Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Laker, Rhianna C ^a   Drake, Joshua C ^a   Wilson, Rebecca J ^a   Lira, Vitor A ^a,d   Lewellen, Bevan M ^a   Ryall, Karen A ^a   Fisher, Carleigh C ^a   Zhang, Mei ^a   Saucerman, Jeffrey J ^a   Goodyear, Laurie J ^b   Kundu, Mondira ^c   Yan, Zhen ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SERINE; SERINE THREONINE PROTEIN KINASE ULK1; TYROSINE;

ADAPTATION; CELLS AND CELL COMPONENTS; CHEMICAL REACTION; ENZYME; INDUCED RESPONSE; MITOCHONDRION; MUSCLE; OXIDATIVE STRESS; PROTEIN;

ADAPTATION; ADULT; AMPK SIGNALING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; IN VIVO STUDY; LYSOSOME; MALE; METABOLIC REGULATION; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PMITOTIMER GENE; PROTEIN PHOSPHORYLATION; REPORTER GENE; SKELETAL MUSCLE; TREADMILL EXERCISE; ANIMAL; C57BL MOUSE; CHEMISTRY; ENZYMOLOGY; EXERCISE; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PROTEIN MOTIF;

MUS;

AMINO ACID MOTIFS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; EXERCISE; HUMANS; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MUSCLE, SKELETAL; OXIDATIVE STRESS; PHOSPHORYLATION;

EID: 85029481023     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00520-9     Document Type: Article

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