Brain inflammation and psoriasis: a [11C]-(R)-PK11195 positron emission tomography study

British Journal of Dermatology

Volumn 175, Issue 5, 2016, Pages 1082-1084

  Hunter, H J A ^a   Hinz, R ^a   Gerhard, A ^a   Talbot, P S ^a   Su, Z ^a   Holland, G ^a   Hopkins, S J ^a   Griffiths, C E M ^a   Kleyn, C E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOLIGAND; CARBON; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; DERMATOLOGY LIFE QUALITY INDEX; HUMAN; LETTER; METABOLIC SYNDROME X; NERVOUS SYSTEM INFLAMMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSORIASIS; PSORIASIS AREA AND SEVERITY INDEX; PSORIASIS VULGARIS; PSYCHOMETRY; WAIST CIRCUMFERENCE; ADOLESCENT; ADULT; CHRONIC DISEASE; COMPLICATION; ENCEPHALITIS; FEMALE; MALE; METABOLISM; MIDDLE AGED; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; CARBON RADIOISOTOPES; CHRONIC DISEASE; ENCEPHALITIS; FEMALE; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PSORIASIS; YOUNG ADULT;

EID: 84983781348     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13788     Document Type: Letter

References (15)

1. Griffiths CEM, Barker JNWN. Psoriasis: pathogenesis and clinical features of psoriasis. Lancet 2007; 370:263–71.
2. Dauden E, Castaneda S, Suarez C et al. Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis. J Eur Acad Dermatol Venereol 2013; 27:1387–404.
3. Dowlatshahi EA, Wakkee M, Arends LR et al. The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: a systematic review and meta-analysis. J Invest Dermatol 2014; 134:1542–51.
4. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27:24–31.
5. Thomson CA, McColl A, Cavanagh J et al. Peripheral inflammation is associated with remote global gene expression changes in the brain. J Neuroinflammation 2014; 11:73.
6. Cagnin A, Gerhard A, Banati RB. In vivo imaging of neuroinflammation. Eur Neuropsychopharmacol 2002; 12:581–6.
7. Gerhard A, Pavese N, Hotton G et al. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 2006; 21:404–12.
8. Gerhard A, Schwarz J, Myers R et al. Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study. NeuroImage 2005; 24:591–5.
9. Su Z, Herholz K, Gerhard A et al. [(1)(1)C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches. Eur J Nucl Med Mol Imaging 2013; 40:1406–19.
10. Drake C, Boutin H, Jones MS et al. Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun 2011; 25:1113–22.
11. Hannestad J, Gallezot JD, Schafbauer T et al. Endotoxin-induced systemic inflammation activates microglia: [(1)(1)C]PBR28 positron emission tomography in nonhuman primates. NeuroImage 2012; 63:232–9.
12. Garden GA, Moller T. Microglia biology in health and disease. J Neuroimmune Pharmacol 2006; 1:127–37.
13. Hammers A, Allom R, Koepp MJ et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 2003; 19:224–47.
14. Singh N, Hopkins SJ, Hulme S et al. The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial. J Neuroinflammation 2014; 11:1.
15. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007; 445:866–73.