indexed keywords

PROTEIN; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; CARBON; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT; TSPO PROTEIN, HUMAN;

ADULT; ANTERIOR CINGULATE; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXERCISE; FEMALE; HUMAN; IN VIVO STUDY; INFLAMMATION; INSULA; MAJOR DEPRESSION; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SUICIDAL IDEATION; UPREGULATION; VOXEL BASED MORPHOMETRY; BRAIN MAPPING; CINGULATE GYRUS; DIAGNOSTIC IMAGING; METABOLISM; MULTIVARIATE ANALYSIS; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX;

ADULT; BRAIN MAPPING; CARBON RADIOISOTOPES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GYRUS CINGULI; HUMANS; INFLAMMATION; ISOQUINOLINES; MALE; MICROGLIA; MULTIVARIATE ANALYSIS; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; RADIOPHARMACEUTICALS; RECEPTORS, GABA; SEVERITY OF ILLNESS INDEX; SUICIDAL IDEATION;

EID: 85029565119     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2017.08.005     Document Type: Article

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